The psychiatric GWAS consortium: big science comes to psychiatry.
paper
Cited
Public
- Authors
- Sullivan, Patrick F
- Year
- 2010
- Journal
- Neuron
- PMID
- 20955924
- DOI
- 10.1016/j.neuron.2010.10.003
- PMCID
- PMC2991765
The Psychiatric GWAS Consortium was founded with the aim of conducting statistically rigorous and comprehensive GWAS meta-analyses for five major psychiatric disorders: ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia. In the era of GWAS and high-throughput genomics, a major trend has been the emergence of collaborative, consortia approaches. Taking advantage of the scale that collaborative consortia approaches can bring to a problem, the PGC has been a major driver in psychiatric genetics and provides a model for how similar approaches may be applied to other disease communities.
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| # | Section | Preview |
|---|---|---|
| 20 | The practical side of the PGC | The PGC encourages a responsible approach to management of intellectual property derived from⦠|
| 21 | The practical side of the PGC | Finally, all PGS members were required to share the commitment to protect the confidentiality of⦠|
| 22 | How can genetics inform neurobiology? | The fundamental goal of the PGC is to derive βmapsβ of the genetic architecture for the majorβ¦ |
| 23 | How can genetics inform neurobiology? | For scientists who study processes fundamental to the development of the central nervous system and⦠|
| 24 | How can genetics inform neurobiology? | It has now been widely observed that GWAS findings only infrequently implicate the βusualβ¦ |
| 25 | How can genetics inform neurobiology? | Historically, there has been a gap between psychiatric genetics and neuroscience. In an idealized⦠|
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21β26 of 26
| Name | Type |
|---|---|
| ADHD | phenotype |
| age-related macular degeneration | phenotype |
| anorexia nervosa | phenotype |
| AUT | phenotype |
| autism | phenotype |
| BiP | phenotype |
| bipolar disorder | phenotype |
| central nervous system | anatomy |
| CFH | gene |
| consortia | cohort |
| copy number variation | variant |
| Crohn's disease | phenotype |
| dbGaP | cohort |
| genetic loci | cohort |
| genetic variants | cohort |
| HapMap3 | cohort |
| major depressive disorder | phenotype |
| Major histocompatibility region local | gene |
| mega-analysis results local | drug |
| mood disorders | phenotype |
| next-generation sequencing data | drug |
| obsessive-compulsive disorder | phenotype |
| PGC | cohort |
| PGs | drug |
| phenotype | phenotype |
| psychiatric disorders | phenotype |
| Psychiatric Genome-Wide Association Consortium local | cohort |
| schizophrenia | phenotype |
| SCZ | phenotype |
| SNP | cohort |
| type 2 diabetes | phenotype |
| working groups local | cohort |
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