Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study.
- Authors
- Perez de los Cobos, Jose; Baiget, Montserrat; Trujols, Joan; Sinol, Nuria; Volpini, Victor; Banuls, Enrique; Calafell, Francesc; Luquero, Elena; del Rio, Elisabeth; Alvarez, Enric
- Year
- 2007
- Journal
- Behavioral and brain functions : BBF
- PMID
- 17543096
- DOI
- 10.1186/1744-9081-3-25
- PMCID
- PMC1892032
BACKGROUND: Conflicting associations with heroin dependence have been found involving the A1 allele of dopamine D2 receptor gene (DRD2) TaqI A polymorphism. METHODS: We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients (207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects (98 males and 47 females). RESULTS: The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls (P = 0.011, odds ratio = 5.48, 95% CI 1.26-23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls (24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07-2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender (odds ratio = 1.77, 95% CI 1.15-2.70). CONCLUSION: Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males.
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| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
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| Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. | Levran O et al. | — | 2015 | → |
| A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. | Spellicy CJ et al. | — | 2014 | → |
| Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants. | Levran O et al. | — | 2014 | → |
| ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. | Spellicy CJ et al. | — | 2013 | → |
| ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. | Nelson EC et al. | — | 2013 | → |
| Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction. | Mehić-Basara N et al. | — | 2013 | → |
| HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations. | Jacobs MM et al. | — | 2013 | → |
| Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. | Vereczkei A et al. | — | 2013 | → |
| The aldehyde dehydrogenase 2 gene is associated with heroin dependence. | Wang TY et al. | — | 2012 | → |
| Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies. | Chen D et al. | — | 2011 | → |
| Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. | Blum K et al. | — | 2011 | → |
| Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. | Lohoff FW et al. | — | 2010 | → |
| Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample. | López-Castromán J et al. | — | 2009 | → |
| Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. | Doehring A et al. | — | 2009 | → |
| Genetics of dopamine receptors and drug addiction: a comprehensive review. | Le Foll B et al. | — | 2009 | → |
| Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. | Doehring A et al. | — | 2009 | → |
| Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). | Blum K et al. | — | 2009 | → |
| The ANKK1 kinase gene and psychiatric disorders. | Ponce G et al. | — | 2009 | → |
| The interaction of DRD2 and violent victimization on depression: an analysis by gender and race. | Vaske J et al. | — | 2009 | → |
| Environmental contingencies and genetic propensities: social capital, educational continuation, and dopamine receptor gene DRD2. | Shanahan MJ et al. | — | 2008 | → |
| Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. | Verdejo-García A et al. | — | 2008 | → |