Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study.
paper
Cited
Public
- Authors
- Perez de los Cobos, Jose; Baiget, Montserrat; Trujols, Joan; Sinol, Nuria; Volpini, Victor; Banuls, Enrique; Calafell, Francesc; Luquero, Elena; del Rio, Elisabeth; Alvarez, Enric
- Year
- 2007
- Journal
- Behavioral and brain functions : BBF
- PMID
- 17543096
- DOI
- 10.1186/1744-9081-3-25
- PMCID
- PMC1892032
BACKGROUND: Conflicting associations with heroin dependence have been found involving the A1 allele of dopamine D2 receptor gene (DRD2) TaqI A polymorphism. METHODS: We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients (207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects (98 males and 47 females). RESULTS: The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls (P = 0.011, odds ratio = 5.48, 95% CI 1.26-23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls (24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07-2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender (odds ratio = 1.77, 95% CI 1.15-2.70). CONCLUSION: Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males.
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| # | Section | Preview |
|---|---|---|
| 20 | Abbreviations | SUD: substance use disorders |
| 21 | Competing interests | The author(s) declare that they have no competing interests. |
| 22 | Authors' contributions | JP made substantial contributions to the conception and design of the study, the interpretation of⦠|
| 23 | Authors' contributions | JT made substantial contributions to the conception and design of the study, assisted with the⦠|
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