International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

paper Cited Public

Authors: Nievergelt, Caroline M; Maihofer, Adam X; Klengel, Torsten; Atkinson, Elizabeth G; Chen, Chia-Yen; Choi, Karmel W; Coleman, Jonathan R I; Dalvie, Shareefa; Duncan, Laramie E; Gelernter, Joel; Levey, Daniel F; Logue, Mark W; Polimanti, Renato; Provost, Allison C; Ratanatharathorn, Andrew; Stein, Murray B; Torres, Katy; Aiello, Allison E; Almli, Lynn M; Amstadter, Ananda B; Andersen, Søren B; Andreassen, Ole A; Arbisi, Paul A; Ashley-Koch, Allison E; Austin, S Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G; Beckham, Jean C; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Børglum, Anders D; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A; Bustamante, Angela C; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R; Caldas-de-Almeida, José M; Dale, Anders M; Daly, Mark J; Daskalakis, Nikolaos P; Deckert, Jürgen; Delahanty, Douglas L; Dennis, Michelle F; Disner, Seth G; Domschke, Katharina; Dzubur-Kulenovic, Alma; Erbes, Christopher R; Evans, Alexandra; Farrer, Lindsay A; Feeny, Norah C; Flory, Janine D; Forbes, David; Franz, Carol E; Galea, Sandro; Garrett, Melanie E; Gelaye, Bizu; Geuze, Elbert; Gillespie, Charles; Uka, Aferdita Goci; Gordon, Scott D; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; Hauser, Michael A; Heath, Andrew C; Hemmings, Sian M J; Hougaard, David Michael; Jakovljevic, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Junglen, Angela G; Karstoft, Karen-Inge; Kaufman, Milissa L; Kessler, Ronald C; Khan, Alaptagin; Kimbrel, Nathan A; King, Anthony P; Koen, Nastassja; Kranzler, Henry R; Kremen, William S; Lawford, Bruce R; Lebois, Lauren A M; Lewis, Catrin E; Linnstaedt, Sarah D; Lori, Adriana; Lugonja, Bozo; Luykx, Jurjen J; Lyons, Michael J; Maples-Keller, Jessica; Marmar, Charles; Martin, Alicia R; Martin, Nicholas G; Maurer, Douglas; Mavissakalian, Matig R; McFarlane, Alexander; McGlinchey, Regina E; McLaughlin, Katie A; McLean, Samuel A; McLeay, Sarah; Mehta, Divya; Milberg, William P; Miller, Mark W; Morey, Rajendra A; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B; Neale, Benjamin M; Nelson, Elliot C; Nordentoft, Merete; Norman, Sonya B; O'Donnell, Meaghan; Orcutt, Holly K; Panizzon, Matthew S; Peters, Edward S; Peterson, Alan L; Peverill, Matthew; Pietrzak, Robert H; Polusny, Melissa A; Rice, John P; Ripke, Stephan; Risbrough, Victoria B; Roberts, Andrea L; Rothbaum, Alex O; Rothbaum, Barbara O; Roy-Byrne, Peter; Ruggiero, Ken; Rung, Ariane; Rutten, Bart P F; Saccone, Nancy L; Sanchez, Sixto E; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V; Seng, Julia S; Sheerin, Christina M; Silove, Derrick; Smith, Alicia K; Smoller, Jordan W; Sponheim, Scott R; Stein, Dan J; Stevens, Jennifer S; Sumner, Jennifer A; Teicher, Martin H; Thompson, Wesley K; Trapido, Edward; Uddin, Monica; Ursano, Robert J; van den Heuvel, Leigh Luella; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A; Williamson, Douglas E; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J; Wolff, Jonathan D; Yehuda, Rachel; Young, Ross McD; Young, Keith A; Zhao, Hongyu; Zoellner, Lori A; Liberzon, Israel; Ressler, Kerry J; Haas, Magali; Koenen, Karestan C
Year: 2019
Journal: Nature communications
PMID: 31594949
DOI: 10.1038/s41467-019-12576-w
PMCID: PMC6783435

Fig. 1

Manhattan plots from meta-analyses of PTSD GWAS, showing the top variants in six independent genome-wide significant loci. Results are shown for subjects of European (EUA; a) and African ancestry (AFA; c), and for sex-stratified analyses in EUA men (b) and AFA men (d), respectively. Sex-stratified analyses for women were not significant (Supplementary Fig. 4). The red line represents genome-wide significance at P < 5 × 10−8. Note: rs148757321 and rs142174523 do not remain significant after Bonferroni-adjustment for sex-stratified analyses (at P < 1.67 × 10−8)

LLM interpretation

This figure consists of four Manhattan plots (a-d) showing the results of PTSD GWAS meta-analyses for European ancestry (EUA; a, b) and African ancestry (AFA; c, d) populations, with (b) and (d) specifically representing men. The x-axes represent chromosomal positions and the y-axes represent $-\log_{10}(p\text{-value})$, with a red horizontal line indicating the genome-wide significance threshold at $P < 5 \times 10^{-8}$. Several top variants are highlighted in red and labeled with their rsIDs, showing significant peaks on different chromosomes across the four groups.

Fig. 2

Genetic risk score (PRS) predictions for PTSD. a Using PTSD subjects from the UK Biobank (UKB) as discovery sample, odds ratios (OR) for PTSD per PRS quintile relative to the first quintile show a significant increase in different PGC PTSD target samples. For example, UKB men in the 5th quintile have 40% higher odds to develop PTSD than UKB men in the lowest quintile, when using women from the same population as a training set. b PRS predictions of re-experiencing symptoms in the external replication cohort from the Million Veteran Program (MVP) using the overall PGC2 as discovery sample show a highly significant increase in PTSD re-experiencing symptoms per PRS quintile. Sample sizes in different training and target sets include: UKB women: 6845 PTSD, 64,099 controls; UKB men: 3,544 PTSD, 51,700 controls; UKB: 10,389 PTSD, 115,799 controls; PGC1.5: 10,213 PTSD, 27,445 controls; PGC2: 23,212 PTSD, 151,447 controls; MVP: 146,660 participants with re-experiencing symptoms assessments. Analyses include only subjects of European ancestry

LLM interpretation

This figure consists of two dot plots with error bars showing the relationship between polygenic risk score (PRS) quintiles and PTSD risk or symptoms. Panel (a) displays quintile odds ratios (95% CI) for three training-to-target combinations (UKB women $\rightarrow$ UKB men, UKB men $\rightarrow$ UKB women, and UKB $\rightarrow$ PGC 1.5), all showing an upward trend in odds as the PRS quintile increases. Panel (b) shows the quintile beta (95% CI) for the PGC2 $\rightarrow$ MVP training-to-target set, demonstrating a steady increase in re-experiencing symptoms across the five PRS quintiles.

Fig. 3

Commonality of genetic correlations between PTSD and other psychiatric disorders and traits with GWAS summary statistics on LD Hub. Psychiatric traits include a PTSD, b MDD, c SCZ, d BPD and e ADHD and their genetic correlations with traits from psychiatric, anthropomorphic, smoking behavior, reproductive, aging, education, autoimmune and cardiometabolic categories. Only traits with at least one significant correlation with the 5 psychiatric disorders are shown. Error bars indicate 95% confidence limits. Solid points indicate significant correlation after Bonferroni correction. The total number of correlations tested were 235 for PTSD, 221 for MDD, 172 for SCZ, 196 for BPD and 219 for ADHD

LLM interpretation

This figure consists of five forest plots (a-e) showing the genetic correlations ($r_g$) between five psychiatric disorders (PTSD, MDD, SCZ, BPD, and ADHD) and various traits categorized by color. The x-axis represents the genetic correlation coefficient ranging from -1.0 to 1.0, while the y-axis lists the traits. Solid points indicate correlations that are significant after Bonferroni correction, with error bars representing 95% confidence limits.

#	Section	Preview
80	Methods — Conditional analyses to test for disease specific effects	Mendelian randomization analysis of significant LD independent psychiatric trait SNPs (r2 < 0.05,…
81	Methods — Reporting summary	Further information on research design is available in the Nature Research Reporting Summary linked…
82	Supplementary information	Supplementary Information Dataset 1 Dataset 2 Dataset 3 Reporting Summary Description of Additional…

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Causal associations between posttraumatic stress disorder and type 2 diabetes.	Song Y et al.	—	2025	→
Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study.	Gao Y et al.	—	2025	→
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.	Yao X et al.	—	2025	→
Childhood maltreatment and mental health: causal links to depression, anxiety, non-fatal self-harm, suicide attempts, and PTSD.	Zhang Z et al.	—	2025	→
Childhood trauma and subclinical hypomania in early adulthood: A genetically informative study.	Gonzalez-Calvo I et al.	—	2025	→
Chronic overlapping pain conditions and nociplastic pain.	Johnston KJA et al.	—	2025	→
Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder.	Barr PB et al.	—	2025	→
Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits.	Miller AK et al.	—	2025	→
Estudio De La Vida Bajo Estres: Methodological Overview and Baseline Data Analysis of a Case-Control Investigation of Risk and Resiliency Factors for Traumatic Stress in Colombia.	Robinson M et al.	—	2025	→
Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach.	Prapiadou S et al.	—	2025	→
Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders.	Song Q et al.	—	2025	→
Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.	Deng WQ et al.	—	2025	→
Extinction of Contextual Fear Memory and Passive Avoidance Memory and Subsequent Anxiety-like and Depressive-like Behavior of A53T and A53T-L444P Mice.	Bunnell E et al.	—	2025	→
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice.	van Doeselaar L et al.	—	2025	→
General practitioners' knowledge of psychotraumatism in Burkina Faso in a context of security challenges.	Sawadogo KCC et al.	—	2025	→
Genetic architecture of RNA editing, splicing and gene expression in schizophrenia.	Choudhury M et al.	—	2025	→
Genetic causal effects of multi-site chronic pain on post-traumatic stress disorder: Evidence from a two-sample, two-step Mendelian randomization study.	Wang Z et al.	—	2025	→
Genetic insights into the role of mitochondria-related genes in mental disorders: An integrative multi-omics analysis.	Lu Y et al.	—	2025	→
Genetic predisposition for negative affect predicts mental health burden during the COVID-19 pandemic.	Schowe AM et al.	—	2025	→
Genetic predisposition to digital device use and the risk of five psychiatric disorders.	Liu Q et al.	—	2025	→
Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis.	Abudusalamu R et al.	—	2025	→
Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.	Petrican R et al.	—	2025	→
[Genetic variants associated with the development of stress disorders: A systematic review of GWAS].	Zorkina YA et al.	—	2025	→
Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders.	Gong W et al.	—	2025	→
Human blood metabolites and risk of post-traumatic stress disorder: A Mendelian randomization study.	Wei Y et al.	—	2025	→
Immune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis.	Yang J et al.	—	2025	→
Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study.	Xiang L et al.	—	2025	→
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.	Seah C et al.	—	2025	→
Innovations in Meta-Analytic and Computational Methods in the Neuroscientific Investigation of Psychiatric and Neurological Disorders.	Miller CH et al.	—	2025	→
Integrating brain imaging features and genomic profiles for the subtyping of major depression.	Yin L et al.	—	2025	→
Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders.	Ding H et al.	—	2025	→
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood.	Allegrini AG et al.	—	2025	→
In the genetics of the beholder: gene-environment interplay for internalising and externalising behaviours using polygenic scores and adolescent perceptions of parenting.	Rainy NR et al.	—	2025	→
Investigating shared risk variants and genetic etiology between Alzheimer's disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis.	Dang W et al.	—	2025	→
Investigating the molecular 'scars' of PTSD in the human brain.	Marroquin Rivera A et al.	—	2025	→
Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons.	Goes FS et al.	—	2025	→
Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain.	Jajoo A et al.	—	2025	→
Mapping the cellular etiology of schizophrenia and complex brain phenotypes.	Duncan LE et al.	—	2025	→
Mediating Role of Trauma Connecting Psychiatric Family History and Adolescent Mental Health.	Chaiyachati BH et al.	—	2025	→
Merkel cell stimulation in fear and sensory signaling.	Korgan AC et al.	—	2025	→
Methodological and Interpretational Issues in the PsyRiskMR Database.	Zhao J	—	2025	→
Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach.	Liu D et al.	—	2025	→
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.	Johnson EC et al.	—	2025	→
New Insights into Complex PTSD Treatment: Focus on TAAR1 Agonists.	Tseilikman DV et al.	—	2025	→
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches.	Höffler KD et al.	—	2025	→
Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des résultats du traitement antidépresseur à l'aide des scores de risque polygéniques : Rapport sur l'étude CAN-BIND-1.	Magarbeh L et al.	—	2025	→
Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.	Brewin CR et al.	—	2025	→
Preliminary Insights Into the Relationship Between the Gut Microbiome and Host Genome in Posttraumatic Stress Disorder.	O'Hare MA et al.	—	2025	→
Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches.	Lund IO et al.	—	2025	→
Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research.	Kalungi A et al.	—	2025	→
Psychiatric genetics in the diverse landscape of Latin American populations.	Bruxel EM et al.	—	2025	→
PTSD and epigenetic aging: a longitudinal meta-analysis.	Zhao X et al.	—	2025	→
Remembering and forgetting: A dynamic social retrieval theory of posttraumatic stress.	Zoellner LA et al.	—	2025	→
Risk and Protective Factors in Dancers Exposed to Trauma.	Thomson P et al.	—	2025	→
Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.	Moo-Choy A et al.	—	2025	→
Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus.	Guo X et al.	—	2025	→
Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis.	Li G et al.	—	2025	→
Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.	Liu A et al.	—	2025	→
Stress dynamics that maintain posttraumatic stress disorder across 20 years.	Ringwald WR et al.	—	2025	→
The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study.	Wu C et al.	—	2025	→
The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis.	Zhao L et al.	—	2025	→
The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years.	Olff M et al.	—	2025	→
The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes.	Gui Y et al.	—	2025	→
Transcranial magnetic stimulation for obsessive-compulsive disorder and post-traumatic stress disorder: A comprehensive systematic review and analysis of therapeutic benefits, cortical targets, and psychopathophysiological mechanisms.	Vicheva P et al.	—	2025	→
Unraveling the shared genetic foundations of neurodevelopmental and psychiatric disorders: Insights from comprehensive genome-wide analyses.	Maimaiti A et al.	—	2025	→
Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders.	Liwayiding A et al.	—	2025	→
A Baseline Model of PTSD From the ACES Cohort.	Millington DJ et al.	—	2024	→
A concerted neuron-astrocyte program declines in ageing and schizophrenia.	Ling E et al.	—	2024	→
An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD.	Miller MW et al.	—	2024	→
Approaches to enable equitable psychiatric genetic research in Africa.	Kalungi A et al.	—	2024	→
Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization.	Mi C et al.	—	2024	→
Association of air pollutants with psychiatric disorders: a two-sample Mendelian randomization.	Ma YY et al.	—	2024	→
Association of Chronic Obstructive Pulmonary Disease with Risk of Psychiatric Disorders: A Two-Sample Mendelian Randomization Study.	Zhang Q et al.	—	2024	→
Associations among Trauma Exposure, Post-Traumatic Stress Symptoms and Alcohol Use in Black/African American Treatment-Seeking Adults.	Moskal D et al.	—	2024	→
Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury.	Edwards AC et al.	—	2024	→
Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder.	Song Y et al.	—	2024	→
Causal Associations between Posttraumatic Stress Disorder and COVID-19.	Baranova A et al.	—	2024	→
Causal influences of neuropsychiatric disorders on Alzheimer's disease.	Baranova A et al.	—	2024	→
Causal Relationship Between Post-Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study.	Wang J et al.	—	2024	→
Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.	Wang S et al.	—	2024	→
Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects.	Montgomery KR et al.	—	2024	→
Clinical associations with treatment resistance in depression: An electronic health record study.	Coombes BJ et al.	—	2024	→
Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes.	Li M et al.	—	2024	→
Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome.	Hicks EM et al.	—	2024	→
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.	Bigdeli TB et al.	—	2024	→
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.	Johnson EC et al.	—	2024	→
Decoding Sex Differences in PTSD Heritability: A Comprehensive Twin Study.	Katrinli S et al.	—	2024	→
Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.	Vilar-Ribó L et al.	—	2024	→
Dissecting the genetic and causal relationship between sleep-related traits and common brain disorders.	Xue B et al.	—	2024	→
Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records.	Løkhammer S et al.	—	2024	→
DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study.	Schuurmans IK et al.	—	2024	→
Early biological and psychosocial factors associated with PTSD onset and persistence in youth.	Williams KC et al.	—	2024	→
Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes.	Maihofer AX et al.	—	2024	→
Effects of sex and gender on the etiologies and presentation of select internalizing psychopathologies.	Singh K et al.	—	2024	→
Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese.	Xu L et al.	—	2024	→
Evidence for strong genetic correlations among internalizing psychopathology and related self-reported measures using both genomic and twin/adoptive approaches.	Gustavson DE et al.	—	2024	→
Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits.	Mize TJ et al.	—	2024	→
Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood.	Breunig S et al.	—	2024	→
Executive Function and Impulsivity Predict Distinct Genetic Variance in Internalizing Problems, Externalizing Problems, Thought Disorders, and Compulsive Disorders: A Genomic Structural Equation Modeling Study.	Gustavson DE et al.	—	2024	→
Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study.	Jácome-Ferrer P et al.	—	2024	→
Fibroblasts as an in vitro model of circadian genetic and genomic studies.	Francia M et al.	—	2024	→
Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study.	Xu WM et al.	—	2024	→
Genetic architecture distinguishes tinnitus from hearing loss.	Clifford RE et al.	—	2024	→
Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.	Ning C et al.	—	2024	→
Genetic association between post-traumatic stress disorder and cardiovascular disease: A scoping review.	Lim A et al.	—	2024	→
Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?	Iakunchykova O et al.	—	2024	→
Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes.	Pathak GA et al.	—	2024	→
Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci.	Lori A et al.	—	2024	→
Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts.	Kals M et al.	—	2024	→
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.	Nievergelt CM et al.	—	2024	→
Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems.	Hannigan LJ et al.	—	2024	→
Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?	Patas K et al.	—	2024	→
Interaction of Brain-derived Neurotrophic Factor, Exercise, and Fear Extinction: Implications for Post-traumatic Stress Disorder.	Antolasic EJ et al.	—	2024	→
Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization.	Marchi M et al.	—	2024	→
Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs.	Modestino EJ et al.	—	2024	→
Lifestyle Factors Counteract the Neurodevelopmental Impact of Genetic Risk for Accelerated Brain Aging in Adolescence.	Petrican R et al.	—	2024	→
Longitudinal method comparison: modeling polygenic risk for post-traumatic stress disorder over time in individuals of African and European ancestry.	Passero K et al.	—	2024	→
Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study.	Hui J et al.	—	2024	→
Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.	Chakrabarty A et al.	—	2024	→
Neurobiology and Treatment of Posttraumatic Stress Disorder.	Shalev A et al.	—	2024	→
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder.	Andrade-Brito DE et al.	—	2024	→
Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis.	You Z et al.	—	2024	→
Nightmares share genetic risk factors with sleep and psychiatric traits.	Ollila HM et al.	—	2024	→
No Replication of Alzheimer's Disease Genetics as a Moderator of Combat Exposure's Association with PTSD risk in 138,592 Combat Veterans.	Wolf EJ et al.	—	2024	→
Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study.	Liu H et al.	—	2024	→
Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins.	Shah AJ et al.	—	2024	→
[Posttraumatic stress disorder clinical guidelines and treatment standards: focus on the symptoms of the psychophysiological arousal].	Vasileva AV	—	2024	→
Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions - a review.	Davis LL et al.	—	2024	→
Potential causal association between gut microbiome and posttraumatic stress disorder.	He Q et al.	—	2024	→
Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health.	Lv Y et al.	—	2024	→
Prediction of post-traumatic stress disorder in family members of ICU patients: a machine learning approach.	Dupont T et al.	—	2024	→
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation.	Carey CE et al.	—	2024	→
PTSD biomarkers: Neuroendocrine signaling to epigenetic variants.	Sbisa A et al.	—	2024	→
Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis.	Suo X et al.	—	2024	→
Seven psychiatric traits and the risk of increased carotid intima-media thickness: a Mendelian randomization study.	He K et al.	—	2024	→
Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses.	Xu Z et al.	—	2024	→
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.	Daskalakis NP et al.	—	2024	→
Testing Quantitative and Qualitative Sex Effects in a National Swedish Twin-Sibling Study of Posttraumatic Stress Disorder.	Amstadter AB et al.	—	2024	→
The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.	Cabrera-Mendoza B et al.	—	2024	→
The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault.	Bugiga AVG et al.	—	2024	→
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.	Zaretsky TG et al.	—	2024	→
The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis.	Liu Y et al.	—	2024	→
The shared genetic etiology of antisocial behavior and psychiatric disorders: Insights from pleiotropy and causality analysis.	Wang S et al.	—	2024	→
The structure of psychiatric comorbidity without selection and assortative mating.	Ayorech Z et al.	—	2024	→
The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function.	Jiang W et al.	—	2024	→
Topologically associating domains define the impact of de novo promoter variants on autism spectrum disorder risk.	Nakamura T et al.	—	2024	→
Transcriptomic Evaluation of a Stress Vulnerability Network Using Single-Cell RNA Sequencing in Mouse Prefrontal Cortex.	Hing B et al.	—	2024	→
Unveiling ancestral threads: Exploring CCR5 ∆32 mutation frequencies in Colombian populations for HIV/AIDS therapeutics.	Barrios-Navas A et al.	—	2024	→
Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing.	Petrican R et al.	—	2023	→
Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies.	Womersley JS et al.	—	2023	→
Altered Fear Behavior in Aeroallergen House Dust Mite Exposed C57Bl/6 Mice: A Model of Th2-skewed Airway Inflammation.	Allgire E et al.	—	2023	→
Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort	Dahrendorff J et al.	—	2023	—
Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort.	Dahrendorff J et al.	—	2023	→
A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data.	Zheng Y et al.	—	2023	→
A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder.	Lewis BR et al.	—	2023	→
Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.	Zeamer AL et al.	—	2023	→
Associations between brain gene expression perturbations implicated by COVID-19 and psychiatric disorders.	Gao Y et al.	—	2023	→
Associations of polygenic risk scores with posttraumatic stress symptom trajectories following combat deployment.	Campbell-Sills L et al.	—	2023	→
A statistical genetic investigation of psychiatric resilience.	Cusack SE et al.	—	2023	→
Biological Embedding of Early-Life Adversity and a Scoping Review of the Evidence for Intergenerational Epigenetic Transmission of Stress and Trauma in Humans.	Zhou A et al.	—	2023	→
Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.	Yu Y et al.	—	2023	→
Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study.	Yang X et al.	—	2023	→
Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis.	Li B et al.	—	2023	→
Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study.	Lu T et al.	—	2023	→
Common genetic variants contribute to heritability of age at onset of schizophrenia.	Sada-Fuente E et al.	—	2023	→
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions.	Pergola G et al.	—	2023	→
Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review.	Núñez-Rios DL et al.	—	2023	→
Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes.	Bountress KE et al.	—	2023	→
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.	Waszczuk MA et al.	—	2023	→
Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study.	Zhao H et al.	—	2023	→
Dissecting the causal association between inflammation and post-traumatic stress disorder: A bidirectional Mendelian randomization study.	Zuo C et al.	—	2023	→
General <i>v</i>. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study.	Waszczuk MA et al.	—	2023	→
Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.	Zeng Y et al.	—	2023	→
Genetic liability to mental disorders in relation to the risk of hypertension.	Huangfu N et al.	—	2023	→
Genetic liability to posttraumatic stress disorder and its association with postpartum depression.	Bang Madsen K et al.	—	2023	→
Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus.	Wang J et al.	—	2023	→
Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults.	Hayes JP et al.	—	2023	→
Genetics and epigenetics of stress: New avenues for an old concept.	Soliva-Estruch M et al.	—	2023	→
Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.	Ashley-Koch AE et al.	—	2023	→
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.	Saenz de Viteri S et al.	—	2023	→
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.	Docherty AR et al.	—	2023	→
High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders.	Penner-Goeke S et al.	—	2023	→
Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.	Kimbrel NA et al.	—	2023	→
Identifying genetic loci that are associated with changes in gene expression in PTSD in a South African cohort.	Swart PC et al.	—	2023	→
Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information.	Gedik H et al.	—	2023	→
Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank.	Mollon J et al.	—	2023	→
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk.	Powell SK et al.	—	2023	→
Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders.	Chen M et al.	—	2023	→
Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis.	Zhou S et al.	—	2023	→
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain.	Bhattacharya A et al.	—	2023	→
Machine learning within the Parkinson's progression markers initiative: Review of the current state of affairs.	Gerraty RT et al.	—	2023	→
Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits.	Toste CC et al.	—	2023	→
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder.	Sudre G et al.	—	2023	→
Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects.	Ayorech Z et al.	—	2023	→
Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders.	Chen W et al.	—	2023	→
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.	Guintivano J et al.	—	2023	→
Methyl-CpG binding protein 2 expression is associated with symptom severity in patients with PTSD in a sex-dependent manner.	Cosentino L et al.	—	2023	→
Methylome-wide association study of anxiety disorders.	Hettema JM et al.	—	2023	→
Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.	Muhie S et al.	—	2023	→
No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.	Mattonet K et al.	—	2023	→
Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry.	Restrepo-Lozano JM et al.	—	2023	→
Outpatient Pharmacogenomic Screenings to Prevent Addiction, Overdose, and Suicide.	Yarlagadda A et al.	—	2023	→
Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.	Petrican R et al.	—	2023	→
Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women.	Maslahati T et al.	—	2023	→
Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution.	Grotzinger AD et al.	—	2023	→
Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.	Stein MB et al.	—	2023	→
Polygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress Disorder and Hippocampal Subregion Volumes in Middle Childhood.	Pine JG et al.	—	2023	→
Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort.	Duncan L et al.	—	2023	→
Post-Traumatic Stress Disorder and Risk of Degenerative Synucleinopathies: Systematic Review and Meta-Analysis.	Jones MB et al.	—	2023	→
Potential oxidative stress related targets of mitochondria-focused therapy of PTSD.	Kmita H et al.	—	2023	→
Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.	Gong W et al.	—	2023	→
Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder.	Hiscox LV et al.	—	2023	→
Shared genetic influences on depression and menopause symptoms.	Meijsen JJ et al.	—	2023	→
Sleep Health at the Genomic Level: Six Distinct Factors and Their Relationships With Psychopathology.	Morrison CL et al.	—	2023	→
Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders.	Seah C et al.	—	2023	→
The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice.	Rodriguez LA et al.	—	2023	→
The genetic architecture of human amygdala volumes and their overlap with common brain disorders.	Ou YN et al.	—	2023	→
The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation.	Xiao L et al.	—	2023	→
The link between post-traumatic stress disorder and systemic lupus erythematosus.	Goldschen L et al.	—	2023	→
The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.	Wendt FR et al.	—	2023	→
Trauma Matters: Integrating Genetic and Environmental Components of PTSD.	Marchese S et al.	—	2023	→
Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.	Martin E et al.	—	2023	→
Adiponectin gene polymorphisms and posttraumatic stress disorder symptoms among female rape survivors: an exploratory study.	Vuong E et al.	—	2022	→
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci.	Kimbrel NA et al.	—	2022	→
Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach.	Bountress KE et al.	—	2022	→
Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort.	Weber H et al.	—	2022	→
Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study.	Bustamante D et al.	—	2022	→
Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study.	Tamman AJF et al.	—	2022	→
Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder.	Zhang Z et al.	—	2022	→
Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.	Núñez-Rios DL et al.	—	2022	→
Detecting genetic heterogeneities in response to trauma: The case of 9/11.	Furuya S et al.	—	2022	→
Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.	Maihofer AX et al.	—	2022	→
Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.	Coon H et al.	—	2022	→
FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin.	Qiu B et al.	—	2022	→
Genetic and Social-Environmental Influences on Posttraumatic Stress Disorder.	Lawn RB	—	2022	→
Genetic correlation and causality assessment between post-traumatic stress disorder and coronary artery disease-related traits.	Akosile W et al.	—	2022	→
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders.	Reay WR et al.	—	2022	→
Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder.	Zhang F et al.	—	2022	→
Genetics in psychiatry: Methods, clinical applications and future perspectives.	Fabbri C	—	2022	→
Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders.	Okhuijsen-Pfeifer C et al.	—	2022	→
Genome-wide association study of posttraumatic stress disorder among childhood cancer survivors: results from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.	Lu D et al.	—	2022	→
How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID).	Kennedy HL et al.	—	2022	→
Identifying pleiotropic genes for complex phenotypes with summary statistics from a perspective of composite null hypothesis testing.	Wang T et al.	—	2022	→
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.	Werner MCF et al.	—	2022	→
Immunogenetics of posttraumatic stress disorder (PTSD) in women veterans.	James LM et al.	—	2022	→
Infection Polygenic Factors Account for a Small Proportion of the Relationship Between Infections and Mental Disorders.	Shorter JR et al.	—	2022	→
Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder.	Wingo TS et al.	—	2022	→
Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study.	Liu D et al.	—	2022	→
Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women.	Schultebraucks K et al.	—	2022	→
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation.	Dunsmoor JE et al.	—	2022	→
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores.	Weissbrod O et al.	—	2022	→
Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy.	Seligowski AV et al.	—	2022	→
Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease.	Venkateswaran S et al.	—	2022	→
MicroRNA binding site variation is enriched in psychiatric disorders.	Geaghan MP et al.	—	2022	→
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.	Seah C et al.	—	2022	→
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.	Velasco ER et al.	—	2022	→
Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.	Kiewa J et al.	—	2022	→
Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD).	Magwai T et al.	—	2022	→
Polygenic prediction of PTSD trajectories in 9/11 responders.	Waszczuk MA et al.	—	2022	→
Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events.	Wendt FR et al.	—	2022	→
Posttraumatic Stress Disorder Brain Transcriptomics: Convergent Genomic Signatures Across Biological Sex.	Wang J et al.	—	2022	→
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.	Ressler KJ et al.	—	2022	→
Post-traumatic stress disorder in the Canadian Longitudinal Study on Aging: A genome-wide association study.	Zai CC et al.	—	2022	→
Prefrontal cortex, amygdala, and threat processing: implications for PTSD.	Alexandra Kredlow M et al.	—	2022	→
Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study.	Gardoki-Souto I et al.	—	2022	→
Prospective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms.	Acheson DT et al.	—	2022	→
Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder.	Acheson DT et al.	—	2022	→
Psychological resilience and neurodegenerative risk: A connectomics-transcriptomics investigation in healthy adolescent and middle-aged females.	Petrican R et al.	—	2022	→
Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.	Mundy J et al.	—	2022	→
Rare copy number variation in posttraumatic stress disorder.	Maihofer AX et al.	—	2022	→
Revisiting the Need for a PTSD Brain Bank; Commentary on Friedman.	Vermetten E et al.	—	2022	→
Risk of Parkinson Disease Among Adults With vs Without Posttraumatic Stress Disorder.	Barer Y et al.	—	2022	→
RNA-seq analysis of gene expression profiles in posttraumatic stress disorder, Parkinson's disease and schizophrenia identifies roles for common and distinct biological pathways.	Hemmings SMJ et al.	—	2022	→
Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression.	Haas-Neill S et al.	—	2022	→
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.	Blokland GAM et al.	—	2022	→
Shared genetic links between frontotemporal dementia and psychiatric disorders.	Li C et al.	—	2022	→
Stability of polygenic scores across discovery genome-wide association studies.	Schultz LM et al.	—	2022	→
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.	Reay WR et al.	—	2022	→
The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients.	Misganaw B et al.	—	2022	→
The main effect and gene-environment interaction effect of the <i>ADCYAP1R1</i> polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms-A longitudinal analysis.	Zhang J et al.	—	2022	→
The role of the immune system in posttraumatic stress disorder.	Katrinli S et al.	—	2022	→
Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?	Ney LJ et al.	—	2022	→
Trauma in Context: an Integrative Treatment Model.	Zilberstein K	—	2022	→
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.	Polimanti R et al.	—	2022	→
Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population.	Schlauch KA et al.	—	2022	→
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.	Wendt FR et al.	—	2022	→
What Do We Know About the Genetic Architecture of Psychopathology?	Giangrande EJ et al.	—	2022	→
A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders.	Song W et al.	—	2021	→
A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.	Lu H et al.	—	2021	→
A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population.	Swart PC et al.	—	2021	→
Apolipoprotein E (<i>APOE</i>) ε4 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning.	Wooten T et al.	—	2021	→
Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach.	Monson ET et al.	—	2021	→
Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms.	Allgire E et al.	—	2021	→
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations.	Panyard DJ et al.	—	2021	→
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.	van Rheenen W et al.	—	2021	→
Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents.	Daskalakis NP et al.	—	2021	→
Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients.	Stertz L et al.	—	2021	→
CPEB3-dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice.	Lu WH et al.	—	2021	→
Cross-Platform Evaluation of Commercially Targeted and Untargeted Metabolomics Approaches to Optimize the Investigation of Psychiatric Disease.	Chaby LE et al.	—	2021	→
Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition.	Muniz Carvalho C et al.	—	2021	→
Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support.	Muniz Carvalho C et al.	—	2021	→
Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.	Yang R et al.	—	2021	→
Epigenetic marks in suicide: a review.	Ramos-Rosales DF et al.	—	2021	→
Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis.	Sumner JA et al.	—	2021	→
From genetics to systems biology of stress-related mental disorders.	Dalvie S et al.	—	2021	→
Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Major Depressive Disorder.	Garrett ME et al.	—	2021	→
Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder.	Bountress KE et al.	—	2021	→
Genetically predicted education attainment in relation to somatic and mental health.	Yuan S et al.	—	2021	→
Genetic interactions with stressful environments in depression and addiction.	Burmeister M et al.	—	2021	→
Genetic predisposition to alcohol dependence: The combined role of polygenic risk to general psychopathology and to high alcohol consumption.	Facal F et al.	—	2021	→
Genetics of substance use disorders in the era of big data.	Gelernter J et al.	—	2021	→
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.	Stein MB et al.	—	2021	→
Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia.	Nishizawa D et al.	—	2021	→
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.	Mullins N et al.	—	2021	→
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.	Clements CC et al.	—	2021	→
Genomic factors underlying sex differences in trauma-related disorders.	Ponomareva OY et al.	—	2021	→
Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study.	Ni JJ et al.	—	2021	→
Immune system regulation and role of the human leukocyte antigen in posttraumatic stress disorder.	Katrinli S et al.	—	2021	→
Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.	Chatzinakos C et al.	—	2021	→
Integration of peripheral transcriptomics, genomics, and interactomics following trauma identifies causal genes for symptoms of post-traumatic stress and major depression.	Wuchty S et al.	—	2021	→
Mapping the transcriptomics landscape of post-traumatic stress disorder symptom dimensions in World Trade Center responders.	Kuan PF et al.	—	2021	→
Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders.	Song W et al.	—	2021	→
Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering.	Shaw DM et al.	—	2021	→
Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint.	Ikeda M et al.	—	2021	→
Polygenic risk scoring to assess genetic overlap and protective factors influencing posttraumatic stress, depression, and chronic pain after motor vehicle collision trauma.	Lobo JJ et al.	—	2021	→
Posttraumatic Stress Disorder and Cardiovascular Disease: State of the Science, Knowledge Gaps, and Research Opportunities.	O'Donnell CJ et al.	—	2021	→
Posttraumatic Stress Disorder and Chronic Pain Conditions in Men: A Twin Study.	Gasperi M et al.	—	2021	→
Posttraumatic stress disorder: from gene discovery to disease biology.	Polimanti R et al.	—	2021	→
Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study.	Bountress KE et al.	—	2021	→
PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L.	Katrinli S et al.	—	2021	→
PTSD: Past, present and future implications for China.	Zhou YG et al.	—	2021	→
Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation.	Moore SR et al.	—	2021	→
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain.	Tran MN et al.	—	2021	→
TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda.	Kalungi A et al.	—	2021	→
The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics.	Al Jowf GI et al.	—	2021	→
The social and winding road between inflammation and PTSD.	Ursini G et al.	—	2021	→
The Validity of Brief Phenotyping in Population Biobanks for Psychiatric Genome-Wide Association Studies on the Biobank Scale.	Coleman JRI	—	2021	→
Title: "Labels Matter: Is it stress or is it Trauma?"	Richter-Levin G et al.	—	2021	→
Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development.	Lori A et al.	—	2021	→
Transcriptomic organization of the human brain in post-traumatic stress disorder.	Girgenti MJ et al.	—	2021	→
Transcriptomics of the depressed and PTSD brain.	Zhang J et al.	—	2021	→
Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders.	Ressler KJ	—	2021	→
Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease.	Matsunaga H et al.	—	2021	→
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.	Zheng Y et al.	—	2021	→
Unveiling the Pathogenesis of Psychiatric Disorders Using Network Models.	Zuo Y et al.	—	2021	→
Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder.	Zhou P et al.	—	2021	→
What work-related exposures are associated with post-traumatic stress disorder? A systematic review with meta-analysis.	Coenen P et al.	—	2021	→
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.	Huckins LM et al.	—	2020	→
An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.	Logue MW et al.	—	2020	→
A principal component approach to improve association testing with polygenic risk scores.	Coombes BJ et al.	—	2020	→
Assessment of Posttraumatic Stress Disorder and Educational Achievement in Sweden.	Vilaplana-Pérez A et al.	—	2020	→
Associations between the development of PTSD symptoms and longitudinal changes in the DNA methylome of deployed military servicemen: A comparison with polygenic risk scores.	van der Wal SJ et al.	—	2020	→
Associations of cigarette smoking with psychiatric disorders: evidence from a two-sample Mendelian randomization study.	Yuan S et al.	—	2020	→
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.	Quach BC et al.	—	2020	→
Genomic influences on self-reported childhood maltreatment.	Dalvie S et al.	—	2020	→
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective.	Wendt FR et al.	—	2020	→
Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.	Snijders C et al.	—	2020	→
Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma.	Lewkowich I et al.	—	2020	→
Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes.	Lind MJ et al.	—	2020	→
Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort.	Shen H et al.	—	2020	→
Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function.	Brown LC et al.	—	2020	→
Psychophysiological approaches to understanding the impact of trauma exposure.	Rockstroh BS et al.	—	2020	→
Sex differences in post-traumatic stress disorder risk: autonomic control and inflammation.	Fonkoue IT et al.	—	2020	→
Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.	Lutz MW et al.	—	2020	→
Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD).	Sheerin CM et al.	—	2020	→
The long-term consequences of trauma and posttraumatic stress disorder symptoms on later life cognitive function and dementia risk.	Nilaweera D et al.	—	2020	→
Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders.	Ressler KJ	—	2020	→
TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.	Chatzinakos C et al.	—	2020	→
Vesicular monoamine transporter 2 mediates fear behavior in mice.	Branco RC et al.	—	2020	→
A decennial review of psychotraumatology: what did we learn and where are we going?	Olff M et al.	—	2019	→