Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
- Authors
- Ripke, Stephan; O'Dushlaine, Colm; Chambert, Kimberly; Moran, Jennifer L; Kรคhler, Anna K; Akterin, Susanne; Bergen, Sarah E; Collins, Ann L; Crowley, James J; Fromer, Menachem; Kim, Yunjung; Lee, Sang Hong; Magnusson, Patrik K E; Sanchez, Nick; Stahl, Eli A; Williams, Stephanie; Wray, Naomi R; Xia, Kai; Bettella, Francesco; Borglum, Anders D; Bulik-Sullivan, Brendan K; Cormican, Paul; Craddock, Nick; de Leeuw, Christiaan; Durmishi, Naser; Gill, Michael; Golimbet, Vera; Hamshere, Marian L; Holmans, Peter; Hougaard, David M; Kendler, Kenneth S; Lin, Kuang; Morris, Derek W; Mors, Ole; Mortensen, Preben B; Neale, Benjamin M; O'Neill, Francis A; Owen, Michael J; Milovancevic, Milica Pejovic; Posthuma, Danielle; Powell, John; Richards, Alexander L; Riley, Brien P; Ruderfer, Douglas; Rujescu, Dan; Sigurdsson, Engilbert; Silagadze, Teimuraz; Smit, August B; Stefansson, Hreinn; Steinberg, Stacy; Suvisaari, Jaana; Tosato, Sarah; Verhage, Matthijs; Walters, James T; Multicenter Genetic Studies of Schizophrenia Consortium; Levinson, Douglas F; Gejman, Pablo V; Kendler, Kenneth S; Laurent, Claudine; Mowry, Bryan J; O'Donovan, Michael C; Owen, Michael J; Pulver, Ann E; Riley, Brien P; Schwab, Sibylle G; Wildenauer, Dieter B; Dudbridge, Frank; Holmans, Peter; Shi, Jianxin; Albus, Margot; Alexander, Madeline; Campion, Dominique; Cohen, David; Dikeos, Dimitris; Duan, Jubao; Eichhammer, Peter; Godard, Stephanie; Hansen, Mark; Lerer, F Bernard; Liang, Kung-Yee; Maier, Wolfgang; Mallet, Jacques; Nertney, Deborah A; Nestadt, Gerald; Norton, Nadine; O'Neill, Francis A; Papadimitriou, George N; Ribble, Robert; Sanders, Alan R; Silverman, Jeremy M; Walsh, Dermot; Williams, Nigel M; Wormley, Brandon; Psychosis Endophenotypes International Consortium; Arranz, Maria J; Bakker, Steven; Bender, Stephan; Bramon, Elvira; Collier, David; Crespo-Facorro, Benedicto; Hall, Jeremy; Iyegbe, Conrad; Jablensky, Assen; Kahn, Rene S; Kalaydjieva, Luba; Lawrie, Stephen; Lewis, Cathryn M; Lin, Kuang; Linszen, Don H; Mata, Ignacio; McIntosh, Andrew; Murray, Robin M; Ophoff, Roel A; Powell, John; Rujescu, Dan; Van Os, Jim; Walshe, Muriel; Weisbrod, Matthias; Wiersma, Durk; Wellcome Trust Case Control Consortium 2; Donnelly, Peter; Barroso, Ines; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden P; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Spencer, Chris C A; Band, Gavin; Bellenguez, Cรฉline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard D; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Donnelly, Peter; Langford, Cordelia; Hunt, Sarah E; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T; Liddle, Jennifer; Potter, Simon C; Ravindrarajah, Radhi; Ricketts, Michelle; Tashakkori-Ghanbaria, Avazeh; Waller, Matthew J; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Barroso, Ines; Deloukas, Panos; Mathew, Christopher G; Blackwell, Jenefer M; Brown, Matthew A; Corvin, Aiden P; McCarthy, Mark I; Spencer, Chris C A; Bramon, Elvira; Corvin, Aiden P; O'Donovan, Michael C; Stefansson, Kari; Scolnick, Edward; Purcell, Shaun; McCarroll, Steven A; Sklar, Pamela; Hultman, Christina M; Sullivan, Patrick F
- Year
- 2013
- Journal
- Nature genetics
- PMID
- 23974872
- DOI
- 10.1038/ng.2742
- PMCID
- PMC3827979
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
Manhattan plot of the Swedish and PGC schizophrenia meta-analysis results. The x-axis is chromosomal position and the y-axis is โlog10(P). The red line is the genome-wide significance level (5ร10โ8). Gene locations are indicated.
LLM interpretation
This is a Manhattan plot showing the results of a schizophrenia meta-analysis, with the x-axis representing chromosomal position (1โ22) and the y-axis representing $-\log_{10}(P)$. Multiple genomic loci across several chromosomes exceed the red genome-wide significance threshold ($5 \times 10^{-8}$), with the most prominent peaks located on chromosomes 6 and 12. Specific significant genes and intergenic regions are labeled above their respective peaks.
Risk score profiling results using the PGC schizophrenia results as the discovery set and the Sweden data as the testing set. The x-axis shows ten P value thresholds (PT = 10โ4, 10โ3, โฆ, 1). The y-axis is the Nagelkerke pseudo R2, the proportion of variance in case-control status explained by the risk score profile. The number atop each vertical bar is the P value for the capacity of the risk score profile to predict case-control status for that PT.
LLM interpretation
This bar chart shows the Nagelkerke pseudo $R^2$ (proportion of variance in case-control status explained) across ten P-value thresholds (PT) ranging from 0.0001 to 1. The $R^2$ value increases as the PT increases, plateauing at approximately 0.06 for PT values of 0.1 and above. Each bar is annotated with a P-value indicating the predictive capacity of the risk score profile, with all values showing high statistical significance (ranging from $1\text{e-}26$ to $9\text{e-}115$).
The main figure shows the results of ABPA modeling based on the Sweden + PGC results (population risk 0.01). The x-axis is the estimated number of SNPs on a log10 scale, and the y-axis estimates the total variance in liability explained. The results for five conditions are shown: schizophrenia (this analysis, red) and, for comparison, results from a published analysis of myocardial infarction (MI, purple), type 2 diabetes mellitus (T2D, blue), celiac disease (green), and rheumatoid arthritis (RA, teal). 71 The schizophrenia results are based on 1000 Genomes imputation, and the others on HapMap3 imputation. Color intensity reflects the probability density with darker colors indicating higher density. Contour lines show 50% and 95% credible regions for SCZ, and 95% credible regions for the other diseases. The insets depict estimated SNP distributions for the five disorders: (a) distribution of SNPs in terms of the variance in liability explained per SNP and (b) the estimated distribution of SNP genotypic relative risks (GRR). We again stress that multiple qualifiers are essential in interpreting these estimates.
LLM interpretation
This figure is a density plot with contour lines showing the results of ABPA modeling for five conditions: schizophrenia (SCZ, red), myocardial infarction (MI, purple), type 2 diabetes (T2D, blue), celiac disease (green), and rheumatoid arthritis (RA, teal). The x-axis represents the number of disease-associated GWAS SNPs on a $\log_{10}$ scale, and the y-axis represents the total liability-scale variance explained. Two insets show the density distributions for per-SNP liability-scale variance explained (a) and genotypic relative risk (b).
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| Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development. | Howell KR et al. | โ | 2020 | โ |
| Neuronal Plasticity: Neuronal Organization is Associated with Neurological Disorders. | Dhuriya YK et al. | โ | 2020 | โ |
| Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients. | Li M et al. | โ | 2020 | โ |
| NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity. | Nakashima A et al. | โ | 2020 | โ |
| Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation. | Goodman SJ et al. | โ | 2020 | โ |
| Overdispersed gene expression in schizophrenia. | Huang G et al. | โ | 2020 | โ |
| Pathogenesis and management of Brugada syndrome in schizophrenia: A scoping review. | Rastogi A et al. | โ | 2020 | โ |
| Penalized regression and model selection methods for polygenic scores on summary statistics. | Pattee J et al. | โ | 2020 | โ |
| Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies. | Mongan D et al. | โ | 2020 | โ |
| Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity. | Liu S et al. | โ | 2020 | โ |
| Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia. | Qin Y et al. | โ | 2020 | โ |
| Polygenic Risk Scores for Subtyping of Schizophrenia. | Chen J et al. | โ | 2020 | โ |
| Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia. | Singh SM et al. | โ | 2020 | โ |
| Proof-of-concept study of a multi-gene risk score in adolescent bipolar disorder. | Dimick MK et al. | โ | 2020 | โ |
| Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers. | Choi KW et al. | โ | 2020 | โ |
| Rare variants and biological pathways identified in treatment-refractory depression. | McClain LL et al. | โ | 2020 | โ |
| RDoC and Psychopathology among Youth: Misplaced Assumptions and an Agenda for Future Research. | Beauchaine TP et al. | โ | 2020 | โ |
| Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using <i>Galnac4s-6st</i>-Knockout Mice. | Nadanaka S et al. | โ | 2020 | โ |
| Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights. | Zamanpoor M | โ | 2020 | โ |
| Specificity and Continuity of Schizophrenia and Bipolar Disorder: Relation to Biomarkers. | Yamada Y et al. | โ | 2020 | โ |
| Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders. | Hammerschlag AR et al. | โ | 2020 | โ |
| SZDB2.0: an updated comprehensive resource for schizophrenia research. | Wu Y et al. | โ | 2020 | โ |
| The complement system in schizophrenia: where are we now and what's next? | Woo JJ et al. | โ | 2020 | โ |
| The effect of LRRK2 loss-of-function variants in humans. | Whiffin N et al. | โ | 2020 | โ |
| The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese. | Han H et al. | โ | 2020 | โ |
| The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation. | Comer AL et al. | โ | 2020 | โ |
| The influence of dopaminergic polymorphisms on selective stopping. | Rincรณn-Pรฉrez I et al. | โ | 2020 | โ |
| The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology. | Smeland OB et al. | โ | 2020 | โ |
| Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. | Bakshi K et al. | โ | 2020 | โ |
| Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks. | Bareลกiฤ A et al. | โ | 2020 | โ |
| Whole-Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health. | Zhou X et al. | โ | 2020 | โ |
| Wnt receptor gene <i>FZD1</i> was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort. | Liu X et al. | โ | 2020 | โ |
| Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome. | Panagiotakos G et al. | โ | 2019 | โ |
| Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia. | Horsdal HT et al. | โ | 2019 | โ |
| Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness. | Hayes JF et al. | โ | 2019 | โ |
| Attenuation of Novelty-Induced Hyperactivity of <i>Gria1-/-</i> Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics. | Aitta-Aho T et al. | โ | 2019 | โ |
| A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia. | Pacheco A et al. | โ | 2019 | โ |
| Biological and practical implications of genome-wide association study of schizophrenia using Bayesian variable selection. | Rowe B et al. | โ | 2019 | โ |
| CACNA1C risk variant affects microstructural connectivity of the amygdala. | Koch K et al. | โ | 2019 | โ |
| Case Report of Childhood-Onset Psychosis in a Patient with a Known WNT10A Mutation. | Kobza AO et al. | โ | 2019 | โ |
| Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives. | Popovic D et al. | โ | 2019 | โ |
| Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder. | Guan J et al. | โ | 2019 | โ |
| Common-variant associations with fragile X syndrome. | Crowley JJ et al. | โ | 2019 | โ |
| Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. | Mรคki-Marttunen T et al. | โ | 2019 | โ |
| Detection of Putative Functional Single Nucleotide Polymorphisms in Blood Pressure Loci and Validation of Association Between Single Nucleotide Polymorphism in WBP1L and Hypertension in the Chinese Han Population. | Zhang H et al. | โ | 2019 | โ |
| Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. | Deak JD et al. | โ | 2019 | โ |
| Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms. | Greenwood TA et al. | โ | 2019 | โ |
| Essential genetic findings in neurodevelopmental disorders. | Cardoso AR et al. | โ | 2019 | โ |
| Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder. | Pineda-Cirera L et al. | โ | 2019 | โ |
| Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk. | Huo Y et al. | โ | 2019 | โ |
| Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. | Walker RL et al. | โ | 2019 | โ |
| Genetics of obsessive-compulsive disorder. | Purty A et al. | โ | 2019 | โ |
| Genetic Studies of Tic Disorders and Tourette Syndrome. | Qi Y et al. | โ | 2019 | โ |
| Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults: A Case-Control Study. | Dahlin AM et al. | โ | 2019 | โ |
| Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species. | Sykes L et al. | โ | 2019 | โ |
| Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. | Ikeda M et al. | โ | 2019 | โ |
| Genome-wide association study identifies 30 loci associated with bipolar disorder. | Stahl EA et al. | โ | 2019 | โ |
| Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk. | Wang AW et al. | โ | 2019 | โ |
| Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model. | Ni G et al. | โ | 2019 | โ |
| GWAS of Behavioral Traits. | Mehta D et al. | โ | 2019 | โ |
| Hippocampal-prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1. | Bygrave AM et al. | โ | 2019 | โ |
| Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells. | Nakashima A et al. | โ | 2019 | โ |
| Identification of Specific Nuclear Genetic Loci and Genes That Interact With the Mitochondrial Genome and Contribute to Fecundity in <i>Caenorhabditis elegans</i>. | Zhu Z et al. | โ | 2019 | โ |
| Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci. | Wu Y et al. | โ | 2019 | โ |
| Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank. | Neilson E et al. | โ | 2019 | โ |
| Improving Imputation Accuracy by Inferring Causal Variants in Genetic Studies. | Wu Y et al. | โ | 2019 | โ |
| Integration of methylation QTL and enhancer-target gene maps with schizophrenia GWAS summary results identifies novel genes. | Wu C et al. | โ | 2019 | โ |
| Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis. | Trotta A et al. | โ | 2019 | โ |
| Machine learning in schizophrenia genomics, a case-control study using 5,090 exomes. | Trakadis YJ et al. | โ | 2019 | โ |
| Methylation age acceleration does not predict mortality in schizophrenia. | Kowalec K et al. | โ | 2019 | โ |
| MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice. | Yan HL et al. | โ | 2019 | โ |
| Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability. | Reynolds RH et al. | โ | 2019 | โ |
| Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. | Guo SM et al. | โ | 2019 | โ |
| Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients. | Ma L et al. | โ | 2019 | โ |
| Next-generation sequencing refines the genetic architecture of Greek GnRH-deficient patients. | Stamou MI et al. | โ | 2019 | โ |
| Non-coding RNAs: the gatekeepers of neural network activity. | Zampa F et al. | โ | 2019 | โ |
| Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort. | Escott-Price V et al. | โ | 2019 | โ |
| Polygenic risk score increases schizophrenia liability through cognition-relevant pathways. | Toulopoulou T et al. | โ | 2019 | โ |
| Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. | Vornholt E et al. | โ | 2019 | โ |
| Preventing discrimination based on psychiatric risk biomarkers. | Brannan C et al. | โ | 2019 | โ |
| Protein-Protein Interaction Network Analysis Reveals Several Diseases Highly Associated with Polycystic Ovarian Syndrome. | Ramly B et al. | โ | 2019 | โ |
| Reduced cortical thickness related to single nucleotide polymorphisms in the major histocompatibility complex region in antipsychotic-naive schizophrenia. | Tao B et al. | โ | 2019 | โ |
| Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: A PET and MRI study in the maternal immune stimulation animal model. | Casquero-Veiga M et al. | โ | 2019 | โ |
| Schizophrenia and Hereditary Polyneuropathy: <i>PMP22</i> Deletion as a Common Pathophysiological Link? | Endres D et al. | โ | 2019 | โ |
| Schizophrenia Identification Using Multi-View Graph Measures of Functional Brain Networks. | Xiang Y et al. | โ | 2019 | โ |
| Social and non-social autism symptoms and trait domains are genetically dissociable. | Warrier V et al. | โ | 2019 | โ |
| Statistical Association Mapping of Population-Structured Genetic Data. | Najafi A et al. | โ | 2019 | โ |
| Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis. | Rees E et al. | โ | 2019 | โ |
| Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia. | Hu Z et al. | โ | 2019 | โ |
| The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study. | D'Ambrosio E et al. | โ | 2019 | โ |
| The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia. | Rammos A et al. | โ | 2019 | โ |
| Toward an animal model of borderline personality disorder. | Corniquel MB et al. | โ | 2019 | โ |
| Towards a Unifying Cognitive, Neurophysiological, and Computational Neuroscience Account of Schizophrenia. | Heinz A et al. | โ | 2019 | โ |
| Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development. | Xu X et al. | โ | 2019 | โ |
| Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies. | Schwabe I et al. | โ | 2019 | โ |
| Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review. | Prata DP et al. | โ | 2019 | โ |
| Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness. | Mayne PE et al. | โ | 2019 | โ |
| Zinc finger proteins in psychiatric disorders and response to psychotropic medications. | Squassina A et al. | โ | 2019 | โ |
| A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia. | Sakamoto K et al. | โ | 2018 | โ |
| A copy number variation generated by complicated organization of PCDHA gene cluster is associated with egg performance traits in Xinhua E-strain. | Huang T et al. | โ | 2018 | โ |
| A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders. | de Sena Cortabitarte A et al. | โ | 2018 | โ |
| Age at first birth in women is genetically associated with increased risk of schizophrenia. | Ni G et al. | โ | 2018 | โ |
| A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. | Ikeda M et al. | โ | 2018 | โ |
| Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients. | Karis K et al. | โ | 2018 | โ |
| A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. | Li W et al. | โ | 2018 | โ |
| An approximate Bayesian significance test for genomic evaluations. | Wittenburg D et al. | โ | 2018 | โ |
| A Neuroscience-Oriented Research Approach to Borderline Personality Disorder. | Stanley B et al. | โ | 2018 | โ |
| A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme. | Magri C et al. | โ | 2018 | โ |
| A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains. | Ranlund S et al. | โ | 2018 | โ |
| Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population. | Yang Y et al. | โ | 2018 | โ |
| Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans. | Rovnรฝ R et al. | โ | 2018 | โ |
| Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population. | Hui L et al. | โ | 2018 | โ |
| Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains. | Blakey R et al. | โ | 2018 | โ |
| Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system. | Micu I et al. | โ | 2018 | โ |
| Axon guidance pathway genes are associated with schizophrenia risk. | Wang Z et al. | โ | 2018 | โ |
| Beyond heritability: improving discoverability in imaging genetics. | Fan CC et al. | โ | 2018 | โ |
| Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients. | Ermakov EA et al. | โ | 2018 | โ |
| Ca2+ Channels in Anterior Pituitary Somatotrophs: A Therapeutic Perspective. | Nussinovitch I | โ | 2018 | โ |
| Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease. | Nanou E et al. | โ | 2018 | โ |
| Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia. | Song JHT et al. | โ | 2018 | โ |
| Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells. | Hoffmann A et al. | โ | 2018 | โ |
| Combining multi-modality data for searching biomarkers in schizophrenia. | Guo S et al. | โ | 2018 | โ |
| Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia. | Chang X et al. | โ | 2018 | โ |
| Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. | Pardiรฑas AF et al. | โ | 2018 | โ |
| Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. | Yang CP et al. | โ | 2018 | โ |
| Control of CNS functions by RNA-binding proteins in neurological diseases. | Zhou Y et al. | โ | 2018 | โ |
| Double hits in schizophrenia. | Vorstman JAS et al. | โ | 2018 | โ |
| Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection? | Solana C et al. | โ | 2018 | โ |
| Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia. | Matosin N et al. | โ | 2018 | โ |
| Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls. | Cosgrove D et al. | โ | 2018 | โ |
| eHealth provides a novel opportunity to exploit the advantages of the Nordic countries in psychiatric genetic research, building on the public health care system, biobanks, and registries. | Andreassen OA | โ | 2018 | โ |
| Embracing Psychosis: A Cognitive Insight Intervention Improves Personal Narratives and Meaning-Making in Patients With Schizophrenia. | Moritz S et al. | โ | 2018 | โ |
| Empirical Bayes Estimation of Semi-parametric Hierarchical Mixture Models for Unbiased Characterization of Polygenic Disease Architectures. | Nishino J et al. | โ | 2018 | โ |
| Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. | Hackinger S et al. | โ | 2018 | โ |
| Examining the role of common and rare mitochondrial variants in schizophrenia. | Gonรงalves VF et al. | โ | 2018 | โ |
| Exploring Genetic Variation that Influences Brain Methylation in Attention-Deficit/Hyperactivity Disorder | Pineda-Cirera L et al. | โ | 2018 | โ |
| Fetal Origins of Mental Disorders? An Answer Based on Mendelian Randomization. | Arafat S et al. | โ | 2018 | โ |
| From Maps to Multi-dimensional Network Mechanisms of Mental Disorders. | Braun U et al. | โ | 2018 | โ |
| Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. | Sundararajan T et al. | โ | 2018 | โ |
| Further evidence for the genetic association between <i>CACNA1I</i> and schizophrenia. | Xie Y et al. | โ | 2018 | โ |
| Gene-environment interaction and psychiatric disorders: Review and future directions. | Assary E et al. | โ | 2018 | โ |
| Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation. | Donohoe G et al. | โ | 2018 | โ |
| Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations. | Yang Y et al. | โ | 2018 | โ |
| Genetic risk mechanisms of posttraumatic stress disorder in the human brain. | Bharadwaj RA et al. | โ | 2018 | โ |
| Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. | Lu Y et al. | โ | 2018 | โ |
| Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes. | Stokowy T et al. | โ | 2018 | โ |
| Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence. | Hiemstra M et al. | โ | 2018 | โ |
| Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. | Smit DJA et al. | โ | 2018 | โ |
| Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning. | Lyall AE et al. | โ | 2018 | โ |
| HAHap: a read-based haplotyping method using hierarchical assembly. | Lin YY et al. | โ | 2018 | โ |
| Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland. | Martin AR et al. | โ | 2018 | โ |
| Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. | Hilker R et al. | โ | 2018 | โ |
| How can genetics help understand the relationship between cognitive dysfunction and schizophrenia? | Smeland OB et al. | โ | 2018 | โ |
| Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. | Ermakov EA et al. | โ | 2018 | โ |
| Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue. | Bhalala OG et al. | โ | 2018 | โ |
| Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia. | Ma J et al. | โ | 2018 | โ |
| Imaging genetics of schizophrenia in the post-GWAS era. | Arslan A | โ | 2018 | โ |
| Improving genetic prediction by leveraging genetic correlations among human diseases and traits. | Maier RM et al. | โ | 2018 | โ |
| Integrating eQTL data with GWAS summary statistics in pathway-based analysis with application to schizophrenia. | Wu C et al. | โ | 2018 | โ |
| Integration of Enhancer-Promoter Interactions with GWAS Summary Results Identifies Novel Schizophrenia-Associated Genes and Pathways. | Wu C et al. | โ | 2018 | โ |
| Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. | Zhou Y et al. | โ | 2018 | โ |
| Investigating the genetic architecture of general and specific psychopathology in adolescence. | Jones HJ et al. | โ | 2018 | โ |
| <i>VRK2</i>, a Candidate Gene for Psychiatric and Neurological Disorders. | Li M et al. | โ | 2018 | โ |
| JEPEGMIX2: improved gene-level joint analysis of eQTLs in cosmopolitan cohorts. | Chatzinakos C et al. | โ | 2018 | โ |
| Jointly determining significance levels of primary and replication studies by controlling the false discovery rate in two-stage genome-wide association studies. | Jiang W et al. | โ | 2018 | โ |
| LSMM: a statistical approach to integrating functional annotations with genome-wide association studies. | Ming J et al. | โ | 2018 | โ |
| Male increase in brain gene expression variability is linked to genetic risk for schizophrenia. | Chen J et al. | โ | 2018 | โ |
| Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges. | Arslan A | โ | 2018 | โ |
| Meta-analysis of GABRB2 polymorphisms and the risk of schizophrenia combined with GWAS data of the Han Chinese population and psychiatric genomics consortium. | Zhang T et al. | โ | 2018 | โ |
| Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response. | Quednow BB et al. | โ | 2018 | โ |
| Method to estimate the approximate samples size that yield a certain number of significant GWAS signals in polygenic traits. | Bacanu SA et al. | โ | 2018 | โ |
| microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease. | Thomas KT et al. | โ | 2018 | โ |
| Models of Schizotypy: The Importance of Conceptual Clarity. | Grant P et al. | โ | 2018 | โ |
| Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory. | Wang C et al. | โ | 2018 | โ |
| National-scale precision medicine for psychiatric disorders in Sweden. | Bergen SE et al. | โ | 2018 | โ |
| Next-generation sequencing analysis of multiplex families with atypical psychosis. | Okayama T et al. | โ | 2018 | โ |
| Non-coding RNA dysregulation in the amygdala region of schizophrenia patients contributes to the pathogenesis of the disease. | Liu Y et al. | โ | 2018 | โ |
| Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease. | Johnson SC | โ | 2018 | โ |
| Outgroup emotion processing in the vACC is modulated by childhood trauma and CACNA1C risk variant. | Krautheim JT et al. | โ | 2018 | โ |
| Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. | Cheng Y et al. | โ | 2018 | โ |
| Perspectives of psychiatric investigators and IRB chairs regarding benefits of psychiatric genetics research. | Roberts LW et al. | โ | 2018 | โ |
| Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. | Bogdan R et al. | โ | 2018 | โ |
| Polygenic Risk Scores, School Achievement, and Risk for Schizophrenia: A Danish Population-Based Study. | Sรธrensen HJ et al. | โ | 2018 | โ |
| Predicting Violent Behavior: What Can Neuroscience Add? | Poldrack RA et al. | โ | 2018 | โ |
| Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. | Alachkar A et al. | โ | 2018 | โ |
| Psychiatric Genomics: An Update and an Agenda. | Sullivan PF et al. | โ | 2018 | โ |
| Psychiatry and developmental psychopathology: Unifying themes and future directions. | Beauchaine TP et al. | โ | 2018 | โ |
| Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia. | Teng S et al. | โ | 2018 | โ |
| Re-assessment of multiple testing strategies for more efficient genome-wide association studies. | Otani T et al. | โ | 2018 | โ |
| Recently evolved human-specific methylated regionsย are enriched in schizophrenia signals. | Banerjee N et al. | โ | 2018 | โ |
| Regulation of the Expression of the Psychiatric Risk Gene <i>Cacna1c</i> during Associative Learning. | Sykes L et al. | โ | 2018 | โ |
| Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. | Zhao L et al. | โ | 2018 | โ |
| Replication of GWAS identified miR-137 and its target gene polymorphisms in Schizophrenia of South Indian population and meta-analysis with Psychiatric Genomics Consortium. | Sudesh R et al. | โ | 2018 | โ |
| Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder. | Nishino J et al. | โ | 2018 | โ |
| Sequence and Haplotypes Variation of the Ovine Uncoupling Protein-1 Gene (UCP1) and Their Association with Growth and Carcass Traits in New Zealand Romney Lambs. | An Q et al. | โ | 2018 | โ |
| The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. | Xiao X et al. | โ | 2018 | โ |
| The Complex Interaction of Mitochondrial Genetics and Mitochondrial Pathways in Psychiatric Disease. | Cuperfain AB et al. | โ | 2018 | โ |
| The contribution of alternative splicing to genetic risk for psychiatric disorders. | Reble E et al. | โ | 2018 | โ |
| The effect of weight on mental health: New evidence using genetic IVs. | Willage B | โ | 2018 | โ |
| The Emerging Immunogenetic Architecture of Schizophrenia. | Pouget JG | โ | 2018 | โ |
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| The impact of epigenomic next-generation sequencing approaches on our understanding of neuropsychiatric disorders. | Schang AL et al. | โ | 2018 | โ |
| The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis. | Vogel BO et al. | โ | 2018 | โ |
| The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner. | Page SC et al. | โ | 2018 | โ |
| Tracing Early Neurodevelopment in Schizophrenia with Induced Pluripotent Stem Cells. | Ahmad R et al. | โ | 2018 | โ |
| Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia. | Olde Loohuis LM et al. | โ | 2018 | โ |
| Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model. | Duan J et al. | โ | 2018 | โ |
| Unbiased lipidomic profiling reveals metabolomic changes during the onset and antipsychotics treatment of schizophrenia disease. | Yan L et al. | โ | 2018 | โ |
| Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders. | Calafato MS et al. | โ | 2018 | โ |
| Using Full Genomic Information to Predict Disease: Breaking Down the Barriers Between Complex and Mendelian Diseases. | Jordan DM et al. | โ | 2018 | โ |
| Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism. | St Clair D et al. | โ | 2018 | โ |
| Voltage-gated calcium channel activity and complex related genes and schizophrenia: A systematic investigation based on Han Chinese population. | Zhang T et al. | โ | 2018 | โ |
| Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection. | Vuckovic D et al. | โ | 2018 | โ |
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| A Gene-Based Analysis of Acoustic Startle Latency. | Smith AK et al. | โ | 2017 | โ |
| Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia. | Sanderson DJ et al. | โ | 2017 | โ |
| Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31. | Bodea CA et al. | โ | 2017 | โ |
| An update on stem cell biology and engineering for brain development. | Parr CJC et al. | โ | 2017 | โ |
| Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease. | Powell SK et al. | โ | 2017 | โ |
| A Quarter Century of Progress in Psychiatric Genetics. | Smoller JW | โ | 2017 | โ |
| A Recurrent De Novo Nonsense Variant in ZSWIM6 Results in Severe Intellectual Disability without Frontonasal or Limb Malformations. | Palmer EE et al. | โ | 2017 | โ |
| A review of molecular genetic studies of neurocognitive deficits in schizophrenia. | Zai G et al. | โ | 2017 | โ |
| Association between the variability of the ABCA13 gene and the risk of major depressive disorder and schizophrenia in the Han Chinese population. | Chen J et al. | โ | 2017 | โ |
| Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population. | Guo W et al. | โ | 2017 | โ |
| Association of Common Variants in TGFA with Increased Risk of Knee Osteoarthritis Susceptibility. | Cui G et al. | โ | 2017 | โ |
| Attempts to replicate genetic associations with schizophrenia in a cohort from north India. | Prasad S et al. | โ | 2017 | โ |
| Can lncRNAs be indicators for the diagnosis of early onset or acute schizophrenia and distinguish major depressive disorder and generalized anxiety disorder?-A cross validation analysis. | Cui X et al. | โ | 2017 | โ |
| Challenges and opportunities for the development of new antipsychotic drugs. | Forray C et al. | โ | 2017 | โ |
| Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients. | Voisey J et al. | โ | 2017 | โ |
| Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis. | Rivera NV et al. | โ | 2017 | โ |
| Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population. | Yu H et al. | โ | 2017 | โ |
| Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms. | Schmitt A et al. | โ | 2017 | โ |
| Controlling the joint local false discovery rate is more powerful than meta-analysis methods in joint analysis of summary statistics from multiple genome-wide association studies. | Jiang W et al. | โ | 2017 | โ |
| Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies. | Hattab MW et al. | โ | 2017 | โ |
| Danger: High Voltage-The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology. | Schampel A et al. | โ | 2017 | โ |
| D-cycloserine in Schizophrenia: New Strategies for Improving Clinical Outcomes by Enhancing Plasticity. | Goff DC | โ | 2017 | โ |
| Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future. | Alural B et al. | โ | 2017 | โ |
| Direct evidence for a polygenic etiology in familial multiple myeloma. | Halvarsson BM et al. | โ | 2017 | โ |
| DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele. | Dyrvig M et al. | โ | 2017 | โ |
| DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia. | Pergola G et al. | โ | 2017 | โ |
| Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. | Wangler MF et al. | โ | 2017 | โ |
| Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis. | Ham S et al. | โ | 2017 | โ |
| Drug enrichment and discovery from schizophrenia genome-wide association results: an analysis and visualisation approach. | Gaspar HA et al. | โ | 2017 | โ |
| Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness. | Kato TA et al. | โ | 2017 | โ |
| Effects of environmental risks and polygenic loading for schizophrenia on cortical thickness. | Neilson E et al. | โ | 2017 | โ |
| Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. | Hoffmann A et al. | โ | 2017 | โ |
| Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 ร DISC1. | O'Tuathaigh CM et al. | โ | 2017 | โ |
| Ethical Application of Precision Medicine to Schizophrenia Management. | Daws S | โ | 2017 | โ |
| Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses. | Xiao X et al. | โ | 2017 | โ |
| Evaluation of shared genetic susceptibility loci between autoimmune diseases and schizophrenia based on genome-wide association studies. | Hoeffding LK et al. | โ | 2017 | โ |
| Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. | Charney AW et al. | โ | 2017 | โ |
| Evidence of AS3MT<sup>d2d3</sup>-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders. | Li L et al. | โ | 2017 | โ |
| Extracellular matrix alterations in the ketamine model of schizophrenia. | Matuszko G et al. | โ | 2017 | โ |
| Fast admixture analysis and population tree estimation for SNP and NGS data. | Cheng JY et al. | โ | 2017 | โ |
| Gene2Function: An Integrated Online Resource for Gene Function Discovery. | Hu Y et al. | โ | 2017 | โ |
| Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data. | Malavia TA et al. | โ | 2017 | โ |
| Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia. | Zong L et al. | โ | 2017 | โ |
| Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese. | Lu W et al. | โ | 2017 | โ |
| Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. | Devor A et al. | โ | 2017 | โ |
| Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses. | Pandey H et al. | โ | 2017 | โ |
| Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity. | Liu X et al. | โ | 2017 | โ |
| Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics. | Giegling I et al. | โ | 2017 | โ |
| Genetics of Schizophrenia: Overview of Methods, Findings and Limitations. | Henriksen MG et al. | โ | 2017 | โ |
| Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. | Li Z et al. | โ | 2017 | โ |
| Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior. | Tielbeek JJ et al. | โ | 2017 | โ |
| Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. | Witt SH et al. | โ | 2017 | โ |
| Genome-Wide Association Study of Psychosis Proneness in the Finnish Population. | Ortega-Alonso A et al. | โ | 2017 | โ |
| Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls. | Morey RA et al. | โ | 2017 | โ |
| Genomic Analysis of Genotype-by-Social Environment Interaction for <i>Drosophila melanogaster</i> Aggressive Behavior. | Rohde PD et al. | โ | 2017 | โ |
| Genomic approaches to the assessment of human spina bifida risk. | Ross ME et al. | โ | 2017 | โ |
| Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth. | Lee SH et al. | โ | 2017 | โ |
| GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact. | Austen JM et al. | โ | 2017 | โ |
| Haplotype phasing of whole human genomes using bead-based barcode partitioning in a single tube. | Zhang F et al. | โ | 2017 | โ |
| Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis. | Blokland GAM et al. | โ | 2017 | โ |
| HLAscan: genotyping of the HLA region using next-generation sequencing data. | Ka S et al. | โ | 2017 | โ |
| Human induced pluripotent stem cells for modelling neurodevelopmental disorders. | Ardhanareeswaran K et al. | โ | 2017 | โ |
| Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function. | Smeland OB et al. | โ | 2017 | โ |
| Identification of genetic loci shared between schizophrenia and the Big Five personality traits. | Smeland OB et al. | โ | 2017 | โ |
| Identification of shared risk loci and pathways for bipolar disorder and schizophrenia. | Forstner AJ et al. | โ | 2017 | โ |
| Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies. | van Kesteren CF et al. | โ | 2017 | โ |
| Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1ฮฑ Neurodevelopmental Signal Transduction. | Thomas KT et al. | โ | 2017 | โ |
| Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. | Tischfield DJ et al. | โ | 2017 | โ |
| Microarray gene-expression study in fibroblast and lymphoblastoid cell lines from antipsychotic-naรฏve first-episode schizophrenia patients. | Gassรณ P et al. | โ | 2017 | โ |
| Migrainomics - identifying brain and genetic markers of migraine. | Nyholt DR et al. | โ | 2017 | โ |
| Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease. | Hayes JP et al. | โ | 2017 | โ |
| Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways. | Higgins GA et al. | โ | 2017 | โ |
| MiR-137: an important player in neural development and neoplastic transformation. | Mahmoudi E et al. | โ | 2017 | โ |
| MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls. | Cosgrove D et al. | โ | 2017 | โ |
| Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease. | Devaraju P et al. | โ | 2017 | โ |
| Molecular Mechanisms of Transcription Factor 4 in Pitt Hopkins Syndrome. | Rannals MD et al. | โ | 2017 | โ |
| Multimodal Neuroimaging in Schizophrenia: Description and Dissemination. | Aine CJ et al. | โ | 2017 | โ |
| Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. | Leonenko G et al. | โ | 2017 | โ |
| Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus. | Gianfrancesco O et al. | โ | 2017 | โ |
| Perinatal Asphyxia in Rat Alters Expression of Novel Schizophrenia Risk Genes. | Paparelli A et al. | โ | 2017 | โ |
| Pharmacogenetics of antidepressant response: A polygenic approach. | Garcรญa-Gonzรกlez J et al. | โ | 2017 | โ |
| PKBฮณ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. | Howell KR et al. | โ | 2017 | โ |
| Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. | Mรคki-Marttunen T et al. | โ | 2017 | โ |
| Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations. | Wang T et al. | โ | 2017 | โ |
| Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations. | Liu B et al. | โ | 2017 | โ |
| Polygenic Risk Score associated with specific symptom dimensions in first-episode psychosis. | Sengupta SM et al. | โ | 2017 | โ |
| Polygenic scores via penalized regression on summary statistics. | Mak TSH et al. | โ | 2017 | โ |
| Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia. | John J et al. | โ | 2017 | โ |
| Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia. | Funk AJ et al. | โ | 2017 | โ |
| Potential Value of Genomic Copy Number Variations in Schizophrenia. | Zhuo C et al. | โ | 2017 | โ |
| Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls. | Cremaschi L et al. | โ | 2017 | โ |
| Progress in Genetic Studies of Tourette's Syndrome. | Qi Y et al. | โ | 2017 | โ |
| Progress in genome-wide association studies of schizophrenia in Han Chinese populations. | Yue W et al. | โ | 2017 | โ |
| Psychosis risk research versus daily prognosis uncertainties: A qualitative study of French youth psychiatrists' attitudes toward predictive practices. | Benoit L et al. | โ | 2017 | โ |
| Recent Advances in Experimental Whole Genome Haplotyping Methods. | Huang M et al. | โ | 2017 | โ |
| Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. | Terrillion CE et al. | โ | 2017 | โ |
| Relationship between serum calcium and neuropsychological performance might indicate etiological heterogeneity underlying cognitive deficits in schizophrenia and depression. | Sharma A et al. | โ | 2017 | โ |
| Role of 108 schizophrenia-associated loci in modulating psychopathological dimensions in schizophrenia and bipolar disorder. | Fabbri C et al. | โ | 2017 | โ |
| Schizophrenia and the neurodevelopmental continuum:evidence from genomics. | Owen MJ et al. | โ | 2017 | โ |
| Sequencing and de novo assembly of 150 genomes from Denmark as a population reference. | Maretty L et al. | โ | 2017 | โ |
| Short communication: Genetic association between schizophrenia and cannabis use. | Verweij KJ et al. | โ | 2017 | โ |
| Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks. | Wu M et al. | โ | 2017 | โ |
| Spatial and temporal expression patterns of genes around nine neuroticism-associated loci. | Ohi K et al. | โ | 2017 | โ |
| Synaptic activity: An emerging player in schizophrenia. | Sarkar A et al. | โ | 2017 | โ |
| SZDB: A Database for Schizophrenia Genetic Research. | Wu Y et al. | โ | 2017 | โ |
| SZGR 2.0: a one-stop shop of schizophrenia candidate genes. | Jia P et al. | โ | 2017 | โ |
| The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. | McCammon JM et al. | โ | 2017 | โ |
| The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies. | Harari JH et al. | โ | 2017 | โ |
| The Clinical Challenge of Autoimmune Psychosis: Learning from Anti-NMDA Receptor Autoantibodies. | Ellul P et al. | โ | 2017 | โ |
| The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. | Boerner T et al. | โ | 2017 | โ |
| The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities. | Pruessner M et al. | โ | 2017 | โ |
| The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. | Qvist P et al. | โ | 2017 | โ |
| The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function. | Olde Loohuis NF et al. | โ | 2017 | โ |
| The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. | Chang H et al. | โ | 2017 | โ |
| The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. | Ou J et al. | โ | 2017 | โ |
| The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus. | Christiansen GB et al. | โ | 2017 | โ |
| The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples. | Minicฤ CC et al. | โ | 2017 | โ |
| Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls. | Morgan CJ et al. | โ | 2017 | โ |
| Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains. | Hoffman GE et al. | โ | 2017 | โ |
| Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders. | Rutkowski TP et al. | โ | 2017 | โ |
| Variation in global DNA hydroxymethylation with age associated with schizophrenia. | Jiang T et al. | โ | 2017 | โ |
| What has GWAS done for HLA and disease associations? | Kennedy AE et al. | โ | 2017 | โ |
| Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. | Tang J et al. | โ | 2017 | โ |
| A Case for Returning to Multiplex Families for Further Understanding the Heritability of Schizophrenia: A Psychiatrist's Perspective. | DeLisi LE | โ | 2016 | โ |
| A cis-eQTL in AHI1 confers risk to schizophrenia in European populations. | Ren Z et al. | โ | 2016 | โ |
| Across-cohort QC analyses of GWAS summary statistics from complex traits. | Chen GB et al. | โ | 2016 | โ |
| A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder. | Atakhorrami M et al. | โ | 2016 | โ |
| A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. | Chang C et al. | โ | 2016 | โ |
| A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression. | Warburton A et al. | โ | 2016 | โ |
| A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. | Li M et al. | โ | 2016 | โ |
| A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia. | Hughes T et al. | โ | 2016 | โ |
| Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis. | Wu JQ et al. | โ | 2016 | โ |
| AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. | Peltola MA et al. | โ | 2016 | โ |
| A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation. | Nucifora LG et al. | โ | 2016 | โ |
| Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population. | Khan RA et al. | โ | 2016 | โ |
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| Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia. | Jin C et al. | โ | 2016 | โ |
| Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants. | Hauberg ME et al. | โ | 2016 | โ |
| A network of synaptic genes associated with schizophrenia and bipolar disorder. | Forero DA et al. | โ | 2016 | โ |
| An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. | Hannon E et al. | โ | 2016 | โ |
| A novel 3q29 deletion associated with autism, intellectual disability, psychiatric disorders, and obesity. | Biamino E et al. | โ | 2016 | โ |
| A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans. | Bigdeli TB et al. | โ | 2016 | โ |
| Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders. | Gassรณ P et al. | โ | 2016 | โ |
| Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. | Montano C et al. | โ | 2016 | โ |
| Autophagy and Schizophrenia: A Closer Look at How Dysregulation of Neuronal Cell Homeostasis Influences the Pathogenesis of Schizophrenia. | Schneider JL et al. | โ | 2016 | โ |
| A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue. | van den Oord EJ et al. | โ | 2016 | โ |
| Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function. | Thomson PA et al. | โ | 2016 | โ |
| Biomarkers for drug development in early psychosis: Current issues and promising directions. | Goff DC et al. | โ | 2016 | โ |
| Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Risk of Schizophrenia: A Meta-analysis of Case-Control Studies. | Kheirollahi M et al. | โ | 2016 | โ |
| Childhood body mass index and risk of schizophrenia in relation to childhood age, sex and age of first contact with schizophrenia. | Sรธrensen HJ et al. | โ | 2016 | โ |
| Clinical studies of neuroinflammatory mechanisms in schizophrenia. | Watkins CC et al. | โ | 2016 | โ |
| Cognitive endophenotypes inform genome-wide expression profiling in schizophrenia. | Zheutlin AB et al. | โ | 2016 | โ |
| Colocalization of GWAS and eQTL Signals Detects Target Genes. | Hormozdiari F et al. | โ | 2016 | โ |
| Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies. | Mieth B et al. | โ | 2016 | โ |
| Common alleles contribute to schizophrenia in CNV carriers. | Tansey KE et al. | โ | 2016 | โ |
| Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population. | Zhang QQ et al. | โ | 2016 | โ |
| Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population. | Yin X et al. | โ | 2016 | โ |
| Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis. | Rao S et al. | โ | 2016 | โ |
| Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population. | Khan RA et al. | โ | 2016 | โ |
| Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain. | Guan L et al. | โ | 2016 | โ |
| Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. | Pers TH et al. | โ | 2016 | โ |
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| Covariance Association Test (CVAT) Identifies Genetic Markers Associated with Schizophrenia in Functionally Associated Biological Processes. | Rohde PD et al. | โ | 2016 | โ |
| Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation. | Butler MG et al. | โ | 2016 | โ |
| Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naรฏve First Episode Psychosis. | Noto C et al. | โ | 2016 | โ |
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| DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder. | Walker RM et al. | โ | 2016 | โ |
| DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review. | Teroganova N et al. | โ | 2016 | โ |
| DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient. | Wang L et al. | โ | 2016 | โ |
| Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. | Gaskin PL et al. | โ | 2016 | โ |
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| Enrichment of SNPs in Functional Categories Reveals Genes Affecting Complex Traits. | Zhao H et al. | โ | 2016 | โ |
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| Evaluation of voltage-dependent calcium channel ฮณ gene families identified several novel potential susceptible genes to schizophrenia. | Guan F et al. | โ | 2016 | โ |
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| Genetic Correlation Analysis Suggests Association between Increased Self-Reported Sleep Duration in Adults and Schizophrenia and Type 2 Diabetes. | Byrne EM et al. | โ | 2016 | โ |
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| MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. | Wu S et al. | โ | 2016 | โ |
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| Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. | Carroll LS et al. | โ | 2016 | โ |
| Myelination-related genes are associated with decreased white matter integrity in schizophrenia. | Chavarria-Siles I et al. | โ | 2016 | โ |
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| Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population. | Jones HJ et al. | โ | 2016 | โ |
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| Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. | Wright C et al. | โ | 2016 | โ |
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