Effects of acute alcohol on excitability in the CNS.
paper
Cited
Public
- Authors
- Harrison, Neil L; Skelly, Mary Jane; Grosserode, Emma K; Lowes, Daniel C; Zeric, Tamara; Phister, Sara; Salling, Michael C
- Year
- 2017
- Journal
- Neuropharmacology
- PMID
- 28479395
- DOI
- 10.1016/j.neuropharm.2017.04.007
- PMCID
- PMC5657304
Alcohol has many effects on brain function and hence on human behavior, ranging from anxiolytic and mild disinhibitory effects, sedation and motor incoordination, amnesia, emesis, hypnosis and eventually unconsciousness. In recent years a variety of studies have shown that acute and chronic exposure to alcohol can modulate ion channels that regulate excitability. Modulation of intrinsic excitability provides another way in which alcohol can influence neuronal network activity, in addition to its actions on synaptic inputs. In this review, we review "low dose" effects [between 2 and 20Β mM EtOH], and "medium dose"; effects [between 20 and 50Β mM], by considering in turn each of the many networks and brain regions affected by alcohol, and thereby attempt to integrate inΒ vitro physiological studies in specific brain regions (e.g. amygdala, ventral tegmental area, prefrontal cortex, thalamus, cerebellum etc.) within the context of alcohol's behavioral actions inΒ vivo (e.g. anxiolysis, euphoria, sedation, motor incoordination). This article is part of the Special Issue entitled "Alcoholism".
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