Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes.

paper Cited Public

Authors: Gold, Allison B; Lerman, Caryn
Year: 2012
Journal: Human genetics
PMID: 22290489
DOI: 10.1007/s00439-012-1143-9
PMCID: PMC3864572

#	Section	Preview
40	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA4	The A529T polymorphism in the CHRNA4 gene has been shown to influence varying responses to nicotine…
41	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA4	In human studies, SNPs or haplotypes of the CHRNA4 gene have been associated with nicotine…
42	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA4	An independent sample of smokers with the rs2236196 polymorphism reported increased sensitivity to…
43	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA4	Evidence from animal and human studies supports a role for variation in the CHRNA4 gene in altering…
44	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNB2	nAChRs that contain both α4 and β2 subunits are the most abundant in the brain, and nicotine has…
45	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNB2	Knockout mice that lack the β2 subunit do not self-administer nicotine and do not show…
46	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNB2	The affective and cognitive signs of nicotine withdrawal are believed to be an important factor in…
47	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNB2	There is evidence to support the role of the β2 subunit in smoking cessation in humans. rs2072661…
48	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNB2	It is apparent from the animal and human studies which reviewed that CHRNB2 is an important gene in…
49	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	α7 nACh receptors are homomeric, comprising of five α7 subunits. Along with α4β2* nAChRs, α7…
50	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	The role of the α7 subunit, encoded by the CHRNA7 gene, in nicotine dependence or withdrawal is not…
51	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	α7 KO mice have been widely studied to explore the role of this subunit in nicotine’s effects.…
52	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	the somatic signs of MEC-precipitated withdrawal and exhibited normal MLA-precip-itated nicotine…
53	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	after prolonged nicotine exposure in rats (Markou and Paterson 2001), but consistent with Salas et…
54	Nicotinic acetylcholine receptor (nAChR) subunits — CHRNA7	There are very few human genetic studies examining the role of the CHRNA7 gene with smoking behavior…
55	Acetylcholine synthesis — Choline acetyltransferase (ChAT)	ChAT is responsible for the synthesis and modulation of endogenous acetylcholine (Whittaker 1988).…
56	Acetylcholine synthesis — Choline acetyltransferase (ChAT)	In a sample of treatment-seeking smokers and an independent sample of family-based non-treatment…
57	Acetylcholine synthesis — Choline acetyltransferase (ChAT)	To date, few human genetic association studies have examined the role of ChAT in smoking cessation.…
58	Pharmacokinetics of nicotine	Cigarette smoking produces a rapid distribution of nicotine through the bloodstream and nicotine…
59	Pharmacokinetics of nicotine	The elimination half-life of nicotine is around 2 h. Among several nicotine metabolites, the major…

Name	Type
31,266 smokers GWAS local	cohort
3HC/cotinine local	phenotype
3-hydroxycotinine	drug
3′-hydroxycotinine local	drug
471 Caucasian smokers local	cohort
7-day point-prevalence local	phenotype
A529T local	variant
abstinence	phenotype
abstinence rates	phenotype
acetylcholine	drug
addiction	phenotype
adolescent animals	cohort
adolescent smoking	phenotype
adult rats	cohort
Adult treatment-seeking smokers local	cohort
affective signs of nicotine withdrawal local	phenotype
affective signs of withdrawal local	phenotype
affective symptoms	phenotype
Affective withdrawal signs local	phenotype
African American	cohort
African-American light smokers local	cohort
African-Americans	cohort
aging-induced cognitive impairments local	phenotype
alcohol	phenotype
anterior ventral tegmental area local	anatomy
Anterior VTA local	anatomy
antinociceptive effects local	phenotype
anxiety-like behavior	phenotype
anxiety-related behavior loss local	phenotype
Asian	cohort
attentional performance	phenotype
aversion	phenotype
aversion loss local	phenotype
aversive effects	phenotype
brain	anatomy
bupropion	drug
bupropion placebo-controlled randomized clinical trial local	cohort
C57BL/6J	cohort
Ca2+	drug
candidate gene study cohort local	cohort
case-control sample	cohort
Caucasians	cohort
Caucasian sample	cohort
cell body local	anatomy
central nervous system	anatomy
Cessation medication local	drug
cessation phenotypes local	phenotype
cessation treatment response local	phenotype
Chat	gene
cholinergic genes	gene
CHRNA10	gene
CHRNA2	gene
Chrna3	gene
Chrna4	gene
CHRNA4 A529T knock-in mice local	cohort
CHRNA4 Leu9'Ala local	variant
CHRNA4 Leu9Ser local	variant
CHRNA5	gene
CHRNA5-CHRNA3-CHRNB4 cluster	gene
CHRNA5-CHRNA3-CHRNB4 haplotype local	variant
CHRNA5_D398 local	variant
CHRNA5_D398N local	variant
CHRNA5 KO mice local	cohort
Chrna6	gene
Chrna7	gene
CHRNA8	gene
CHRNA9	gene
Chrnb2	gene
Chrnb3	gene
Chrnb4	gene
CHRNB4 African-American variant local	variant
CHRNB4 Caucasian variant local	variant
CHRNB4 knockout mice local	cohort
cigarettes	phenotype
clinical trials	cohort
CNS sensitivity to cholinergic stimulation local	phenotype
cocaine	phenotype
cognition	phenotype
cognitive flexibility	phenotype
cognitive signs of nicotine withdrawal local	phenotype
cognitive withdrawal symptoms local	phenotype
Cohort_291_EU local	cohort
Cohort_426_EU local	cohort
conditioned place aversion	phenotype
conditioned place preference	phenotype
Contextual cues local	phenotype
contextual fear conditioning deficits local	phenotype
continued use	phenotype
cotinine	drug
craving	phenotype
current smoking	phenotype
CYP2A6	gene
CYP2A6*1 local	variant
CYP2A61/1B local	variant
CYP2A6*1B local	variant
CYP2B6	gene
CYP2B6*4 allele local	variant
CYP2B6*6 haplotype local	variant
CYP2B6 K262R local	variant
CYP2B6 Q172H local	variant
DAT1 VNTR	variant
decreased likelihood of smoking cessation local	phenotype
dendrite	anatomy
Diminished nicotine sensitivity local	phenotype
discovery sample (472 European ancestry smokers) local	cohort
dopamine	drug
dopaminergic neurons	anatomy
DRD2	gene
DRD2-Taq1A local	variant
early smokers local	cohort
endogenous acetylcholine local	drug
enzyme	drug
epibatidine local	drug
European American smokers local	cohort
European ancestry	cohort
European women (2,474) local	cohort
extended transdermal nicotine therapy local	drug
Fagerström Test for Nicotine Dependence	phenotype
families	cohort
Family-based local	cohort
family-based non-treatment seekers local	cohort
faster nicotine and cotinine clearance local	phenotype
former smokers	phenotype
full sample	cohort
Galantamine local	drug
genetic factors	cohort
genetic variants	cohort
haplotypes	variant
Heavier smoking local	phenotype
heavy smoking	phenotype
higher 3-HC/cotinine ratios local	phenotype
High sensitivity α4* nAChRs response local	phenotype
hippocampus	anatomy
Hispanic	phenotype
Hoft et al. 2009 study local	cohort
human smokers local	cohort
hyperalgesia	phenotype
Hypothermic response to nicotine local	phenotype
inability to stop smoking local	phenotype
Increased anxiety local	phenotype
independent sample of smokers local	cohort
independent smoker cohort local	cohort
Inhaler local	drug
Initial abstinence local	phenotype
initial cessation local	phenotype
Initial sensitivity	phenotype
interpeduncular nucleus	anatomy
Jewish females local	cohort
K262R local	variant
Koreans	cohort
lapse local	phenotype
Lapse local	phenotype
large-scale genetic association cohort local	cohort
learning	phenotype
learning and memory deficits local	phenotype
Leu9Ser knock-in mice local	cohort
locus coeruleus	anatomy
long-term abstinence	phenotype
loss of control	phenotype
Lozenge local	drug
maternal smoking	phenotype
Maximal functional response to acetylcholine local	phenotype
mecamylamine	drug
medial habenula	anatomy
memory	phenotype
men	cohort
mesoaccumbens reward pathway local	anatomy
mesocorticolimbic dopaminergic pathways local	anatomy
methyllycaconitine	drug
mice	cohort
Na+	drug
nAChR subunit genes local	gene
nAChR subunits local	gene
neuronal excitability	phenotype
neuronal integration local	phenotype
neuronal nicotinic acetylcholine receptors local	gene
neurotransmitter release	phenotype
never smokers	phenotype
nicotine	drug
nicotine addiction	phenotype
nicotine clearance	phenotype
nicotine clearance rates local	phenotype
Nicotine cravings local	phenotype
nicotine dependence	phenotype
nicotine gum	drug
nicotine-induced seizures	phenotype
nicotine metabolism	phenotype
nicotine metabolism genes local	gene
nicotine metabolite ratio local	other
nicotine metabolite ratio	phenotype
nicotine metabolizing enzymes local	gene
nicotine nasal spray	drug
nicotine patch	drug
nicotine patch study local	cohort
Nicotine preference local	phenotype
nicotine replacement therapy	drug
nicotine reward	phenotype
nicotine sensitivity	phenotype
nicotine transdermal patch local	drug
nicotine use	phenotype
nicotine withdrawal	phenotype
nicotinic acetylcholine receptor	drug
Non-somatic signs of withdrawal local	phenotype
non-somatic withdrawal symptoms local	phenotype
normal activity allele local	phenotype
normal metabolizers local	phenotype
NRT	drug
NRTs local	drug
nucleus accumbens	anatomy
opioid	drug
other substances	phenotype
peripheral nervous system	anatomy
phenotype	phenotype
physical withdrawal symptoms local	phenotype
Plasma nicotine concentration local	phenotype
Poor motor learning local	phenotype
Positive motivational effects of nicotine local	phenotype
positive reinforcement	phenotype
posterior ventral tegmental area local	anatomy
presynaptic site local	anatomy
preterminal site local	anatomy
Preventable deaths local	phenotype
Psychosocial factors	phenotype
pVTA local	anatomy
pVTA dopaminergic neurons local	anatomy
pVTA dopaminergic neurons local	phenotype
Q172H local	variant
quit rate local	phenotype
quitting success	phenotype
race/ethnicity	phenotype
rats	cohort
Reduced antinociceptive effect local	phenotype
reduced CYP2A6 activity local	phenotype
reduced metabolizers local	phenotype
regular smoking	phenotype
Reinforcing properties of nicotine	phenotype
relapse	phenotype
response to bupropion local	phenotype
Response to bupropion treatment local	phenotype
response to nicotine therapy local	phenotype
Response to pharmaco-therapy local	phenotype
reward	phenotype
rewarding effects	phenotype
rs1044396	variant
rs1051730	variant
rs11072768 local	variant
rs12914008	variant
rs12914385	variant
rs12915366 local	variant
rs13280604 local	variant
rs1917810 local	variant
rs2072661	variant
rs2236196	variant
rs2304297 local	variant
rs3787138	variant
rs3811450 local	variant
rs4105144	variant
rs4262952 local	variant
rs4950 local	variant
rs518425 local	variant
rs6062899 local	variant
rs6090384 local	variant
rs6494212	variant
rs680244	variant
rs7004381 local	variant
rs8192475	variant
saline	drug
sensitivity to acute effects of smoking local	phenotype
sensitization	phenotype
severe inattention local	phenotype
slow metabolizer	phenotype
smokers treated with varenicline local	cohort
smoking	phenotype
smoking abstinence	phenotype
smoking behavior	phenotype
smoking cessation	phenotype
smoking cessation outcomes local	phenotype
smoking cessation therapies local	drug
smoking dependence	phenotype
smoking heaviness	phenotype
smoking initiation	phenotype
smoking persistence	phenotype
smoking phenotypes	phenotype
smoking relapse	phenotype
SNP	cohort
SNPs in CHRNA5-CHRNA3-CHRNB4 gene cluster local	variant
Somatic hyperalgesia local	phenotype
somatic signs local	phenotype
Somatic signs of withdrawal local	phenotype
somatic symptoms of nicotine withdrawal local	phenotype
somatic withdrawal symptoms local	phenotype
Somatic withdrawal symptoms local	phenotype
spatial working memory	phenotype
striatum	anatomy
subjective response to nicotine local	phenotype
Successful quitting	phenotype
T529A local	variant
Thorgeirsson and Stefansson sample (1,891 women) local	cohort
time to relapse	phenotype
tobacco use	phenotype
tolerance	phenotype
trace fear conditioning deficits local	phenotype
transdermal nicotine therapy local	drug
transdermal NRT	drug
transdermal patch	drug
treatment gains local	phenotype
treatment response	phenotype
treatment-seeking smokers	cohort
two independent trials local	cohort
United States	cohort
unsuccessful quit attempts local	phenotype
varenicline	drug
varenicline treatment cohort local	cohort
ventral striatum	anatomy
ventral tegmental area	anatomy
visuospatial attention local	phenotype
VTA	anatomy
wild-type mice	cohort
withdrawal	phenotype
withdrawal effects from drugs of abuse local	phenotype
withdrawal severity	phenotype
women	cohort
working memory	phenotype
α4 KO mice local	cohort
α4α6* nAChRs local	drug
α4β2* nAChRs local	drug
α6* nAChR local	gene
α7 agonists local	drug
α7 antagonists local	drug
α7 KO mice local	cohort
α7 nAChRs local	drug
αBgtx local	drug
α-conotoxin MII local	drug
α-conotoxin MII(H9A;L15A) local	drug
β2 KO mice local	cohort

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In this knowledge base

Title	Year	PMID
Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.	2015	26142345
Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.	2013	23941313

External

Title	Authors	Journal	Year	Link
Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment.	Chen LS et al.	—	2023	→
How has the brain disease model of addiction contributed to tobacco control?	Hall W et al.	—	2023	→
Structure-activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm.	Thabet RH et al.	—	2023	→
Association of Polymorphism <i>CHRNA5</i> and <i>CHRNA3</i> Gene in People Addicted to Nicotine.	Chmielowiec K et al.	—	2022	→
Rodent models for nicotine withdrawal.	Chellian R et al.	—	2021	→
Korean male active smokers: quantifying their smoking habits and the transformation factor among biomarkers in urine and blood.	Yang J et al.	—	2020	→
The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence.	Khabour OF et al.	—	2020	→
Chronic Obstructive Pulmonary Disease Risk and Smoking Cessation Changes Induced by <i>CHRNA5-A3</i> and <i>CHRNB3-A6</i> Variation in a Chinese Male Population.	Zhao L et al.	—	2019	→
Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence.	Garcia-Rivas V et al.	—	2019	→
From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.	Salloum NC et al.	—	2018	→
Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.	Chen LS et al.	—	2018	→
Pathways to precision medicine in smoking cessation treatments.	Chen LS et al.	—	2018	→
Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.	Ou WC et al.	—	2017	→
Neuregulin signaling pathway in smoking behavior.	Gupta R et al.	—	2017	→
Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons.	Chang GQ et al.	—	2016	→
The Sociopharmacology of Tobacco Addiction: Implications for Understanding Health Disparities.	Leventhal AM	—	2016	→
What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses.	Le Foll B	—	2016	→
An evolutionary medicine approach to understanding factors that contribute to chronic obstructive pulmonary disease.	Aoshiba K et al.	—	2015	→
Effect of genotype and methylation of CYP2D6 on smoking behaviour.	Tiili EM et al.	—	2015	→
Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.	Chen LS et al.	—	2015	→
Nicotine withdrawal.	McLaughlin I et al.	—	2015	→
Genetics and smoking.	Loukola A et al.	—	2014	→
Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers.	Lazary J et al.	—	2014	→
Plasma cotinine levels in cigarette smokers: impact of mental health and other correlates.	Bot M et al.	—	2014	→
Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis.	Lebbe EK et al.	—	2014	→
Biomarkers for smoking cessation.	Bough KJ et al.	—	2013	→
Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.	David SP et al.	—	2013	→
Pharmacogenetic smoking cessation intervention in a health care setting: a pilot feasibility study.	McClure JB et al.	—	2013	→
Pharmacogenetics of chronic obstructive pulmonary disease.	Hizawa N	—	2013	→
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.	Sim SC et al.	—	2013	→
The genetics of addiction.	Volkow ND et al.	—	2012	→