LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.
paper
Cited
Public
- Authors
- Zheng, Jie; Erzurumluoglu, A Mesut; Elsworth, Benjamin L; Kemp, John P; Howe, Laurence; Haycock, Philip C; Hemani, Gibran; Tansey, Katherine; Laurin, Charles; Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium; Pourcain, Beate St; Warrington, Nicole M; Finucane, Hilary K; Price, Alkes L; Bulik-Sullivan, Brendan K; Anttila, Verneri; Paternoster, Lavinia; Gaunt, Tom R; Evans, David M; Neale, Benjamin M
- Year
- 2017
- Journal
- Bioinformatics (Oxford, England)
- PMID
- 27663502
- DOI
- 10.1093/bioinformatics/btw613
- PMCID
- PMC5542030
MOTIVATION: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously. RESULTS: In this manuscript, we describe LD Hub - a centralized database of summary-level GWAS results for 173 diseases/traits from different publicly available resources/consortia and a web interface that automates the LD score regression analysis pipeline. To demonstrate functionality and validate our software, we replicated previously reported LD score regression analyses of 49 traits/diseases using LD Hub; and estimated SNP heritability and the genetic correlation across the different phenotypes. We also present new results obtained by uploading a recent atopic dermatitis GWAS meta-analysis to examine the genetic correlation between the condition and other potentially related traits. In response to the growing availability of publicly accessible GWAS summary-level results data, our database and the accompanying web interface will ensure maximal uptake of the LD score regression methodology, provide a useful database for the public dissemination of GWAS results, and provide a method for easily screening hundreds of traits for overlapping genetic aetiologies. AVAILABILITY AND IMPLEMENTATION: The web interface and instructions for using LD Hub are available at http://ldsc.broadinstitute.org/ CONTACT: jie.zheng@bristol.ac.ukSupplementary information: Supplementary data are available at Bioinformatics online.
Fig. 1.
Scope and features of LD Hub. The LD Hub server provides three features: (i) Test Centre, which is an automatic LD score regression platform, (ii) Lookup Center, which allows users to lookup LD score regression results for their trait(s) of interest and (iii) GWAShare Center, which allows users to share their GWAS summary results and contribute to the field
Fig. 2.
Contents of LD Hub. In total, data for 173 traits are included in LD Hub, which consist of 18 diseases, 48 complex traits and 107 metabolites
Fig. 3.
Schematic of LD Hub workflow. To start using LD Hub, users are required to login using a GMail (compatible) account. Once logged in, the users can then navigate their way around, selecting the features and databases they are interested in
Fig 4
Comparison of genetic correlation results between LD Hub and previously reported LD score regression results. Double blue lines represent genetic correlation results from LD Hub, and the black single lines represent genetic correlation results from previously reported LD score regression results. The discrepancies can be attributed to the minor changes in the quality control processes and the replacement of some GWAS results with more recent versions
1β20 of 32
Next β
| Name | Type |
|---|---|
| 1000 Genomes Project | cohort |
| 23andMe | cohort |
| asthma | phenotype |
| Atopic dermatitis | phenotype |
| autoimmune diseases | phenotype |
| complex diseases | phenotype |
| complex traits | phenotype |
| Crohn's disease | phenotype |
| custom chip local | drug |
| Database local | cohort |
| disease | phenotype |
| EAGLE consortium | cohort |
| eczema | phenotype |
| European ancestry | cohort |
| European population | cohort |
| exome chip local | drug |
| Filaggrin local | gene |
| FLG local | gene |
| genetic correlation | phenotype |
| GWAS | cohort |
| GWAS backbone chip local | drug |
| GWAShare Center local | cohort |
| GWAS studies local | cohort |
| GWAS summary-level data local | cohort |
| GWAS summary-level data local | drug |
| GWAS summary-level datasets local | cohort |
| Hemani et al local | cohort |
| heritability | phenotype |
| immune markers local | phenotype |
| immuno chip local | drug |
| LD Hub | cohort |
| LD Score regression local | cohort |
| Lookup Center local | cohort |
| Medically relevant risk factors/complex traits local | phenotype |
| meta-analyses local | phenotype |
| metabo chip local | drug |
| metabolites | drug |
| MHC | gene |
| MR-Base local | cohort |
| non-European ancestry | cohort |
| psych chip local | drug |
| rheumatoid arthritis | phenotype |
| SNP | cohort |
| SNP heritability | phenotype |
| Test Center local | cohort |
| traits/diseases local | phenotype |
| ulcerative colitis | phenotype |
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| 1000 Genomes Project Consortium. (2012) An integrated map of genetic variation from 1,092 human genomes. Nature, 491, 56β65. [TQ1]2312822610.1038/nature11632PMC3498066 | β | β | β |
| BatailleV. et al (2012) The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data. J. Eur. Acad. Dermatol. Venereol., 26, 1067β1073.2224344610.1111/j.1468-3083.2011.04444.x | β | β | β |
| BenyaminB. et al (2013) Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol. Psychiatry, 19, 253β258.2335815610.1038/mp.2012.184PMC3935975 | β | β | β |
| BerndtS. et al (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat. Genet., 45, 501β512.2356360710.1038/ng.2606PMC3973018 | β | β | β |
| BoraskaV. et al (2014) A genome-wide association study of anorexia nervosa. Mol. Psychiatry, 19, 1085β1094.2451456710.1038/mp.2013.187PMC4325090 | β | β | β |
| BradfieldJ. et al (2012) A genome-wide association meta-analysis identifies new childhood obesity loci. Nat. Genet., 44, 526β531.2248462710.1038/ng.2247PMC3370100 | β | β | β |
| Bulik-Sullivan et al (2015a) LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet., 47, 291β295.2564263010.1038/ng.3211PMC4495769 | β | β | β |
| Bulik-Sullivan et al (2015b) An atlas of genetic correlations across human diseases and traits. Nat. Genet., 47, 1236β1241.2641467610.1038/ng.3406PMC4797329 | β | β | β |
| Cross-Disorder Group of the Psychiatric Genomics Consortium. (2013) Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 381, 1371β1379.2345388510.1016/S0140-6736(12)62129-1PMC3714010 | β | β | β |
| DastaniZ. et al (2012) Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet., 8, e1002607.2247920210.1371/journal.pgen.1002607PMC3315470 | β | β | β |
| Davey SmithG., EbrahimS. (2003) Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease?Int. J. Epidemiol., 32, 1β22.1268999810.1093/ije/dyg070 | β | β | β |
| de MoorM. et al (2010) Meta-analysis of genome-wide association studies for personality. Mol. Psychiatry, 17, 337β349.2117377610.1038/mp.2010.128PMC3785122 | β | β | β |
| DupuisJ. et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet., 42, 105β116.2008185810.1038/ng.520PMC3018764 | β | β | β |
| EastE.M. (1916) Studies on size inheritance in Nicotiana. Genetics, 1, 164β176.1724585410.1093/genetics/1.2.164PMC1193657 | β | β | β |
| EstradaK. et al (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet., 44, 491β501.2250442010.1038/ng.2249PMC3338864 | β | β | β |
| EvansD.M., Davey SmithG. (2015) Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu. Rev. Genomics Hum. Genet., 16, 327β350.2593905410.1146/annurev-genom-090314-050016 | β | β | β |
| FinucaneH.K. et al (2015) Partitioning heritability by functional category using GWAS summary statistics. Nat. Genet., 47, 1228β1235.2641467810.1038/ng.3404PMC4626285 | β | β | β |
| FisherR.A. (1918) The correlation between relatives on the supposition of Mendelian inheritance. Philos. Transac. R. Soc. Edinburgh, 52, 399β433. | β | β | β |
| FurbergH. et al (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat. Genet., 42, 441β447.2041889010.1038/ng.571PMC2914600 | β | β | β |
| GusevA. et al (2014) Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am. J. Hum. Genet., 95, 535β552.2543972310.1016/j.ajhg.2014.10.004PMC4225595 | β | β | β |
| HindorffL.A. et al (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA., 106, 9362β9367.1947429410.1073/pnas.0903103106PMC2687147 | β | β | β |
| HorikoshiM. et al (2012) New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat. Genet., 45, 76β82.2320212410.1038/ng.2477PMC3605762 | β | β | β |
| HuffmanJ. et al (2015) Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLos One, 10, e0119752.2581178710.1371/journal.pone.0119752PMC4374966 | β | β | β |
| International HapMap 3 Consortium. (2010) Integrating common and rare genetic variation in diverse human populations. Nature, 467, 52β58.2081145110.1038/nature09298PMC3173859 | β | β | β |
| KettunenJ. et al (2016) Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat. Commun., 23, 11122.10.1038/ncomms11122PMC481458327005778 | β | β | β |
| LambertJ. et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet., 45, 1452β1458.2416273710.1038/ng.2802PMC3896259 | β | β | β |
| Lango AllenH. et al (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467, 832β838.2088196010.1038/nature09410PMC2955183 | β | β | β |
| LeeH. et al (2011) Estimating missing heritability for disease from genome-wide association studies. Am. J. Hum. Genet., 88, 294β305.2137630110.1016/j.ajhg.2011.02.002PMC3059431 | β | β | β |
| LeeH. et al (2012) Estimation of pleiotropy between complex diseases using SNP-derived genomic relationships and restricted maximum likelihood. Bioinformatics, 28, 2540β2542.2284398210.1093/bioinformatics/bts474PMC3463125 | β | β | β |
| LiuJ.Z. et al (2015) Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet., 47, 979β986.2619291910.1038/ng.3359PMC4881818 | β | β | β |
| ManningA. et al (2012) A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat. Genet., 44, 659β669.2258122810.1038/ng.2274PMC3613127 | β | β | β |
| MoffattM.F. et al (2007) Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 448, 470β473.1761149610.1038/nature06014 | β | β | β |
| MorrisA. et al (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet., 44, 981β990.2288592210.1038/ng.2383PMC3442244 | β | β | β |
| NealeB. et al (2010) Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry, 49, 884β897.2073262510.1016/j.jaac.2010.06.008PMC2928252 | β | β | β |
| NikpayM. et al (2015) A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet., 47, 1121β1130.2634338710.1038/ng.3396PMC4589895 | β | β | β |
| OkadaY. et al (2013) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506, 376β381.2439034210.1038/nature12873PMC3944098 | β | β | β |
| PaternosterL. et al (2015) Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat. Genet., 47, 1449β1456.2648287910.1038/ng.3424PMC4753676 | β | β | β |
| PattaroC. et al (2016) Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat. Commun., 21, 10023.10.1038/ncomms10023PMC473574826831199 | β | β | β |
| PerryJ. et al (2014) Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514, 92β97.2523187010.1038/nature13545PMC4185210 | β | β | β |
| RietveldC. et al (2013) GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science, 340, 1467β1471.2372242410.1126/science.1235488PMC3751588 | β | β | β |
| RietveldC. et al (2014) Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proc. Natl. Acad. Sci., 111, 13790β13794.2520198810.1073/pnas.1404623111PMC4183313 | β | β | β |
| RipkeS. et al (2012) A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry, 18, 497β511.2247287610.1038/mp.2012.21PMC3837431 | β | β | β |
| RipkeS. et al (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421β427.2505606110.1038/nature13595PMC4112379 | β | β | β |
| SandilandsA. et al (2007) Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat. Genet., 39, 650β654.1741763610.1038/ng2020 | β | β | β |
| SaxenaR. et al (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet., 42, 142β148.2008185710.1038/ng.521PMC2922003 | β | β | β |
| SegrΓ¨A.V. et al (2010) Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet., 6, e1001058.2071434810.1371/journal.pgen.1001058PMC2920848 | β | β | β |
| ShunginD. et al (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518, 187β196.2567341210.1038/nature14132PMC4338562 | β | β | β |
| Simon-SanchezJ. et al (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet., 41, 1308β1312.1991557510.1038/ng.487PMC2787725 | β | β | β |
| SklarP. et al (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet., 43, 977β983.2192697210.1038/ng.943PMC3637176 | β | β | β |
| SoranzoN. et al (2010) Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways. Diabetes, 59, 3229β3239.2085868310.2337/db10-0502PMC2992787 | β | β | β |
| SpeedD. et al (2012) Improved heritability estimation from genome-wide SNPs. Am J Hum Genet, 91, 1011β1021.2321732510.1016/j.ajhg.2012.10.010PMC3516604 | β | β | β |
| SpeliotesE. et al (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet., 42, 937β948.2093563010.1038/ng.686PMC3014648 | β | β | β |
| TaalH. et al (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat. Genet., 44, 532β538.2250441910.1038/ng.2238PMC3773913 | β | β | β |
| TeslovichT. et al (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature, 466, 707β713.2068656510.1038/nature09270PMC3039276 | β | β | β |
| TeumerA. et al (2016) Genome-wide association studies identify genetic loci associated with albuminuria in diabetes. Diabetes, 65, 803β817.2663173710.2337/db15-1313PMC4764151 | β | β | β |
| van den BergS. et al (2014) Harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the genetics of personality consortium: an application of item response theory. Behav. Genet., 44, 295β313.2482847810.1007/s10519-014-9654-xPMC4057636 | β | β | β |
| van der ValkR. et al (2014) A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum. Mol. Genet., 24, 1155β1168.2528165910.1093/hmg/ddu510PMC4447786 | β | β | β |
| WelterD. et al (2014) The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res., 42, D1001βD1006.2431657710.1093/nar/gkt1229PMC3965119 | β | β | β |
| YangJ. et al (2010) Common SNPS explain a large proportion of the heritability for human height. Nat. Genet., 42, 565β569.2056287510.1038/ng.608PMC3232052 | β | β | β |
| YangJ. et al (2011) GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet., 88, 76β82.2116746810.1016/j.ajhg.2010.11.011PMC3014363 | β | β | β |
| ZhengJ. et al (2013) Sequential sentinel SNP Regional Association Plots (SSS-RAP): an approach for testing independence of SNP association signals using meta-analysis data. Ann. Hum. Genet., 77, 67β79.2327839110.1111/j.1469-1809.2012.00737.x | β | β | β |
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Application of Mendelian Randomization in Cardiovascular Disease: Bibliometric Analysis and Visualization from 2003 to 2024. | Guo S et al. | β | 2026 | β |
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| Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study. | Skelton M et al. | β | 2025 | β |
| Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease. | Khan A et al. | β | 2025 | β |
| Genome-wide association study of REM sleep behavior disorder in Parkinson's disease. | Sosero YL et al. | β | 2025 | β |
| Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. | Kang M et al. | β | 2025 | β |
| Global burden of peripheral arterial disease (1990-2021), global burden trends and the impact of blood lead on peripheral arterial disease: a multidimensional analysis based on NHANES, GBD, and Mendelian randomization. | Yan C et al. | β | 2025 | β |
| Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses. | Panagiotaropoulou G et al. | β | 2025 | β |
| Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis. | Oliva M et al. | β | 2025 | β |
| JointPRS: A data-adaptive framework for multi-population genetic risk prediction incorporating genetic correlation. | Xu L et al. | β | 2025 | β |
| Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies. | Fominykh V et al. | β | 2025 | β |
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| No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation. | Qi J et al. | β | 2025 | β |
| Revealing the genetic and immunological crosstalk between SLE and ccRCC: An integrative genomic analysis approach. | Lin F et al. | β | 2025 | β |
| Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation using the FIND model. | Fan X et al. | β | 2025 | β |
| The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study. | Wu C et al. | β | 2025 | β |
| The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases. | Konieczny MJ et al. | β | 2025 | β |
| The protective effect of higher serum TAG (51:4) levels against Parkinson's disease. | Jing Y et al. | β | 2025 | β |
| Thyroiditis and human blood metabolites: A mendelian randomization study. | Shao L et al. | β | 2025 | β |
| TidyGWAS: a scalable approach for standardized cleaning of genome-wide association study summary statistics. | Harder A et al. | β | 2025 | β |
| Uncovering Potential Susceptibility Genes for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization Analysis. | Xu Y et al. | β | 2025 | β |
| Uncovering potential therapeutic targets for autoimmune hepatitis using proteome-wide Mendelian randomization. | Li C et al. | β | 2025 | β |
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| Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study. | Wu XP et al. | β | 2024 | β |
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| Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease. | Bergstedt J et al. | β | 2024 | β |
| Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics. | Jeong S et al. | β | 2024 | β |
| Genetic Analysis of Perceived Youthfulness Reveals Differences in How Men's and Women's Age Is Assessed. | Ingold N et al. | β | 2024 | β |
| Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study. | Zhu G et al. | β | 2024 | β |
| Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study. | Gao X et al. | β | 2024 | β |
| Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms. | HeikkilΓ€ A et al. | β | 2024 | β |
| Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis. | Bekenova NB et al. | β | 2024 | β |
| Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. | Mbarek H et al. | β | 2024 | β |
| Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program. | Merritt VC et al. | β | 2024 | β |
| Improved estimation of functional enrichment in SNP heritability using feasible generalized least squares. | Xiong Z et al. | β | 2024 | β |
| Investigating the shared genetic architecture between breast and ovarian cancers. | Shi X et al. | β | 2024 | β |
| Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis. | Kim D et al. | β | 2024 | β |
| Mendelian randomization analysis using multiple biomarkers of an underlying common exposure. | Jin J et al. | β | 2024 | β |
| Polygenic Risk Associations with Clinical Characteristics and Recurrence of Dupuytren Disease. | Riesmeijer SA et al. | β | 2024 | β |
| Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study. | Elsheikh SSM et al. | β | 2024 | β |
| Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects. | Ahlqvist VH et al. | β | 2024 | β |
| Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations. | Capalbo A et al. | β | 2024 | β |
| The causal relationship between type 2 diabetes mellitus and isolated REM sleep behavior disorder: results from multivariable and network Mendelian randomization analysis. | Zhang RY et al. | β | 2024 | β |
| The goldmine of GWAS summary statistics: a systematic review of methods and tools. | Kontou PI et al. | β | 2024 | β |
| White Matter Tract Integrity Is Reduced in Depression and in Individuals With Genetic Liability to Depression. | Nothdurfter D et al. | β | 2024 | β |
| Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context. | Willis TW et al. | β | 2023 | β |
| A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores. | Kang M et al. | β | 2023 | β |
| A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia. | Jiang C et al. | β | 2023 | β |
| A sex-specific genome-wide association study of depression phenotypes in UK Biobank. | Silveira PP et al. | β | 2023 | β |
| Association between homocysteine and nonalcoholic fatty liver disease: Mendelian randomisation study. | Fu L et al. | β | 2023 | β |
| Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies. | Zhang C et al. | β | 2023 | β |
| Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data. | Fu L et al. | β | 2023 | β |
| Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. | Medina-Gomez C et al. | β | 2023 | β |
| Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. | Fernandez-Rozadilla C et al. | β | 2023 | β |
| Deciphering the genetic architecture of human brain structure and function: a brief survey on recent advances of neuroimaging genomics. | Zhao X et al. | β | 2023 | β |
| Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries. | An U et al. | β | 2023 | β |
| Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. | Als TD et al. | β | 2023 | β |
| Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data. | Nam Y et al. | β | 2023 | β |
| Dissecting the genetic heterogeneity of gastric cancer. | Hess T et al. | β | 2023 | β |
| Distilling causality between physical activity traits and obesity via Mendelian randomization. | Wang Z et al. | β | 2023 | β |
| Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. | Yu Chen H et al. | β | 2023 | β |
| Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose. | Qiao Z et al. | β | 2023 | β |
| Estimation of Genetic Correlation Between Rheumatoid Arthritis and Multiple Sclerosis Using Summary Statistics from Genome-Wide Association Studies. | ΓztornacΔ± RO | β | 2023 | β |
| European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. | Budu-Aggrey A et al. | β | 2023 | β |
| Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value. | Moore A et al. | β | 2023 | β |
| Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata. | Sliz E et al. | β | 2023 | β |
| Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders. | Nudel R et al. | β | 2023 | β |
| Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment. | Ter Kuile AR et al. | β | 2023 | β |
| Genetic insights into resting heart rate and its role in cardiovascular disease. | van de Vegte YJ et al. | β | 2023 | β |
| Genetic relationship between the immune system and autism. | Arenella M et al. | β | 2023 | β |
| Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. | Demontis D et al. | β | 2023 | β |
| Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders. | Yao X et al. | β | 2023 | β |
| Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits. | Mocci E et al. | β | 2023 | β |
| Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. | Austin-Zimmerman I et al. | β | 2023 | β |
| Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases. | Tomasoni M et al. | β | 2023 | β |
| Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors. | Klimentidis YC et al. | β | 2023 | β |
| Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. | Klarin D et al. | β | 2023 | β |
| Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders. | Hatoum AS et al. | β | 2023 | β |
| Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure. | RΓ€mΓΆ JT et al. | β | 2023 | β |
| GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer. | Koel M et al. | β | 2023 | β |
| GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. | International League Against Epilepsy Consortium on Complex Epilepsies | β | 2023 | β |
| GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. | Docherty AR et al. | β | 2023 | β |
| GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. | Lagou V et al. | β | 2023 | β |
| GWAS on retinal vasculometry phenotypes. | Jiang X et al. | β | 2023 | β |
| Hidden Genetic Regulation of Human Complex Traits via Brain Isoforms. | Pan L et al. | β | 2023 | β |
| Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score. | Morita Y et al. | β | 2023 | β |
| Inferring the Genetic Influences on Psychological Traits Using MRI Connectivity Predictive Models: Demonstration with Cognition. | Hatoum AS et al. | β | 2023 | β |
| Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA. | Tervi A et al. | β | 2023 | β |
| Leveraging IgG N-glycosylation to infer the causality between T2D and hypertension. | Wang H et al. | β | 2023 | β |
| Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases. | Reynolds RH et al. | β | 2023 | β |
| Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization. | Zheng J et al. | β | 2023 | β |
| Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. | Kavousi M et al. | β | 2023 | β |
| Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry. | Restrepo-Lozano JM et al. | β | 2023 | β |
| Novel Genetic Determinants of Dental Maturation in Children. | Grgic O et al. | β | 2023 | β |
| PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders. | Topaloudi A et al. | β | 2023 | β |
| Positive association between omega-3/6 polyunsaturated fatty acids and idiopathic normal pressure hydrocephalus: a mendelian randomization study. | Li J et al. | β | 2023 | β |
| SDPRX: A statistical method for cross-population prediction of complex traits. | Zhou G et al. | β | 2023 | β |
| Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity. | Christiansen CE et al. | β | 2023 | β |
| The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits. | Costanzo MC et al. | β | 2023 | β |
| topr: an R package for viewing and annotating genetic association results. | Juliusdottir T | β | 2023 | β |
| Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study. | Moen GH et al. | β | 2023 | β |
| A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy. | Athanasiadis G et al. | β | 2022 | β |
| Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse. | Pujol-Gualdo N et al. | β | 2022 | β |
| A genetic correlation scan identifies blood proteins associated with bone mineral density. | Xu J et al. | β | 2022 | β |
| A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension. | Xiao X et al. | β | 2022 | β |
| A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci. | Kimbrel NA et al. | β | 2022 | β |
| A genome-wide association study of total child psychiatric problems scores. | Neumann A et al. | β | 2022 | β |
| A meta-analysis on the heritability of vertebrate telomere length. | Chik HYJ et al. | β | 2022 | β |
| A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma. | Seviiri M et al. | β | 2022 | β |
| Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis. | Choquet H et al. | β | 2022 | β |
| An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript. | Riveros-Mckay F et al. | β | 2022 | β |
| An integrated framework for local genetic correlation analysis. | Werme J et al. | β | 2022 | β |
| Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study. | Nethander M et al. | β | 2022 | β |
| Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study. | Choquet H et al. | β | 2022 | β |
| Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis. | Liao C et al. | β | 2022 | β |
| Associations between alcohol use and accelerated biological ageing. | BΓΈstrand SMK et al. | β | 2022 | β |
| Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms. | Xie A et al. | β | 2022 | β |
| Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma. | Asefa NG et al. | β | 2022 | β |
| Can adult polygenic scores improve prediction of body mass index in childhood? | Lange K et al. | β | 2022 | β |
| Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study. | Fu L et al. | β | 2022 | β |
| Common Genetic Variation and Age of Onset of Anorexia Nervosa. | Watson HJ et al. | β | 2022 | β |
| Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. | Dejanovic B et al. | β | 2022 | β |
| Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci. | Fadista J et al. | β | 2022 | β |
| Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology. | Ahmed M et al. | β | 2022 | β |
| Correlations between complex human phenotypes vary by genetic background, gender, and environment. | Elgart M et al. | β | 2022 | β |
| Cross-trait assortative mating is widespread and inflates genetic correlation estimates. | Border R et al. | β | 2022 | β |
| Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms. | Sirignano L et al. | β | 2022 | β |
| Discovery of 42 genome-wide significant loci associated with dyslexia. | Doust C et al. | β | 2022 | β |
| Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. | Mullins N et al. | β | 2022 | β |
| Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. | Maihofer AX et al. | β | 2022 | β |
| Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families. | Ahangari M et al. | β | 2022 | β |
| Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study. | Clarke SLN et al. | β | 2022 | β |
| Exploring Lead loci shared between schizophrenia and Cardiometabolic traits. | He Q et al. | β | 2022 | β |
| Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide. | Coon H et al. | β | 2022 | β |
| Genetic analysis of over half a million people characterises C-reactive protein loci. | Said S et al. | β | 2022 | β |
| Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms. | Mathieu S et al. | β | 2022 | β |
| Genetic Associations and Architecture of Asthma-COPD Overlap. | John C et al. | β | 2022 | β |
| Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease. | Sun Y et al. | β | 2022 | β |
| Genetic Landscape of the ACE2 Coronavirus Receptor. | Yang Z et al. | β | 2022 | β |
| Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. | Liu L et al. | β | 2022 | β |
| Genetics and causality in the educational attainment-coronary artery disease relationship. | Okbay A | β | 2022 | β |
| Genetics in parkinson's disease: From better disease understanding to machine learning based precision medicine. | Aborageh M et al. | β | 2022 | β |
| Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. | Vogelezang S et al. | β | 2022 | β |
| Genetic trade-offs between complex diseases and longevity. | Hu D et al. | β | 2022 | β |
| Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people. | Eising E et al. | β | 2022 | β |
| Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. | Wang Z et al. | β | 2022 | β |
| Genome-wide association analysis and replication in 810,625 individuals with varicose veins. | Ahmed WU et al. | β | 2022 | β |
| Genome-Wide Association Analysis of Over 170,000 Individuals from the UK Biobank Identifies Seven Loci Associated with Dietary Approaches to Stop Hypertension (DASH) Diet. | Mompeo O et al. | β | 2022 | β |
| Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss. | Trpchevska N et al. | β | 2022 | β |
| Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer. | Dong Q et al. | β | 2022 | β |
| Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression. | Cheng B et al. | β | 2022 | β |
| Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms. | Qi G et al. | β | 2022 | β |
| Genome-wide association study meta-analysis identifies three novel loci for circulating anti-MΓΌllerian hormone levels in women. | Verdiesen RMG et al. | β | 2022 | β |
| Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors | Docherty AR et al. | β | 2022 | β |
| Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways. | Kim Y et al. | β | 2022 | β |
| Genome-Wide Association Study of Adhesive Capsulitis Suggests Significant Genetic Risk Factors. | Kulm S et al. | β | 2022 | β |
| Genome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohorts. | Klimentidis YC et al. | β | 2022 | β |
| Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test. | Fontanillas P et al. | β | 2022 | β |
| Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects. | Krohn L et al. | β | 2022 | β |
| Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. | Lahti J et al. | β | 2022 | β |
| Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. | Jansen IE et al. | β | 2022 | β |
| Genomic insights in ascending aortic size and distensibility. | Benjamins JW et al. | β | 2022 | β |
| GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating Ξ±-Klotho levels. | Gergei I et al. | β | 2022 | β |
| Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. | Mattheisen M et al. | β | 2022 | β |
| Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores. | PrivΓ© F et al. | β | 2022 | β |
| Identifying pleiotropic genes for major psychiatric disorders with GWAS summary statistics using multivariate adaptive association tests. | Wang Y et al. | β | 2022 | β |
| Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses. | Fu L et al. | β | 2022 | β |
| Integration of Distinct Analysis Strategies Improves Tissue-Trait Association Identification. | Yang Z et al. | β | 2022 | β |
| Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia. | PardiΓ±as AF et al. | β | 2022 | β |
| Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children. | de Lima RMS et al. | β | 2022 | β |
| Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits. | Sonti S et al. | β | 2022 | β |
| Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction. | Garcia-Etxebarria K et al. | β | 2022 | β |
| Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations. | Wang K et al. | β | 2022 | β |
| Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals. | Strom NI et al. | β | 2022 | β |
| Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2. | Pott J et al. | β | 2022 | β |
| Multi-ancestry genome-wide association study of asthma exacerbations. | Herrera-Luis E et al. | β | 2022 | β |
| Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. | Pervjakova N et al. | β | 2022 | β |
| Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma. | Liyanage UE et al. | β | 2022 | β |
| Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia. | Wang H et al. | β | 2022 | β |
| Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis. | Wang Y et al. | β | 2022 | β |
| Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond. | Walker VM et al. | β | 2022 | β |
| Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia. | Restuadi R et al. | β | 2022 | β |
| Population-based meta-analysis and gene-set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids. | Handelman SK et al. | β | 2022 | β |
| Reconstructing SNP allele and genotype frequencies from GWAS summary statistics. | Yang Z et al. | β | 2022 | β |
| Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. | Blokland GAM et al. | β | 2022 | β |
| Shared Genetics and Causality Between Decaffeinated Coffee Consumption and Neuropsychiatric Diseases: A Large-Scale Genome-Wide Cross-Trait Analysis and Mendelian Randomization Analysis. | Yin B et al. | β | 2022 | β |
| SNP-based heritability and selection analyses: Improved models and new results. | Speed D et al. | β | 2022 | β |
| The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes. | Mitchell BL et al. | β | 2022 | β |
| The Immune Underpinnings of Barrett's-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-Conspirators. | Tambunting L et al. | β | 2022 | β |
| The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study. | Foote IF et al. | β | 2022 | β |
| Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. | Tielbeek JJ et al. | β | 2022 | β |
| Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis. | Sliz E et al. | β | 2022 | β |
| Using genetic variation to disentangle the complex relationship between food intake and health outcomes. | Pirastu N et al. | β | 2022 | β |
| webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study. | Cao C et al. | β | 2022 | β |
| XPXP: improving polygenic prediction by cross-population and cross-phenotype analysis. | Xiao J et al. | β | 2022 | β |
| A cross-population atlas of genetic associations for 220 human phenotypes. | Sakaue S et al. | β | 2021 | β |
| Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. | Prins BP et al. | β | 2021 | β |
| A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics. | Zhou G et al. | β | 2021 | β |
| A Genome-Wide Association Study of Childhood Body Fatness. | Warner ET et al. | β | 2021 | β |
| A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. | Wightman DP et al. | β | 2021 | β |
| A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. | Choquet H et al. | β | 2021 | β |
| A model and test for coordinated polygenic epistasis in complex traits. | Sheppard B et al. | β | 2021 | β |
| Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores. | Rao S et al. | β | 2021 | β |
| An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs. | Cordell HJ et al. | β | 2021 | β |
| Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume. | Thompson A et al. | β | 2021 | β |
| Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis. | Niu P et al. | β | 2021 | β |
| Bench Research Informed by GWAS Results. | Kondratyev NV et al. | β | 2021 | β |
| Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization. | Lukkunaprasit T et al. | β | 2021 | β |
| Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics. | Zhang Y et al. | β | 2021 | β |
| Computational Tools for Causal Inference in Genetics. | Richardson TG et al. | β | 2021 | β |
| Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. | Byrne EM et al. | β | 2021 | β |
| Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects. | Xue H et al. | β | 2021 | β |
| Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. | Goodrich JK et al. | β | 2021 | β |
| Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression. | Yao Y et al. | β | 2021 | β |
| Developmental Cascades from Polygenic and Prenatal Substance Use to Adolescent Substance Use: Leveraging Severity and Directionality of Externalizing and Internalizing Problems to Understand Pubertal and Harsh Discipline-Related Risk. | Marceau K et al. | β | 2021 | β |
| Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes. | Fanfani V et al. | β | 2021 | β |
| Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants. | Rosoff DB et al. | β | 2021 | β |
| Emerging Methods and Resources for BiologicalΒ Interrogation of Neuropsychiatric Polygenic Signal. | Uffelmann E et al. | β | 2021 | β |
| Epigenome-wide association study of mitochondrial genome copy number. | Wang P et al. | β | 2021 | β |
| Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data. | Warrington NM et al. | β | 2021 | β |
| Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk. | Shigemizu D et al. | β | 2021 | β |
| Evidence for shared genetics between physical activity, sedentary behaviour and adiposity-related traits. | Schnurr TM et al. | β | 2021 | β |
| Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. | Pazoki R et al. | β | 2021 | β |
| Genetic and clinical analyses of psychosis spectrum symptoms in a large multiethnic youth cohort reveal significant link with ADHD. | Olde Loohuis LM et al. | β | 2021 | β |
| Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts. | Fabbri C et al. | β | 2021 | β |
| Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function. | Reay WR et al. | β | 2021 | β |
| Genetic Correlation and Bidirectional Causal Association Between Type 2 Diabetes and Pulmonary Function. | Zhu J et al. | β | 2021 | β |
| Genetic determinants of daytime napping and effects on cardiometabolic health. | Dashti HS et al. | β | 2021 | β |
| Genetic mechanisms of critical illness in COVID-19. | Pairo-Castineira E et al. | β | 2021 | β |
| Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight. | Beck JJ et al. | β | 2021 | β |
| Genetic predictors of educational attainment and intelligence test performance predict voter turnout. | AarΓΈe L et al. | β | 2021 | β |
| Genetic predictors of participation in optional components of UK Biobank. | Tyrrell J et al. | β | 2021 | β |
| Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations. | Pingault JB et al. | β | 2021 | β |
| Genetics of Sleep and Insights into Its Relationship with Obesity. | Dashti HS et al. | β | 2021 | β |
| Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. | Xue A et al. | β | 2021 | β |
| Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium. | Peterson RE et al. | β | 2021 | β |
| Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. | Eijsbouts C et al. | β | 2021 | β |
| Genome-wide Association Analysis Across 16,956 Patients Identifies a Novel Genetic Association Between BMP6, NIPAL1, CNGA1 and Spondylosis. | Zhang Y et al. | β | 2021 | β |
| Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. | Garnier S et al. | β | 2021 | β |
| Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. | DeMichele-Sweet MAA et al. | β | 2021 | β |
| Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent. | Buchwald J et al. | β | 2021 | β |
| Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. | McCartney DL et al. | β | 2021 | β |
| Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. | Bigdeli TB et al. | β | 2021 | β |
| Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis. | Tietz AK et al. | β | 2021 | β |
| Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. | Simcoe M et al. | β | 2021 | β |
| Genome-Wide Association Study of 2,093 Cases With Idiopathic Polyneuropathy and 445,256 Controls Identifies First Susceptibility Loci. | Winsvold BS et al. | β | 2021 | β |
| Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. | Mullins N et al. | β | 2021 | β |
| Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. | Forstner AJ et al. | β | 2021 | β |
| Genome-Wide Association Study of Peripheral Artery Disease. | van Zuydam NR et al. | β | 2021 | β |
| Genome-wide association study of stimulant dependence. | Cox J et al. | β | 2021 | β |
| Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. | Wells HRR et al. | β | 2021 | β |
| Genome-Wide Meta-Analysis Identifies Two Novel Risk Loci for Epilepsy. | Song M et al. | β | 2021 | β |
| Genomic analysis of diet composition finds novel loci and associations with health and lifestyle. | Meddens SFW et al. | β | 2021 | β |
| GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility. | Eriksson D et al. | β | 2021 | β |
| GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. | Wu Y et al. | β | 2021 | β |
| GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome. | Bonfiglio F et al. | β | 2021 | β |
| GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS. | Pritikin JN et al. | β | 2021 | β |
| Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups. | Wang YF et al. | β | 2021 | β |
| Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder. | Bonelli R et al. | β | 2021 | β |
| Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics. | Lam M et al. | β | 2021 | β |
| Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study. | Tan VY et al. | β | 2021 | β |
| Joint Analysis of Genome-Wide Association Data Reveals No Genetic Correlations Between Low Back Pain and Neurodegenerative Diseases. | Wu P et al. | β | 2021 | β |
| Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the <i>TRANK1</i> gene loci. | Ambati A et al. | β | 2021 | β |
| Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry. | Sanna M et al. | β | 2021 | β |
| More practical differentially private publication of key statistics in GWAS. | Yamamoto A et al. | β | 2021 | β |
| Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons. | Khoury S et al. | β | 2021 | β |
| Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior. | de Vlaming R et al. | β | 2021 | β |
| New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis. | Choquet H et al. | β | 2021 | β |
| No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study. | Chen H et al. | β | 2021 | β |
| Notes on Three Decades of Methodology Workshops. | Maes HH | β | 2021 | β |
| Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations. | Zheng JS et al. | β | 2021 | β |
| PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics. | Lee CH et al. | β | 2021 | β |
| Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis. | Strom NI et al. | β | 2021 | β |
| Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study. | Jia L et al. | β | 2021 | β |
| RΓ‘pidoPGS: a rapid polygenic score calculator for summary GWAS data without a test dataset. | Reales G et al. | β | 2021 | β |
| Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. | Roychowdhury T et al. | β | 2021 | β |
| Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review. | Baselmans BML et al. | β | 2021 | β |
| Sex- and age-specific genetic analysis of chronic back pain. | Freidin MB et al. | β | 2021 | β |
| Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. | Lagou V et al. | β | 2021 | β |
| Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank. | Johnston KJA et al. | β | 2021 | β |
| snpXplorer: a web application to explore human SNP-associations and annotate SNP-sets. | Tesi N et al. | β | 2021 | β |
| Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles. | Noordam R et al. | β | 2021 | β |
| SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits. | Zhang Y et al. | β | 2021 | β |
| Systems epidemiology of metabolomics measures reveals new relationships between lipoproteins and other small molecules. | Drenos F | β | 2021 | β |
| The Boulder Workshop Question Box. | Evans DM | β | 2021 | β |
| The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare. | Hanscombe KB et al. | β | 2021 | β |
| The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis. | Wilkinson JM et al. | β | 2021 | β |
| The genetic predisposition to longevity acts through behavioral phenotypes in females. | Van der Auwera S et al. | β | 2021 | β |
| The total and direct effects of systolic and diastolic blood pressure on cardiovascular disease and longevity using Mendelian randomisation. | Chan II et al. | β | 2021 | β |
| The variant call format provides efficient and robust storage of GWAS summary statistics. | Lyon MS et al. | β | 2021 | β |
| Unveiling the Pathogenesis of Psychiatric Disorders Using Network Models. | Zuo Y et al. | β | 2021 | β |
| Utility of polygenic embryo screening for disease depends on the selection strategy. | Lencz T et al. | β | 2021 | β |
| Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study. | Yoon KJ et al. | β | 2021 | β |
| Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease. | Lasconi C et al. | β | 2021 | β |
| Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease. | Crawford AA et al. | β | 2021 | β |
| Workshop proceedings: GWAS summary statistics standards and sharing. | MacArthur JAL et al. | β | 2021 | β |
| A comparison of robust Mendelian randomization methods using summary data. | Slob EAW et al. | β | 2020 | β |
| Age dependent association of inbreeding with risk for schizophrenia in Egypt. | McClain L et al. | β | 2020 | β |
| A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes. | Christou MA et al. | β | 2020 | β |
| A large-scale genetic correlation scan identified the plasma proteins associated with brain function related traits. | Liang C et al. | β | 2020 | β |
| A major role for common genetic variation in anxiety disorders. | Purves KL et al. | β | 2020 | β |
| A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer. | Ray D et al. | β | 2020 | β |
| Are vitamins relevant to cancer risks? A Mendelian randomization investigation. | Cheng WW et al. | β | 2020 | β |
| Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. | Zhang YD et al. | β | 2020 | β |
| Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study. | Zhou H et al. | β | 2020 | β |
| Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. | Holland D et al. | β | 2020 | β |
| Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty. | Kalra G et al. | β | 2020 | β |
| Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes. | CΓ³rdova-Palomera A et al. | β | 2020 | β |
| Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UK Biobank. | Strawbridge RJ et al. | β | 2020 | β |
| CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. | Wang J et al. | β | 2020 | β |
| Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank. | Lehto K et al. | β | 2020 | β |
| Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study. | Dardani C et al. | β | 2020 | β |
| Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence. | Huggett SB et al. | β | 2020 | β |
| Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women. | Lee MA et al. | β | 2020 | β |
| Comparison of Adopted and Nonadopted Individuals Reveals Gene-Environment Interplay for Education in the UK Biobank. | Cheesman R et al. | β | 2020 | β |
| Criteria for evaluating risk prediction of multiple outcomes. | Dudbridge F | β | 2020 | β |
| Diverse phenotypic measurements of wellbeing: Heritability, temporal stability and the variance explained by polygenic scores. | Jamshidi J et al. | β | 2020 | β |
| Evaluating and improving heritability models using summary statistics. | Speed D et al. | β | 2020 | β |
| Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk. | Richard D et al. | β | 2020 | β |
| Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder. | Yilmaz Z et al. | β | 2020 | β |
| Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. | Quach BC et al. | β | 2020 | β |
| Exploring the Genomic Architectures of Health, Physical Traits and Antisocial Behavioral Outcomes: A Brief Report. | Tielbeek JJ et al. | β | 2020 | β |
| Factors associated with sharing e-mail information and mental health survey participation in large population cohorts. | Adams MJ et al. | β | 2020 | β |
| Fine-scale population structure in the UK Biobank: implications for genome-wide association studies. | Cook JP et al. | β | 2020 | β |
| Functional validity, role, and implications of heavy alcohol consumption genetic loci. | Thompson A et al. | β | 2020 | β |
| Gene co-expression networks in peripheral blood capture dimensional measures of emotional and behavioral problems from the Child Behavior Checklist (CBCL). | Hess JL et al. | β | 2020 | β |
| Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software. | Jin X et al. | β | 2020 | β |
| Generalized mean <i>p</i>-values for combining dependent tests: comparison of generalized central limit theorem and robust risk analysis. | Wilson DJ | β | 2020 | β |
| Genetic aetiology of self-harm ideation and behaviour. | Campos AI et al. | β | 2020 | β |
| Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. | Jelenkovic A et al. | β | 2020 | β |
| Genetic and functional insights into the fractal structure of the heart. | Meyer HV et al. | β | 2020 | β |
| Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. | Klarin D et al. | β | 2020 | β |
| Genetic basis of falling risk susceptibility in the UK Biobank Study. | Trajanoska K et al. | β | 2020 | β |
| Genetic correlations and causal inferences in ischemic stroke. | Cai H et al. | β | 2020 | β |
| Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. | van Zuydam NR et al. | β | 2020 | β |
| Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. | Adams MJ et al. | β | 2020 | β |
| Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis. | Parisinos CA et al. | β | 2020 | β |
| Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. | Li C et al. | β | 2020 | β |
| Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure. | Rode M et al. | β | 2020 | β |
| Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours. | van de Vegte YJ et al. | β | 2020 | β |
| Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. | Revez JA et al. | β | 2020 | β |
| Genome-Wide Association Study Identifies Genetic Associations with Perceived Age. | Roberts V et al. | β | 2020 | β |
| Genome-wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder. | Harvey PD et al. | β | 2020 | β |
| Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases. | Simcoe MJ et al. | β | 2020 | β |
| Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits. | Niarchou M et al. | β | 2020 | β |
| Genome wide association study of incomplete hippocampal inversion in adolescents. | Cury C et al. | β | 2020 | β |
| Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. | Bakker MK et al. | β | 2020 | β |
| Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. | Xu K et al. | β | 2020 | β |
| Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents. | Docherty AR et al. | β | 2020 | β |
| Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. | Chen J et al. | β | 2020 | β |
| Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. | Zhou H et al. | β | 2020 | β |
| Genome-wide Study Identifies Association between HLA-B<sup>β</sup>55:01 and Self-Reported Penicillin Allergy. | Krebs K et al. | β | 2020 | β |
| Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan. | Hollis B et al. | β | 2020 | β |
| Heritability of the Fibromyalgia Phenotype Varies by Age. | Dutta D et al. | β | 2020 | β |
| High-definition likelihood inference of genetic correlations across human complex traits. | Ning Z et al. | β | 2020 | β |
| Identification of novel loci associated with infant cognitive ability. | Sun R et al. | β | 2020 | β |
| Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism. | Satterstrom FK et al. | β | 2020 | β |
| Let's call it the effect allele: a suggestion for GWAS naming conventions. | Wootton RE et al. | β | 2020 | β |
| LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations. | Ming J et al. | β | 2020 | β |
| Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. | Erzurumluoglu AM et al. | β | 2020 | β |
| Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes. | Lind MJ et al. | β | 2020 | β |
| Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry. | Clifford RE et al. | β | 2020 | β |
| Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. | Tobias JH et al. | β | 2020 | β |
| Phenome-wide and genome-wide analyses of quality of life in schizophrenia. | Pazoki R et al. | β | 2020 | β |
| Polygenic Influences on Pubertal Timing and Tempo and Depressive Symptoms in Boys and Girls. | Horvath G et al. | β | 2020 | β |
| Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications. | Aragam KG et al. | β | 2020 | β |
| Reproducible Genetic Risk Loci for Anxiety: Results From βΌ200,000 Participants in the Million Veteran Program. | Levey DF et al. | β | 2020 | β |
| Septic Shock: A Genomewide Association Study and Polygenic Risk Score Analysis. | D'Urso S et al. | β | 2020 | β |
| Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma. | Dong J et al. | β | 2020 | β |
| Shared genetic background between children and adults with attention deficit/hyperactivity disorder. | Rovira P et al. | β | 2020 | β |
| Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. | Ruderfer DM et al. | β | 2020 | β |
| Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. | Smit RAJ et al. | β | 2020 | β |
| The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: AΒ meta-analysis and Mendelian randomisation analysis. | Zheng JS et al. | β | 2020 | β |
| The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship. | Li QS et al. | β | 2020 | β |
| The behavioral, cellular and immune mediators of HIV-1 acquisition: New insights from population genetics. | Powell TR et al. | β | 2020 | β |
| The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study. | Zheng J et al. | β | 2020 | β |
| The genetic architecture of sporadic and multiple consecutive miscarriage. | Laisk T et al. | β | 2020 | β |
| The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study. | Peters T et al. | β | 2020 | β |
| The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. | Parker K et al. | β | 2020 | β |
| Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. | Richardson TG et al. | β | 2020 | β |
| Using genetics for social science. | Harden KP et al. | β | 2020 | β |
| A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. | Wiberg A et al. | β | 2019 | β |
| A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. | van der Lee SJ et al. | β | 2019 | β |
| A global overview of pleiotropy and genetic architecture in complex traits. | Watanabe K et al. | β | 2019 | β |
| A machine-compiled database of genome-wide association studies. | Kuleshov V et al. | β | 2019 | β |
| A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity. | Rosa M et al. | β | 2019 | β |
| A meta-analysis of genome-wide association studies identifies multiple longevity genes. | Deelen J et al. | β | 2019 | β |
| A meta-analysis of genome-wide association studies of epigenetic age acceleration. | Gibson J et al. | β | 2019 | β |
| Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals. | Garfield V et al. | β | 2019 | β |
| Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration. | Grassmann F et al. | β | 2019 | β |
| Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits. | Legge SE et al. | β | 2019 | β |
| Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. | Liu M et al. | β | 2019 | β |
| Asthma and affective traits in adults: a genetically informative study. | Lehto K et al. | β | 2019 | β |
| A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. | Bradfield JP et al. | β | 2019 | β |
| Biological and clinical insights from genetics of insomnia symptoms. | Lane JM et al. | β | 2019 | β |
| Biological insights into multiple birth: genetic findings from UK Biobank. | Mbarek H et al. | β | 2019 | β |
| Computational Approaches for Identification of Pleiotropic Biomarker Profiles in Psychiatry. | Cao H et al. | β | 2019 | β |
| Current opportunities to catalyze research in nutrition and cancer prevention - an interdisciplinary perspective. | Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group | β | 2019 | β |
| Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders. | Sullivan PF et al. | β | 2019 | β |
| Demographic and evolutionary trends in ovarian function and aging. | Laisk T et al. | β | 2019 | β |
| Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. | Demontis D et al. | β | 2019 | β |
| Disease classification: from phenotypic similarity to integrative genomics and beyond. | Dozmorov MG | β | 2019 | β |
| Disentangling the genetics of lean mass. | Karasik D et al. | β | 2019 | β |
| DNA methylation aging clocks: challenges and recommendations. | Bell CG et al. | β | 2019 | β |
| Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. | Evans DM et al. | β | 2019 | β |
| Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. | Schmitz LL et al. | β | 2019 | β |
| Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. | An J et al. | β | 2019 | β |
| Genetic architecture of human thinness compared to severe obesity. | Riveros-McKay F et al. | β | 2019 | β |
| Genetic architecture of subcortical brain structures in 38,851 individuals. | Satizabal CL et al. | β | 2019 | β |
| Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. | Ferreira MAR et al. | β | 2019 | β |
| Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. | Laville V et al. | β | 2019 | β |
| Genetic correlations of polygenic disease traits: from theory to practice. | van Rheenen W et al. | β | 2019 | β |
| Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. | Sakornsakolpat P et al. | β | 2019 | β |
| Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates AΞ², tau, immunity and lipid processing. | Kunkle BW et al. | β | 2019 | β |
| Genetics of Anxiety and Stress-Related Disorders-Toward a Bottom-up Cross-Disorder Psychopathology. | Domschke K et al. | β | 2019 | β |
| Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. | Wilman HR et al. | β | 2019 | β |
| Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. | Jones SE et al. | β | 2019 | β |
| Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. | Meier SM et al. | β | 2019 | β |
| Genome-wide analyses of psychological resilience in U.S. Army soldiers. | Stein MB et al. | β | 2019 | β |
| Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci. | Dudding T et al. | β | 2019 | β |
| Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. | Shungin D et al. | β | 2019 | β |
| Genome-Wide Assessment for RestingΒ Heart Rate and Shared Genetics WithΒ Cardiometabolic Traits and Type 2 Diabetes. | Guo Y et al. | β | 2019 | β |
| Genome-wide association analysis of 95β549 individuals identifies novel loci and genes influencing optic disc morphology. | Han X et al. | β | 2019 | β |
| Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. | Wang H et al. | β | 2019 | β |
| Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. | Gallagher CS et al. | β | 2019 | β |
| Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. | Teumer A et al. | β | 2019 | β |
| Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment. | Nagtegaal AP et al. | β | 2019 | β |
| Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions. | Cabana-DomΓnguez J et al. | β | 2019 | β |
| Genome-wide association study identifies 30 loci associated with bipolar disorder. | Stahl EA et al. | β | 2019 | β |
| Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. | Koshimizu H et al. | β | 2019 | β |
| Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. | Watson HJ et al. | β | 2019 | β |
| Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. | Dashti HS et al. | β | 2019 | β |
| Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. | Kranzler HR et al. | β | 2019 | β |
| Genome-wide association study of breakfast skipping links clock regulation with food timing. | Dashti HS et al. | β | 2019 | β |
| Genome-wide association study of knee pain identifies associations with <i>GDF5</i> and <i>COL27A1</i> in UK Biobank. | Meng W et al. | β | 2019 | β |
| Genome-Wide Association Study of Latent Cognitive Measures in Adolescence: Genetic Overlap With Intelligence and Education. | Donati G et al. | β | 2019 | β |
| Genome-wide association study of multisite chronic pain in UK Biobank. | Johnston KJA et al. | β | 2019 | β |
| Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. | Gelernter J et al. | β | 2019 | β |
| Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. | Helgeland Γ et al. | β | 2019 | β |
| Genome-wide estimates of heritability and genetic correlations in essential tremor. | Diez-Fairen M et al. | β | 2019 | β |
| Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease. | Huan T et al. | β | 2019 | β |
| Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis. | Fadista J et al. | β | 2019 | β |
| Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. | Howard DM et al. | β | 2019 | β |
| Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. | Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu et al. | β | 2019 | β |
| GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits. | Pazoki R et al. | β | 2019 | β |
| GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank. | Wells HRR et al. | β | 2019 | β |
| GWAS of Behavioral Traits. | Mehta D et al. | β | 2019 | β |
| GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. | Couto Alves A et al. | β | 2019 | β |
| Heritability and genetic variance of dementia with Lewy bodies. | Guerreiro R et al. | β | 2019 | β |
| Identification of 12 genetic loci associated with human healthspan. | Zenin A et al. | β | 2019 | β |
| Identification of common genetic risk variants for autism spectrum disorder. | Grove J et al. | β | 2019 | β |
| Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. | Tachmazidou I et al. | β | 2019 | β |
| Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals. | Freidin MB et al. | β | 2019 | β |
| Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species. | Bubier JA et al. | β | 2019 | β |
| International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. | Nievergelt CM et al. | β | 2019 | β |
| Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. | Kalman JL et al. | β | 2019 | β |
| Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. | Haworth S et al. | β | 2019 | β |
| Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. | Warrington NM et al. | β | 2019 | β |
| Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures. | Zheng J et al. | β | 2019 | β |
| Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects. | Qi G et al. | β | 2019 | β |
| Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. | Hsu YH et al. | β | 2019 | β |
| New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. | Hwang LD et al. | β | 2019 | β |
| Patterns of Psychiatric Comorbidity and Genetic Correlations Provide New Insights Into Differences Between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder. | Solberg BS et al. | β | 2019 | β |
| Predicting Polygenic Risk of Psychiatric Disorders. | Martin AR et al. | β | 2019 | β |
| Psychiatric genetics and the structure of psychopathology. | Smoller JW et al. | β | 2019 | β |
| Screening Human Embryos for Polygenic Traits Has Limited Utility. | Karavani E et al. | β | 2019 | β |
| Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. | Bandres-Ciga S et al. | β | 2019 | β |
| Social and non-social autism symptoms and trait domains are genetically dissociable. | Warrier V et al. | β | 2019 | β |
| Subset testing and analysis of multiple phenotypes. | Derkach A et al. | β | 2019 | β |
| SumHer better estimates the SNP heritability of complex traits from summary statistics. | Speed D et al. | β | 2019 | β |
| Summary statistic analyses can mistake confounding bias for heritability. | Holmes JB et al. | β | 2019 | β |
| Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. | Tin A et al. | β | 2019 | β |
| The analysis of causal relationships between blood lipid levels and BMD. | Cherny SS et al. | β | 2019 | β |
| The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. | Middeldorp CM et al. | β | 2019 | β |
| The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease. | Bandres-Ciga S et al. | β | 2019 | β |
| The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight. | Bandres-Ciga S et al. | β | 2019 | β |
| The genetics of vitamin D. | Jiang X et al. | β | 2019 | β |
| The polygenic nature of telomere length and the anti-ageing properties of lithium. | Coutts F et al. | β | 2019 | β |
| The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public. | van der Spek RAA et al. | β | 2019 | β |
| The role of sex in the genomics ofΒ human complex traits. | Khramtsova EA et al. | β | 2019 | β |
| Type I Error Rates and Parameter Bias in Multivariate Behavioral Genetic Models. | Verhulst B et al. | β | 2019 | β |
| Untangling the genomics of noise-induced hearing loss and tinnitus: Contributions of Mus musculus and Homo sapiens. | Clifford RE et al. | β | 2019 | β |
| Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight. | Hwang LD et al. | β | 2019 | β |
| Using Polygenic Scores in Social Science Research: Unraveling Childlessness. | Verweij RM et al. | β | 2019 | β |
| Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. | Liu X et al. | β | 2019 | β |
| A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773). | Meng W et al. | β | 2018 | β |
| Beyond heritability: improving discoverability in imaging genetics. | Fan CC et al. | β | 2018 | β |
| Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank. | Tikkanen E et al. | β | 2018 | β |
| Challenges and opportunities in stroke genetics. | Malik R et al. | β | 2018 | β |
| Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities. | Fadason T et al. | β | 2018 | β |
| Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. | van der Lee SJ et al. | β | 2018 | β |
| Common genetic variants contribute to risk of rare severe neurodevelopmental disorders. | Niemi MEK et al. | β | 2018 | β |
| Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. | PardiΓ±as AF et al. | β | 2018 | β |
| Consortium-based genome-wide meta-analysis for childhood dental caries traits. | Haworth S et al. | β | 2018 | β |
| Daily Drinking Is Associated with Increased Mortality. | Hartz SM et al. | β | 2018 | β |
| Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. | Yap CX et al. | β | 2018 | β |
| Elucidating the genetic basis of social interaction and isolation. | Day FR et al. | β | 2018 | β |
| Embracing polygenicity: a review of methods and tools for psychiatric genetics research. | Maier RM et al. | β | 2018 | β |
| Enabling precision medicine via standard communication of HTS provenance, analysis, and results. | Alterovitz G et al. | β | 2018 | β |
| Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits. | Zhang Y et al. | β | 2018 | β |
| Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. | Ni G et al. | β | 2018 | β |
| Evaluation of a genetic risk score based on creatinine-estimated glomerular filtration rate and its association with kidney outcomes. | Thio CHL et al. | β | 2018 | β |
| Exploring the genetic correlations of antisocial behaviour and life history traits. | Tielbeek JJ et al. | β | 2018 | β |
| Extracting stability increases the SNP heritability of emotional problems in young people. | Cheesman R et al. | β | 2018 | β |
| Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. | Mahajan A et al. | β | 2018 | β |
| Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). | Ren H et al. | β | 2018 | β |
| Genetically determined schizophrenia is not associated with impaired glucose homeostasis. | Polimanti R et al. | β | 2018 | β |
| Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. | Kanai M et al. | β | 2018 | β |
| Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits. | Chen X et al. | β | 2018 | β |
| Genetic Correlation Profile of Schizophrenia Mirrors Epidemiological Results and Suggests Link Between Polygenic and Rare Variant (22q11.2) Cases of Schizophrenia. | Duncan LE et al. | β | 2018 | β |
| Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. | Tylee DS et al. | β | 2018 | β |
| Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data. | DiPrete TA et al. | β | 2018 | β |
| Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity. | Peng S et al. | β | 2018 | β |
| Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. | Lu Y et al. | β | 2018 | β |
| Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. | Chen CY et al. | β | 2018 | β |
| Genetic variation in the <i>SIM1</i> locus is associated with erectile dysfunction. | Jorgenson E et al. | β | 2018 | β |
| Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. | Ligthart S et al. | β | 2018 | β |
| Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa. | Warrier V et al. | β | 2018 | β |
| Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. | Zengini E et al. | β | 2018 | β |
| Genome-wide analysis of insomnia disorder. | Stein MB et al. | β | 2018 | β |
| Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. | Wray NR et al. | β | 2018 | β |
| Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. | Smit DJA et al. | β | 2018 | β |
| Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. | Waage J et al. | β | 2018 | β |
| Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. | Vojinovic D et al. | β | 2018 | β |
| Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. | Ferguson A et al. | β | 2018 | β |
| Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. | Howard DM et al. | β | 2018 | β |
| Genome-wide association study of developmental dysplasia of the hip identifies an association with <i>GDF5</i>. | Hatzikotoulas K et al. | β | 2018 | β |
| Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE. | Klimentidis YC et al. | β | 2018 | β |
| Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. | International League Against Epilepsy Consortium on Complex Epilepsies | β | 2018 | β |
| Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank. | Hall LS et al. | β | 2018 | β |
| Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. | Petridis C et al. | β | 2018 | β |
| Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. | Suri P et al. | β | 2018 | β |
| Genomic Analyses of Visual Cognition: Perceptual Rivalry and Top-Down Control. | Chen B et al. | β | 2018 | β |
| GWAS identifies 14 loci for device-measured physical activity and sleep duration. | Doherty A et al. | β | 2018 | β |
| GWAS of epigenetic aging rates in blood reveals a critical role for TERT. | Lu AT et al. | β | 2018 | β |
| Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits. | Qi G et al. | β | 2018 | β |
| Identification of nine new susceptibility loci for endometrial cancer. | O'Mara TA et al. | β | 2018 | β |
| Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length. | Laisk T et al. | β | 2018 | β |
| Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. | Medina-Gomez C et al. | β | 2018 | β |
| Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. | Polimanti R et al. | β | 2018 | β |
| Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. | Edwards AC et al. | β | 2018 | β |
| Multi-polygenic score approach to trait prediction. | Krapohl E et al. | β | 2018 | β |
| Multi-trait analysis of genome-wide association summary statistics using MTAG. | Turley P et al. | β | 2018 | β |
| PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics. | Zheng J et al. | β | 2018 | β |
| Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. | Bogdan R et al. | β | 2018 | β |
| Proteomic analysis of postsynaptic proteins in regions of the human neocortex. | Roy M et al. | β | 2018 | β |
| Real-life helping behaviours in North America: A genome-wide association approach. | Primes G et al. | β | 2018 | β |
| Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment. | Strawbridge RJ et al. | β | 2018 | β |
| The Genetic Sphygmomanometer: an argument for routine genome-wide genotyping in the population and a new view on its use to inform clinical practice. | Timpson NJ et al. | β | 2018 | β |
| The MR-Base platform supports systematic causal inference across the human phenome. | Hemani G et al. | β | 2018 | β |
| The new genetics of intelligence. | Plomin R et al. | β | 2018 | β |
| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | β | 2018 | β |
| Why is there selective subcortical vulnerability in ADHD? Clues from postmortem brain gene expression data. | Hess JL et al. | β | 2018 | β |
| 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. | Gorski M et al. | β | 2017 | β |
| 10 Years of GWAS Discovery: Biology, Function, and Translation. | Visscher PM et al. | β | 2017 | β |
| 2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio. | Lin BD et al. | β | 2017 | β |
| A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis. | Munz M et al. | β | 2017 | β |
| A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics. | Lu Q et al. | β | 2017 | β |
| Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al. | Boedhoe PSW et al. | β | 2017 | β |
| Cognitive genomics: Searching for the genetic roots of neuropsychological functioning. | Bearden CE et al. | β | 2017 | β |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | β | 2017 | β |
| Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. | Polimanti R et al. | β | 2017 | β |
| Dissecting the genetics of complex traits using summary association statistics. | Pasaniuc B et al. | β | 2017 | β |
| Genetically-Predicted Adult Height and Alzheimer's Disease. | Larsson SC et al. | β | 2017 | β |
| Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior. | Tielbeek JJ et al. | β | 2017 | β |
| Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. | Akiyama M et al. | β | 2017 | β |
| Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. | Lee JC et al. | β | 2017 | β |
| Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112β117). | Clarke TK et al. | β | 2017 | β |
| Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. | Joshi PK et al. | β | 2017 | β |
| GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. | Pirastu N et al. | β | 2017 | β |
| Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. | Kemp JP et al. | β | 2017 | β |
| Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. | Lam M et al. | β | 2017 | β |
| Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits. | Sumner JA et al. | β | 2017 | β |
| Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. | Holmes MV et al. | β | 2017 | β |
| Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. | Sapkota Y et al. | β | 2017 | β |
| No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes. | Johnson EC et al. | β | 2017 | β |
| Phenome-wide heritability analysis of the UK Biobank. | Ge T et al. | β | 2017 | β |
| Recent Developments in Mendelian Randomization Studies. | Zheng J et al. | β | 2017 | β |
| Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. | Ferreira MA et al. | β | 2017 | β |
| Statistical methods to detect pleiotropy in human complex traits. | Hackinger S et al. | β | 2017 | β |
| Widespread covariation of early environmental exposures and trait-associated polygenic variation. | Krapohl E et al. | β | 2017 | β |
| Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. | Polimanti R et al. | β | 2017 | β |
| Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. | Lotta LA et al. | β | 2016 | β |
| Limited common origins of multiple adult health-related behaviors: Evidence from U.S. twins. | Sudharsanan N et al. | β | 2016 | β |