Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
paper
Cited
Public
- Authors
- Ohoshi, Yuji; Takahashi, Shun; Yamada, Shinichi; Ishida, Takuya; Tsuda, Kumi; Tsuji, Tomikimi; Terada, Masaki; Shinosaki, Kazuhiro; Ukai, Satoshi
- Year
- 2019
- Journal
- Brain and behavior
- PMID
- 31283112
- DOI
- 10.1002/brb3.1357
- PMCID
- PMC6710197
INTRODUCTION: The corpus callosum serves the essential role of relaying cognitive information between the homologous regions in the left and the right hemispheres of the brain. Cognitive impairment is a core dysfunction of schizophrenia, but much of its pathophysiology is unknown. The aim of this study was to elucidate the association between microstructural abnormalities of the corpus callosum and cognitive dysfunction in schizophrenia. METHODS: We examined stepwise multiple regression analysis to investigate the relationship of the fractional anisotropy (FA) of callosal fibers in each segment with z-scores of each brief assessment of cognition in schizophrenia subtest and cognitive composite score in all subjects (19 patients with schizophrenia [SZ group] and 19 healthy controls [HC group]). Callosal fibers were separated into seven segments based on their cortical projection using tract-specific analysis of diffusion tensor imaging. RESULTS: The FA of callosal fibers in the temporal segment was significantly associated with z-scores of token motor test, Tower of London test, and the composite score. In the SZ group, the FA of callosal fibers in the temporal segment was significantly associated with the z-score of the Tower of London test. In addition, the FA of callosal fibers in temporal segment showed significant negative association with the positive and negative syndrome scale negative score in the SZ group. Compared to the HC group, the FA in temporal segment was significantly decreased in the SZ group. CONCLUSION: Our results suggest that microstructural abnormalities in the callosal white matter fibers connecting bilateral temporal lobe cortices contribute to poor executive function and severe negative symptom in patients with schizophrenia.
Segmentation of corpus callosum by tractography. The corpus callosum was subdivided into seven separate segments using a two‐regions‐of‐interest (ROIs) fiber tracking approach in accordance with a determined rule and specific anatomical landmarks. The seven segments are, in order from most front to most back, as follows: orbital frontal (OF), anterior frontal (AF), superior frontal (SF), superior parietal (SP), posterior parietal (PP), temporal (Temp), and occipital (Occ)
Locations of secondary regions‐of‐interest (ROI) to separate fibers projecting to different cortical areas
Scattergram for the association between fractional anisotropy (FA) of callosal fibers in the temporal segment and score of Tower of London test in the schizophrenia (SZ) group
Scattergram for the FA of callosal fibers in the OF, AF, SF, SP, PP, Temp, and Occ segments in HC and SZ groups. The black bars represent means of each segment. Data marked * are significant at p < 0.025. AF, anterior frontal; FA, fractional anisotropy; HC, healthy controls; Occ, occipital; OF, orbital frontal; PP, posterior parietal; SF, superior frontal; SP, superior parietal; SZ, schizophrenia; Temp, temporal
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effect of Group Cognitive Behavioral Therapy on Patients with Early-Onset Schizophrenia. | Hu J et al. | — | 2024 | → |
| SARS-CoV2 evokes structural brain changes resulting in declined executive function. | Deuter D et al. | — | 2024 | → |
| White Matter Fiber Tracking Method with Adaptive Correction of Tracking Direction. | Zheng Q et al. | — | 2024 | → |
| White matter tracts and executive functions: a review of causal and correlation evidence. | Ribeiro M et al. | — | 2024 | → |
| Adult outcome of preterm birth: Implications for neurodevelopmental theories of psychosis. | Vanes LD et al. | — | 2022 | → |
| An atlas of white matter anatomy, its variability, and reproducibility based on constrained spherical deconvolution of diffusion MRI. | Radwan AM et al. | — | 2022 | → |
| Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study. | Seitz-Holland J et al. | — | 2022 | → |
| Computational modeling of electric fields for prefrontal tDCS across patients with schizophrenia and mood disorders. | Uenishi S et al. | — | 2022 | → |
| Corpus Callosum Microstructural Tract Integrity Relates to Longer Emotion Recognition Reaction Time in People with Schizophrenia. | Burke T et al. | — | 2022 | → |
| DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801. | Sun ZY et al. | — | 2022 | → |
| Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review. | Zhang F et al. | — | 2022 | → |
| Behavioral and neurobiological changes in a novel mouse model of schizophrenia induced by the combination of cuprizone and MK-801. | Sun ZY et al. | — | 2021 | → |
| Human-specific enrichment of schizophrenia risk-genes in callosal neurons of the developing neocortex | Zuccaro E et al. | — | 2021 | — |
| Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia. | Tyburski E et al. | — | 2021 | → |
| The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences. | Meyers JL et al. | — | 2021 | → |
| White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients. | Podwalski P et al. | — | 2021 | → |
| Mechanism of visual network dysfunction in relapsing-remitting multiple sclerosis and its relation to cognition. | Cooray GK et al. | — | 2020 | → |
| Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study. | Ohoshi Y et al. | — | 2019 | → |