The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample.

paper Primary Public

Authors: Kuo, Sally I-Chun; McCutcheon, Vivia V; Bucholz, Kathleen K; Dick, Danielle M; Aliev, Fazil; Meyers, Jacquelyn L; Brislin, Sarah J; Chan, Grace; Edenberg, Howard J; Kamarajan, Chella; Kramer, John; Kuperman, Samuel; Lai, Dongbing; Plawecki, Martin H; Sartor, Carolyn E; Schuckit, Marc A; Salvatore, Jessica E
Year: 2025
Journal: JAACAP open
PMID: 41367971
DOI: 10.1016/j.jaacop.2025.06.001
PMCID: PMC12684652

#	Section	Preview
20	Results — Analyses Predicting Intercept, Slope, and Quadratic Curvature of the Longitudinal Course of Heavy Episodic Drinking — Parental Separation	As shown in Table 3, in the EA sample, parental separation was associated with a higher HED…
21	Results — Analyses Predicting Intercept, Slope, and Quadratic Curvature of the Longitudinal Course of Heavy Episodic Drinking — Parental Relationship Discord	As shown in Table 3, in the EA sample, parental relationship discord was not associated with the…
22	Results — Sensitivity Analyses	To check the robustness of the findings, we conducted a series of post hoc analyses using parental…
23	Results — Sensitivity Analyses	In the EA sample, the patterns of associations from these sensitivity analyses were largely…
24	Discussion	This study expanded upon existing literature by examining how parental separation, discord, and…
25	Discussion	In the EA sample, parental separation and parental relationship discord were associated with…
26	Discussion	Problematic alcohol use polygenic scores were associated with escalation (linear slope) and…
27	Discussion	course of HED over time is influenced by both children’s polygenic predispositions and their…
28	Discussion	In the AA sample, parental relationship discord was associated with a more rapid escalation of HED…
29	Discussion	In our sample, rates of parental separation were higher in the AA (66%) compared to EA (40%)…
30	Discussion	In the AA sample, we did not find evidence that polygenic loading for problematic alcohol use was…
31	Discussion	Contrary to our expectation, parental history of AUD was also not associated with the longitudinal…
32	Discussion	Our results should be considered in light of several limitations. First, COGA is a high-risk sample,…
33	Discussion	following parental separation.50 Fourth, because young adult participants were asked to…
34	Discussion	directly assessed in the present study. Future research should examine whether the observed…
35	Discussion	In conclusion, in a high-risk sample enriched for familial risk of alcohol use disorder, we found…
36	CRediT authorship contribution statement	Sally I-Chun Kuo: Writing – review & editing, Writing – original draft, Formal analysis, Data…

Name	Type
1000 Genomes Project	cohort
AA	cohort
AA sample	cohort
adolescent heavy drinking local	phenotype
adolescent participants	cohort
adolescents	cohort
African American	cohort
African American (AA) Sample local	cohort
African-like group local	cohort
African-Like Sample local	cohort
Age at first assessment	phenotype
age at initiation of regular drinking local	phenotype
Age at initiation of regular drinking local	phenotype
age at last assessment	phenotype
alcohol	phenotype
Alcohol Initiation	phenotype
alcohol-related behaviors	phenotype
Alcohol Use Disorder	phenotype
AUD	phenotype
baseline assessment	cohort
Black females	cohort
change over time local	phenotype
children’s adjustment local	phenotype
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
discrimination	phenotype
EA	cohort
EA participants	cohort
early initiation	phenotype
EA sample	cohort
European American (EA) Sample local	cohort
European ancestry	cohort
European-like group local	cohort
familial dysfunction local	phenotype
Familial dysfunction local	phenotype
familial stressors local	phenotype
Familial stressors local	phenotype
family conflict	phenotype
frequency of HED local	phenotype
heavy drinking	phenotype
HED	phenotype
High-risk longitudinal sample local	cohort
high-risk sample	cohort
High-risk sample enriched for familial risk of alcohol use disorder local	cohort
Household chaos local	phenotype
initial status local	phenotype
Number of assessments local	phenotype
offspring	cohort
parental alcoholism	phenotype
parental divorce/separation	phenotype
parental education	phenotype
parental relationship discord	phenotype
Parental separation and discord local	phenotype
parenting	phenotype
participants	cohort
PGSPAU local	phenotype
PGSPAU local	variant
Polygenic predisposition for problematic alcohol use local	variant
polygenic risk score	cohort
problematic alcohol use	phenotype
Problematic Alcohol Use Polygenic Score local	drug
Problematic Alcohol Use Polygenic Score (PGSPAU) local	phenotype
problematic alcohol use polygenic scores local	phenotype
PRS-CS	drug
self-identified race local	phenotype
Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) Interview local	cohort
sex	phenotype
Sex, female local	phenotype
single-parent household local	phenotype
Single-parent households local	phenotype
systemic stressors local	phenotype
White girls local	cohort
young adults	cohort

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The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample.

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