Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.
- Authors
- Vogel, Carla I G; Scherag, André; Brönner, Günter; Nguyen, Thuy T; Wang, Hai-Jun; Grallert, Harald; Bornhorst, Alexa; Rosskopf, Dieter; Völzke, Henry; Reinehr, Thomas; Rief, Winfried; Illig, Thomas; Wichmann, H-Erich; Schäfer, Helmut; Hebebrand, Johannes; Hinney, Anke
- Year
- 2009
- Journal
- BMC medical genetics
- PMID
- 19254363
- DOI
- 10.1186/1471-2350-10-19
- PMCID
- PMC2654891
BACKGROUND: Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR. We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies. METHODS: Genotyping was performed by MALDI-TOF, ARMS-PCR and RFLP. The family-study: 761 German families with at least one extremely obese child or adolescent (n = 1,041) and both parents (n = 1,522). Case-control study: (a) German obese children (n = 333) and (b) obese adults (n = 987) in comparison to 588 adult lean controls. The two cross-sectional population-based studies: KORA (n = 8,269) and SHIP (n = 4,310). RESULTS: We detected over-transmission of the A-allele of rs2302382 in the German families (pTDT-Test = 0.0089). In the combined case-control sample, we estimated an odd ratio of 1.54 (95%CI 1.09;2.19, pCA-Test = 0.014) for homozygotes of the rs2302382 A-allele compared to individuals with no A-allele. A similar trend was found in KORA where the rs2302382 A-allele led to an increase of 0.12 BMI units (p = 0.136). In SHIP, however, the A-allele of rs2302382 was estimated to contribute an average decrease of 0.27 BMI units (p-value = 0.031). CONCLUSION: Our data suggest a potential relevance of GIPR variants for obesity. However, additional studies are warranted in light of the conflicting results obtained in one of the two population-based studies.
LD structure of GIPR. LD structure of GIPR region using data from HapMap analysed by Haploview using the Spine LD algorithm. Only SNP rs1800437 is informative as LD in HapMap (ellipse). The physical localization for the other two SNPs (rs8111428 and rs2302382) was represented manually with arrows. The pairwise r2 values are represented in the diamonds.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | 2010 | 20201924 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Glucose-dependent insulinotropic polypeptide (GIP). | Müller TD et al. | — | 2025 | → |
| Molecular impact of single nucleotide polymorphisms in GIPR gene among type 2 diabetes mellitus patients in the Saudi population. | Alkudmani ZS et al. | — | 2025 | → |
| Sweet Taste Receptors' Genetic Variability in Advanced Potential Targets of Obesity. | Wagner-Reguero S et al. | — | 2025 | → |
| Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't. | Novikoff A et al. | — | 2024 | → |
| Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354. | Rees TA et al. | — | 2024 | → |
| Transforming obesity: The advancement of multi-receptor drugs. | Kusminski CM et al. | — | 2024 | → |
| Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. | Yammine L et al. | — | 2023 | → |
| Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study. | Tsermpini EE et al. | — | 2022 | → |
| Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes. | Kizilkaya HS et al. | — | 2021 | → |
| Incretin hormones: Their role in health and disease. | Nauck MA et al. | — | 2018 | → |
| Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders. | Paschetta E et al. | — | 2011 | → |
| Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease. | Estep M et al. | — | 2010 | → |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | — | 2010 | → |