Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.

paper Cited Public

Authors: Markunas, Christina A; Quinn, Kaia S; Collins, Ann L; Garrett, Melanie E; Lachiewicz, Ave M; Sommer, Jennifer L; Morrissey-Kane, Erin; Kollins, Scott H; Anastopoulos, Arthur D; Ashley-Koch, Allison E
Year: 2010
Journal: Psychiatric genetics
PMID: 20032819
DOI: 10.1097/YPG.0b013e3283351209
PMCID: PMC3085270

#	Section	Preview
0	Introduction	Attention-deficit/hyperactivity disorder (AD/HD) is a common psychiatric disorder, characterized by…
1	Introduction	AD/HD has a complex etiology, influenced by both genetic and environmental factors. Evidence for a…
2	Introduction	Importantly, much of the genetic analysis for AD/HD defined the phenotype from a qualitative…
3	Introduction	help to address phenotypic heterogeneity. Endophenotypes for neuropsychiatric conditions can take a…
4	Introduction	the correlation with affection status and having a heritable component, are important for selecting…
5	Introduction	Historically, most candidate genes for AD/HD were selected based on their involvement in…
6	Introduction	(P=0.03) among individuals with the inversion compared with individuals without the inversion (Efron…
7	Introduction	in the brain. They found that DOCK3 was expressed at the highest levels in the frontal, temporal,…
8	Introduction	DOCK3, a presenilin-binding protein, belongs to the DOCK180 family of proteins and is highly…
9	Introduction	SLC9A9 is a Na+/H+ exchanger protein that is localized to the golgi and postgolgi endocytic…
10	Introduction	Based on the inversion, inv(3)(p21 : q24), that cosegregates with an AD/HD-like phenotype in a…
11	Methods — Study population	A total of 167 families were ascertained for the study if at least one child between the ages of 5…
12	Methods — Study population	the primary caregiver, (ii) was diagnosed with a pervasive developmental disorder, (iii) displayed…
13	Methods — Conners’ Parent and Teacher Rating Scales	The revised, long versions of the CPRS and CTRS of AD/HD symptoms were collected on affected and…
14	Methods — Conners’ Parent and Teacher Rating Scales	T-scores are scores that are relative to a normative group, or the population average. For example,…
15	Methods — Conners’ Continuous Performance Test	All willing family members were administered the CPT. The CPT and associated measurements have been…
16	Methods — Conners’ Continuous Performance Test	T-scores, which are adjusted for age and sex, were calculated for all measurements. The normative…
17	Methods — Genotyping and quality control	A subset of our parents and children (n=452 individuals) were genotyped using the Illumina Infinium…
18	Methods — Genotyping and quality control	Quality of the Illumina data was assessed using PLINK (http://pngu.mgh.harvard.edu/purcell/plink/)…
19	Methods — Genotyping and quality control	To address the multiple testing problem, a minimal number of haplotype-tagging SNPs present on the…

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In this knowledge base

Title	Year	PMID
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.	2013	23089632
Functional evaluation of autism-associated mutations in NHE9.	2013	24065030

External

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