Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.

paper Cited Public

Authors: Yang, Bao-Zhu; Han, Shizhong; Kranzler, Henry R; Farrer, Lindsay A; Elston, Robert C; Gelernter, Joel
Year: 2012
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 22354695
DOI: 10.1002/ajmg.b.32037
PMCID: PMC3920832

#	Section	Preview
20	DISCUSSION	Linkage analysis using the derived measure of MSD as phenotype could increase power to detect shared…
21	DISCUSSION	would be better phenotypes. For that reason, the key to selecting an appropriate number of clusters…
22	DISCUSSION	powerful than the joint linkage method [Mangin et al., 1998] in the presence of pleiotropy [Kaabi…
23	DISCUSSION	Three particularly promising candidate genes, GABRA4, GABRB1 and CLOCK, are located within or very…
24	DISCUSSION	The CLOCK gene, located within the 1-lod support interval of the linkage peak on chromosome 4,…
25	DISCUSSION	The autosome-wide significant linkage peak on chromosome 4 was observed in EAs only. Notably,…
26	DISCUSSION	In summary, we identified an autosome-wide linkage peak for MSD in EAs and several suggestive…

Citation	PMID	DOI	Status
Abarca, C et al., Proc Natl Acad Sci USA, 2002, Cocaine sensitization and reward are under the influence of circadian genes and rhythm	12084940	10.1073/pnas.142039099	Cited
Abecasis, GR et al., Am J Hum Genet, 2005, Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers	16252236	10.1086/497345	Cited
Abecasis, GR et al., Nat Genet, 2002, Merlin–rapid analysis of dense genetic maps using sparse gene flow trees	11731797	10.1038/ng786	Cited
Acuna-Goycolea, C et al., J Neurosci, 2010, Cannabinoids excite circadian clock neurons	20668190	10.1523/JNEUROSCI.5838-09.2010	Cited
Agrawal, A et al., Addiction, 2008, Are there genetic influences on addiction: Evidence from family, adoption and twin studies	18494843	10.1111/j.1360-0443.2008.02213.x	Cited
Belknap, JK et al., Trends Pharmacol Sci, 2008, Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse	18774184	10.1016/j.tips.2008.07.010	Cited
Bierut, LJ et al., Arch Gen Psychiatry, 1998, Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism	9819066	10.1001/archpsyc.55.11.982	Primary
Cloninger, CR, Science, 1987, Neurogenetic adaptive mechanisms in alcoholism	2882604	10.1126/science.2882604	Cited
Covault, J et al., Neuropsychopharmacology, 2008, Markers in the 5’-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene	17507911	10.1038/sj.npp.1301456	Cited
Diagnostic and Statistical Manual of Mental Disorders IV, 1994	—	—	—
Edenberg, HJ et al., Am J Hum Genet, 2004, Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations	15024690	10.1086/383283	Primary
Enoch, MA et al., Biol Psychiatry, 2010, The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence	19833324	10.1016/j.biopsych.2009.08.019	Cited
Enoch, MA et al., Neuropsychopharmacology, 2009, GABRG1 and GABRA2 as independent predictors for alcoholism in two populations	18818659	10.1038/npp.2008.171	Cited
Falush, D et al., Genetics, 2003, Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies	12930761	10.1093/genetics/164.4.1567	Cited
Falush, D et al., Mol Ecol Notes, 2007, Inference of population structure using multilocus genotype data: Dominant markers and null alleles	18784791	10.1111/j.1471-8286.2007.01758.x	Cited
Gelernter, J et al., Am J Hum Genet, Genomewide linkage scan for opioid dependence and related traits	16642432	10.1086/503631	Cited
Gelernter, J et al., Am J Med Genet Part B, 2004, Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking	15211640	10.1002/ajmg.b.30019	Cited
Gelernter, J et al., Am J Med Genet Part B, 2005, Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine-related trait and cocaine-induced paranoia	15909294	10.1002/ajmg.b.30189	Cited
Gelernter, J et al., Biol Psychiatry, 2007, Genomewide linkage scan for nicotine dependence: Identification of a chromosome 5 risk locus	17081504	10.1016/j.biopsych.2006.08.023	Cited
Gelernter, J et al., Biol Psychiatry, 2009, Dense genomewide linkage scan for alcohol dependence in African Americans: Significant linkage on chromosome 10	18930185	10.1016/j.biopsych.2008.08.036	Cited
Gelernter, J et al., Hum Mol Genet, Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations	17085484	10.1093/hmg/ddl426	Cited
Grucza, RA et al., Alcohol Res Health, 2006, Co-occurring risk factors for alcohol dependence and habitual smoking: Update on findings from the Collaborative Study on the Genetics of Alcoholism	17373405	—	Primary
Han, S et al., Biol Psychiatry, 2010, Meta-analysis of 15 genome-wide linkage scans of smoking behavior	19819424	10.1016/j.biopsych.2009.08.028	Cited
Huizink, AC et al., J Stud Alcohol Drugs, 2010, Tobacco, cannabis, and other illicit drug use among Finnish adolescent twins: Causal relationship or correlated liabilities?	20105408	10.15288/jsad.2010.71.5	Cited
Ittiwut, C et al., Alcohol Clin Exp Res, 2011, GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans	21919924	10.1111/j.1530-0277.2011.01637.x	Cited
Johansen, CT et al., Nat Genet, 2010, Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia	20657596	10.1038/ng.628	Cited
Johanson, CE et al., Exp Clin Psychopharmacol, 1999, The effects of cocaine on mood and sleep in cocaine-dependent males	10609968	10.1037//1064-1297.7.4.338	Cited
Kaabi, B et al., Am J Hum Genet, 2006, Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: Strong evidence for a chromosome 4 risk locus	16532386	10.1086/501072	Cited
Kaabi, B et al., Genet Epidemiol, 2003, New multivariate test for linkage, with application to pleiotropy: Fuzzy Haseman-Elston	12687642	10.1002/gepi.10234	Cited
Kaufman, L et al., Finding groups in data: An introduction to cluster analysis, 1990	—	—	—
Kendler, KS et al., Am J Psychiatry, 2003, Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins	12668357	10.1176/appi.ajp.160.4.687	Cited
Kruglyak, L et al., Am J Hum Genet, 1998, Linkage thresholds for two-stage genome scans	9529350	10.1086/301792	Cited
Lander, E et al., Nat Genet, 1995, Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results	7581446	10.1038/ng1195-241	Cited
Lappalainen, J et al., Alcohol Clin Exp Res, 2005, Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population	15834213	10.1097/01.alc.0000158938.97464.90	Cited
Lei, SF et al., Hum Genet, 2009, Genome-wide association scan for stature in Chinese: Evidence for ethnic specific loci	19030899	10.1007/s00439-008-0590-9	Cited
Leshner, AI, Science, 1997, Addiction is a brain disease, and it matters	9311924	10.1126/science.278.5335.45	Cited
Lewis, JP et al., Diabetes, 2008, Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies	18443202	10.2337/db07-1319	Cited
Li, MD et al., Mol Psychiatry, 2008, Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample	17579606	10.1038/sj.mp.4002038	Cited
Luo, X et al., Hum Mol Genet, 2007, Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans	17185388	10.1093/hmg/ddl460	Cited
Luo, X et al., Neuropsychopharmacology, 2006, ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: Results from HWD tests and case-control association studies	16237392	10.1038/sj.npp.1300925	Cited
Luthar, SS et al., Int J Addict, 1993, Substance misuse and comorbid psychopathology in a high-risk group: A study of siblings of cocaine misusers	8478155	10.3109/10826089309039639	Cited
Mangin, B et al., Biometrics, 1998, Pleiotropic QTL analysis	—	—	—
McClung, CA et al., Proc Natl Acad Sci USA, 2005, Regulation of dopaminergic transmission and cocaine reward by the Clock gene	15967985	10.1073/pnas.0503584102	Cited
McGovern, MP et al., Psychiatr Serv, 2005, Relapse of substance use disorder and its prevention among persons with co-occurring disorders	16215194	10.1176/appi.ps.56.10.1270	Cited
McLellan, AT et al., JAMA, 2000, Drug dependence, a chronic medical illness: Implications for treatment, insurance, and outcomes evaluation	11015800	10.1001/jama.284.13.1689	Cited
McPeek, MS et al., Am J Hum Genet, 2000, Statistical tests for detection of misspecified relationships by use of genome-screen data	10712219	10.1086/302800	Cited
Merikangas, KR et al., Arch Gen Psychiatry, 1998, Familial transmission of substance use disorders	9819065	10.1001/archpsyc.55.11.973	Cited
Metten, P et al., Behav Pharmacol, 1994, Common genetic determinants of severity of acute withdrawal from ethanol, pentobarbital and diazepam in inbred mice	11224305	10.1097/00008877-199408000-00014	Cited
Metten, P et al., Pharmacol Biochem Behav, 1999, Genetic determinants of severity of acute withdrawal from diazepam in mice: Commonality with ethanol and pentobarbital	10418790	10.1016/s0091-3057(99)00017-9	Cited
Mirin, SM et al., Compr Psychiatry, 1991, Psychopathology in drug abusers and their families	2001619	10.1016/0010-440x(91)90068-n	Cited
Myles, S et al., BMC Med Genomics, 2008, Worldwide population differentiation at disease-associated SNPs	18533027	10.1186/1755-8794-1-22	Cited
O’Connell, JR et al., Am J Hum Genet, 1998, PedCheck: A program for identification of genotype incompatibilities in linkage analysis	9634505	10.1086/301904	Cited
Panhuysen, CI et al., Neuropsychopharmacology, 2010, Confirmation and generalization of an alcohol-dependence locus on chromosome 10q	20147890	10.1038/npp.2010.1	Cited
Pickens, RW et al., Arch Gen Psychiatry, 1991, Heterogeneity in the inheritance of alcoholism. A study of male and female twins	1984758	10.1001/archpsyc.1991.01810250021002	Cited
Pickens, RW et al., Drug Alcohol Depend, 1995, Common genetic mechanisms in alcohol, drug, and mental disorder comorbidity	8529532	10.1016/0376-8716(95)01151-n	Cited
Pierucci-Lagha, A et al., Drug Alcohol Depend, 2005, Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA)	15896927	10.1016/j.drugalcdep.2005.04.005	Cited
Pierucci-Lagha, A et al., Drug Alcohol Depend, 2007, Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)	17590536	10.1016/j.drugalcdep.2007.04.014	Cited
Pritchard, JK et al., Genetics, 2000, Inference of population structure using multilocus genotype data	10835412	10.1093/genetics/155.2.945	Cited
Purcell, S et al., Am J Hum Genet, 2007, PLINK: A tool set for whole-genome association and population-based linkage analyses	17701901	10.1086/519795	Cited
Rebbeck, TR et al., Carcinogenesis, 2009, Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women	19028704	10.1093/carcin/bgn247	Cited
Results from the 2008 National Survey on Drug Use and Health: National Findings, 2009	—	—	—
Rewal, M et al., J Neurosci, 2009, Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol	19144854	10.1523/JNEUROSCI.3199-08.2009	Cited
Rounsaville, BJ et al., Arch Gen Psychiatry, 1991, Psychiatric diagnoses of treatment-seeking cocaine abusers	1984761	10.1001/archpsyc.1991.01810250045005	Cited
Rousseeuw, PJ, J Comput Appl Math, 1987, Silhouettes: A graphical aid to the interpretation and validation of cluster analysis	—	—	—
Sawcer, S et al., Genet Epidemiol, 1997, Empirical genomewide significance levels established by whole genome simulations	9181352	10.1002/(SICI)1098-2272(1997)14:3<223::AID-GEPI1>3.0.CO;2-6	Cited
Schierenbeck, T et al., Sleep Med Rev, 2008, Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana	18313952	10.1016/j.smrv.2007.12.004	Cited
Sham, PC et al., Am J Hum Genet, 2002, Powerful regression-based quantitative-trait linkage analysis of general pedigrees	12111667	10.1086/341560	Cited
Sherva, R et al., Neuropsychopharmacology, 2010, Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes	20485328	10.1038/npp.2010.64	Cited
Stinson, FS et al., Drug Alcohol Depend, 2005, Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions	16157233	10.1016/j.drugalcdep.2005.03.009	Cited
Tsuang, MT et al., Arch Gen Psychiatry, 1998, Co-occurrence of abuse of different drugs in men: The role of drug-specific and shared vulnerabilities	9819064	10.1001/archpsyc.55.11.967	Cited
Walsh, T et al., Science, 2008, Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia	18369103	10.1126/science.1155174	Cited
Yang, BZ et al., Alcohol Clin Exp Res, 2008, Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence	18828801	10.1111/j.1530-0277.2008.00800.x	Cited

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Title	Year	PMID
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Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.	2014	23958962

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