The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.

paper Cited Public

Authors: Ray, Lara A; Barr, Christina S; Blendy, Julie A; Oslin, David; Goldman, David; Anton, Raymond F
Year: 2012
Journal: Alcoholism, clinical and experimental research
PMID: 21895723
DOI: 10.1111/j.1530-0277.2011.01633.x
PMCID: PMC3249007

#	Section	Preview
0	GENETIC ASSOCIATION STUDIES	Several genetic association studies have tested the relationship between the Asn40Asp SNP and…
1	GENETIC ASSOCIATION STUDIES	While the vast majority of the studies have focused on adult samples, a recent study examining AUD…
2	GENETIC ASSOCIATION STUDIES	To integrate the case and control genetic studies, a meta-analysis was completed including 22…
3	GENETIC ASSOCIATION STUDIES	that African Americans displayed a lower degree of methylation between cases and controls (Nielsen…
4	GENETIC ASSOCIATION STUDIES	Although the etiological implication of this polymorphism is unclear on the basis of association…
5	BEHAVIORAL STUDIES OF ALCOHOLISM	A number of human laboratory studies employing behavioral pharmacology and experimental designs have…
6	BEHAVIORAL STUDIES OF ALCOHOLISM	A series of studies focusing on behavioral mechanisms of alcohol reward have shown that compared to…
7	BEHAVIORAL STUDIES OF ALCOHOLISM	Additional experimental studies have found that male carriers of the Asp40 allele report higher…
8	BEHAVIORAL STUDIES OF ALCOHOLISM	A laboratory study showed that Asp40 carriers displayed stronger automatic approach tendencies for…
9	BEHAVIORAL STUDIES OF ALCOHOLISM	In summary, a number of experimental paradigms have afforded a more comprehensive test of the…
10	NEUROIMAGING STUDIES	A few studies have examined the Asn40Asp SNP using neuroimaging methods. A study by Filbey and…
11	NEUROIMAGING STUDIES	A recent report combined a placebo-controlled intravenous alcohol administration with positron…
12	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	The first pharmacogenetic reports of the Asn40Asp SNP were from studies of naloxone, an opioid…
13	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	as compared to Asn40 homozygotes (Oslin et al., 2003). As these findings emerged, influential…
14	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	Results from the COMBINE Study showed that carriers of the Asp40 allele receiving naltrexone plus…
15	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	Additional studies have examined the Asn40Asp SNP and naltrexone pharmacogenetics. A controlled…
16	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	Given the known minor allele frequency imbalance across ethnic groups, extension of these findings…
17	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	A laboratory-based study of naloxone comparing individuals of European ancestry to those of Asian…
18	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	than in individuals of European ancestry (<1%) and Hispanics (3%) (Gelernter et al., 1999). Ethnic…
19	PHARMACOGENETIC STUDIES AND CLINICAL TRIALS	As with the other lines of inquiry reviewed herein, pharmacogenetic studies of naltrexone and OPRM1…

Citation	PMID	DOI	Status
Anton, RF et al., Arch Gen Psychiatry, 2008, An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study	18250251	10.1001/archpsyc.65.2.135	Cited
Arias, A et al., Drug Alcohol Depend, 2006, Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis	16387451	10.1016/j.drugalcdep.2005.11.024	Cited
Baros, AM et al., Alcohol Clin Exp Res, 2008, Naltrexone and cognitive behavioral therapy for the treatment of alcohol dependence: do sex differences exist?	18336635	10.1111/j.1530-0277.2008.00633.x	Cited
Barr, CS et al., Arch Gen Psychiatry, 2007, Association of a functional polymorphism in the muopioid receptor gene with alcohol response and consumption in male rhesus macaques	17339526	10.1001/archpsyc.64.3.369	Cited
Barr, CS et al., Biol Psychiatry, 2010, Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus	19748082	10.1016/j.biopsych.2009.07.026	Cited
Barr, CS et al., Proc Natl Acad Sci USA, 2008, Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates	18378897	10.1073/pnas.0710225105	Cited
Bart, G et al., Neuropsychopharmacology, 2005, Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden	15525999	10.1038/sj.npp.1300598	Cited
Befort, K et al., J Biol Chem, 2001, A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling	11067846	10.1074/jbc.M006352200	Cited
Bergen, AW et al., Mol Psychiatry, 1997, Mu opioid receptor gene variants: lack of association with alcohol dependence	9399694	10.1038/sj.mp.4000331	Cited
Beyer, A et al., J Neurochem, 2004, Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor	15086512	10.1111/j.1471-4159.2004.02340.x	Cited
Boettiger, CA et al., Pharmacol Biochem Behav, 2009, Now or later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network	19258022	10.1016/j.pbb.2009.02.008	Cited
Bond, C et al., Proc Natl Acad Sci USA, 1998, Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction	9689128	10.1073/pnas.95.16.9608	Cited
Crowley, JJ et al., Psychiatr Genet, 2003, A genetic association study of the mu opioid receptor and severe opioid dependence	12960749	10.1097/00041444-200309000-00006	Cited
Ducat, E et al., Addict Biol, Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic–pituitary–adrenal axis adrenocorticotropic hormone stress response to metyrapone	21507151	10.1111/j.1369-1600.2011.00313.x	Cited
Ducci, F et al., Addiction, 2008, Genetic approaches to addiction: genes and alcohol	18422824	10.1111/j.1360-0443.2008.02203.x	Cited
Ehlers, CL et al., BMC Med Genet, 2008, Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians	18433502	10.1186/1471-2350-9-35	Cited
Filbey, FM et al., Alcohol Clin Exp Res, Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes	18540916	10.1111/j.1530-0277.2008.00692.x	Cited
Filbey, FM et al., Neuropsychopharmacology, Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry	17653109	10.1038/sj.npp.1301513	Cited
Franke, P et al., Am J Med Genet, 2001, Nonreplication of association between muopioid-receptor gene (OPRM1) A118G polymorphism and substance dependence	11424981	—	Cited
Garbutt, JC et al., JAMA, 2005, Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial	15811981	10.1001/jama.293.13.1617	Cited
Gelernter, J et al., Alcohol Clin Exp Res, 2007, Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study	17374034	10.1111/j.1530-0277.2007.00339.x	Cited
Gelernter, J et al., Hum Genet, 2009, Genetics of alcohol dependence	19533172	10.1007/s00439-009-0701-2	Cited
Gelernter, J et al., Mol Psychiatry, 1999, Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects	10523821	10.1038/sj.mp.4000556	Cited
Gianoulakis, C, Curr Top Med Chem, 2009, Endogenous opioids and addiction to alcohol and other drugs of abuse	19747123	10.2174/156802609789630956	Cited
Goldman, D et al., J Stud Alcohol, 2005, COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms	16223057	10.15288/jsas.2005.s15.56	Cited
Hernandez-Avila, CA et al., Am J Med Genet B Neuropsychiatr Genet, 2003, Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)	12627468	10.1002/ajmg.b.10054	Cited
Hernandez-Avila, CA et al., Pharmacogenet Genomics, 2007, Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation	18004207	10.1097/FPC.0b013e3282f0b99c	Cited
Hines, LM et al., Dialogues Clin Neurosci, 2005, Alcoholism: the dissection for endophenotypes	16262210	10.31887/DCNS.2005.7.2/lhines	Cited
Hoehe, MR et al., Hum Mol Genet, 2000, Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence	11092766	10.1093/hmg/9.19.2895	Cited
Kendler, KS et al., Arch Gen Psychiatry, 1997, Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949	9040286	10.1001/archpsyc.1997.01830140090015	Cited
Kim, SG et al., Psychopharmacology (Berl), 2009, A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients	18795264	10.1007/s00213-008-1330-5	Cited
Kim, SG, Nihon Arukoru Yakubutsu Igakkai Zasshi, 2009, Gender differences in the genetic risk for alcohol dependence—the results of a pharmacogenetic study in Korean alcoholics	20077761	—	Cited
Koob, G et al., Am J Psychiatry, 2007, Stress, dysregulation of drug reward pathways, and the transition to drug dependence	17671276	10.1176/appi.ajp.2007.05030503	Cited
Kranzler, HR et al., Alcohol Clin Exp Res, 1998, Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1)	9756053	—	Cited
Kranzler, HR et al., Curr Pharm Des, 2010, Pharmacogenetics of alcohol and alcohol dependence treatment	20482509	10.2174/138161210791516387	Cited
Kranzler, HR et al., J Clin Psychopharmacol, 2009, Targeted naltrexone for problem drinkers	19593174	10.1097/JCP.0b013e3181ac5213	Cited
Kreek, MJ, Mol Psychiatry, 1996, Opiates, opioids and addiction	9118348	—	Cited
Kroslak, T et al., J Neurochem, 2007, The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor	17877633	10.1111/j.1471-4159.2007.04738.x	Cited
Kuehn, BM, JAMA, 2009, Findings on alcohol dependence point to promising avenues for targeted therapies	19383946	10.1001/jama.2009.535	Cited
Lesko, LJ et al., Nat Rev Drug Discov, 2004, Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective	15340386	10.1038/nrd1499	Cited
Lesko, LJ et al., Pharmacogenomics, 2010, DNA, drugs and chariots: on a decade of pharmacogenomics at the US FDA	20350131	10.2217/pgs.10.16	Cited
Levran, O et al., J Hum Genet, 2011, Haplotype block structure of the genomic region of the mu opioid receptor gene	21160491	10.1038/jhg.2010.150	Cited
Luo, X et al., Am J Med Genet B Neuropsychiatr Genet, 2003, Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans	12815747	10.1002/ajmg.b.20034	Cited
Mague, SD et al., Proc Natl Acad Sci USA, 2009, Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior	19528658	10.1073/pnas.0901800106	Cited
McGeary, JE et al., Alcohol Clin Exp Res, 2006, Genetic moderators of naltrexone’s effects on alcohol cue reactivity	16899031	10.1111/j.1530-0277.2006.00156.x	Cited
Miller, GM et al., Mol Psychiatry, 2004, A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression	14699447	10.1038/sj.mp.4001378	Cited
Miranda, R et al., Alcohol Clin Exp Res, 2010, Initial evidence of an association between OPRM1 and adolescent alcohol misuse	19860800	10.1111/j.1530-0277.2009.01073.x	Cited
Nielsen, DA et al., Hum Genet, 2010, Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts	20237803	10.1007/s00439-010-0807-6	Cited
Nielsen, DA et al., Neuropsychopharmacology, 2009, Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts	18650805	10.1038/npp.2008.108	Cited
Ooteman, W et al., Addict Biol, 2009, Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators	19523047	10.1111/j.1369-1600.2009.00159.x	Cited
Oroszi, G et al., Alcohol Clin Exp Res, 2009, OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach	19053977	10.1111/j.1530-0277.2008.00846.x	Cited
Oroszi, G et al., Pharmacogenomics, 2004, Alcoholism: genes and mechanisms	15584875	10.1517/14622416.5.8.1037	Cited
Oslin, DW et al., Addict Biol, 2006, Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone	16961767	10.1111/j.1369-1600.2006.00036.x	Cited
Oslin, DW et al., Neuropsychopharmacology, 2003, A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients	12813472	10.1038/sj.npp.1300219	Cited
O’Brien, CP, Arch Gen Psychiatry, 2008, Prospects for a genomic approach to the treatment of alcoholism	18250250	10.1001/archgenpsychiatry.2007.32	Cited
Plomin, R et al., Nat Rev Genet, 2009, Common disorders are quantitative traits	19859063	10.1038/nrg2670	Cited
Pratt, WM et al., Alcohol Alcohol, 2009, Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior	19240053	10.1093/alcalc/agp007	Cited
Prescott, CA et al., Am J Psychiatry, 1999, Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins	9892295	10.1176/ajp.156.1.34	Cited
Ramchandani, VA et al., Mol Psychiatry, 2011, A genetic determinant of the striatal dopamine response to alcohol in men	20479755	10.1038/mp.2010.56	Cited
Ravindranathan, A et al., Proc Natl Acad Sci USA, 2009, Functional characterization of human variants of the mu-opioid receptor gene	19528663	10.1073/pnas.0904509106	Cited
Ray, LA et al., Alcohol Clin Exp Res, 2004, A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans	15608594	10.1097/01.alc.0000148114.34000.b9	Cited
Ray, LA et al., Alcohol Clin Exp Res, Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the ASP40 allele of the OPRM1 gene: a pilot investigation	20528823	10.1111/j.1530-0277.2010.01233.x	Cited
Ray, LA et al., Arch Gen Psychiatry, 2007, Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study	17768272	10.1001/archpsyc.64.9.1069	Cited
Ray, LA et al., Curr Pharm Des, Application of human laboratory models to pharmacotherapy development for alcohol dependence	20482505	10.2174/138161210791516422	Cited
Ray, LA et al., Drug Alcohol Depend, 2009, Naltrexone for the treatment of alcohol dependence among African Americans: results from the COMBINE Study	19717248	10.1016/j.drugalcdep.2009.07.006	Cited
Ray, LA et al., J Abnorm Psychol, Polymorphisms of the muopioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment	20141248	10.1037/a0017550	Cited
Ray, LA et al., Subst Use Misuse, Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism	20590398	10.3109/10826084.2010.482427	Cited
Ray, LA, Alcohol Clin Exp Res, 2011, Stress-induced and cue-induced craving for alcohol in heavy drinkers: preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes	21039637	10.1111/j.1530-0277.2010.01333.x	Cited
Robinson, TE et al., Brain Res Brain Res Rev, 1993, The neural basis of drug craving: an incentive-sensitization theory of addiction	8401595	10.1016/0165-0173(93)90013-p	Cited
Schinka, JA et al., Mol Psychiatry, 2002, A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances	11840318	10.1038/sj.mp.4000951	Cited
Setiawan, E et al., Alcohol Clin Exp Res, 2011, The effect of naltrexone on alcohol’s stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype	21410481	10.1111/j.1530-0277.2011.01446.x	Cited
Shi, J et al., Hum Mutat, 2002, Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin	11933204	10.1002/humu.9026	Cited
Tan, EC et al., Neuroreport, 2003, Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations	12657887	10.1097/00001756-200303240-00008	Cited
Tate, SK et al., Nat Genet, 2004, Will tomorrow’s medicines work for everyone?	15508001	10.1038/ng1437	Cited
Tidey, JW et al., Alcohol Clin Exp Res, 2008, Moderators of naltrexone’s effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment	18028530	10.1111/j.1530-0277.2007.00545.x	Cited
Town, T et al., Am J Med Genet, 1999, Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency	10490697	—	Cited
Vallender, EJ et al., Drug Alcohol Depend, 2010, A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys	20153935	10.1016/j.drugalcdep.2010.01.005	Cited
van den Wildenberg, E et al., Alcohol Clin Exp Res, 2007, A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers	17207095	10.1111/j.1530-0277.2006.00258.x	Cited
Wand, GS et al., Neuropsychopharmacology, 2002, The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade	11751037	10.1016/S0893-133X(01)00294-9	Cited
Way, BM et al., Proc Natl Acad Sci USA, 2009, Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection	19706472	10.1073/pnas.0812612106	Cited
Wiers, RW et al., Genes Brain Behav, 2009, Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele	19016889	10.1111/j.1601-183X.2008.00454.x	Cited
Xuei, X et al., Am J Med Genet B Neuropsychiatr Genet, 2007, The opioid system in alcohol and drug dependence: family-based association study	17503481	10.1002/ajmg.b.30531	Primary
Xuei, X et al., Mol Psychiatry, 2006, Association of the kappa-opioid system with alcohol dependence	16924269	10.1038/sj.mp.4001882	Primary
Zhang, Y et al., J Biol Chem, 2005, Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G	16046395	10.1074/jbc.M504942200	Cited

In this knowledge base

Title	Year	PMID
A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.	2018	29623680
A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use.	2017	28273335
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.	2016	25039301
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Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.	2013	23136901
Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.	2013	23240711
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.	2012	22954510
Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.	2012	22551036
Translational genetic approaches to substance use disorders: bridging the gap between mice and humans.	2012	22170288

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Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent.	Lim AC et al.	—	2019	→
Pharmacogenetics of alcohol use disorder treatments: an update.	Hartwell EE et al.	—	2019	→
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Pharmacogenetic Effects of Naltrexone in Individuals of East Asian Descent: Human Laboratory Findings from a Randomized Trial.	Ray LA et al.	—	2018	→
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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
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Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research.	Bujarski S et al.	—	2016	→
Neural substrates of cue reactivity: association with treatment outcomes and relapse.	Courtney KE et al.	—	2016	→
Subjective Response to Alcohol as a Research Domain Criterion.	Ray LA et al.	—	2016	→
Alcohol Consumption in Healthy OPRM1 G Allele Carriers and Its Association with Impulsive Behavior.	Pfeifer P et al.	—	2015	→
A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.	Bilbao A et al.	—	2015	→
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Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.	Robinson JE et al.	—	2015	→
Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation.	Zhou Y et al.	—	2014	→
A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence.	Wong CJ et al.	—	2014	→
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking in alcohol-preferring (P) and Long Evans rats.	Henderson-Redmond A et al.	—	2014	→
Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues.	Ray LA et al.	—	2014	→
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Pharmacogenetic approaches in the treatment of alcohol use disorders: addressing clinical utility and implementation thresholds.	Hendershot CS	—	2014	→
Pharmacologic treatment of alcoholism.	Anton RF et al.	—	2014	→
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Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders.	Rutter JL et al.	—	2014	→
Toward personalized medicine in the pharmacotherapy of alcohol use disorder: targeting patient genes and patient goals.	Batki SL et al.	—	2014	→
Alcoholism and liver disease in Mexico: genetic and environmental factors.	Roman S et al.	—	2013	→
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Fronto-striatal functional connectivity during response inhibition in alcohol dependence.	Courtney KE et al.	—	2013	→
Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects.	Weerts EM et al.	—	2013	→
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Large-scale polymorphism discovery in macaque G-protein coupled receptors.	Goswami DB et al.	—	2013	→
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Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population.	Manini AF et al.	—	2013	→
Pharmacological challenge with naloxone and cue exposure in alcohol dependence: results of a randomized, double-blind placebo-controlled trial.	Lieb M et al.	—	2013	→
Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.	Miranda R et al.	—	2013	→
Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.	Ray LA et al.	—	2013	→
The addictive dimensionality of obesity.	Volkow ND et al.	—	2013	→
Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment.	Kranzler HR et al.	—	2013	→
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.	Ashenhurst JR et al.	—	2012	→
Imidazoline derivatives: a patent review (2006--present).	Guan X et al.	—	2012	→
Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.	Anton RF et al.	—	2012	→
Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.	Kreek MJ et al.	—	2012	→
Pharmacogenetically driven treatments for alcoholism: are we there yet?	Arias AJ et al.	—	2012	→
Pharmacogenetics of alcoholism: a clinical neuroscience perspective.	Ray LA et al.	—	2012	→
Propofol increases µ-opioid receptor expression in SH-SY5Y human neuroblastoma cells.	Li Z et al.	—	2012	→
Translational genetic approaches to substance use disorders: bridging the gap between mice and humans.	Palmer AA et al.	—	2012	→