Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.
paper
Cited
Public
- Authors
- Gelernter, Joel; Sun, Ning; Polimanti, Renato; Pietrzak, Robert; Levey, Daniel F; Bryois, Julien; Lu, Qiongshi; Hu, Yiming; Li, Boyang; Radhakrishnan, Krishnan; Aslan, Mihaela; Cheung, Kei-Hoi; Li, Yuli; Rajeevan, Nallakkandi; Sayward, Frederick; Harrington, Kelly; Chen, Quan; Cho, Kelly; Pyarajan, Saiju; Sullivan, Patrick F; Quaden, Rachel; Shi, Yunling; Hunter-Zinck, Haley; Gaziano, J Michael; Concato, John; Zhao, Hongyu; Stein, Murray B; Department of Veterans Affairs Cooperative Studies Program (#575B) and Million Veteran Program
- Year
- 2019
- Journal
- Nature neuroscience
- PMID
- 31358989
- DOI
- 10.1038/s41593-019-0447-7
- PMCID
- PMC6953633
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.
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| Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors. | Schultebraucks K et al. | — | 2021 | → |
| PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L. | Katrinli S et al. | — | 2021 | → |
| PTSD: Past, present and future implications for China. | Zhou YG et al. | — | 2021 | → |
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| TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda. | Kalungi A et al. | — | 2021 | → |
| The <i>ADCYAP1R1</i> Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population. | Wang L et al. | — | 2021 | → |
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| Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. | Huckins LM et al. | — | 2020 | → |
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| Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218. | Jurkiewicz M et al. | — | 2020 | → |
| Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. | Polimanti R et al. | — | 2020 | → |
| Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder. | Snijders C et al. | — | 2020 | → |
| Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance. | Birnie MT et al. | — | 2020 | → |
| Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function. | Brown LC et al. | — | 2020 | → |
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| Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. | Levey DF et al. | — | 2020 | → |
| Test of the dynamic interplay between DSM-5 PTSD symptom clusters in children and adolescents. | Li G et al. | — | 2020 | → |
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| International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. | Nievergelt CM et al. | — | 2019 | → |
| Investigating Individual Pre-trauma Susceptibility to a PTSD-Like Phenotype in Animals. | Alexander KS et al. | — | 2019 | → |
| Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War. | Dieter JN et al. | — | 2019 | → |