Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.

paper Cited Public

Authors: Pergadia, Michele L; Agrawal, Arpana; Loukola, Anu; Montgomery, Grant W; Broms, Ulla; Saccone, Scott F; Wang, Jen C; Todorov, Alexandre A; Heikkilä, Kauko; Statham, Dixie J; Henders, Anjali K; Campbell, Megan J; Rice, John P; Todd, Richard D; Heath, Andrew C; Goate, Alison M; Peltonen, Leena; Kaprio, Jaakko; Martin, Nicholas G; Madden, Pamela A F
Year: 2009
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 19180564
DOI: 10.1002/ajmg.b.30924
PMCID: PMC2995916

#	Section	Preview
20	Results	0.72, but correlations between DSM-IV NW and a definition of nicotine dependence using a cut-off of…
21	Results	Linkage analyses revealed several loci with suggestive or significant linkage for DSM-IV NW. The…
22	Results	Chromosomal regions with multipoint LODs greater than 1.5 for DSM-IV NW in sample specific or…
23	Discussion	The most notable finding from this report on DSM-IV Nicotine Withdrawal (NW) is a linkage signal…
24	Discussion	Inclusion of samples with lower and higher levels of tobacco use may have increased our ability to…
25	Discussion	contain genes contributing independently to NW vulnerability. Across societies, women were…
26	Discussion	There is evidence from other studies that chromosome 11 may harbor genes associated with smoking…
27	Discussion	al., 2008). Interestingly, at the height of our Finnish multipoint peak, around 20 cM, Wang et al.…
28	Discussion	The positions for at least nine possible candidate genes lie within or near the two regions…
29	Discussion	kinase gene ANKK1. Positive reports of association with various aspects of smoking…
30	Discussion	Reports suggest that variations in TPH are associated with impulse control problems (New et al.,…
31	Discussion	In this study, we also found modest multipoint elevations for DSM-IV NW on chromosomes 6 (for the…
32	Discussion	There are a number of limitations to our findings that temper our conclusions. Given that we used…
33	Discussion	adjusted p value < .05). The lack of consistency between Australian and Finnish samples may also be…

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In this knowledge base

Title	Year	PMID
Smokescreen: a targeted genotyping array for addiction research.	2016	26921259
Meta-analysis of genome-wide association studies for personality.	2012	21173776
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.	2010	20158304
Nicotine withdrawal symptoms in adolescent and adult twins.	2010	20707706
Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample.	2009	19959688

External

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