Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.
paper
Primary
Public
- Authors
- Edenberg, Howard J; McClintick, Jeanette N
- Year
- 2018
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 30320893
- DOI
- 10.1111/acer.13904
- PMCID
- PMC6286250
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes contribute to the risk, as does the environment. Although the total genetic contribution to risk is substantial, most individual variations make only very small contributions. By far the strongest contributors are functional variations in 2 genes involved in alcohol (ethanol [EtOH]) metabolism. A functional variant in alcohol dehydrogenase 1B (ADH1B) is protective in people of European and Asian descent, and a different functional variant in the same gene is protective in those of African descent. A strongly protective variant in aldehyde dehydrogenase 2 (ALDH2) is essentially only found in Asians. This highlights the need to study a wide range of populations. The likely mechanism of protection against heavy drinking and AUDs in both cases is alteration in the rate of metabolism of EtOH that at least transiently elevates acetaldehyde. Other ADH and ALDH variants, including functional variations in ADH1C, have also been implicated in affecting drinking behavior and risk for alcoholism. The pattern of linkage disequilibrium in the ADH region and the differences among populations complicate analyses, particularly of regulatory variants. This critical review focuses upon the ADH and ALDH genes as they affect AUDs.
Primary pathway of alcohol metabolism.The oxidation of alcohol to acetaldehyde is reversible in vitro, but in vivo the overall reaction goes strongly toward acetate due to the activity of ALDH2. The ADH and ALDH enzymes that carry out most of the metabolism are shown.
Expression of ADH mRNA in selected tissues.Data are in median transcripts per million transcripts (tpm), from GTEx version 7 (gtexportal.org, exported 15 April 2018) (GTEx Consortium, 2013). ADH genes are shown in numerical order, left to right, within each tissue. Inset shows enlarged image of stomach, brain (maximum tpm across all brain tissues) and whole blood.
ADH region of chromosome 4.ADH genes are arranged head-to-tail along chromosome 4, and transcribed in the opposite direction. Numbers below the line are distances between genes, in kb.
Expression of key ALDH RNAs in selected tissues.Data are median tpm, from GTEx version 7 (exported 15 April 2018) (GTEx Consortium, 2013).
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| AdachiJ, MizoiY, FukunagaT, OgawaY, ImamichiH (1989) Comparative study on ethanol elimination and blood acetaldehyde between alcoholics and control subjects. Alcohol Clin Exp Res 13:601β604.268845610.1111/j.1530-0277.1989.tb00389.x | β | β | β |
| AgrawalA, LynskeyMT, TodorovAA, SchrageAJ, LittlefieldAK, GrantJD, ZhuQ, NelsonEC, MaddenPA, BucholzKK, SherKJ, HeathAC (2011) A candidate gene association study of alcohol consumption in young women. Alcohol Clin Exp Res 35:550β558.2114325110.1111/j.1530-0277.2010.01372.xPMC3239405 | β | β | β |
| American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders: DSM-5, AMERICAN PSYCHIATRIC PUBLISHING. | β | β | β |
| BaikI, ChoNH, KimSH, HanBG, ShinC (2011) Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. Am J Clin Nutr 93:809β816.2127038210.3945/ajcn.110.001776 | β | β | β |
| BiernackaJM, GeskeJR, SchneeklothTD, FryeMA, CunninghamJM, ChoiDS, TappCL, LewisBR, DrewsMS, TLP, ColbyCL, Hall-FlavinDK, LoukianovaLL, HeitJA, MrazekDA, KarpyakVM (2013) Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. PLoS One 8:e58798.2351655810.1371/journal.pone.0058798PMC3596339 | β | β | β |
| BierutLJ, AgrawalA, BucholzKK, DohenyKF, LaurieC, PughE, FisherS, FoxL, HowellsW, BertelsenS, HinrichsAL, AlmasyL, BreslauN, CulverhouseRC, DickDM, EdenbergHJ, ForoudT, GruczaRA, HatsukamiD, HesselbrockV, JohnsonEO, KramerJ, KruegerRF, KupermanS, LynskeyM, MannK, NeumanRJ, NothenMM, NurnbergerJIJr., PorjeszB, RidingerM, SacconeNL, SacconeSF, SchuckitMA, TischfieldJA, WangJC, RietschelM, GoateAM, RiceJP, GeneEASC (2010) A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A 107:5082β5087.2020292310.1073/pnas.0911109107PMC2841942 | β | β | β |
| BierutLJ, GoateAM, BreslauN, JohnsonEO, BertelsenS, FoxL, AgrawalA, BucholzKK, GruczaR, HesselbrockV, KramerJ, KupermanS, NurnbergerJ, PorjeszB, SacconeNL, SchuckitM, TischfieldJ, WangJC, ForoudT, RiceJP, EdenbergHJ (2012) ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry 17:445β450.2196892810.1038/mp.2011.124PMC3252425 | β | β | β |
| BirleyAJ, JamesMR, DicksonPA, MontgomeryGW, HeathAC, MartinNG, WhitfieldJB (2009) ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. Hum Mol Genet 18:1533β1542.1919362810.1093/hmg/ddp060PMC2664151 | β | β | β |
| BjerregaardP, MikkelsenSS, BeckerU, HansenT, TolstrupJS (2014) Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns. Drug Alcohol Depend 144:239β244.2531158110.1016/j.drugalcdep.2014.09.774 | β | β | β |
| BorrasE, CoutelleC, RosellA, Fernandez-MuixiF, BrochM, CrosasB, HjelmqvistL, LorenzoA, GutierrezC, SantosM, SzczepanekM, HeiligM, QuattrocchiP, FarresJ, VidalF, RichartC, MachT, BogdalJ, JornvallH, SeitzHK, CouzigouP, ParesX (2000) Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatol. 31:984β989.10.1053/he.2000.597810733556 | β | β | β |
| BosronWF, EhrigT, LiT-K (1993) Genetic factors in alcohol metabolism and alcoholism. Semin.Liver.Dis. 13:126β135.833760110.1055/s-2007-1007344 | β | β | β |
| BosronWF, LiT-K (1981) Genetic determinants of alcohol and aldehyde dehydrogenases and alcohol metabolism. Semin.Liver.Dis. 1:179β188.705130110.1055/s-2008-1041746 | β | β | β |
| CarrLG, ForoudT, StewartT, CastelluccioP, EdenbergHJ, LiTK (2002) Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. Am J Med Genet 112:138β143.1224454610.1002/ajmg.10674 | β | β | β |
| ChenCC, LuRB, ChenYC, WangMF, ChangYC, LiTK, YinSJ (1999a) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. American journal of human genetics 65:795β807.1044158810.1086/302540PMC1377988 | β | β | β |
| ChenHJ, TianH, EdenbergHJ (2005) Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression. Hum Mutat 25:150β155.1564361010.1002/humu.20127 | β | β | β |
| ChenYC, LuRB, PengGS, WangMF, WangHK, KoHC, ChangYC, LuJJ, LiTK, YinSJ (1999b) Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcoholism, clinical and experimental research 23:1853β1860.10630602 | β | β | β |
| ChenYC, PengGS, TsaoTP, WangMF, LuRB, YinSJ (2009) Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenetics and genomics 19:588β599.1958477110.1097/FPC.0b013e32832ecf2e | β | β | β |
| ChiY-C, LeeS-L, LeeY-P, LaiC-L, YinS-J (2018) Modeling of Human Hepatic and Gastrointestinal Ethanol Metabolism With Kinetic Mechanism-Based Full Rate Equations of the Component Alcohol Dehydrogenase Isozymes and Allozymes. Chemical Research in Toxicology.10.1021/acs.chemrestox.8b0000329847918 | β | β | β |
| ChoiIG, SonHG, YangBH, KimSH, LeeJS, ChaiYG, SonBK, KeeBS, ParkBL, KimLH, ChoiYH, ShinHD (2005) Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. Hum Mutat 26:224β234.1608631510.1002/humu.20209 | β | β | β |
| ChouW-Y, StewartMJ, CarrLG, ZhengD, StewartTR, WilliamsA, PinaireJ, CrabbDW (1999) An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength. Alcohol.Clin.Exp.Res. 26:963β968.10397279 | β | β | β |
| ClarkeTK, AdamsMJ, DaviesG, HowardDM, HallLS, PadmanabhanS, MurrayAD, SmithBH, CampbellA, HaywardC, PorteousDJ, DearyIJ, McIntoshAM (2017) Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). Mol Psychiatry 22:1376β1384.2893769310.1038/mp.2017.153PMC5622124 | β | β | β |
| ConsortiumGTEx (2013) The Genotype-Tissue Expression (GTEx) project. Nat Genet 45:580β585.2371532310.1038/ng.2653PMC4010069 | β | β | β |
| CrabbDW, EdenbergHJ, BosronWF, LiTK (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83:314β316.256296010.1172/JCI113875PMC303676 | β | β | β |
| DayFR, OngKK, PerryJRB (2018) Elucidating the genetic basis of social interaction and isolation. Nature communications 9:2457.10.1038/s41467-018-04930-1PMC603010029970889 | β | β | β |
| DohmenK, BaraonaE, IshibashiH, PozzatoG, MorettiM, MatsunagaC, FujimotoK, LieberCS (1996) Ethnic differences in gastric s-alcohol dehydrogenase activity and ethanol first-pass metabolism. Alcohol.Clin.Exp.Res. 20:1569β1576.898620510.1111/j.1530-0277.1996.tb01701.x | β | β | β |
| DroganD, SheldrickAJ, SchutzeM, KnuppelS, AndersohnF, di GiuseppeR, HerrmannB, WillichSN, GarbeE, BergmannMM, BoeingH, WeikertC (2012) Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis. PLoS One 7:e32176.2236381010.1371/journal.pone.0032176PMC3283737 | β | β | β |
| DuesterG, FarresJ, FelderMR, HolmesRS, HoogJO, ParesX, PlappBV, YinSJ, JornvallH (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem Pharmacol 58:389β395.1042475710.1016/s0006-2952(99)00065-9 | β | β | β |
| EdenbergHJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30:5β13.17718394PMC3860432 | β | β | β |
| EdenbergHJ (2012) Genes contributing to the development of alcoholism: an overview. Alcohol research : current reviews 34:336β338.2313404910.35946/arcr.v34.3.08PMC3711246 | β | β | β |
| EdenbergHJ, BosronWF (2018) Alcohol Dehydrogenases, in Comprehensive Toxicology, Third Edition, Vol. 10, Comprehensive Toxicology, Third Edition. (MCQUEEN CA ed, pp 126β145, Oxford:Elsevier Ltd. | β | β | β |
| EdenbergHJ, ForoudT (2013) Genetics and alcoholism. Nature reviews. Gastroenterology & hepatology 10:487β494.2371231310.1038/nrgastro.2013.86PMC4056340 | β | β | β |
| EdenbergHJ, JeromeRE, LiM (1999) Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. Pharmacogenetics 9:25β30.1020863910.1097/00008571-199902000-00004 | β | β | β |
| EdenbergHJ, XueiX, ChenHJ, TianH, WetherillLF, DickDM, AlmasyL, BierutL, BucholzKK, GoateA, HesselbrockV, KupermanS, NurnbergerJ, PorjeszB, RiceJ, SchuckitM, TischfieldJ, BegleiterH, ForoudT (2006) Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet 15:1539β1549.1657160310.1093/hmg/ddl073 | β | β | β |
| EhlersCL, LiangT, GizerIR (2012) ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. Am J Drug Alcohol Abuse 38:389β394.2293107110.3109/00952990.2012.694526PMC3498484 | β | β | β |
| EhlersCL, Montane-JaimeK, MooreS, ShafeS, JosephR, CarrLG (2007) Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad. Alcohol Clin Exp Res 31:216β220.1725061210.1111/j.1530-0277.2006.00298.x | β | β | β |
| EhlersCL, SpenceJP, WallTL, GilderDA, CarrLG (2004) Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. Alcohol Clin Exp Res 28:1481β1486.1559707910.1097/01.alc.0000141821.06062.20 | β | β | β |
| FrankJ, CichonS, TreutleinJ, RidingerM, MattheisenM, HoffmannP, HermsS, WodarzN, SoykaM, ZillP, MaierW, MossnerR, GaebelW, DahmenN, ScherbaumN, SchmalC, SteffensM, LucaeS, IsingM, Muller-MyhsokB, NothenMM, MannK, KieferF, RietschelM (2012) Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addict Biol 17:171β180.2200447110.1111/j.1369-1600.2011.00395.xPMC3245349 | β | β | β |
| GelernterJ, KranzlerHR, ShervaR, AlmasyL, KoestererR, SmithAH, AntonR, PreussUW, RidingerM, RujescuD, WodarzN, ZillP, ZhaoH, FarrerLA (2014) Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Mol Psychiatry 19:41β49.2416640910.1038/mp.2013.145PMC4165335 | β | β | β |
| GelernterJ, ZhouH, NunezYZ, MutiranguraA, MalisonRT, KalayasiriR (2018) Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. Alcohol Clin Exp Res 42:861β868.2946042810.1111/acer.13614PMC5916336 | β | β | β |
| GizerIR, EdenbergHJ, GilderDA, WilhelmsenKC, EhlersCL (2011) Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. Alcohol Clin Exp Res 35:2008β2018.2163527510.1111/j.1530-0277.2011.01552.xPMC3197765 | β | β | β |
| GoeddeHW, AgarwalDP, FritzeG, Meier-TackmannD, SinghS, BeckmannG, BhatiaK, ChenLZ, FangB, LiskerR, (1992) Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 88:344β346.173383610.1007/BF00197271 | β | β | β |
| GoeddeHW, AgarwalDP, HaradaS (1983) The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism. Isozymes Curr Top Biol Med Res 8:175β193.6354997 | β | β | β |
| GoeddeHW, HaradaS, AgarwalDP (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51:331β334.51116510.1007/BF00283404 | β | β | β |
| GuindaliniC, ScivolettoS, FerreiraRG, BreenG, ZilbermanM, PelusoMA, ZatzM (2005) Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. Am J Psychiatry 162:1005β1007.1586380810.1176/appi.ajp.162.5.1005 | β | β | β |
| HaradaS, AgarwalDP, GoeddeHW (1981) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 2:982.10.1016/s0140-6736(81)91172-76117742 | β | β | β |
| HaradaS, AgarwalDP, GoeddeHW, TagakiS, IshikawaB (1982) Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan [letter]. Lancet 2:827.612670110.1016/s0140-6736(82)92722-2 | β | β | β |
| HaradaS, AgarwalDP, GoeddeHW, TakagiS (1983) Blood ethanol and acetaldehyde levels in Japanese alcoholics and controls. Pharmacol Biochem Behav 18 Suppl 1:139β140.663482910.1016/0091-3057(83)90161-2 | β | β | β |
| HaradaS, OkuboT, NakamuraT, FujiiC, NomuraF, HiguchiS, TsutsumiM (1999) A novel polymorphism (β357G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism. Alcohol.Clin.Exp.Res. 23:958β962.10397278 | β | β | β |
| HartAB, KranzlerHR (2015) Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. Alcohol Clin Exp Res 39:1312β1327.2611098110.1111/acer.12792PMC4515198 | β | β | β |
| HartAB, LynchKG, FarrerL, GelernterJ, KranzlerHR (2016) Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? Addict Biol 21:924β938.2582880910.1111/adb.12244PMC4591076 | β | β | β |
| Haschemi NassabM, RheinM, HeeseP, GlahnA, FrielingH, LinnebankM, BleichS, KornhuberJ, HeberleinA, GrallertH, PetersA, RawalR, StrauchK, HillemacherT (2015) No association between the ALDH2 promoter polymorphism rs886205, alcohol dependence, and risky alcohol consumption in a German population. Psychiatr Genet 25:41β42.2541963710.1097/YPG.0000000000000073 | β | β | β |
| HasebaT, OhnoY (2010) A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3). Int J Environ Res Public Health 7:1076β1092.2061701910.3390/ijerph7031076PMC2872310 | β | β | β |
| HasinD, AharonovichE, LiuX, MammanZ, MatseoaneK, Carr AndLG, LiTK (2002) Alcohol dependence symptoms and alcohol dehydrogenase 2 polymorphism: Israeli Ashkenazis, Sephardics, and recent Russian immigrants. Alcohol Clin Exp Res 26:1315β1321.1235192410.1097/01.ALC.0000029597.07916.A9 | β | β | β |
| HiguchiS, MatsushitaS, ImazekiH, KinoshitaT, TakagiS, KonoH (1994) Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741β742.10.1016/s0140-6736(94)91629-27907720 | β | β | β |
| HurleyTD, EdenbergHJ (2012) Genes encoding enzymes involved in ethanol metabolism. Alcohol research : current reviews 34:339β344.2313405010.35946/arcr.v34.3.09PMC3756590 | β | β | β |
| HurleyTD, EdenbergHJ, LiT-K (2002) The Pharmacogenomics of alcoholism, in Pharmacogenomics: The Search for Individualized Therapies, Pharmacogenomics: The Search for Individualized Therapies, pp 417β441, Wiley-VCH. | β | β | β |
| HusemoenLL, FengerM, FriedrichN, TolstrupJS, Beenfeldt FredriksenS, LinnebergA (2008) The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. Alcoholism, clinical and experimental research 32:1984β1991.10.1111/j.1530-0277.2008.00780.x18782342 | β | β | β |
| JacksonB, BrockerC, ThompsonDC, BlackW, VasiliouK, NebertDW, VasiliouV (2011) Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Hum Genomics 5:283β303.2171219010.1186/1479-7364-5-4-283PMC3392178 | β | β | β |
| JacksonBC, ReiganP, MillerB, ThompsonDC, VasiliouV (2015) Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling. Pharm Res 32:1648β1662.2541369210.1007/s11095-014-1564-3PMC4382438 | β | β | β |
| JairamS, EdenbergHJ (2014a) An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7. Gene 547:239β244.2497150510.1016/j.gene.2014.06.047PMC4136687 | β | β | β |
| JairamS, EdenbergHJ (2014b) Single-nucleotide polymorphisms interact to affect ADH7 transcription. Alcohol Clin Exp Res 38:921β929.2451255210.1111/acer.12340PMC3984380 | β | β | β |
| JorgensonE, ThaiKK, HoffmannTJ, SakodaLC, KvaleMN, BandaY, SchaeferC, RischN, MertensJ, WeisnerC, ChoquetH (2017) Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol Psychiatry 22:1359β1367.2848540410.1038/mp.2017.101PMC5568932 | β | β | β |
| KendlerKS, KalsiG, HolmansPA, SandersAR, AggenSH, DickDM, AlievF, ShiJ, LevinsonDF, GejmanPV (2011) Genomewide Association Analysis of Symptoms of Alcohol Dependence in the Molecular Genetics of Schizophrenia (MGS2) Control Sample. Alcoholism, clinical and experimental research 35:963β975.10.1111/j.1530-0277.2010.01427.xPMC308347321314694 | β | β | β |
| KimuraM, KimuraS, MatsushitaS, KashimaH, HiguchiS (2006) ALDH2 promoter polymorphism has no effect on the risk for alcoholism. Alcohol Alcohol 41:368β371.1662483610.1093/alcalc/agl028 | β | β | β |
| KlyosovAA (1996) Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes. Biochemistry 35:4457β4467.860519510.1021/bi9521102 | β | β | β |
| KuoPH, KalsiG, PrescottCA, HodgkinsonCA, GoldmanD, van den OordEJ, AlexanderJ, JiangC, SullivanPF, PattersonDG, WalshD, KendlerKS, RileyBP (2008) Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcoholism, clinical and experimental research 32:785β795.10.1111/j.1530-0277.2008.00642.xPMC266579018331377 | β | β | β |
| LatellaMC, Di CastelnuovoA, de LorgerilM, ArnoutJ, CappuccioFP, KroghV, SianiA, van DongenM, DonatiMB, de GaetanoG, IacovielloL, European Collaborative Group of the IP (2009) Genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors: results from the IMMIDIET study. Atherosclerosis 207:284β290.1944738910.1016/j.atherosclerosis.2009.04.022 | β | β | β |
| LeeSL, HoogJO, YinSJ (2004) Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. Pharmacogenetics 14:725β732.1556487910.1097/00008571-200411000-00003 | β | β | β |
| LekM, KarczewskiKJ, MinikelEV, SamochaKE, BanksE, FennellT, OβDonnell-LuriaAH, WareJS, HillAJ, CummingsBB, TukiainenT, BirnbaumDP, KosmickiJA, DuncanLE, EstradaK, ZhaoF, ZouJ, Pierce-HoffmanE, BerghoutJ, CooperDN, DeflauxN, DePristoM, DoR, FlannickJ, FromerM, GauthierL, GoldsteinJ, GuptaN, HowriganD, KiezunA, KurkiMI, MoonshineAL, NatarajanP, OrozcoL, PelosoGM, PoplinR, RivasMA, Ruano-RubioV, RoseSA, RuderferDM, ShakirK, StensonPD, StevensC, ThomasBP, TiaoG, Tusie-LunaMT, WeisburdB, WonHH, YuD, AltshulerDM, ArdissinoD, BoehnkeM, DaneshJ, DonnellyS, ElosuaR, FlorezJC, GabrielSB, GetzG, GlattSJ, HultmanCM, KathiresanS, LaaksoM, McCarrollS, McCarthyMI, McGovernD, McPhersonR, NealeBM, PalotieA, PurcellSM, SaleheenD, ScharfJM, SklarP, SullivanPF, TuomilehtoJ, TsuangMT, WatkinsHC, WilsonJG, DalyMJ, MacArthurDG, Exome AggregationC (2016) Analysis of protein-coding genetic variation in 60,706 humans. Nature 536:285β291.2753553310.1038/nature19057PMC5018207 | β | β | β |
| LiD, ZhaoH, GelernterJ (2011) Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry 70:504β512.2149779610.1016/j.biopsych.2011.02.024PMC3142297 | β | β | β |
| LiD, ZhaoH, GelernterJ (2012a) Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. Hum Genet 131:1361β1374.2247662310.1007/s00439-012-1163-5PMC3557796 | β | β | β |
| LiD, ZhaoH, GelernterJ (2012b) Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Hum Genet 131:725β737.2210231510.1007/s00439-011-1116-4PMC3548401 | β | β | β |
| LiH, MukherjeeN, SoundararajanU, TarnokZ, BartaC, KhaliqS, MohyuddinA, KajunaSL, MehdiSQ, KiddJR, KiddKK (2007) Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet 81:842β846.1784701010.1086/521201PMC2227934 | β | β | β |
| LindPA, ErikssonCJ, WilhelmsenKC (2008) The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population. Hum Genomics 3:24β35.1912908810.1186/1479-7364-3-1-24PMC3525184 | β | β | β |
| LinnebergA, Gonzalez-QuintelaA, VidalC, JorgensenT, FengerM, HansenT, PedersenO, HusemoenLL (2010) Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clin Exp Allergy 40:123β130.2020570010.1111/j.1365-2222.2009.03398.x | β | β | β |
| LuczakSE, GlattSJ, WallTL (2006) Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. Psychol Bull 132:607β621.1682216910.1037/0033-2909.132.4.607 | β | β | β |
| LuoX, KranzlerHR, ZuoL, LappalainenJ, YangBZ, GelernterJ (2006a) ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. Neuropsychopharmacology 31:1085β1095.1623739210.1038/sj.npp.1300925 | β | β | β |
| LuoX, KranzlerHR, ZuoL, WangS, SchorkNJ, GelernterJ (2006b) Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet 78:973β987.1668564810.1086/504113PMC1474098 | β | β | β |
| MacgregorS, LindPA, BucholzKK, HansellNK, MaddenPA, RichterMM, MontgomeryGW, MartinNG, HeathAC, WhitfieldJB (2009) Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Human molecular genetics 18:580β593.1899692310.1093/hmg/ddn372PMC2722191 | β | β | β |
| MatsuoK, HirakiA, HiroseK, ItoH, SuzukiT, WakaiK, TajimaK (2007) Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. Hum Mutat 28:506β510.1728560110.1002/humu.20477 | β | β | β |
| MeyersJL, ShmulewitzD, WallMM, KeyesKM, AharonovichE, SpivakB, WeizmanA, FrischA, EdenbergHJ, GelernterJ, GrantBF, HasinD (2015) Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers. Addict Biol 20:205β214.2416491710.1111/adb.12102PMC3999313 | β | β | β |
| MizoiY, TatsunoY, AdachiJ, KogameM, FukunagaT, FujiwaraS, HishidaS, IjiriI (1983) Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese. Pharmacol Biochem Behav 18 Suppl 1:127β133.635615610.1016/0091-3057(83)90159-4 | β | β | β |
| MizoiY, YamamotoK, UenoY, FukunagaT, HaradaS (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29:707β710.7695788 | β | β | β |
| MooreS, Montane-JaimeK, ShafeS, JosephR, CrooksH, CarrLG, EhlersCL (2007) Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago. J Stud Alcohol Drugs 68:192β196.1728633710.15288/jsad.2007.68.192 | β | β | β |
| MunozX, AmianoP, CelorrioD, DorronsoroM, SanchezMJ, HuertaJM, BarricarteA, ArriolaL, NavarroC, Molina-MontesE, ChirlaqueMD, ArdanazE, RodriguezL, DuellEJ, HijonaE, Herreros-VillanuevaM, SalaN, BujandaL (2012) Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). Addiction 107:2117β2127.2269070610.1111/j.1360-0443.2012.03970.x | β | β | β |
| NeumarkYD, FriedlanderY, DurstR, LeitersdorfE, JaffeD, RamchandaniVA, OβConnorS, CarrLG, LiTK (2004) Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. Alcohol Clin Exp Res 28:10β14.1474529710.1097/01.ALC.0000108667.79219.4D | β | β | β |
| NeumarkYD, FriedlanderY, ThomassonHR, LiTK (1998) Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: a pilot study. J Stud Alcohol 59:133β139.950029910.15288/jsa.1998.59.133 | β | β | β |
| Norden-KrichmarTM, GizerIR, WilhelmsenKC, SchorkNJ, EhlersCL (2014) Protective variant associated with alcohol dependence in a Mexican American cohort. BMC Med Genet 15:136.2552789310.1186/s12881-014-0136-zPMC4337107 | β | β | β |
| NuutinenHU, SalaspuroMP, ValleM, LindrosKO (1984) Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls. Eur J Clin Invest 14:306β311.643432610.1111/j.1365-2362.1984.tb01186.x | β | β | β |
| OlfsonE, EdenbergHJ, NurnbergerJJr., AgrawalA, BucholzKK, AlmasyLA, ChorlianD, DickDM, HesselbrockVM, KramerJR, KupermanS, PorjeszB, SchuckitMA, TischfieldJA, WangJC, WetherillL, ForoudTM, RiceJ, GoateA, BierutLJ (2014) An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcohol Clin Exp Res 38:2541β2549.2525746110.1111/acer.12524PMC4256939 | β | β | β |
| OsierM, PakstisAJ, KiddJR, LeeJF, YinSJ, KoHC, EdenbergHJ, LuRB, KiddKK (1999) Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet 64:1147β1157.1009090010.1086/302317PMC1377839 | β | β | β |
| OstbergLJ, PerssonB, HoogJO (2016) Computational studies of human class V alcohol dehydrogenase - the odd sibling. BMC Biochem 17:16.2745595610.1186/s12858-016-0072-yPMC4960878 | β | β | β |
| OttoJM, HendershotCS, CollinsSE, LiangT, WallTL (2013) Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2. Alcohol Clin Exp Res 37:164β169.2259120910.1111/j.1530-0277.2012.01835.xPMC3440549 | β | β | β |
| ParkBL, KimJW, CheongHS, KimLH, LeeBC, SeoCH, KangTC, NamYW, KimGB, ShinHD, ChoiIG (2013) Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Hum Genet 132:657β668.2345609210.1007/s00439-013-1281-8 | β | β | β |
| PengGS, ChenYC, WangMF, LaiCL, YinSJ (2014a) ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings. Pharmacogenet Genomics 24:607β617.2536552810.1097/FPC.0000000000000096 | β | β | β |
| PengQ, GizerIR, LibigerO, BizonC, WilhelmsenKC, SchorkNJ, EhlersCL (2014b) Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. Am J Med Genet B Neuropsychiatr Genet 165B:673β683.2527006410.1002/ajmg.b.32272PMC4364382 | β | β | β |
| PengQ, GizerIR, WilhelmsenKC, EhlersCL (2017) Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. Alcohol Clin Exp Res 41:1695β1704.2881563510.1111/acer.13480PMC5626638 | β | β | β |
| PochareddyS, EdenbergHJ (2010) Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). Gene 460:1β7.2036329810.1016/j.gene.2010.03.013PMC2896571 | β | β | β |
| PochareddyS, EdenbergHJ (2011) Variation in the ADH1B proximal promoter affects expression. Chem Biol Interact 191:38β41.2116839610.1016/j.cbi.2010.12.007PMC3075324 | β | β | β |
| PolimantiR, GelernterJ (2018) ADH1B: From alcoholism, natural selection, and cancer to the human phenome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177:113β125.10.1002/ajmg.b.32523PMC561776228349588 | β | β | β |
| QuillenEE, ChenXD, AlmasyL, YangF, HeH, LiX, WangXY, LiuTQ, HaoW, DengHW, KranzlerHR, GelernterJ (2014) ALDH2 is associated to alcohol dependence and is the major genetic determinant of βdaily maximum drinksβ in a GWAS study of an isolated rural Chinese sample. Am J Med Genet B Neuropsychiatr Genet 165B:103β110.2427761910.1002/ajmg.b.32213PMC4149216 | β | β | β |
| RajeevanH, SoundararajanU, KiddJR, PakstisAJ, KiddKK (2012) ALFRED: an allele frequency resource for research and teaching. Nucleic Acids Research 40:D1010βD1015.2203915110.1093/nar/gkr924PMC3245092 | β | β | β |
| RietschelM, TreutleinJ (2013) The genetics of alcohol dependence. Ann N Y Acad Sci 1282:39β70.2317093410.1111/j.1749-6632.2012.06794.x | β | β | β |
| Sanchez-RoigeS, FontanillasP, ElsonSL, andMe ResearchT, GrayJC, de WitH, DavisLK, MacKillopJ, PalmerAA (2017) Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol10.1111/adb.12574PMC698818629058377 | β | β | β |
| Sanchez-RoigeS, PalmerAA, FontanillasP, ElsonSL, 23andMe Research Team, Substance Use Disorder Working Group of the Psychiatric Genetics Consortium, AdamsMJ, HowardDM, EdenbergHJ, DaviesG, CristRC, DearyIJ, McIntoshA, ClarkeTK (2018) Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,958). bioRxiv 275917. | β | β | β |
| SchumannG, CoinLJ, LourdusamyA, CharoenP, BergerKH, StaceyD, DesrivieresS, AlievFA, KhanAA, AminN, AulchenkoYS, BakalkinG, BakkerSJ, BalkauB, BeulensJW, BilbaoA, de BoerRA, BeuryD, BotsML, BreetveltEJ, CauchiS, Cavalcanti-ProencaC, ChambersJC, ClarkeTK, DahmenN, de GeusEJ, DickD, DucciF, EastonA, EdenbergHJ, EskoT, Fernandez-MedardeA, ForoudT, FreimerNB, GiraultJA, GrobbeeDE, GuarreraS, GudbjartssonDF, HartikainenAL, HeathAC, HesselbrockV, HofmanA, HottengaJJ, IsohanniMK, KaprioJ, KhawKT, KuehnelB, LaitinenJ, LobbensS, LuanJ, ManginoM, MaroteauxM, MatulloG, McCarthyMI, MuellerC, NavisG, NumansME, NunezA, NyholtDR, Onland-MoretCN, OostraBA, OβReillyPF, PalkovitsM, PenninxBW, PolidoroS, PoutaA, ProkopenkoI, RicceriF, SantosE, SmitJH, SoranzoN, SongK, SovioU, StumvollM, SurakkI, ThorgeirssonTE, ThorsteinsdottirU, TroakesC, TyrfingssonT, TonjesA, UiterwaalCS, UitterlindenAG, van der HarstP, van der SchouwYT, StaehlinO, VogelzangsN, VollenweiderP, WaeberG, WarehamNJ, WaterworthDM, WhitfieldJB, WichmannEH, WillemsenG, WittemanJC, YuanX, ZhaiG, ZhaoJH, ZhangW, MartinNG, MetspaluA, DoeringA, ScottJ, SpectorTD, LoosRJ, BoomsmaDI, MooserV, PeltonenL, StefanssonK, van DuijnCM, VineisP, SommerWH, KoonerJS, SpanagelR, HeberleinUA, JarvelinMR, ElliottP (2011) Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A 108:7119β7124.2147145810.1073/pnas.1017288108PMC3084048 | β | β | β |
| SchumannG, LiuC, OβReillyP, GaoH, SongP, XuB, RuggeriB, AminN, JiaT, PreisS, Segura LepeM, AkiraS, BarbieriC, BaumeisterS, CauchiS, ClarkeT-K, EnrothS, FischerK, HΓ€llforsJ, HarrisSE, HieberS, HoferE, HottengaJ-J, JohanssonΓ , JoshiPK, KaartinenN, LaitinenJ, LemaitreR, LoukolaA, LuanJa, LyytikΓ€inenL-P, ManginoM, ManichaikulA, MbarekH, MilaneschiY, MoayyeriA, MukamalK, NelsonC, NettletonJ, PartinenE, RawalR, RobinoA, RoseL, SalaC, SatohT, SchmidtR, SchrautK, ScottR, SmithAV, StarrJM, TeumerA, TrompetS, UitterlindenAG, VenturiniC, VergnaudA-C, VerweijN, VitartV, VuckovicD, WedenojaJ, YengoL, YuB, ZhangW, ZhaoJH, BoomsmaDI, ChambersJ, ChasmanDI, DanielaT, de GeusE, DearyI, ErikssonJG, EskoT, EulenburgV, FrancoOH, FroguelP, GiegerC, GrabeHJ, GudnasonV, GyllenstenU, HarrisTB, HartikainenA-L, HeathAC, HockingL, HofmanA, HuthC, JarvelinM-R, JukemaJW, KaprioJ, KoonerJS, KutalikZ, LahtiJ, LangenbergC, LehtimΓ€kiT, LiuY, MaddenPAF, MartinN, MorrisonA, PenninxB, PirastuN, PsatyB, RaitakariO, RidkerP, RoseR, RotterJI, SamaniNJ, SchmidtH, SpectorTD, StottD, StrachanD, TzoulakiI, van der HarstP, van DuijnCM, Marques-VidalP, VollenweiderP, WarehamNJ, WhitfieldJB, WilsonJ, WolffenbuttelB, BakalkinG, EvangelouE, LiuY, RiceKM, DesriviΓ¨resS, KliewerSA, MangelsdorfDJ, MΓΌllerCP, LevyD, ElliottP (2016) KLB is associated with alcohol drinking, and its gene product Ξ²-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences 113:14372β14377 PMID: .2791179510.1073/pnas.1611243113PMC5167198 | β | β | β |
| ScottDM, TaylorRE (2007) Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. Alcohol Res Health 30:18β21.17718396PMC3860436 | β | β | β |
| ShenYC, FanJH, EdenbergHJ, LiTK, CuiYH, WangYF, TianCH, ZhouCF, ZhouRL, WangJ, ZhaoZL, XiaGY (1997) Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 21:1272β1277.9347089 | β | β | β |
| ShervaR, RiceJP, NeumanRJ, RochbergN, SacconeNL, BierutLJ (2009) Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. Alcohol Clin Exp Res 33:848β857.1929832210.1111/j.1530-0277.2009.00904.xPMC2892966 | β | β | β |
| ShibuyaA, YasunamiM, YoshidaA (1989) Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers. Hum.Genet. 82:14β16.271477510.1007/BF00288263 | β | β | β |
| SinghS, ChenY, MatsumotoA, OrlickyDJ, DongH, ThompsonDC, VasiliouV (2015) ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun 463:768β773.2608611110.1016/j.bbrc.2015.06.011PMC4517591 | β | β | β |
| SmithM, HopkinsonDA, HarrisH (1971) Developmental changes and polymorphism in human alcohol dehydrogenase. Ann Hum Genet 34:251β271.554843410.1111/j.1469-1809.1971.tb00238.x | β | β | β |
| SpenceJP, LiangT, ErikssonCJ, TaylorRE, WallTL, EhlersCL, CarrLG (2003) Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. Alcohol Clin Exp Res 27:1389β1394.1450639810.1097/01.ALC.0000087086.50089.59PMC4560114 | β | β | β |
| StagosD, ChenY, BrockerC, DonaldE, JacksonBC, OrlickyDJ, ThompsonDC, VasiliouV (2010) Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab Dispos 38:1679β1687.2061618510.1124/dmd.110.034678PMC2957164 | β | β | β |
| StewartMJ, MalekK, XiaoQ, DippleKM, CrabbDW (1995) The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 211:144β151.777908010.1006/bbrc.1995.1789 | β | β | β |
| StrombergP, SvenssonS, HedbergJJ, NordlingE, HoogJO (2002) Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2. Cell Mol Life Sci 59:552β559.1196413310.1007/s00018-002-8447-1PMC11337534 | β | β | β |
| TakeshitaT, MaoXQ, MorimotoK (1996) The contribution of polymorphism in the alcohol dehydrogenase beta subunit to alcohol sensitivity in a Japanese population. Hum.Genet. 97:409β413.883423310.1007/BF02267057 | β | β | β |
| TakeuchiF, IsonoM, NabikaT, KatsuyaT, SugiyamaT, YamaguchiS, KobayashiS, OgiharaT, YamoriY, FujiokaA, KatoN (2011) Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J 75:911β918.2137240710.1253/circj.cj-10-0774 | β | β | β |
| The 1000 Genomes Project Consortium, AutonA, BrooksLD, DurbinRM, GarrisonEP, KangHM, KorbelJO, MarchiniJL, McCarthyS, McVeanGA, AbecasisGR (2015) A global reference for human genetic variation. Nature 526:68β74.2643224510.1038/nature15393PMC4750478 | β | β | β |
| ThomassonHR, BeardJD, LiT-K (1995) ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol.Clin.Exp.Res. 19:1494β1499.874981610.1111/j.1530-0277.1995.tb01013.x | β | β | β |
| ThomassonHR, CrabbDW, EdenbergHJ, LiTK, HwuHG, ChenCC, YehEK, YinSJ (1994) Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 18:640β643.794366810.1111/j.1530-0277.1994.tb00923.x | β | β | β |
| ThomassonHR, EdenbergHJ, CrabbDW, MaiXL, JeromeRE, LiTK, WangSP, LinYT, LuRB, YinSJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677β681.2014795PMC1682953 | β | β | β |
| TolstrupJS, NordestgaardBG, RasmussenS, Tybjaerg-HansenA, GronbaekM (2008) Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. Pharmacogenomics J 8:220β227.1792385310.1038/sj.tpj.6500471 | β | β | β |
| TreutleinJ, CichonS, RidingerM, WodarzN, SoykaM, ZillP, MaierW, MoessnerR, GaebelW, DahmenN, FehrC, ScherbaumN, SteffensM, LudwigKU, FrankJ, WichmannHE, SchreiberS, DraganoN, SommerWH, Leonardi-EssmannF, LourdusamyA, Gebicke-HaerterP, WienkerTF, SullivanPF, NothenMM, KieferF, SpanagelR, MannK, RietschelM (2009) Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 66:773β784.1958156910.1001/archgenpsychiatry.2009.83PMC4229246 | β | β | β |
| TreutleinJ, FrankJ, KieferF, RietschelM (2014) ADH1B Arg48His allele frequency map: filling in the gap for Central Europe. Biol Psychiatry 75:e15.2401182010.1016/j.biopsych.2013.05.042 | β | β | β |
| VasiliouV, PappaA, EsteyT (2004) Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism. Drug Metab Rev 36:279β299.1523785510.1081/dmr-120034001 | β | β | β |
| VasiliouV, ThompsonDC, SmithC, FujitaM, ChenY (2013) Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells. Chem Biol Interact 202:2β10.2315988510.1016/j.cbi.2012.10.026PMC4128326 | β | β | β |
| WallTL, CarrLG, EhlersCL (2003) Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. Am J Psychiatry 160:41β46.1250580010.1176/appi.ajp.160.1.41 | β | β | β |
| WaltersRK, AdamsMJ, AdkinsAE, AlievF, BacanuS-A, BatzlerA, BertelsenS, BiernackaJ, BigdeliTB, ChenL-S, ClarkeT-K, ChouY-L, DegenhardtF, DochertyAR, FontanillasP, FooJ, FoxL, FrankJ, GieglingI, GordonS, HackL, HartzSM, Heilmann-HeimbachS, HermsS, HodgkinsonC, HoffmannP, HottengaJ-J, KennedyMA, Alanne-KinnunenM, KonteB, LahtiJ, Lahti-PulkkinenM, LigthartL, LoukolaA-M, MaherBS, MbarekH, McIntoshAM, McQueenMB, MilaneschiY, PalviainenT, PearsonJF, PetersonRE, PolimantiR, RipattiS, RyuE, SacconeNL, SalvatoreJE, Sanchez-RoigeS, SchwandtM, ShervaR, StreitF, StrohmaierJ, ThomasN, WangJ-C, WebbBT, WedowR, WetherillL, WillsAG, BoardmanJD, ChenD, ChoiD-S, CopelandWE, CulverhouseRC, DahmenN, DegenhardtL, DomingueBW, ElsonSL, FryeM, GΓ€belW, IsingM, JohnsonEC, KeyesM, KieferF, KramerJ, KupermanS, LucaeS, LynskeyMT, MaierW, MannK, MΓ€nnistΓΆS, McClintickJN, MeyersJL, MΓΌller-MyhsokB, NurnbergerJI, PalotieA, PreussU, RΓ€ikkΓΆnenK, ReynoldsMD, RidingerM, ScherbaumN, ShuckitM, SoykaM, TreutleinJ, WittS, WodarzN, ZillP, AdkinsDE, BodenJM, BoomsmaD, BierutLJ, BrownSA, BucholzKK, CichonS, CostelloEJ, de WitH, DiazgranadosN, DickDM, ErikssonJG, FarrerLA, ForoudTM, GillespieNA, GoateAA, GoldmanD, GruczaRA, HancockDB, HarrisKM, HeathAC, HesselbrockV, HewittJK, HopferC, HorwoodJ, IaconoW, JohnsonEO, KaprioJA, KarpyakV, KendlerKS, KranzlerHR, KrauterK, LichtensteinP, LindPA, McGueM, MacKillopJ, MaddenPAF, MaesH, MagnussonP, MartinNG, MedlandSE, MontgomeryGW, NelsonEC, NΓΆthenM, PalmerAA, PedersenNL, PenninxBWJH, PorjeszB, RiceJP, RietschelM, RileyBP, RoseR, RujescuD, ShenP-H, SilbergJ, StallingsMC, TarterRE, VanyukovMM, VriezeS, WallTL, WhitfieldJB, ZhaoH, NealeBM, GelernterJ, EdenbergHJ, AgrawalA(2018) Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. bioRxiv 257311.10.1038/s41593-018-0275-1PMC643020730482948 | β | β | β |
| WardRJ, McPhersonAJ, ChowC, EalingJ, ShermanDI, YoshidaA, PetersTJ (1994) Identification and characterisation of alcohol-induced flushing in Caucasian subjects. Alcohol Alcohol 29:433β438.7986281 | β | β | β |
| WarrenKR, LiTK (2005) Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol 73:195β203.1578649610.1002/bdra.20125 | β | β | β |
| WayM, McQuillinA, SainiJ, RupareliaK, LydallGJ, GuerriniI, BallD, SmithI, QuadriG, ThomsonAD, Kasiakogia-WorlleyK, CherianR, GunwardenaP, RaoH, KottalgiG, PatelS, HillmanA, DouglasE, QureshiSY, ReynoldsG, JauharS, OβKaneA, DedmanA, SharpS, KandaswamyR, DarK, CurtisD, MorganMY, GurlingHM (2015) Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. Addict Biol 20:594β604.2473549010.1111/adb.12141 | β | β | β |
| WayMJ, AliMA, McQuillinA, MorganMY (2017) Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. PLoS One 12:e0177009.2859483710.1371/journal.pone.0177009PMC5464525 | β | β | β |
| WhitfieldJB (1997) Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol.Alcohol. 32:613β619.937370410.1093/oxfordjournals.alcalc.a008303 | β | β | β |
| WhitfieldJB (2002) Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations. Am J Hum Genet 71:1247β1250; author reply 1250β1241.1245218010.1086/344287PMC385114 | β | β | β |
| XiaoQ, WeinerH, CrabbDW (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98:2027β2032.890332110.1172/JCI119007PMC507646 | β | β | β |
| XuK, KranzlerHR, ShervaR, SartorCE, AlmasyL, KoestererR, ZhaoH, FarrerLA, GelernterJ (2015) Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. Alcohol Clin Exp Res 39:1137β1147.2603628410.1111/acer.12751PMC4706077 | β | β | β |
| XuYL, CarrLG, BosronWF, LiTK, EdenbergHJ (1988) Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209β214.339705910.1016/0888-7543(88)90004-3 | β | β | β |
| YoshidaA, DaveV, WardRJ, PetersTJ (1989) Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann.Hum.Genet. 53:1β7.272989410.1111/j.1469-1809.1989.tb01116.x | β | β | β |
| ZakhariS (2006) Overview: how is alcohol metabolized by the body? Alcohol Res Health 29:245β254.17718403PMC6527027 | β | β | β |
| ZhouJ, WeinerH (2000) Basis for half-of-the-site reactivity and the dominance of the K487 oriental subunit over the E487 subunit in heterotetrameric human liver mitochondrial aldehyde dehydrogenase. Biochemistry 39:12019β12024.1100961610.1021/bi001221k | β | β | β |
| ZintzarasE, StefanidisI, SantosM, VidalF (2006) Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology 43:352β361.1644036210.1002/hep.21023 | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects. | Hart SFM et al. | β | 2026 | β |
| Genome-wide meta-analyses of cross substance use disorders in diverse populations. | Lai D et al. | β | 2026 | β |
| Long-term impact of embryonic ethanol exposure on gene expression and executive functions in zebrafish. | Lima Filho RO et al. | β | 2026 | β |
| Rapid and simple lateral flow detection for ADH1B and ALDH2 genotyping: PCR-restriction digestion-adapter ligation-lateral flow (PRALL) assay. | Shirasu N et al. | β | 2026 | β |
| Activation of hepatic alcohol metabolism by enzymatic porcine placenta hydrolysate in rats. | Shin J et al. | β | 2025 | β |
| Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome. | Borrego-Ruiz A et al. | β | 2025 | β |
| Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review. | Zhou W et al. | β | 2025 | β |
| Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer. | Liu T et al. | β | 2025 | β |
| Comparative Evaluation of Combined Denoising and Resolution Enhancement Algorithms for Intravital Two-Photon Imaging of Organs. | Bohlooli Darian S et al. | β | 2025 | β |
| Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. | Banjan B et al. | β | 2025 | β |
| Deciphering the Role of Oroxylin A in Liver Fibrosis. | Wang S et al. | β | 2025 | β |
| Decoding the Liver-Heart Axis in Cardiometabolic Diseases. | Capone F et al. | β | 2025 | β |
| Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism. | Sun Z et al. | β | 2025 | β |
| Establishment and application of murine models of alcoholic liver disease: A narrative review. | Liu M et al. | β | 2025 | β |
| "General Addiction Liability" Revisited. | Watts AL et al. | β | 2025 | β |
| Identification of glycolysis-related genes and analysis of potential prognostic clinical application in oral squamous cell carcinoma. | Chen R et al. | β | 2025 | β |
| Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. | Icick R et al. | β | 2025 | β |
| Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development. | Yadav AK et al. | β | 2025 | β |
| Maternal alcohol consumption during pregnancy and child development: Role of ADH1B and ALDH2 gene polymorphisms-The Yamanashi Adjunct Study of the Japan Environment and Children's Study. | Miyake K et al. | β | 2025 | β |
| Population genomics advances in frontier ethnic minorities in China. | Chen H et al. | β | 2025 | β |
| Recent advances in alcohol metabolism: from the gut to the brain. | Goldman MR et al. | β | 2025 | β |
| Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain. | Cherif A et al. | β | 2025 | β |
| Relationship between age-related hearing loss and alcohol consumption in a Japanese population. | Takahashi H et al. | β | 2025 | β |
| Relationship Between Postoperative Acute Kidney Injury and Early Extubation After Pediatric Liver Transplant. | Sahinturk H et al. | β | 2025 | β |
| Role of Metabolism onΒ Alcohol Preference, Addiction, and Treatment. | Quintanilla ME et al. | β | 2025 | β |
| Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic. | Pham KH et al. | β | 2025 | β |
| Serum Ξ²-klotho is a potential biomarker for diagnosing alcoholic liver disease and differentiating from nonalcoholic fatty liver disease. | Fang C et al. | β | 2025 | β |
| Soybean genomeβwide association study of seed weight, protein, and oil content in the southeastern USA. | Patel J et al. | β | 2025 | β |
| The Pathophysiology of Alcohol-Associated Liver Disease: Focusing on Superoxide Dismutase 1 as a Therapeutic Target. | Gopal T et al. | β | 2025 | β |
| Unraveling time-dependent genetic components underlying alcohol response. | Hikino K et al. | β | 2025 | β |
| Acetaldehyde-mediated increase in glutamatergic and N-acetylaspartate neurometabolite levels in the midcingulate cortex of ALDH2*1/*2 heterozygous young adults. | Ueno F et al. | β | 2024 | β |
| Alcohol consumption and allergic diseases: Mendelian randomization evidence from China. | Zhu C et al. | β | 2024 | β |
| Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis. | Wakabayashi I | β | 2024 | β |
| Alcohol consumption and heart failure: a dose-response meta-analysis. | Wong B et al. | β | 2024 | β |
| Alcohol consumption and risk of psoriasis: Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population. | Jordan A et al. | β | 2024 | β |
| Alcohol Use Disorder Polygenic Score Compared With Family History and ADH1B. | Lai D et al. | β | 2024 | β |
| ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism. | Luo J et al. | β | 2024 | β |
| A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. | Jennings MV et al. | β | 2024 | β |
| Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice. | Koh AP et al. | β | 2024 | β |
| Dual peroxisome proliferator-activated receptor Ξ±/Ξ΄ agonists: Hope for the treatment of alcohol-associated liver disease? | Zhang XY et al. | β | 2024 | β |
| Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens. | Zhang H et al. | β | 2024 | β |
| Genetic and environmental influence on alcohol intent and alcohol sips among U.S. children-Effects across sex, race, and ethnicity. | Puga T et al. | β | 2024 | β |
| Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk. | Ni Z et al. | β | 2024 | β |
| Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations | Lai D et al. | β | 2024 | β |
| Global Gene Expression Profiling and Bioinformatics Analysis Reveal Downregulated Biomarkers as Potential Indicators for Hepatocellular Carcinoma. | Mestareehi A | β | 2024 | β |
| How to survive enormous amounts of alcohol. | Spanagel R | β | 2024 | β |
| Human adaptations to diet: Biological and cultural coevolution. | Jelenkovic A et al. | β | 2024 | β |
| Introduction: Approved treatments for alcohol use disorder by regulatory agencies. | Camarini R et al. | β | 2024 | β |
| Oxytocin as a treatment for alcohol use disorder and heavy drinking: A narrative review. | Rastogi K et al. | β | 2024 | β |
| Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. | Li X et al. | β | 2024 | β |
| Relationship between moderate alcohol consumption, genetic polymorphisms and body weight in a population sample of Puerto Madryn, Argentina | PΓ©rez LO et al. | β | 2024 | β |
| Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes. | McKay L et al. | β | 2024 | β |
| The biochemistry of the carcinogenic alcohol metabolite acetaldehyde. | Thomas LA et al. | β | 2024 | β |
| The genetical genomic path to understanding why rats and humans consume too much alcohol. | Tabakoff B et al. | β | 2024 | β |
| The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers. | Hatta W et al. | β | 2024 | β |
| The web-based self-reported survey of Alcohol Use Disorders Identification Test and associated factors in Japan. | Toyama T et al. | β | 2024 | β |
| 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. | Gameiro-Ros I et al. | β | 2023 | β |
| Aged Garlic Extract Prevents Alcohol-Induced Cytotoxicity through Induction of Aldehyde Dehydrogenase 2 inΒ theΒ LiverΒ ofΒ Mice. | Kitakaze T et al. | β | 2023 | β |
| Alcohol and breast cancer. | Starek-Εwiechowicz B et al. | β | 2023 | β |
| Alcohol use disorder in community management of chronic liver diseases. | Leggio L et al. | β | 2023 | β |
| Aldehyde-Associated MutagenesisβCurrent State of Knowledge. | Vijayraghavan S et al. | β | 2023 | β |
| [Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting]. | Yang Q et al. | β | 2023 | β |
| ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1. | Deza-Ponzio R et al. | β | 2023 | β |
| Association between genetic risk of alcohol consumption and alcohol-related morbidity and mortality under different alcohol policy conditions: Evidence from the Finnish alcohol price reduction of 2004. | Lahtinen H et al. | β | 2023 | β |
| Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam. | Hoang YTT et al. | β | 2023 | β |
| Emerging bone marrow failure syndromes- new pieces to an unsolved puzzle. | Feurstein S | β | 2023 | β |
| Environmental neurology: Concepts and short history of an interdisciplinary approach to etiology, treatment and prevention. | Reis J et al. | β | 2023 | β |
| Estimating Prevalence of Bereavement, Its Contribution to Risk for Binge Drinking, and Other High-Risk Health States in a State Population Survey, 2019 Georgia Behavioral Risk Factor Surveillance Survey. | Miles TP et al. | β | 2023 | β |
| Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. | Kawai Y et al. | β | 2023 | β |
| Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. | Bountress KE et al. | β | 2023 | β |
| Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. | Kember RL et al. | β | 2023 | β |
| <i>ADH1B</i>, <i>ADH1B/C</i> and <i>CYP2E1</i> Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. | Kukowka A et al. | β | 2023 | β |
| Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics. | Rancelis T et al. | β | 2023 | β |
| Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings. | Bizzaro D et al. | β | 2023 | β |
| Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches. | Devi A et al. | β | 2023 | β |
| Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer. | VillΓ©ger R et al. | β | 2023 | β |
| Multi-omics cannot replace sample size in genome-wide association studies. | Baranger DAA et al. | β | 2023 | β |
| Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis. | Chida K et al. | β | 2023 | β |
| Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. | Yan C et al. | β | 2023 | β |
| Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease. | Wu X et al. | β | 2023 | β |
| Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis. | Zhang B et al. | β | 2023 | β |
| Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach. | Tsubosaka A et al. | β | 2023 | β |
| The Changing Epidemiology of Alcohol-Associated Liver Disease: Gender, Race, and Risk Factors. | Anouti A et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study. | Shen X et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. | Bramness JG et al. | β | 2023 | β |
| A Genome-Wide Association Study Reveals a <i>BDNF</i>-Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures. | Levchenko A et al. | β | 2022 | β |
| Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China. | Cui Y et al. | β | 2022 | β |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | β | 2022 | β |
| Behavioral consequences of the downstream products of ethanol metabolism involved in alcohol use disorder. | Holbrook OT et al. | β | 2022 | β |
| Brain ethanol metabolism and mitochondria. | Waddell J et al. | β | 2022 | β |
| Computational Investigation of Structural Basis for Enhanced Binding of Isoflavone Analogues with Mitochondrial Aldehyde Dehydrogenase. | Zhang Y et al. | β | 2022 | β |
| Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities. | MacKenzie A et al. | β | 2022 | β |
| Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease. | Yang YM et al. | β | 2022 | β |
| Diagnosis by Volatile Organic Compounds in Exhaled Breath in Exhaled Breath from Patients with Gastric and Colorectal Cancers. | Chung J et al. | β | 2022 | β |
| Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations. | Wang L et al. | β | 2022 | β |
| Genetic Association Study Advances Idiopathic Pulmonary Fibrosis Pathophysiology and Health Equity. | Hobbs BD | β | 2022 | β |
| Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. | WistrΓΆm ED et al. | β | 2022 | β |
| Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. | Deak JD et al. | β | 2022 | β |
| Genome-wide meta-analysis of alcohol use disorder in East Asians. | Zhou H et al. | β | 2022 | β |
| Hazardous drinking and alcohol use disorders. | MacKillop J et al. | β | 2022 | β |
| Identification of functional genes associated with the biotransformation of limonene to trans-dihydrocarvone in Klebsiella sp. O852. | Zhang LL et al. | β | 2022 | β |
| <i>Levilactobacillus brevis</i> MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice. | Jung H et al. | β | 2022 | β |
| Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants. | Curtis D | β | 2022 | β |
| Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study. | O'Farrell F et al. | β | 2022 | β |
| Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development. | Fukami T et al. | β | 2022 | β |
| Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression. | Schaschl H et al. | β | 2022 | β |
| Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam. | Hoang YTT et al. | β | 2022 | β |
| Six Types of Tea Reduce Acute Alcoholism in Mice by Enhancing Ethanol Metabolism, Suppressing Oxidative Stress and Inflammation. | Lai X et al. | β | 2022 | β |
| The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates. | Hatoum AS et al. | β | 2022 | β |
| Transcriptome Analysis of Protection by Dendrobium Nobile Alkaloids (DNLA) against Chronic Alcoholic Liver Injury in Mice. | Huang X et al. | β | 2022 | β |
| Virtual Screening of FDA-Approved Drugs for Enhanced Binding with Mitochondrial Aldehyde Dehydrogenase. | Zhou B et al. | β | 2022 | β |
| Acetaldehyde Enhances Alcohol Sensitivity and Protects against Alcoholism: Evidence from Alcohol Metabolism in Subjects with Variant <i>ALDH2*2</i> Gene Allele. | Chen YC et al. | β | 2021 | β |
| Adverse Reactions to Illicit Drugs (Marijuana, Opioids, Cocaine) and Alcohol. | Decuyper II et al. | β | 2021 | β |
| Alcohol and the brain: from genes to circuits. | Egervari G et al. | β | 2021 | β |
| ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis. | Hu YF et al. | β | 2021 | β |
| Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. | Rao X et al. | β | 2021 | β |
| A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism. | Sheraj I et al. | β | 2021 | β |
| Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity. | Zhao Y et al. | β | 2021 | β |
| Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume. | Thompson A et al. | β | 2021 | β |
| Biochemical Mechanisms Associating Alcohol Use Disorders with Cancers. | Rodriguez FD et al. | β | 2021 | β |
| Dimensional Phenotypes in Psychiatric Genetics: Lessons from Genome-Wide Association Studies of Alcohol Use Phenotypes. | Mallard TT et al. | β | 2021 | β |
| Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication. | Pervin Z et al. | β | 2021 | β |
| Ethnic Differences in Serum Levels of microRNAs Potentially Regulating Alcohol Dehydrogenase 1B and Aldehyde Dehydrogenase 2. | Wakabayashi I et al. | β | 2021 | β |
| Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder. | Castaldelli-Maia JM et al. | β | 2021 | β |
| Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. | Clarke TK et al. | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Genetics of substance use disorders in the era of big data. | Gelernter J et al. | β | 2021 | β |
| Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. | Lai D et al. | β | 2021 | β |
| Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population. | Peng Q et al. | β | 2021 | β |
| Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring. | Haan E et al. | β | 2021 | β |
| Metal-Based Catalytic Drug Development for Next-Generation Cancer Therapy. | Fan Z et al. | β | 2021 | β |
| Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization. | Schwartz M et al. | β | 2021 | β |
| Oxidative Stress-A Key Player in the Course of Alcohol-Related Liver Disease. | Michalak A et al. | β | 2021 | β |
| Perspective on Beyond Statistical Significance: Finding Meaningful Effects. | Edenberg HJ | β | 2021 | β |
| Punch-Drunk or Drunken Boxing? The Etiology of Alcohol-Related Physical Violence through Adolescence and Young Adulthood. | Deutsch AR | β | 2021 | β |
| Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Human. | Jung SJ et al. | β | 2021 | β |
| Relationship between rice farming and polygenic scores potentially linked to agriculture in China. | Zhu C et al. | β | 2021 | β |
| Sex Differences in Alcohol Consumption and Alcohol-Associated Liver Disease. | Kezer CA et al. | β | 2021 | β |
| Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD). | Rodriguez FD | β | 2021 | β |
| The Gut Microbiome and Substance Use Disorder. | Russell JT et al. | β | 2021 | β |
| The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation. | Di L et al. | β | 2021 | β |
| Transfer hydrogenation catalysis in cells. | Banerjee S et al. | β | 2021 | β |
| A Call to Action: A Systematic Review Examining the Failure to Include Females and Members of Minoritized Racial/Ethnic Groups in Clinical Trials of Pharmacological Treatments for Alcohol Use Disorder. | Schick MR et al. | β | 2020 | β |
| Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. | Joo YS et al. | β | 2020 | β |
| Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study. | van den Brandt PA et al. | β | 2020 | β |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | β | 2020 | β |
| Alcohol Use and Depression: A Mendelian Randomization Study From China. | Zhu C et al. | β | 2020 | β |
| An update on the role of common genetic variation underlying substance use disorders. | Johnson EC et al. | β | 2020 | β |
| Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population. | Govind P et al. | β | 2020 | β |
| Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration. | Biner O et al. | β | 2020 | β |
| E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2. | Matsumoto S et al. | β | 2020 | β |
| Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms. | Kaminen-Ahola N | β | 2020 | β |
| Flying Together: <i>Drosophila</i> as a Tool to Understand the Genetics of Human Alcoholism. | Lathen DR et al. | β | 2020 | β |
| Hepatic injury and inflammation alter ethanol metabolism and drinking behavior. | Ren T et al. | β | 2020 | β |
| Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. | Thapa KS et al. | β | 2020 | β |
| <i>Ent</i>-Peniciherqueinone Suppresses Acetaldehyde-Induced Cytotoxicity and Oxidative Stress by Inducing ALDH and Suppressing MAPK Signaling. | Oh T et al. | β | 2020 | β |
| Immobilization of alcohol dehydrogenase from Saccharomyces cerevisiae onto carboxymethyl dextran-coated magnetic nanoparticles: a novel route for biocatalyst improvement via epoxy activation. | VasiΔ K et al. | β | 2020 | β |
| Influence of Comorbid Psychiatric Disorders on the Risk of Development of Alcohol Dependence by Genetic Variations of ALDH2 and ADH1B. | Itoh M et al. | β | 2020 | β |
| Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma. | Liu X et al. | β | 2020 | β |
| Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study. | Yan W et al. | β | 2020 | β |
| Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. | Sanchez-Roige S et al. | β | 2020 | β |
| Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects. | Guillot A et al. | β | 2020 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Ethyl glucuronide hair testing: A review. | Biondi A et al. | β | 2019 | β |
| Genetic evidence for assortative mating on alcohol consumption in the UK Biobank. | Howe LJ et al. | β | 2019 | β |
| Genetics of Alcoholism. | Edenberg HJ et al. | β | 2019 | β |
| Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. | Peterson RE et al. | β | 2019 | β |
| Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | β | 2019 | β |
| How Much Do You Drink on Your Heavy DrinkingΒ Day? | Edenberg HJ | β | 2019 | β |
| Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. | Meyers JL et al. | β | 2019 | β |
| Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. | Guillot A et al. | β | 2019 | β |
| The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample. | Johnson EC et al. | β | 2019 | β |