Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia.

paper Cited Public

Authors: Kayser, Jürgen; Tenke, Craig E; Gil, Roberto B; Bruder, Gerard E
Year: 2009
Journal: International journal of psychophysiology : official journal of the International Organization of Psychophysiology
PMID: 19275917
DOI: 10.1016/j.ijpsycho.2009.02.003
PMCID: PMC2757785

Examining visual word recognition memory (WRM) with nose-referenced EEGs, we reported a preserved ERP 'old-new effect' (enhanced parietal positivity 300-800 ms to correctly-recognized repeated items) in schizophrenia ([Kayser, J., Bruder, G.E., Friedman, D., Tenke, C.E., Amador, X.F., Clark, S.C., Malaspina, D., Gorman, J.M., 1999. Brain event-related potentials (ERPs) in schizophrenia during a word recognition memory task. Int. J. Psychophysiol. 34(3), 249-265.]). However, patients showed reduced early negative potentials (N1, N2) and poorer WRM. Because group differences in neuronal generator patterns (i.e., sink-source orientation) may be masked by choice of EEG recording reference, the current study combined surface Laplacians and principal components analysis (PCA) to clarify ERP component topography and polarity and to disentangle stimulus- and response-related contributions. To investigate the impact of stimulus modality, 31-channel ERPs were recorded from 20 schizophrenic patients (15 male) and 20 age-, gender-, and handedness-matched healthy adults during parallel visual and auditory continuous WRM tasks. Stimulus- and response-locked reference-free current source densities (spherical splines) were submitted to unrestricted Varimax-PCA to identify and measure neuronal generator patterns underlying ERPs. Poorer (78.2+/-18.7% vs. 87.8+/-11.3% correct) and slower (958+/-226 vs. 773+/-206 ms) performance in patients was accompanied by reduced stimulus-related left-parietal P3 sources (150 ms pre-response) and vertex N2 sinks (both overall and old/new effects) but modality-specific N1 sinks were not significantly reduced. A distinct mid-frontal sink 50-ms post-response was markedly attenuated in patients. Reductions were more robust for auditory stimuli. However, patients showed increased lateral-frontotemporal sinks (T7 maximum) concurrent with auditory P3 sources. Electrophysiologic correlates of WRM deficits in schizophrenia suggest functional impairments of posterior cortex (stimulus representation) and anterior cingulate (stimulus categorization, response monitoring), primarily affecting memory for spoken words.

#	Section	Preview
20	1. Introduction — 1.4. Reference-free ERP components by means of CSD/PCA methodology	Despite a common belief that a high-density EEG montage (i.e., more than 100 channels) is required…
21	1. Introduction — 1.5. Performance monitoring in schizophrenia	It has been suggested that “willed” intentions are not correctly monitored in schizophrenia…
22	1. Introduction — 1.5. Performance monitoring in schizophrenia	(Kopp and Rist, 1999; Mathalon et al., 2002; Bates et al., 2002). There is some evidence that…
23	1. Introduction — 1.5. Performance monitoring in schizophrenia	Given converging evidence stemming from studies using functional magnetic resonance (fMRI; e.g.,…
24	1. Introduction — 1.5. Performance monitoring in schizophrenia	The ERN belongs to a family of ERP components that are characterized by a distinct medial-frontal…
25	1. Introduction — 1.5. Performance monitoring in schizophrenia	a target count (Kayser and Tenke, 2006a, 2006b; Tenke et al., 1998, 2008). This highly-distinct…
26	1. Introduction — 1.6. The present study	A repeated notion is that P3 abnormalities in schizophrenia are more robust and common with tasks…
27	1. Introduction — 1.6. The present study	closely-matched auditory and visual continuous word recognition memory tasks in healthy adults in a…
28	1. Introduction — 1.6. The present study	The main purpose of the present study was to compare these reference-independent visual and auditory…
29	2. Material and Methods — 2.1. Participants	Twenty-three inpatients and two outpatients (20 male, 5 female) at New York State Psychiatric…
30	2. Material and Methods — 2.1. Participants	Positive and Negative Syndrome Scale (PANSS; Kay et al., 1992). The total BPRS score indicated that…
31	2. Material and Methods — 2.1. Participants	Patients were compared to 20 healthy volunteers (15 men, 5 women) selected from a larger sample (N =…
32	2. Material and Methods — 2.1. Participants	All participants had normal or corrected-to-normal vision. Hearing acuity was assessed using…
33	2. Material and Methods — 2.2. Stimuli and procedure	As the study’s procedural protocol has already been described in detail (Kayser et al., 2007),…
34	2. Material and Methods — 2.2. Stimuli and procedure	For each block, the item sequence consisted of 34 words that repeated once after either a short or a…
35	2. Material and Methods — 2.2. Stimuli and procedure	Auditory word items (484 ms median duration; range 311 to 830 ms) synthesized for a male voice…
36	2. Material and Methods — 2.3. Data acquisition, recording, and artifact procedures	Nose-referenced scalp EEG (AFz ground) was continuously recorded at 200 samples/s from 30 extended…
37	2. Material and Methods — 2.3. Data acquisition, recording, and artifact procedures	Recording epochs of 2,000 ms (including a 300 ms pre-stimulus baseline) were extracted off-line from…
38	2. Material and Methods — 2.3. Data acquisition, recording, and artifact procedures	Stimulus-locked ERP waveforms were averaged from correct, artifact-free trials using the entire 2-s…
39	2. Material and Methods — 2.3. Data acquisition, recording, and artifact procedures	Response-locked ERP waveforms were averaged from 1-s sub-epochs including 700 ms before and 300 ms…

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Title	Year	PMID
Issues and considerations for using the scalp surface Laplacian in EEG/ERP research: A tutorial review.	2015	25920962
The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.	2015	25448264
Auditory event-related potentials and α oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task.	2014	24333745
A neurophysiological deficit in early visual processing in schizophrenia patients with auditory hallucinations.	2012	22803512
Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.	2012	22796039
Current source density (CSD) old/new effects during recognition memory for words and faces in schizophrenia and in healthy adults.	2010	19995583
ERP generator patterns in schizophrenia during tonal and phonetic oddball tasks: effects of response hand and silent count.	2010	21077570
Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.	2010	20456657

Title	Authors	Journal	Year	Link
The late positive event-related potential component is time locked to the decision in recognition memory tasks.	Sun J et al.	—	2024	→
A quantitative model reveals a frequency ordering of prediction and prediction-error signals in the human brain.	Chao ZC et al.	—	2022	→
Behavioral measures of attention and cognitive control during a new auditory working memory paradigm.	Kayser J et al.	—	2020	→
Mapping attention during gameplay: Assessment of behavioral and ERP markers in an auditory oddball task.	Núñez Castellar EP et al.	—	2019	→
An Event Related Potentials Study of Semantic Coherence Effect during Episodic Encoding in Schizophrenia Patients.	Battal Merlet L et al.	—	2018	→
Evidence for a differential contribution of early perceptual and late cognitive processes during encoding to episodic memory impairment in schizophrenia.	Green AE et al.	—	2017	→
Reconstructing the past: The late posterior negativity (LPN) in episodic memory studies.	Mecklinger A et al.	—	2016	→
Reduced Theta-Band Power and Phase Synchrony during Explicit Verbal Memory Tasks in Female, Non-Clinical Individuals with Schizotypal Traits.	Choi JW et al.	—	2016	→
How to stop or change a motor response: Laplacian and independent component analysis approach.	Rangel-Gomez M et al.	—	2015	→
Issues and considerations for using the scalp surface Laplacian in EEG/ERP research: A tutorial review.	Kayser J et al.	—	2015	→
The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.	Kamarajan C et al.	—	2015	→
Auditory event-related potentials and α oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task.	Kayser J et al.	—	2014	→
A neurophysiological deficit in early visual processing in schizophrenia patients with auditory hallucinations.	Kayser J et al.	—	2012	→
Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.	Tenke CE et al.	—	2012	→
Explicit and implicit memory in female college students with schizotypal traits: an event-related potential study.	Song BY et al.	—	2011	→
Current source density (CSD) old/new effects during recognition memory for words and faces in schizophrenia and in healthy adults.	Kayser J et al.	—	2010	→
ERP generator patterns in schizophrenia during tonal and phonetic oddball tasks: effects of response hand and silent count.	Kayser J et al.	—	2010	→
Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.	Kayser J et al.	—	2010	→

Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia.

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