Neuroimaging of children following prenatal drug exposure.
paper
Cited
Public
- Authors
- Derauf, Chris; Kekatpure, Minal; Neyzi, Nurunisa; Lester, Barry; Kosofsky, Barry
- Year
- 2009
- Journal
- Seminars in cell & developmental biology
- PMID
- 19560049
- DOI
- 10.1016/j.semcdb.2009.03.001
- PMCID
- PMC2704485
Recent advances in MR-based brain imaging methods have provided unprecedented capabilities to visualize the brain. Application of these methods has allowed identification of brain structures and patterns of functional activation altered in offspring of mothers who used licit (e.g., alcohol and tobacco) and illicit (e.g., cocaine, methamphetamine, and marijuana) drugs during pregnancy. Here we review that literature, which though somewhat limited by the complexities of separating the specific effects of each drug from other confounding variables, points to sets of interconnected brain structures as being altered following prenatal exposure to drugs of abuse. In particular, dopamine-rich cortical (e.g., frontal cortex) and subcortical (e.g., basal ganglia) fetal brain structures show evidence of vulnerability to intrauterine drug exposure suggesting that during brain development drugs of abuse share a specific profile of developmental neurotoxicity. Such brain malformations may shed light on mechanisms underlying prenatal drug-induced brain injury, may serve as bio-markers of significant intrauterine drug exposure, and may additionally be predictors of subsequent neuro-developmental compromise. Wider clinical use of these research-based non-invasive methods will allow for improved diagnosis and allocation of therapeutic resources for affected infants, children, and young adults.
No figures extracted from this document.
| Name | Type |
|---|---|
| 3,4-methylenedioxymethamphetamine | drug |
| 5-HTTLPR | variant |
| Abnormal development of cerebellar vermis local | phenotype |
| Abstract/visual reasoning local | phenotype |
| accumbens nucleus local | anatomy |
| acetylcholine | drug |
| acoustic cry characteristic alteration local | phenotype |
| ADH1B | gene |
| ADH1C | gene |
| ADHD | phenotype |
| Adolescent smokers with no PEMCS local | cohort |
| adolescent smokers without PEMCS local | cohort |
| Adolescent smokers without prenatal exposure to maternal cigarette smoke local | cohort |
| adolescent smokers with PEMCS local | cohort |
| Adolescent smokers with PEMCS local | cohort |
| adolescent smoking | phenotype |
| adolescent substance use onset local | phenotype |
| adolescents with PEMCS local | cohort |
| Adolescent/young adult participants local | cohort |
| adult CNS local | anatomy |
| adults | cohort |
| aggression | phenotype |
| alcohol | phenotype |
| alcohol dehydrogenase | gene |
| alcohol-exposed group | cohort |
| alcohol-exposed subjects local | cohort |
| alcohol studies local | cohort |
| Alcohol studies local | cohort |
| aldehyde dehydrogenase | gene |
| ALDH2 | gene |
| Altered brain growth and maturation local | phenotype |
| AMP | drug |
| amphetamines | drug |
| amygdala | anatomy |
| animal models | cohort |
| anterior brain region | anatomy |
| Anterior cerebellar vermis local | anatomy |
| Anterior corpus callosum region local | anatomy |
| Anterior cortical and subcortical regions local | anatomy |
| Anterior limb of right internal capsule local | anatomy |
| anterior vermis local | anatomy |
| apoptosis | phenotype |
| Apoptosis-associated gene changes local | phenotype |
| Ascending auditory signals local | phenotype |
| attention | phenotype |
| attentional performance | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| attention problems | phenotype |
| Attention span local | phenotype |
| auditory attention local | phenotype |
| Auditory attention local | phenotype |
| autism | phenotype |
| balance | phenotype |
| basal ganglia | anatomy |
| behavior | phenotype |
| behavioral and neurocognitive deficits local | phenotype |
| behavioral outcomes | phenotype |
| Bilateral lingual gyri local | anatomy |
| Bilateral prefrontal cortex local | anatomy |
| Birth local | phenotype |
| Bookstein et al. study local | cohort |
| brain | anatomy |
| Brain Architecture local | phenotype |
| brain connectivity local | anatomy |
| brain development | phenotype |
| brain function | phenotype |
| Brain imaging community local | cohort |
| Brain imaging findings local | phenotype |
| Brain size alteration local | phenotype |
| brain stem | anatomy |
| brain structure | anatomy |
| brain volume | anatomy |
| brain volumes local | anatomy |
| brain white matter | anatomy |
| cannabinoids | drug |
| caudate nucleus | anatomy |
| CB1 receptor | drug |
| CC sections local | anatomy |
| CC shape variability local | phenotype |
| Cell necrosis local | phenotype |
| central nervous system | anatomy |
| cerebellar hemisphere | anatomy |
| cerebellar vermis | anatomy |
| cerebellum | anatomy |
| cerebral local | anatomy |
| cerebral hemispheres | anatomy |
| childhood conduct disorder | phenotype |
| children | cohort |
| Children (10-14 years) local | cohort |
| Children and young adults with prenatal alcohol exposure local | cohort |
| Children with FAS local | cohort |
| children without prenatal cocaine exposure local | cohort |
| children with PEA local | cohort |
| children with prenatal cocaine exposure local | cohort |
| Children with prenatal cocaine exposure local | cohort |
| Children with prenatal drug exposure local | cohort |
| Children with prenatal ethanol exposure local | cohort |
| choline | drug |
| cholinergic neurotransmission | drug |
| cigarettes | phenotype |
| Cigarette smoking addiction local | phenotype |
| cingulate cortex | anatomy |
| CNS dysfunction | phenotype |
| CNS structural alteration local | phenotype |
| cocaine | phenotype |
| Cocaine-exposed adolescents local | cohort |
| cocaine-exposed children local | cohort |
| Cocaine-exposed children local | cohort |
| Cocaine-exposed infants and children local | cohort |
| cocaine exposure studies local | cohort |
| cognitive and behavioral functioning local | phenotype |
| cognitive control | phenotype |
| Combined intrauterine cocaine and marijuana exposure local | phenotype |
| compensatory_mechanisms local | phenotype |
| Complex visuo-perceptual tasks local | phenotype |
| conduct disorder | phenotype |
| Control adolescents local | cohort |
| control children | cohort |
| control group | cohort |
| controls | cohort |
| control subjects | cohort |
| coordination | phenotype |
| corpus callosum | anatomy |
| cortex | anatomy |
| Cortical architecture alteration local | phenotype |
| Cortical cholinergic transmission local | phenotype |
| Cortical infarcts local | phenotype |
| Cortical sulci local | anatomy |
| cortical thickness | phenotype |
| cortical thickness excess local | phenotype |
| Corticofugal fibers local | anatomy |
| Corticopontine fibers local | anatomy |
| Corticospinal fibers local | anatomy |
| cranial volume local | phenotype |
| Craniofacial anomalies local | phenotype |
| creatine | drug |
| crime | phenotype |
| Current alcohol use local | drug |
| Current marijuana use local | drug |
| Current nicotine use local | drug |
| Current substance abuse local | phenotype |
| Cytoarchitectural alterations in excitatory pyramidal neurons local | phenotype |
| Cytoarchitectural alterations in inhibitory interneurons local | phenotype |
| d-amphetamine | drug |
| decreased fetal growth local | phenotype |
| Decreased gray matter volume in left occipital lobe local | phenotype |
| Decreased gray matter volume in right parietal lobe local | phenotype |
| Decrease in area of corpus callosum local | phenotype |
| Decrease in volume of right anterior cerebellum local | phenotype |
| delayed recognition testing local | phenotype |
| delayed verbal memory local | phenotype |
| delinquency | phenotype |
| delta-9-tetrahydrocannabinol | drug |
| developing neural circuitry local | phenotype |
| Developmental delays local | phenotype |
| D-methamphetamine local | drug |
| dopamine | drug |
| dopaminergic axons local | phenotype |
| Dopaminergic system | drug |
| dopamine rich subcortical regions local | anatomy |
| dopamine synthesis | phenotype |
| Dopamine synthesis and turnover local | phenotype |
| dopamine turnover | phenotype |
| dorsal striatum | anatomy |
| dorsal visual stream local | anatomy |
| DRD1 | gene |
| DRD2 | gene |
| drug dependence | phenotype |
| drug exposed children local | cohort |
| Drug of interest local | drug |
| Drug use during pregnancy local | phenotype |
| Dysmorphic facial appearance local | phenotype |
| Early childhood outcomes local | phenotype |
| Embryonic and fetal mice local | cohort |
| endogenous opioids | drug |
| errors of commission | phenotype |
| errors of omission | phenotype |
| ethanol consumption | phenotype |
| executive function | phenotype |
| executive functioning | phenotype |
| executive functioning deficit local | phenotype |
| Exposed Children local | cohort |
| Exposed group local | cohort |
| externalizing behavioral traits local | phenotype |
| externalizing disorders | phenotype |
| FA | phenotype |
| face recognition | phenotype |
| FASD group local | cohort |
| FAS group local | cohort |
| FAS subjects local | cohort |
| female fetus local | phenotype |
| Female fetus local | phenotype |
| Fetal Alcohol Spectrum Disorder | phenotype |
| Fetal alcohol spectrum disorders | phenotype |
| fetal alcohol syndrome | phenotype |
| fetal brain | anatomy |
| fetal brain development local | phenotype |
| Fetal brain development local | phenotype |
| fetal development local | phenotype |
| fetal hypoxia local | phenotype |
| Fetal rat model local | cohort |
| forebrain | anatomy |
| frontal cortex | anatomy |
| Functional uncoupling of DRD1 from G-protein local | phenotype |
| fusiform gyrus | anatomy |
| GABA | phenotype |
| GABA-driven cortical network activity local | phenotype |
| gene expression | phenotype |
| genu | anatomy |
| Gestational marijuana exposure local | phenotype |
| Global cerebral blood flow local | phenotype |
| Global developmental impairments local | phenotype |
| globus pallidus | anatomy |
| glutamate | drug |
| glutamatergic axons local | phenotype |
| glutamatergic system | drug |
| go/no-go task | phenotype |
| gray matter | anatomy |
| Growth deficiencies local | phenotype |
| Head circumference local | phenotype |
| Head circumference at birth local | phenotype |
| head size | phenotype |
| higher cortical regions local | anatomy |
| hippocampus | anatomy |
| HPA axis dysregulation | anatomy |
| HSD11B2 | gene |
| human brain | anatomy |
| hyperactivity | phenotype |
| Hypoplasia of corpus callosum local | phenotype |
| Hypoplasia of vermis local | phenotype |
| Hypoplastic cerebellar hemispheres local | phenotype |
| hypoxemia local | phenotype |
| hypoxia | phenotype |
| illicit drugs | phenotype |
| illicit drug use | phenotype |
| Imaging results local | phenotype |
| Impaired attention local | phenotype |
| impaired fetal brain development local | phenotype |
| Impaired performance accuracy local | phenotype |
| impulse control deficit local | phenotype |
| impulsivity | phenotype |
| increased_brain_metabolism local | phenotype |
| increased MTL activation local | phenotype |
| Increased white matter volume local | phenotype |
| Indistinct philtrum local | phenotype |
| infants | cohort |
| Infants with PEMCS local | cohort |
| inferior parietal lobe | anatomy |
| inferior parietal lobule | anatomy |
| Inferior parietal region local | anatomy |
| intelligence deficit local | phenotype |
| Interhemispheric Information Transfer local | phenotype |
| internalizing behavioral traits local | phenotype |
| Intrauterine cocaine exposure local | phenotype |
| intrauterine growth restriction local | phenotype |
| intrauterine growth retardation local | phenotype |
| Intrauterine Hypoxia local | phenotype |
| L1CAM local | gene |
| language delay | phenotype |
| Language processing local | phenotype |
| language skill deficit local | phenotype |
| large vessel-distribution strokes local | phenotype |
| lateral ventricle | anatomy |
| Learning difficulties | phenotype |
| learning disabilities | phenotype |
| left caudate nucleus local | anatomy |
| Left cerebellar activity local | anatomy |
| Left Frontal Callosal local | anatomy |
| left frontal region | anatomy |
| Left frontal white matter local | anatomy |
| left inferior frontal gyrus | anatomy |
| Left inferior longitudinal fasciculus local | anatomy |
| Left internal capsule posterior limb local | anatomy |
| left medial prefrontal cortex local | anatomy |
| left occipital lobe local | anatomy |
| Left occipital lobe local | anatomy |
| Left orbito-frontal cortex local | anatomy |
| Left Parieto-Occipital Region local | anatomy |
| left pre-supplemental motor cortex local | anatomy |
| lenticular nucleus local | anatomy |
| licit drugs | drug |
| limbic system | anatomy |
| male fetus local | phenotype |
| Male fetus local | phenotype |
| Malformed posterior vermis local | phenotype |
| marijuana | phenotype |
| marijuana studies local | cohort |
| Marijuana use initiation before age 17 local | phenotype |
| matched controls | cohort |
| maternal anorexia local | phenotype |
| maternal vasoconstriction local | phenotype |
| memory | phenotype |
| mesolimbic dopamine system | drug |
| methamphetamine | drug |
| methamphetamine exposure studies local | cohort |
| METH-exposed children local | cohort |
| microcephaly | phenotype |
| middle frontal cortex local | anatomy |
| Middle frontal cortex local | anatomy |
| mitochondrial dysfunction | phenotype |
| motivation | phenotype |
| motor centers local | anatomy |
| motor coordination | phenotype |
| motor development impairment local | phenotype |
| Motor efficacy local | phenotype |
| myelin | phenotype |
| NAA | drug |
| NAA/Cr local | drug |
| N-acetylaspartate | drug |
| neocortex | anatomy |
| neonatal arousal impairment local | phenotype |
| neonatal brain | anatomy |
| neonatal visual attention local | phenotype |
| neural_plasticity local | phenotype |
| Neurobehavioral effects local | phenotype |
| neurocircuitry vulnerability local | phenotype |
| Neurocognitive deficits | phenotype |
| neuro-cognitive function local | phenotype |
| neurodevelopmental consequences local | phenotype |
| Neurodevelopmental consequences local | phenotype |
| Neurogenesis impairment local | phenotype |
| Neuroimaging | phenotype |
| neurological disorders | phenotype |
| neuronal differentiation | phenotype |
| Neuronal growth modulation local | phenotype |
| neuronal loss | phenotype |
| Neuronal migration local | phenotype |
| Neuronal migration failure local | phenotype |
| Neuronal proliferation local | phenotype |
| Neuronal survival local | phenotype |
| neuropsychological deficits | phenotype |
| Neuro-teratogenic mechanisms local | phenotype |
| neurotoxicity | phenotype |
| Neurotoxicity of prenatal alcohol local | phenotype |
| Newborn and infant state regulation local | phenotype |
| nicotine | drug |
| nicotine withdrawal | phenotype |
| nicotinic acetylcholine receptor | drug |
| nicotinic cholinergic receptors local | phenotype |
| nitric oxide production local | phenotype |
| Non-dysmorphic FASD subjects local | cohort |
| Non-dysmorphic subjects with prenatal alcohol exposure local | cohort |
| Non-exposed adolescents local | cohort |
| Non-Exposed Comparison Children local | cohort |
| Non-human primate model local | cohort |
| non-smokers | phenotype |
| norepinephrine | drug |
| Normative developmental MR data sets local | cohort |
| nucleus accumbens | anatomy |
| object recognition | phenotype |
| occipital cortex | anatomy |
| opiates | drug |
| opioid receptor | drug |
| orbitofrontal cortex | anatomy |
| other substances | phenotype |
| Oxidative DNA damage local | phenotype |
| p53 activation local | phenotype |
| Pachygyria local | phenotype |
| parahippocampal gyrus | anatomy |
| parietal cortex | anatomy |
| p-chloroamphetamine local | drug |
| PEA | drug |
| PEA141 local | cohort |
| PEA144 local | cohort |
| PEA150 local | cohort |
| PEA151 local | cohort |
| PEA group local | cohort |
| PEMCS local | cohort |
| PEMCS local | drug |
| PEMCS local | phenotype |
| Perceptual processing selectivity local | phenotype |
| Perisylvian region local | anatomy |
| Periventricular cysts local | phenotype |
| Periventricular hemorrhage local | phenotype |
| placental blood flow local | phenotype |
| Placental function local | phenotype |
| placental vasculature local | phenotype |
| plasma catecholamines local | drug |
| poor executive functioning | phenotype |
| Poor parenting local | phenotype |
| Posterior cerebellar vermis local | anatomy |
| Posterior corpus callosum region local | anatomy |
| Posterior corpus callosum (splenium) local | anatomy |
| Posterior temporal lobe local | anatomy |
| posterior third of corpus callosum local | anatomy |
| Postnatal motor deficits local | phenotype |
| poverty | phenotype |
| prefrontal cortex | anatomy |
| Prefrontal-striatal circuitry local | anatomy |
| pregnancy | phenotype |
| Prematurity local | phenotype |
| premotor cortex | anatomy |
| prenatal alcohol exposure | phenotype |
| Prenatal and adolescent exposure to cigarette smoke local | phenotype |
| Prenatal caffeine exposure local | drug |
| prenatal CNS development local | phenotype |
| Prenatal CNS development local | phenotype |
| prenatal cocaine exposure local | drug |
| Prenatal Cocaine Exposure Cohort local | cohort |
| prenatal cocaine exposure literature local | cohort |
| prenatal drug-exposed phenotype local | phenotype |
| prenatal drug exposure | drug |
| prenatal drug exposure local | phenotype |
| Prenatal drug exposure local | phenotype |
| Prenatal exposure to maternal cigarette smoke (PEMCS) local | phenotype |
| Prenatal exposure to maternal cigarette smoking local | drug |
| Prenatally cocaine-exposed adolescents local | cohort |
| prenatally cocaine exposed children local | cohort |
| prenatally cocaine-exposed children local | cohort |
| Prenatally Cocaine-Exposed Children local | cohort |
| prenatally exposed group local | cohort |
| Prenatally exposed non-smokers local | cohort |
| prenatal marijuana exposure local | drug |
| prenatal marijuana exposure local | phenotype |
| Prenatal marijuana exposure local | drug |
| Prenatal marijuana exposure local | phenotype |
| Prenatal methamphetamine exposure local | phenotype |
| prenatal nicotine exposure local | cohort |
| Prenatal nicotine exposure | drug |
| Prenatal nicotine exposure local | phenotype |
| prenatal tobacco exposure studies local | cohort |
| pronounced and lasting changes in hippocampal functioning local | phenotype |
| psychopathology | phenotype |
| putamen | anatomy |
| putamen body local | anatomy |
| putaminal volume local | phenotype |
| Rabbit model local | cohort |
| rat model | cohort |
| reaction time | phenotype |
| reactive oxygen species production local | phenotype |
| Reduced cortical gray matter volume local | phenotype |
| Reduced cortical thickness in middle frontal cortex local | phenotype |
| Reduced cortical thickness in orbitofrontal cortex local | phenotype |
| Reduced cortical thickness in parahippocampal cortex local | phenotype |
| reduced MTL activation local | phenotype |
| Reduced whole brain volume local | phenotype |
| Regional corpus callosum area local | anatomy |
| response inhibition | phenotype |
| Right anterior cerebellum local | anatomy |
| right caudate local | anatomy |
| right dorsal frontal region local | anatomy |
| right dorsolateral prefrontal cortex | anatomy |
| right frontal lobe local | anatomy |
| Right Frontal Projection Fibers local | anatomy |
| Right frontal region local | anatomy |
| Right internal capsule anterior limb local | anatomy |
| Right Lateral Temporal Lobe local | anatomy |
| right medial prefrontal cortex local | anatomy |
| right parietal lobe local | anatomy |
| Right parietal lobe local | anatomy |
| Right superior longitudinal fasciculus local | anatomy |
| right superior temporal gyrus | anatomy |
| right ventral prefrontal cortex local | anatomy |
| Rivkin et al. study local | cohort |
| Schizencephaly local | phenotype |
| school failure local | phenotype |
| Self rated assessment of caring local | phenotype |
| self-regulation impairment local | phenotype |
| sensorimotor ability local | phenotype |
| Sensorimotor ability local | phenotype |
| serotonergic axons local | phenotype |
| Serotonergic neurotoxic effects local | phenotype |
| Serotonergic system | drug |
| serotonin | drug |
| serotonin synthesis local | phenotype |
| serotonin transporter density local | phenotype |
| serotonin turnover local | phenotype |
| sex | phenotype |
| short-term memory | phenotype |
| SLC6A2 | gene |
| SLC6A4 | gene |
| smaller_volume local | phenotype |
| Small hippocampi local | phenotype |
| Small palpebral fissures | phenotype |
| Smith et al. study local | cohort |
| smoking | phenotype |
| smoking abstinence | phenotype |
| social and behavioral problems local | phenotype |
| Socio-economically Matched Comparison Group local | cohort |
| spatial memory | phenotype |
| specific brain regions | anatomy |
| splenium | anatomy |
| Stockholm cohort local | cohort |
| striatum | anatomy |
| structural brain alterations local | phenotype |
| study cohort | cohort |
| Subcortical area local | anatomy |
| Subcortical brain structures local | anatomy |
| subcortical regions | anatomy |
| Subependymal cysts local | phenotype |
| subjects | cohort |
| Subjects with PEA local | cohort |
| sub-optimal developmental outcomes local | phenotype |
| Superior brain region local | anatomy |
| Superior temporal lobe local | anatomy |
| sustained attention | phenotype |
| synaptic pruning | phenotype |
| Synaptic remodeling of axonal terminals local | phenotype |
| synaptogenesis | phenotype |
| syntax construction scores local | phenotype |
| Syntax construction scores local | phenotype |
| temporal lobe | anatomy |
| thalamic volume local | phenotype |
| Thalamocortical fibers local | anatomy |
| thalamus | anatomy |
| thick CC local | phenotype |
| thin CC local | phenotype |
| Thin vermillion border local | phenotype |
| tissue density local | phenotype |
| tobacco smoke | phenotype |
| Tobacco smoking women local | cohort |
| Tobacco studies local | cohort |
| tobacco use | phenotype |
| total cranial local | anatomy |
| total parenchymal volume local | anatomy |
| unexposed group local | cohort |
| Unexposed group local | cohort |
| United States | cohort |
| vasoconstriction local | phenotype |
| ventral striatum | anatomy |
| ventral tegmental area | anatomy |
| ventral visual stream | anatomy |
| Verbal learning ability local | phenotype |
| Verbal learning ability impairment local | phenotype |
| verbal learning and memory performance local | phenotype |
| verbal reasoning | phenotype |
| verbal recall local | phenotype |
| visual attention | phenotype |
| visual-motor performance local | phenotype |
| Visual-motor performance local | phenotype |
| visual motor performance scores local | phenotype |
| visual recognition memory local | phenotype |
| Visuo-motor integration local | phenotype |
| Visuo-motor Integration local | phenotype |
| Visuo-spatial memory local | phenotype |
| Visuo-spatial memory deficit local | phenotype |
| Visuo-spatial memory deficits local | phenotype |
| visuo-spatial performance local | phenotype |
| Visuo-spatial working memory local | phenotype |
| white matter | anatomy |
| White matter hypoplasia local | phenotype |
| whole brain | anatomy |
| whole brain volume local | anatomy |
| Wide cortical sulci local | phenotype |
| young adults | cohort |
| younger subjects local | phenotype |
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| Title | Year | PMID |
|---|---|---|
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | 2012 | 22358648 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Investigating Links Between Prenatal Cannabis Exposure and Brain Development Using Magnetic Resonance Imaging Techniques: A Narrative Review. | GonΓ§alves PD et al. | β | 2026 | β |
| Beyond a simple cause and effect relationship: Exploring the long-term outcomes of children prenatally exposed to opioids and other substances. | Burduli E et al. | β | 2025 | β |
| Correlation between metabolite concentrations in the frontal lobes, determined using <sup>1</sup>H-MRS, and IQ in children with foetal alcohol spectrum disorder. | Urbanik A et al. | β | 2025 | β |
| Pathologies in a preterm infant exposed to methamphetamine in utero: Case report and literature review. | YazΔ± Z et al. | β | 2025 | β |
| Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies. | Shah L et al. | β | 2025 | β |
| Epigenetic inheritance of phenotypes associated with parental exposure to cocaine. | Rich MT et al. | β | 2024 | β |
| Prenatal assessment of brain malformations on neuroimaging: an expert panel review. | Pogledic I et al. | β | 2024 | β |
| Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres. | Wang S et al. | β | 2023 | β |
| Parental drug use disorders and youth psychopathology: Meta-analytic review. | Anderson AS et al. | β | 2023 | β |
| Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21. | Min MO et al. | β | 2023 | β |
| The Neurobiology of Methamphetamine Addiction and the Potential to Reduce Misuse Through Conjugate Vaccines Targeting Toll-Like Receptor 4. | Prasad S et al. | β | 2023 | β |
| A Model of Combined Exposure to Nicotine and Tetrahydrocannabinol <i>via</i> Electronic Cigarettes in Pregnant Rats. | Breit KR et al. | β | 2022 | β |
| Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation. | Rather HA et al. | β | 2022 | β |
| Methamphetamine exposure during pregnancy: A meta-analysis of child developmental outcomes. | Kunkler C et al. | β | 2022 | β |
| Alcohol and substance use in pregnancy during the COVID-19 pandemic. | Kar P et al. | β | 2021 | β |
| Association between gestational cannabis exposure and maternal, perinatal, placental, and childhood outcomes. | Ayonrinde OT et al. | β | 2021 | β |
| Clinical Drug Trial Participation: Perspectives of Pregnant Women and Their Spouses. | Zhao Y et al. | β | 2021 | β |
| Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations. | Vassoler FM et al. | β | 2021 | β |
| Pharmacokinetic Effects of Combined Exposure to Nicotine and THC via E-Cigarettes in Pregnant Rats | Breit KR et al. | β | 2021 | β |
| Prenatal Substance Exposure and Developmental Trajectories of Internalizing Symptoms: Toddlerhood to Preadolescence. | Min MO et al. | β | 2021 | β |
| Behavioral development in children with prenatal substance exposure and neonatal abstinence syndrome: Associated factors and implications. | Miller JS et al. | β | 2020 | β |
| Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward. | Bush NR et al. | β | 2020 | β |
| Functional dissection of prenatal drug effects on baby brain and behavioral development. | Salzwedel A et al. | β | 2020 | β |
| Structural brain network development in children following prenatal methamphetamine exposure. | Roos A et al. | β | 2020 | β |
| A review on neuroimaging studies of genetic and environmental influences on early brain development. | Gao W et al. | β | 2019 | β |
| Cognitive function among schoolchildren in Lebanon: association with maternal alcohol drinking and smoking during pregnancy and domestic use of detergents and pesticides during childhood. | Hallit S et al. | β | 2019 | β |
| Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine. | Li Z et al. | β | 2019 | β |
| Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging. | Morie KP et al. | β | 2019 | β |
| Stuttering and gray matter morphometry: A population-based neuroimaging study in young children. | Koenraads SPC et al. | β | 2019 | β |
| Cognitive outcomes in prenatal methamphetamine exposed children aged six to seven years. | Kwiatkowski MA et al. | β | 2018 | β |
| Imaging structural and functional brain development in early childhood. | Gilmore JH et al. | β | 2018 | β |
| Prenatal assessment of cerebellar vermian lobulation: fetal MRI with 3-Tesla postmortem validation. | Dovjak GO et al. | β | 2018 | β |
| Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. | Sirnes E et al. | β | 2017 | β |
| Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure. | Sirnes E et al. | β | 2017 | β |
| Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition. | van der Meer D et al. | β | 2017 | β |
| Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats. | Jablonski SA et al. | β | 2017 | β |
| Effects of prenatal substance exposure on neurocognitive correlates of inhibitory control success and failure. | Roos LE et al. | β | 2017 | β |
| Intergenerational Transmission of Paternal Epigenetic Marks: Mechanisms Influencing Susceptibility to Post-Concussion Symptomology in a Rodent Model. | Hehar H et al. | β | 2017 | β |
| Maternal smoking during pregnancy and offspring antisocial behaviour: findings from a longitudinal investigation of discordant siblings. | Paradis AD et al. | β | 2017 | β |
| Principles of plasticity in the developing brain. | Kolb B et al. | β | 2017 | β |
| Longitudinal changes of amygdala and default mode activation in adolescents prenatally exposed to cocaine. | Li Z et al. | β | 2016 | β |
| Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposure. | Jablonski SA et al. | β | 2016 | β |
| Neurobehavioral Effects from Developmental Methamphetamine Exposure. | Jablonski SA et al. | β | 2016 | β |
| Prenatal Cannabis and Tobacco Exposure in Relation to Brain Morphology: A Prospective Neuroimaging Study in Young Children. | El Marroun H et al. | β | 2016 | β |
| The Impact of Prenatal Ethanol Exposure on Neuroanatomical and Behavioral Development in Mice. | Abbott CW et al. | β | 2016 | β |
| A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy in Psychiatry. | Gold MS et al. | β | 2015 | β |
| Central nervous system deficits in fetal alcohol spectrum disorder. | Roszel EL | β | 2015 | β |
| Development of children born to mothers with mental health problems: subcortical volumes and cognitive performance at 4Β½ years. | BjΓΈrnebekk A et al. | β | 2015 | β |
| Effects of prenatal cocaine exposure on early postnatal rodent brain structure and diffusion properties. | McMurray MS et al. | β | 2015 | β |
| Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes. | Higuera-Matas A et al. | β | 2015 | β |
| Methodological Issues in Assessing the Impact of Prenatal Drug Exposure. | Konijnenberg C | β | 2015 | β |
| Prenatal drug exposure affects neonatal brain functional connectivity. | Salzwedel AP et al. | β | 2015 | β |
| White matter integrity and cognitive performance in children with prenatal methamphetamine exposure. | Roos A et al. | β | 2015 | β |
| Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring. | Sasaki A et al. | β | 2014 | β |
| Cortical thickness and inattention/hyperactivity symptoms in young children: a population-based study. | Mous SE et al. | β | 2014 | β |
| Microstructural abnormalities in language and limbic pathways in orphanage-reared children: a diffusion tensor imaging study. | Kumar A et al. | β | 2014 | β |
| Mid-Gestational Enlargement of Fetal Thalami in Women Exposed to Methadone during Pregnancy. | Schulson M et al. | β | 2014 | β |
| Neonatal opioid withdrawal syndrome. | Sutter MB et al. | β | 2014 | β |
| Prenatal tobacco exposure and brain morphology: a prospective study in young children. | El Marroun H et al. | β | 2014 | β |
| Connectomics signatures of prenatal cocaine exposure affected adolescent brains. | Li K et al. | β | 2013 | β |
| Does prenatal nicotine exposure alter the brain's response to nicotine in adolescence? A neuroanatomical analysis. | Mychasiuk R et al. | β | 2013 | β |
| Dopamine Genetics and Function in Food and Substance Abuse. | Blum K et al. | β | 2013 | β |
| Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. | Ersche KD et al. | β | 2013 | β |
| Prenatal cocaine exposure alters functional activation in the ventral prefrontal cortex and its structural connectivity with the amygdala. | Li Z et al. | β | 2013 | β |
| Prenatal-onset neurodevelopmental disorders secondary to toxins, nutritional deficiencies, and maternal illness. | Graf WD et al. | β | 2013 | β |
| Prevalence of hospitalized live births affected by alcohol and drugs and parturient women diagnosed with substance abuse at liveborn delivery: United States, 1999-2008. | Pan IJ et al. | β | 2013 | β |
| Cognitive and social development in preschool children born to women using substances. | Irner TB et al. | β | 2012 | β |
| Developmental and behavioral consequences of prenatal cocaine exposure: a review. | Lambert BL et al. | β | 2012 | β |
| Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics. | Baewert A et al. | β | 2012 | β |
| Is maternal smoking during pregnancy a causal environmental risk factor for adolescent antisocial behavior? Testing etiological theories and assumptions. | D'Onofrio BM et al. | β | 2012 | β |
| Neural tract development of infants born to methadone-maintained mothers. | Walhovd KB et al. | β | 2012 | β |
| Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero. | Eckstrand KL et al. | β | 2012 | β |
| Prenatal exposure to cigarette smoke or alcohol and cerebellum volume in attention-deficit/hyperactivity disorder and typical development. | de Zeeuw P et al. | β | 2012 | β |
| Subcortical and cortical structural central nervous system changes and attention processing deficits in preschool-aged children with prenatal methamphetamine and tobacco exposure. | Derauf C et al. | β | 2012 | β |
| Substance use during pregnancy and postnatal outcomes. | Irner TB et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| Toxicity effects of methamphetamine on embryonic stem cell-derived neuron. | Meamar R et al. | β | 2012 | β |
| Abnormal brain activation during working memory in children with prenatal exposure to drugs of abuse: the effects of methamphetamine, alcohol, and polydrug exposure. | Roussotte FF et al. | β | 2011 | β |
| Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing. | Bolon B et al. | β | 2011 | β |
| Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. | Akers KG et al. | β | 2011 | β |
| Functional neuroimaging in the examination of effects of prenatal alcohol exposure. | Coles CD et al. | β | 2011 | β |
| Differentiating prenatal exposure to methamphetamine and alcohol versus alcohol and not methamphetamine using tensor-based brain morphometry and discriminant analysis. | Sowell ER et al. | β | 2010 | β |
| The effects of early adversity on the adult and developing brain. | Tomalski P et al. | β | 2010 | β |
| White matter characteristics and cognition in prenatally opiate- and polysubstance-exposed children: a diffusion tensor imaging study. | Walhovd KB et al. | β | 2010 | β |