Translational genetic approaches to substance use disorders: bridging the gap between mice and humans.

paper Cited Public

Authors: Palmer, Abraham A; de Wit, Harriet
Year: 2012
Journal: Human genetics
PMID: 22170288
DOI: 10.1007/s00439-011-1123-5
PMCID: PMC3352994

#	Section	Preview
0	Introduction	In this paper, we explore how genetics studies in mice can be integrated with genetic studies in…
1	Introduction	Studies with model organisms allow experimental manipulations of genotype and environmental factors…
2	Introduction	While most of the above discussion is very general and applies equally well to all traits, this…
3	Introduction	Substance abuse is a multi-factorial illness that results from both genetic and environmental risk…
4	Introduction	Intermediate phenotypes are traits that are presumed to be genetically determined and that are…
5	From mouse to human	In this section, we discuss three examples of research studies that have identified a gene in an…
6	From mouse to human — Multiple PDZ domain protein (Mpdz)	Mpdz was identified as a modulator of ethanol and barbiturate withdrawal seizures using classical…
7	From mouse to human — Multiple PDZ domain protein (Mpdz)	studies have subsequently found modest evidence that SNPs in MPDZ were associated with risk for…
8	From mouse to human — Casein kinase 1 epsilon (Csnk1e)	Csnk1e was identified because it was differentially expressed in mice divergently selected for high…
9	From mouse to human — Casein kinase 1 epsilon (Csnk1e)	volunteers (N = 96) who had received placebo or d-amphetamine (10, 20 mg) in a double-blind,…
10	From mouse to human — Casein kinase 1 epsilon (Csnk1e)	Subsequently, another group identified an association between different SNPs in CSNK1E…
11	From mouse to human — Casein kinase 1 epsilon (Csnk1e)	Since our original study of CSNK1E in humans we have replicated the association between rs135745 and…
12	From mouse to human — Anaplastic lymphoma kinase (Alk)	Alk is regulated by the gene LIM-domain only (Lmo), which is implicated in sensitivity to the…
13	From mouse to human — Anaplastic lymphoma kinase (Alk)	al. 2011b). Finally, the same authors studied several SNPs in the human ALK gene and showed a…
14	From mouse to human — Summary	These three examples illustrate how studies of specific responses to drugs in model organisms can be…
15	From mouse to human — Summary	be modestly helpful relative to randomly selecting genes to study in humans, or simply surveying all…
16	From human to mouse	In this section, we will consider the opposite direction of translation, namely genes that are…
17	From human to mouse — Opioid receptor, mu 1 (OPRM1)	The OPRM1 gene contains a missense mutation in exon 1 that is one of the most heavily studied…
18	From human to mouse — Opioid receptor, mu 1 (OPRM1)	they remain controversial (Mague and Blendy. 2010; Yuferov et al. 2010; Walter and Lotsch 2009;…
19	From human to mouse — Opioid receptor, mu 1 (OPRM1)	with greater dopamine release in response to ethanol in both species. Interestingly, Ramchandani et…

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In this knowledge base

Title	Year	PMID
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368

External

Title	Authors	Journal	Year	Link
The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits.	Antón-Galindo E et al.	—	2023	→
Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies.	Goldberg LR et al.	—	2022	→
Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats.	Peterson VL et al.	—	2020	→
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
Αlpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats.	Comasco E et al.	—	2015	→
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	Hart AB et al.	—	2012	→
Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line.	Bryant CD et al.	—	2012	→
The genetics of addiction.	Volkow ND et al.	—	2012	→