Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: a female twin study.

paper Cited Public

Authors: Knopik, Valerie S; Heath, Andrew C; Bucholz, Kathleen K; Madden, Pamela A F; Waldron, Mary
Year: 2009
Journal: Pharmacology, biochemistry, and behavior
PMID: 19341765
DOI: 10.1016/j.pbb.2009.03.011
PMCID: PMC2758781

#	Section	Preview
20	Methods — Data-analysis — Genetic model-fitting	In order to determine the extent of genetic and environmental influences on risk of INATT, HYP/IMP,…
21	Methods — Data-analysis — Genetic model-fitting	a family more similar to one another. Nonshared or unique environmental effects (E) make members of…
22	Methods — Data-analysis — Genetic model-fitting	Genetic modeling takes advantage of the differing degrees of genetic relatedness among MZ versus DZ…
23	Methods — Data-analysis — Genetic model-fitting	The pattern of twin correlations (MZ vs. DZ) for the four outcomes of interest to this report are…
24	Methods — Data-analysis — Genetic model-fitting	In order to examine the structure of the correlations among INATT, HYP/IMP, CDP, and AlcProb, a…
25	Methods — Data-analysis — Genetic model-fitting	allowed an ADE structure for INATT and HYP/IMP and an ACE structure for CDP and AlcProb and…
26	Methods — Data-analysis — Genetic model-fitting	be explained by additive genetic (a2), dominance (d2), shared (c2) and non-shared environmental…
27	Methods — Data-analysis — Genetic model-fitting	Contrast effects or genetic dominance (non-additivity) pose alternative explanations for the very…
28	Methods — Data-analysis — Genetic model-fitting	Based on the results of fitting linear regression models, we subsequently modified the multivariate…
29	Results	Twin pairs ranged in age from 11 to 23 years, with an average of 15.15 years. 4.6% of mothers met…
30	Results — Parental alcoholism and smoking predicted increased risk of externalizing behavior and alcohol problems	Results indicated that parental alcoholism predicted increased risk of offspring HYP/IMP, CDP, and…
31	Results — Parental alcoholism and smoking predicted increased risk of externalizing behavior and alcohol problems	Substance use during pregnancy, particularly smoking during pregnancy, was also significantly…
32	Results — Parental alcoholism and smoking predicted increased risk of externalizing behavior and alcohol problems	After adjusting for all prenatal and parental risk factors, higher HYP/IMP scores were more likely…
33	Results — Genetic influence on the risk for externalizing behavior and alcohol problems	The parameter estimates and subsequent variance components obtained from fitting the…
34	Results — Genetic and environmental contributions to the comorbidity of externalizing behaviors and alcohol problems	Genetic and environmental covariance and correlation matrices are shown in Table 5. Significant…
35	Discussion	This investigation sought to determine the structure of the comorbidity among four adolescent…
36	Discussion	Major findings from these analyses include: (i) parental risk factors, such as parental alcohol…
37	Discussion	Interestingly, while conduct problems were significantly associated with alcohol problems, there was…
38	Discussion	The present work should be interpreted in the context of its strengths and limitations. First, we…
39	Discussion	using more detailed assessments, including thorough timing and duration of exposure. Third, as with…

Name	Type
A local	phenotype
additive genetic factor local	phenotype
ADHD	phenotype
ADHD subtypes local	phenotype
adolescent alcohol use	phenotype
adolescent female sample local	cohort
adolescent problem behaviors local	phenotype
adolescents	cohort
African American	cohort
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
Alcohol Dependence Symptoms	phenotype
alcoholism	phenotype
Alcohol Problems	phenotype
alcohol-related problems	phenotype
Alcohol Use	phenotype
Alcohol Use Disorder	phenotype
alcohol use disorders	phenotype
antisocial personality disorder	phenotype
attention deficit hyperactivity disorder	phenotype
Behavioral disinhibition trait local	phenotype
Behavioral undercontrol	phenotype
birth weight	phenotype
C1 local	phenotype
Child alcohol problems local	phenotype
Child conduct problems local	phenotype
childhood conduct disorder	phenotype
childhood disruptive behavior local	phenotype
Childhood disruptive behavior local	phenotype
cigarettes	phenotype
Collaborative Studies on the Genetics of Alcoholism	cohort
conduct disorder	phenotype
D local	phenotype
distractibility	phenotype
dizygotic pairs local	cohort
dominance factor local	phenotype
drug	drug
drug dependence	phenotype
drunkenness	phenotype
early alcohol use	phenotype
environmental factors	drug
externalizing behavior	phenotype
externalizing disorders	phenotype
familial risk	cohort
fathers	cohort
G local	phenotype
GABRA2	gene
genetic factors	cohort
heavy alcohol use local	drug
heavy drinking	phenotype
Heavy Prenatal Alcohol Use local	phenotype
Hyperactive/Impulsive local	phenotype
Hyperactive/Impulsive ADHD local	phenotype
hyperactive/impulsivity local	phenotype
hyperactivity	phenotype
identified families local	cohort
illicit drug use	phenotype
impulsivity	phenotype
inattention	phenotype
inattentive ADHD	phenotype
Latent behavioral disinhibition trait local	phenotype
low birth weight	phenotype
Maternal Alcohol Abuse local	phenotype
Maternal Alcohol Dependence local	phenotype
Maternal drinking 1-10 days local	phenotype
Maternal drinking 11-35 days local	phenotype
Maternal drinking >35 days local	phenotype
Maternal drinking during pregnancy local	phenotype
Maternal drinking frequent heavy use local	phenotype
Maternal drinking some heavy use local	phenotype
Maternal regular smoking local	drug
maternal smoking	phenotype
Maternal smoking heavy local	phenotype
Maternal smoking light/moderate local	phenotype
minority local	phenotype
Missouri Adolescent Female Twin Study cohort local	cohort
Missouri population local	cohort
monozygotic pairs local	cohort
mothers	cohort
nicotine	drug
non-shared environmental factor local	phenotype
novelty seeking	phenotype
offspring	cohort
oppositional defiant disorder	phenotype
Oppositional-defiant disorder	phenotype
order	phenotype
parental alcoholism	phenotype
Parental smoking local	phenotype
parents	cohort
paternal alcohol use disorder	phenotype
Paternal regular smoking local	drug
Paternal Smoking local	phenotype
phenotype	phenotype
prenatal alcohol exposure	phenotype
Prenatal smoking local	drug
prenatal substance exposure local	drug
psychiatric disorders	phenotype
psychopathology	phenotype
regular smoking	phenotype
shared environmental factor local	phenotype
Singleton births local	cohort
smoking	phenotype
smoking behavior outside of pregnancy local	phenotype
smoking during pregnancy local	drug
Smoking problems local	phenotype
substance abuse	phenotype
substance use	phenotype
susceptibility genes	cohort
tobacco use	phenotype
Twin cohort	cohort
Twin self-report local	cohort
unique environmental influences	phenotype
Very low birth weight local	phenotype
zygosity groups local	cohort

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In this knowledge base

Title	Year	PMID
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Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood.	2013	23282961
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