Alcohol consumption indices of genetic risk for alcohol dependence.
paper
Cited
Public
- Authors
- Grant, Julia D; Agrawal, Arpana; Bucholz, Kathleen K; Madden, Pamela A F; Pergadia, Michele L; Nelson, Elliot C; Lynskey, Michael T; Todd, Richard D; Todorov, Alexandre A; Hansell, Narelle K; Whitfield, John B; Martin, Nicholas G; Heath, Andrew C
- Year
- 2009
- Journal
- Biological psychiatry
- PMID
- 19576574
- DOI
- 10.1016/j.biopsych.2009.05.018
- PMCID
- PMC3077105
BACKGROUND: Previous research has reported a significant genetic correlation between heaviness of alcohol consumption and alcohol dependence (AD), but this association might be driven by the influence of AD on consumption rather than the reverse. We test the genetic overlap between AD symptoms and a heaviness of consumption measure among individuals who do not have AD. A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk. METHODS: Factor analysis of five alcohol use measures was used to create a measure of heaviness of alcohol consumption. Quantitative genetic analyses of interview data from the 1989 Australian Twin Panel (n = 6257 individuals; M = 29.9 years) assessed the genetic overlap between heaviness of consumption, DSM-IV AD symptoms, DSM-IV AD symptom clustering, and DSM-IV alcohol abuse. RESULTS: Genetic influences accounted for 30%-51% of the variance in the alcohol measures and genetic correlations were .90 or higher for all measures, with the correlation between consumption and dependence symptoms among nondependent individuals estimated at .97 (95% confidence interval: .80-1.00). CONCLUSIONS: Heaviness of consumption and AD symptoms have a high degree of genetic overlap even among nondependent individuals in the general population, implying that genetic influences on dependence risk in the general population are acting to a considerable degree through heaviness of use and that quantitative measures of consumption will likely have a useful role in the identification of genes contributing to AD.
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| Name | Type |
|---|---|
| 1981 Cohort local | cohort |
| 1981 spouse sample local | cohort |
| 1989 twin cohort local | cohort |
| 1989 Twin Cohort local | cohort |
| ADH | gene |
| AD symptom clustering local | phenotype |
| AD symptom count | phenotype |
| AD symptoms | phenotype |
| adverse environmental exposures local | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| Alcohol consumption factor score local | phenotype |
| alcohol consumption measures | phenotype |
| Alcohol consumption patterns local | phenotype |
| Alcohol consumption (quantitative index) local | phenotype |
| alcohol dependence | phenotype |
| Alcohol Dependence Symptoms | phenotype |
| alcoholism | phenotype |
| alcohol metabolism | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| ALDH2 | gene |
| Asian | cohort |
| composite alcohol factor score local | phenotype |
| consumption factor score local | phenotype |
| Consumption Measures local | phenotype |
| Dimensional model | phenotype |
| DSM-based alcohol measures local | phenotype |
| DSM-IV alcohol dependence | phenotype |
| European population | cohort |
| family conflict | phenotype |
| Frequency of Intoxication During Heaviest Use local | phenotype |
| general community twin sample local | cohort |
| heaviness of consumption factor score local | phenotype |
| heavy drinking | phenotype |
| large sibship cohort local | cohort |
| Lifetime AD symptoms local | phenotype |
| like-sex female twin pairs local | cohort |
| like-sex male twin pairs local | cohort |
| marital breakdown local | phenotype |
| Maximum drinks consumed in a 24-hour period local | phenotype |
| Maximum tolerance local | phenotype |
| moderate alcohol dependence local | phenotype |
| Non-AD individuals with AD cotwin local | phenotype |
| Non-AD individuals with non-AD cotwin local | phenotype |
| Non-Jewish European ancestry local | cohort |
| Older Spouse Cohort local | cohort |
| physical abuse | phenotype |
| Polymorphism | cohort |
| Quantitative consumption factor score local | phenotype |
| reproductive delay local | phenotype |
| second older twin sample local | cohort |
| severe alcohol use disorder | phenotype |
| spouse cohort local | cohort |
| spouses of a second older twin sample local | cohort |
| Symptom temporal clustering local | phenotype |
| temporal clustering variable local | phenotype |
| tolerance | phenotype |
| Twin cohort | cohort |
| Twin factor score local | phenotype |
| Twin singletons local | cohort |
| Typical Consumption During Heaviest Use local | phenotype |
| unlike-sex twin pairs local | cohort |
| Volunteer twin sample local | cohort |
| young adult Australian twin cohort local | cohort |
| young adults | cohort |
| Young Adult Twin Cohort local | cohort |
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