Protein kinases and addiction.

paper Cited Public

Authors: Lee, Anna M; Messing, Robert O
Year: 2008
Journal: Annals of the New York Academy of Sciences
PMID: 18991950
DOI: 10.1196/annals.1441.022
PMCID: PMC3050040

#	Section	Preview
80	Protein Kinase C — PKC in Behavioral Responses to Drugs of Abuse — Conditioned Place Preference	Nonselective PKC inhibitors decrease CPP induced by many addictive drugs. In rats, chelerytrhine…
81	Calcium/Calmodulin-Dependent Protein Kinase II	The CaMKII family consists of four closely related genes that encode for α, β, γ, and δ…
82	Calcium/Calmodulin-Dependent Protein Kinase II	Autophosphorylation on Thr-286 disables the auto-inhibitory domain, increases the affinity for…
83	Calcium/Calmodulin-Dependent Protein Kinase II	receptors and contribute to synaptic plasticity and LTP.234 Mutation of the αCaMKII…
84	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	Acute administration of psychostimulants has variable effects on CaMKII activity depending on the…
85	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	There is cross-talk between CaMKII, ERK, and PKA pathways, with CaMKII modulating stimulant-induced…
86	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	Chronic exposure to psychostimulants increases CaMKII activity when given continuously,…
87	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	The effect of chronic nicotine on CaMKII activity has not yet been investigated in animal studies or…
88	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	CaMKII is modulated by cannabinoids and opiates. Acute treatment with low doses of THC in rats…
89	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	Withdrawal from chronic drug treatment has differential effects on CaMKII activity. In rats,…
90	Calcium/Calmodulin-Dependent Protein Kinase II — Effects of Addictive Drugs on CaMKII Signaling	CaMKII activity plays a role in μ-opioid receptor desensitization,251 which may be important for…
91	Calcium/Calmodulin-Dependent Protein Kinase II — CaMKII in Behavioral Responses to Drugs of Abuse — Sensitization	CaMKII contributes to drug-induced hyperlocomotion and locomotor sensitization. In rats, repeated…
92	Calcium/Calmodulin-Dependent Protein Kinase II — CaMKII in Behavioral Responses to Drugs of Abuse — Drug Tolerance	In rats, the development of tolerance to morphine analgesia is attenuated by intrahippocampal…
93	Calcium/Calmodulin-Dependent Protein Kinase II — CaMKII in Behavioral Responses to Drugs of Abuse — Drug Withdrawal	The effect of CaMKII inhibition on drug withdrawal has not been extensively studied. However, some…
94	Calcium/Calmodulin-Dependent Protein Kinase II — CaMKII in Behavioral Responses to Drugs of Abuse — Conditioned Place Preference	CaMKII activity in the hippocampus is important for expression of drug-induced CPP. Repeated…
95	Fyn	Fyn is a member of the Src family of non-receptor tyrosine kinases259 and is expressed throughout…
96	Fyn	Fyn plays an important role in synaptic plasticity and LTP. Knockout of the fyn gene, and not other…
97	Fyn	Fyn interacts with and regulates the function of many neurotransmitter receptors in the brain and…
98	Fyn — Effects of Ethanol on Fyn Signaling	Acute ethanol treatment increases Fyn activity in the rat dorsal striatum,267 cerebral cortex, and…
99	Fyn — Fyn in Behavioral Responses to Ethanol — Ethanol Intoxication and Acute Tolerance	Fyn knockout mice and mice that overexpress Fyn under control of an αCaMKII promoter in the…

Name	Type
3,7-dimethylpro-pargylxanthine local	drug
4-cyano-3-methylisoquinoline local	drug
4-hydroxynonenal	drug
7-OH-DPAT local	drug
A2a antagonist local	drug
Abnormal hippocampal development local	phenotype
acute functional tolerance	phenotype
Acute functional tolerance to ethanol local	phenotype
Acute sensitivity to opiates local	phenotype
acute tolerance to ethanol local	phenotype
ADCY	gene
ADCY1	gene
ADCY2 local	gene
ADCY4 local	gene
ADCY5	gene
ADCY6	gene
ADCY7 local	gene
ADCY8	gene
addiction	phenotype
addictive drug local	drug
adenosine	drug
adenylyl cyclase	drug
Adora2a	gene
alcohol	phenotype
alcohol self-administration	phenotype
alcohol sensitivity	phenotype
Alcohol Use	phenotype
alcohol withdrawal	phenotype
AMPA receptors	drug
amphetamine	drug
amphetamine CPP local	phenotype
amphetamines	drug
amygdala	anatomy
Analgesic response to morphine local	phenotype
analgesic sensitivity local	phenotype
analog-sensitive kinase mutant local	gene
anisomycin local	drug
antisense oligonucleotides against PKCε local	drug
anxiety	phenotype
anxiety-like behavior	phenotype
anxiolytic effect	phenotype
APV	drug
arachidonic acid	drug
astrocytes	phenotype
ATP analogs local	drug
*ATP-γS local	drug
attention deficit hyperactivity disorder	phenotype
auditory fear conditioning	phenotype
autophosphorylated CaMKIIα (synaptosomal) local	phenotype
autophosphorylation of CaMKIIα local	phenotype
autophosphorylation of CaMKIIβ local	phenotype
basolateral amygdala	anatomy
Bdnf	gene
BDNF antisense oligonucleotides local	drug
behavioral disinhibition	phenotype
benzodiazepines	drug
BIIE0246	drug
BIS	phenotype
bisindolylmaleimide I local	drug
bisindolylmaleimides local	drug
BNST	anatomy
B-Raf local	drug
B-Raf local	gene
brain	anatomy
breaking point local	phenotype
calcium	drug
calmodulin	drug
calphostin C local	drug
Calphostin C local	drug
CAMK2 local	gene
CAMK2A	gene
CAMK2B local	gene
CAMK2D	gene
CAMK2G	gene
CaMKI local	gene
CamKII	drug
CaMKII activity local	phenotype
CaMKII antisense oligonucleotides local	drug
CaMKII knockout mice local	cohort
CaMKIIα mRNA local	phenotype
CaMKIIα protein local	phenotype
CaMKIIβ local	variant
CaMKIIβ mRNA local	phenotype
CaMKIIβ protein local	phenotype
CaMKK local	gene
cAMP	drug
Cannabinoid receptor local	drug
Cannabinoid receptor agonist local	drug
cannabinoids	drug
caudate-putamen local	anatomy
CB1 agonist	drug
CB1 antagonist	drug
CB1 receptor	drug
Cdk5 local	drug
Cdk5	gene
CDK5R1 local	gene
central amygdala	anatomy
central nervous system	anatomy
cerebellar cortex	anatomy
cerebellum	anatomy
cerebroventricular space local	anatomy
c-fos local	drug
c-fos	gene
chelerythrine local	drug
Chelerythrine local	drug
choline	drug
Chrna3	gene
Chrna4	gene
CHRNA5	gene
Chrna7	gene
Chrnb2	gene
Chrnb4	gene
chronic ethanol exposure	phenotype
cingulate cortex	anatomy
Cnr1	gene
cocaine	phenotype
cocaine-induced CPP local	phenotype
cocaine-induced hyperlocomotion local	phenotype
cocaine-induced locomotor sensitization local	phenotype
cocaine self-administration	phenotype
cocaine withdrawal	phenotype
cocaine-withdrawn rats local	cohort
conditional Cdk5 knockout mice local	cohort
conditioned place aversion	phenotype
conditioned place preference	phenotype
conditioned reinforcement local	phenotype
consumption	phenotype
cortex	anatomy
cPKC local	drug
CREB local	drug
CREB1	gene
CRF-mediated long-term potentiation (LTP) local	phenotype
cue-induced cocaine seeking local	phenotype
cue-induced drug seeking local	phenotype
Cα local	drug
Cβ local	drug
Cγ local	drug
D1/D5 receptor antagonists local	drug
D1 receptor	drug
DAG	drug
DARPP-32	drug
DARPP-32 knockout mice local	cohort
Deep layers of the prefrontal cortex local	anatomy
Deficient hippocampal LTP local	phenotype
deltaFosB local	variant
depression of hippocampal LTP local	phenotype
diacylglycerol	drug
dopamine	drug
dopamine accumulation local	phenotype
dopamine D1 agonist local	drug
Dopamine D1 receptor local	drug
Dopamine D1 receptor agonist local	drug
Dopamine D2 receptor	drug
dopamine efflux	drug
dopamine release	drug
Dopamine release in NAc local	phenotype
Dopaminergic homeostasis local	phenotype
dopaminergic signaling local	phenotype
dopamine sensitization local	phenotype
Dopamine transporter	drug
dorsal striatum	anatomy
DRD1	gene
DRD2	gene
DRD5	gene
drinks per week	phenotype
drug dependence	phenotype
drug-induced CPP local	phenotype
drug-induced hyperlocomotion local	phenotype
drug-naïve rats local	cohort
drug-seeking behavior	phenotype
Egr1	gene
EGR2	gene
electroconvulsive treatment local	drug
Elk-1 local	drug
Elk-1 local	gene
ELK1 local	gene
epilepsy	phenotype
ERK local	phenotype
ERK1 knockout mice local	cohort
ERK pathway local	phenotype
ERK phosphorylation local	phenotype
ethanol consumption	phenotype
ethanol CPP local	phenotype
ethanol dependence	phenotype
Ethanol-induced LORR local	phenotype
ethanol preference	phenotype
ethanol withdrawal	phenotype
Excess dopaminergic activity local	phenotype
exocytosis	phenotype
Extracellular dopamine local	phenotype
female Fyn knockout mice local	cohort
flunitrazepam	drug
forebrain	anatomy
forskolin	drug
Fos	gene
Fosb	gene
frontal cortex	anatomy
Fyn	gene
FYN -93A>G local	variant
Fyn knockout mice local	cohort
GABA	phenotype
GABAA receptor	drug
GABAA receptor-mediated inhibitory postsynaptic currents local	phenotype
GABA-stimulated current local	phenotype
Gabra1	gene
Gabra4	gene
Gabrg2	gene
GAP43 local	gene
gene transcription	phenotype
Gi/o	drug
Gi/o protein	drug
GluR1	gene
GluR1 subunit local	drug
glutamate	drug
glycine	drug
Glycine currents local	phenotype
GNAI	gene
GNAI3 local	gene
GNAL local	gene
GNAO	gene
Gnas	gene
GNB1_GNG2_complex local	gene
GNB2L1	gene
Go6976 local	drug
Golf protein local	drug
Go protein local	drug
Gq local	drug
Grb2	gene
GRIA1	gene
GRIN2B	gene
GRM1	gene
GRM5	gene
Gs protein local	drug
Gαs local	drug
Gβγ local	drug
H89 local	drug
handling-induced convulsions local	phenotype
heterozygous Cdk5 knockout mice local	cohort
heterozygous Cdk5 null mice local	cohort
Heterozygous Fyn knockout mice local	cohort
hippocampal CA1 region	anatomy
hippocampus	anatomy
HIST1H1 local	gene
HTR6	gene
hyperalgesia	phenotype
hyperlocomotion	phenotype
hypolocomotion local	phenotype
hypothermia	phenotype
ifendopril local	drug
Ifendopril local	drug
Impaired spatial learning local	phenotype
impulsivity	phenotype
inositol triphosphate	drug
isozyme-selective peptide inhibitors local	drug
Kcnj6	gene
KN-62 local	drug
KN62 local	drug
KN93 local	drug
KN93243 local	drug
KN93255 local	drug
knockout mice	cohort
KT5720 local	drug
KW6002 local	drug
Lateral bed nucleus of the stria terminalis local	anatomy
lateral nucleus of the amygdala local	anatomy
limbic system	anatomy
lipid second messengers local	drug
locomotor activity	phenotype
locomotor sensitization	phenotype
locus coeruleus	anatomy
long-term depression	phenotype
long-term potentiation	phenotype
Loss of righting reflex (LORR) local	phenotype
lower midbrain local	anatomy
LTP	phenotype
L-type calcium channel	drug
L-type calcium channel local	phenotype
male Fyn knockout mice local	cohort
MAP2K1	gene
MAP2K2 local	gene
Mapk1	gene
MAPK3	gene
MAPK signaling pathway	drug
medial amygdala	anatomy
medial prefrontal cortex	anatomy
MEK local	drug
MEK local	gene
MEK inhibitors local	drug
mesolimbic dopamine system	drug
methamphetamine	drug
methamphetamine CPP	phenotype
methamphetamine-induced CPP local	phenotype
methamphetamine-withdrawn rats local	cohort
mice	cohort
midbrain	anatomy
MK801 local	drug
monkeys	cohort
morphine	drug
morphine-induced CPP local	phenotype
motivated responding local	phenotype
motivation	phenotype
motor coordination	phenotype
mouse brain	anatomy
Mouse dorsal striatum local	anatomy
Mouse hippocampal neurons local	anatomy
mouse striatum	anatomy
MPEP	drug
MSK1 local	gene
mutant mice	cohort
NAc	anatomy
NAc core	anatomy
naloxone	drug
NEFH	gene
neurite outgrowth	phenotype
neurosteroids	drug
neurotrophin	drug
NG-108-15 cells local	cohort
NGF	drug
nicotine	drug
Nicotinic agonists local	drug
Nicotinic receptor upregulation local	phenotype
NMDA	drug
NMDA agonist local	drug
NMDA-mediated currents local	phenotype
NMDA receptor	drug
nonselective PKC inhibitors local	drug
nonsmoker	cohort
NPC 15437 local	drug
NP rats	cohort
NPY	gene
NPY2R	gene
NPY-Y2 antagonist local	drug
NR1	gene
NR1 subunit local	drug
Nrgn	gene
NTRK1	gene
NTRK2	gene
N-type calcium channel local	drug
N-type calcium channel local	phenotype
nucleus accumbens	anatomy
object recognition	phenotype
olomoucine local	drug
opiates	drug
opioid	drug
opioid dependence	phenotype
opioid receptor	drug
opioid receptor agonist	drug
opioid tolerance	phenotype
OPRM1	cohort
OVF mice local	cohort
p35 local	drug
p35 local	gene
p39 local	gene
p67 local	gene
palatable foods local	phenotype
PA phospho-hydrolase local	drug
para-nitrobenzylmesylate local	drug
parietal cortex	anatomy
PC12 cells	cohort
p-CREB increase local	phenotype
p-CREB induction local	phenotype
PD98059	drug
PDK1 local	gene
Pdyn	gene
PENK	gene
pentobarbital	drug
periaqueductal gray	anatomy
p-ERK local	drug
p-ERK local	phenotype
phorbol esters local	drug
Phorbol esters local	drug
phosphatidic acid local	drug
Phosphatidic acid local	drug
Phosphatidylcholine	drug
phosphatidylinositol-4,5-bis-phosphate local	drug
phospholipase C	drug
Phospholipase D	drug
PICK1 local	gene
PKA	drug
PKA activity local	drug
PKA activity local	phenotype
PKA antisense oligonucleotides local	drug
PKA inhibitor H89 local	drug
PKC	gene
PKC activity local	drug
PKCβI local	gene
PKCβII local	gene
PKCγ knockout mice	cohort
PKCε inhibitor peptide local	drug
PKCε knockout mice	cohort
PLC local	gene
PP-1 local	drug
PP1	gene
PP2 local	drug
PPP1R1B	gene
PPP2CA local	gene
P/Q-type calcium channel local	drug
P rats	cohort
precipitated morphine withdrawal local	cohort
prefrontal cortex	anatomy
Pregnanolone local	drug
preproenkephalin local	gene
PRKACA	gene
PRKCA	gene
PRKCB	gene
PRKCD	gene
PRKCE	gene
PRKCG	gene
PRKCH local	gene
PRKCI local	gene
PRKCQ local	gene
PRKCZ	gene
protein kinase A	drug
Protein kinase C	drug
protein kinase pathways local	drug
Protein phosphatase 2A local	gene
psychomotor sensitization	phenotype
psychostimulants	drug
PTPN5 local	gene
quinpirole local	drug
Raf1	gene
Rap1 local	drug
Rap1 local	gene
Ras	gene
RASGRF1	gene
Rat brain slices local	cohort
rat model	cohort
rats	cohort
Rat striatal neurons local	anatomy
receptor desensitization	phenotype
receptor inhibition local	phenotype
receptor upregulation local	phenotype
reinforced responding local	phenotype
Reinforcing properties of nicotine	phenotype
relapse	phenotype
reward	phenotype
RHOA local	gene
RIIα local	drug
RIIβ local	drug
RIα local	drug
RIβ local	drug
Ro31-8220 local	drug
rodents	cohort
roscovitine	drug
Rp-cAMPS	drug
RSK local	gene
SCH23390 local	drug
second messengers local	drug
self-administration of cocaine local	phenotype
Self-administration of morphine local	phenotype
sensitivity to morphine local	phenotype
serotonin	drug
shakes local	phenotype
SHC local	gene
SKF 81297 local	drug
SKF81297 local	drug
SKF82958 local	drug
SL327 local	drug
SLC29A1 local	gene
SLC6A3	gene
smoking	phenotype
Snap25	gene
somatic withdrawal signs	phenotype
spatial memory	phenotype
Sp-cAMPS local	drug
spinal cord	anatomy
stereotypy	phenotype
stimulants	drug
stress-associated ethanol self-administration local	phenotype
stress hormones	drug
striatum	anatomy
substance abuse	phenotype
sucrose	drug
SYN1	gene
synapsin	gene
synaptic plasticity	phenotype
t-ACPD local	drug
thalamus	anatomy
THC	drug
THC-induced CPP local	phenotype
Thr-286 local	variant
tolerance	phenotype
tolerance to morphine analgesia local	phenotype
transgenic mice	cohort
tremor	phenotype
U0126 local	drug
unprecipitated morphine withdrawal local	cohort
ventral midbrain	anatomy
ventral striatum	anatomy
ventral tegmental area	anatomy
VTA	anatomy
whole brain	anatomy
wild-type controls local	cohort
wild-type mice	cohort
WIN-55212-2 local	drug
withdrawal	phenotype
withdrawal-induced anxiety local	phenotype
α7 nACh receptor local	drug
εRACK local	drug
εRACK local	gene

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In this knowledge base

Title	Year	PMID
Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.	2017	28058793
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.	2013	23607416

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CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin.	Flentke GR et al.	—	2014	→
Chemogenomics knowledgebased polypharmacology analyses of drug abuse related G-protein coupled receptors and their ligands.	Xie XQ et al.	—	2014	→
Inhibition of PKC disrupts addiction-related memory.	Howell KK et al.	—	2014	→
In vivo study of ethanol-activated brain protein kinase A: manipulations of Ca2+ distribution and flux.	Baliño P et al.	—	2014	→
Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats.	Arguello AA et al.	—	2014	→
Role of CA2+/calmodulin on ethanol neurobehavioral effects.	Baliño P et al.	—	2014	→
Cdk5: An Emerging Kinase in Pain Signaling.	Pareek TK et al.	—	2013	→
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.	Kos MZ et al.	—	2013	→
Signaling pathways mediating alcohol effects.	Ron D et al.	—	2013	→
Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma.	Schmidt HD et al.	—	2013	→
The neurobiology of alcohol consumption and alcoholism: an integrative history.	Tabakoff B et al.	—	2013	→
Cocaine facilitates PKC maturation by upregulating its phosphorylation at the activation loop in rat striatal neurons in vivo.	Xue B et al.	—	2012	→
Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain.	Ramos-Miguel A et al.	—	2012	→
Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats.	de Vaca SC et al.	—	2012	→
Substance abuse may be a risk factor for earlier onset of Huntington disease.	Byars JA et al.	—	2012	→
The region-specific activation of Ca2+/calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure.	Wang Y et al.	—	2012	→
CaMKII activation is a novel effector of alcohol's neurotoxicity in neural crest stem/progenitor cells.	Garic A et al.	—	2011	→
Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers.	Ballard ME et al.	—	2011	→
Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons.	Adermark L et al.	—	2011	→
PKMζ maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex.	He YY et al.	—	2011	→
Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens.	Lee AM et al.	—	2011	→
Src family kinases: modulators of neurotransmitter receptor function and behavior.	Ohnishi H et al.	—	2011	→
5-HT6 receptor signal transduction second messenger systems.	Codony X et al.	—	2010	→
Neuroscience of alcoholism: molecular and cellular mechanisms.	Moonat S et al.	—	2010	→
Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.	Olive MF et al.	—	2010	→
Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.	Yuan L et al.	—	2009	→
The Allen Brain Atlas: 5 years and beyond.	Jones AR et al.	—	2009	→