Genome-wide association study of recurrent early-onset major depressive disorder.
paper
Cited
Public
- Authors
- Shi, J; Potash, J B; Knowles, J A; Weissman, M M; Coryell, W; Scheftner, W A; Lawson, W B; DePaulo, J R; Gejman, P V; Sanders, A R; Johnson, J K; Adams, P; Chaudhury, S; Jancic, D; Evgrafov, O; Zvinyatskovskiy, A; Ertman, N; Gladis, M; Neimanas, K; Goodell, M; Hale, N; Ney, N; Verma, R; Mirel, D; Holmans, P; Levinson, D F
- Year
- 2011
- Journal
- Molecular psychiatry
- PMID
- 20125088
- DOI
- 10.1038/mp.2009.124
- PMCID
- PMC6486400
A genome-wide association study was carried out in 1020 case subjects with recurrent early-onset major depressive disorder (MDD) (onset before age 31) and 1636 control subjects screened to exclude lifetime MDD. Subjects were genotyped with the Affymetrix 6.0 platform. After extensive quality control procedures, 671β424 autosomal single nucleotide polymorphisms (SNPs) and 25β068 X chromosome SNPs with minor allele frequency greater than 1% were available for analysis. An additional 1β892β186 HapMap II SNPs were analyzed based on imputed genotypic data. Single-SNP logistic regression trend tests were computed, with correction for ancestry-informative principal component scores. No genome-wide significant evidence for association was observed, assuming that nominal P<5 Γ 10(-8) approximates a 5% genome-wide significance threshold. The strongest evidence for association was observed on chromosome 18q22.1 (rs17077540, P=1.83 Γ 10(-7)) in a region that has produced some evidence for linkage to bipolar-I or -II disorder in several studies, within an mRNA detected in human brain tissue (BC053410) and approximately 75βkb upstream of DSEL. Comparing these results with those of a meta-analysis of three MDD GWAS data sets reported in a companion article, we note that among the strongest signals observed in the GenRED sample, the meta-analysis provided the greatest support (although not at a genome-wide significant level) for association of MDD to SNPs within SP4, a brain-specific transcription factor. Larger samples will be required to confirm the hypothesis of association between MDD (and particularly the recurrent early-onset subtype) and common SNPs.
Genome-wide resultsPanel A shows the association test result for each SNP (genotyped and imputed) as -log10(P-value), for the primary analysis of all subjects. The largest symbols represent P<10β6, and the intermediate-size symbols represent P<10β5. For the same SNPs, Panel B shows the quantile-quantile plot of observed vs. expected Ξ§2 (1df) statistics. The genomic control Ξ» value was 1.032. Manhattan and QQ plots are shown for males and for females separately in online Figures S7 and S14.
Results for selected chromosomal regionsShown from top to bottom of each plot are chromosome ideogram (plotted region marked with vertical red bar); genomic information (RefSeq genes with direction of transcription; and in Panel A, mRNAs); association test results (βlog10[P]) in the primary analysis of all subjects; and HapMap linkage disequilibrium (r2) information.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A review of methods and software for polygenic risk score analysis. | Benoumhani S et al. | β | 2025 | β |
| Peripheral MicroRNA Signatures in Adolescent Depression. | Morgunova A et al. | β | 2025 | β |
| Prevalence of depressive symptoms in the general population with a fully structured interview with skips vs. unconditional sequential assessment: implications for clinical and psychiatric epidemiology studies. | Vilar A et al. | β | 2025 | β |
| The genetics of severe depression. | Franklin CE et al. | β | 2025 | β |
| An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank. | Viejo-Romero M et al. | β | 2024 | β |
| Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review. | Singh MK et al. | β | 2024 | β |
| Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic. | Schumacher MA | β | 2024 | β |
| White matter microstructure and functional connectivity in the brains of infants with Turner syndrome. | Blanchett R et al. | β | 2024 | β |
| Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes. | McGeary JE et al. | β | 2023 | β |
| Chemistry and Function of Glycosaminoglycans in the Nervous System. | Schwartz NB et al. | β | 2023 | β |
| Children with Early-Onset Psychosis Have Increased Burden of Rare <i>GRIN2A</i> Variants. | Hojlo MA et al. | β | 2023 | β |
| Development of cross-species translational paradigms for psychiatric research in the Research Domain Criteria era. | Young JW | β | 2023 | β |
| Genetic and environmental factors influencing neonatal resting-state functional connectivity. | Blanchett R et al. | β | 2023 | β |
| Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers. | Singh P et al. | β | 2023 | β |
| Histories of Dermatan Sulfate Epimerase and Dermatan 4-<i>O</i>-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome. | Mizumoto S et al. | β | 2023 | β |
| Identifying underlying patterns in Alzheimer's disease trajectory: a deep learning approach and Mendelian randomization analysis. | Yi F et al. | β | 2023 | β |
| The genetic basis of major depressive disorder. | Flint J | β | 2023 | β |
| Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals. | Anguita-Ruiz A et al. | β | 2022 | β |
| Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis. | Melhuish Beaupre LM et al. | β | 2022 | β |
| Differential expression of MDGA1 in major depressive disorder. | Li YJ et al. | β | 2022 | β |
| Genetic Mapping of Progressive Ethanol Consumption in the Diversity Outbred Mouse | Tatom Z et al. | β | 2022 | β |
| Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder. | Grant CW et al. | β | 2022 | β |
| Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives. | Lanzetti S et al. | β | 2022 | β |
| The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development. | Mizumoto S et al. | β | 2022 | β |
| Analysis of Major Depression Risk Genes Reveals Evolutionary Conservation, Shared Phenotypes, and Extensive Genetic Interactions. | Sall S et al. | β | 2021 | β |
| Animal models for the study of depressive disorder. | Song J et al. | β | 2021 | β |
| Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis. | Mizumoto S et al. | β | 2021 | β |
| Discriminating bipolar depression from major depressive disorder with polygenic risk scores. | Liebers DT et al. | β | 2021 | β |
| Exome sequencing reveals predominantly de novo variants in disorders with intellectual disability (ID) in the founder population of Finland. | JΓ€rvelΓ€ I et al. | β | 2021 | β |
| Genetic markers for depressive disorders with earlier age at onset. | Kang HJ et al. | β | 2021 | β |
| Identification of putative causal loci in whole-genome sequencing data via knockoff statistics. | He Z et al. | β | 2021 | β |
| Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci. | Swart Y et al. | β | 2021 | β |
| Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis. | Melhuish Beaupre LM et al. | β | 2021 | β |
| The genetic basis of major depression. | Kendall KM et al. | β | 2021 | β |
| Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics. | Shalimova A et al. | β | 2021 | β |
| The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis. | HernΓ‘ndez-DΓaz Y et al. | β | 2021 | β |
| Toward an Extended Definition of Major Depressive Disorder Symptomatology: Digital Assessment and Cross-validation Study. | Martin-Key NA et al. | β | 2021 | β |
| Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes. | Arasappan D et al. | β | 2021 | β |
| Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity. | de Jong TV et al. | β | 2021 | β |
| A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder. | Zhang Y et al. | β | 2020 | β |
| Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder. | Rao S et al. | β | 2020 | β |
| Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population. | Saucedo-Uribe E et al. | β | 2019 | β |
| Genome-wide association study of morbid obesity in Han Chinese. | Chiang KM et al. | β | 2019 | β |
| Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. | Zhang X et al. | β | 2019 | β |
| Glutamate receptor metabotropic 7 (GRM7) gene polymorphisms in mood disorders and attention deficit hyperactive disorder. | Noroozi R et al. | β | 2019 | β |
| GWAS of Behavioral Traits. | Mehta D et al. | β | 2019 | β |
| Identification and characterization of the lncRNA signature associated with overall survival in patients with neuroblastoma. | Yerukala Sathipati S et al. | β | 2019 | β |
| Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. | Li H et al. | β | 2019 | β |
| MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice. | Yan HL et al. | β | 2019 | β |
| Network Analysis of Depression-Related Transcriptomic Profiles. | Miao X et al. | β | 2019 | β |
| Role of inflammation in depression relapse. | Liu CH et al. | β | 2019 | β |
| Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk. | Srivastava A et al. | β | 2019 | β |
| Transcription factor Sp4 is required for hyperalgesic state persistence. | Sheehan K et al. | β | 2019 | β |
| Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression. | Zalar B et al. | β | 2018 | β |
| Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo. | Gouignard N et al. | β | 2018 | β |
| Genetics Factors in Major Depression Disease. | Shadrina M et al. | β | 2018 | β |
| Genome-wide association study of seasonal affective disorder. | Ho KWD et al. | β | 2018 | β |
| Hot Genes in Schizophrenia: How Clinical Datasets Could Help to Refine their Role. | Porcelli S et al. | β | 2018 | β |
| Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice. | Wang X et al. | β | 2018 | β |
| Molecular genetic overlap between migraine and major depressive disorder. | Yang Y et al. | β | 2018 | β |
| Proteoglycans in brain development and pathogenesis. | Schwartz NB et al. | β | 2018 | β |
| The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder. | Xiao X et al. | β | 2018 | β |
| The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. | Ni H et al. | β | 2018 | β |
| A continuum of genetic liability for minor and major depression. | Corfield EC et al. | β | 2017 | β |
| A genetic variant in miRNA binding site of glutamate receptor 4, metabotropic (GRM4) is associated with increased risk of major depressive disorder. | Dadkhah T et al. | β | 2017 | β |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | β | 2017 | β |
| An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. | Direk N et al. | β | 2017 | β |
| Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. | Xiao X et al. | β | 2017 | β |
| Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist. | Martin J et al. | β | 2017 | β |
| Genetics of depressive symptoms in adolescence. | Sallis H et al. | β | 2017 | β |
| Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. | Power RA et al. | β | 2017 | β |
| Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder. | Ernst J et al. | β | 2017 | β |
| Loss-of-function of PTPR Ξ³ and ΞΆ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice. | Cressant A et al. | β | 2017 | β |
| MiR-137: an important player in neural development and neoplastic transformation. | Mahmoudi E et al. | β | 2017 | β |
| Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance. | Fabbri C et al. | β | 2017 | β |
| New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway. | Bowrey HE et al. | β | 2017 | β |
| Noncoding RNAs in Depression. | Lin R et al. | β | 2017 | β |
| The recent progress in animal models of depression. | Wang Q et al. | β | 2017 | β |
| A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val66Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects. | Latsko MS et al. | β | 2016 | β |
| Biosynthesis of glycosaminoglycans: associated disorders and biochemical tests. | Sasarman F et al. | β | 2016 | β |
| Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis. | Rao S et al. | β | 2016 | β |
| Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder. | Luo X et al. | β | 2016 | β |
| Electrophysiological Endophenotypes for Schizophrenia. | Owens EM et al. | β | 2016 | β |
| Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression. | Knowles EE et al. | β | 2016 | β |
| Identification of SLC25A37 as a major depressive disorder risk gene. | Huo YX et al. | β | 2016 | β |
| Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. | Klein M et al. | β | 2016 | β |
| Phenotypically distinct subtypes of psychosis accompany novel or rare variants in four different signaling genes. | Kranz TM et al. | β | 2016 | β |
| Polygenic interactions with environmental adversity in the aetiology of major depressive disorder. | Mullins N et al. | β | 2016 | β |
| Pupillary response abnormalities in depressive disorders. | Laurenzo SA et al. | β | 2016 | β |
| Recurrent major depression and right hippocampal volume: A bivariate linkage and association study. | Mathias SR et al. | β | 2016 | β |
| Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population. | Chen J et al. | β | 2016 | β |
| Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission. | Limon A et al. | β | 2016 | β |
| The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population. | Otowa T et al. | β | 2016 | β |
| Blood transcriptomic markers for major depression: from animal models to clinical settings. | Redei EE et al. | β | 2015 | β |
| Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site. | Le FranΓ§ois B et al. | β | 2015 | β |
| Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the Multi-Ethnic Study of Atherosclerosis. | Ware EB et al. | β | 2015 | β |
| Complex Rearrangement Involving Three Chromosomes, Four Breakpoints and a 2.7-Mb Deletion in the 18q Segment Observed in a Girl with Mild Learning Difficulties. | Kontodiou M et al. | β | 2015 | β |
| Depression sum-scores don't add up: why analyzing specific depression symptoms is essential. | Fried EI et al. | β | 2015 | β |
| Discovering schizophrenia endophenotypes in randomly ascertained pedigrees. | Glahn DC et al. | β | 2015 | β |
| Epidemiological support for genetic variability at hypothalamic-pituitary-adrenal axis and serotonergic system as risk factors for major depression. | Ching-LΓ³pez A et al. | β | 2015 | β |
| Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity. | Jiao H et al. | β | 2015 | β |
| Familiality and SNP heritability of age at onset and episodicity in major depressive disorder. | Ferentinos P et al. | β | 2015 | β |
| Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. | Giniatullina A et al. | β | 2015 | β |
| Gene-environment interaction in major depression: focus on experience-dependent biological systems. | Lopizzo N et al. | β | 2015 | β |
| Genetic determinants of depression: recent findings and future directions. | Dunn EC et al. | β | 2015 | β |
| GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders. | Young JW et al. | β | 2015 | β |
| Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. | Maier R et al. | β | 2015 | β |
| Polygenic risk, stressful life events and depressive symptoms in older adults: a polygenic score analysis. | Musliner KL et al. | β | 2015 | β |
| Problematic assumptions have slowed down depression research: why symptoms, not syndromes are the way forward. | Fried EI | β | 2015 | β |
| Proteoglycans and neuronal migration in the cerebral cortex during development and disease. | Maeda N | β | 2015 | β |
| Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. | Higa KK et al. | β | 2015 | β |
| The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects. | Peyrot WJ et al. | β | 2015 | β |
| A change in hippocampal protocadherin gamma expression in a learned helpless rat. | Garafola CS et al. | β | 2014 | β |
| A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. | Chang LC et al. | β | 2014 | β |
| Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder. | Kandaswamy R et al. | β | 2014 | β |
| Applying polygenic risk scores to postpartum depression. | Byrne EM et al. | β | 2014 | β |
| A recessive genetic model and runs of homozygosity in major depressive disorder. | Power RA et al. | β | 2014 | β |
| Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis. | Zhao X et al. | β | 2014 | β |
| CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population. | He K et al. | β | 2014 | β |
| Chemistry and function of glycosaminoglycans in the nervous system. | Schwartz NB et al. | β | 2014 | β |
| Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation. | Bedson E et al. | β | 2014 | β |
| Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy. | Schneider M et al. | β | 2014 | β |
| Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | Otowa T et al. | β | 2014 | β |
| Genome-wide polygenic scoring for a 14-year long-term average depression phenotype. | Chang SC et al. | β | 2014 | β |
| Human genetic disorders and knockout mice deficient in glycosaminoglycan. | Mizumoto S et al. | β | 2014 | β |
| Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. | Guintivano J et al. | β | 2014 | β |
| Investigating the genetic variation underlying episodicity in major depressive disorder: suggestive evidence for a bipolar contribution. | Ferentinos P et al. | β | 2014 | β |
| Microarray profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder. | Liu Z et al. | β | 2014 | β |
| MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese. | Guan F et al. | β | 2014 | β |
| Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling. | Saia G et al. | β | 2014 | β |
| PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. | Fabbri C et al. | β | 2014 | β |
| Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course? | Wilson S et al. | β | 2014 | β |
| The gender-specific association of EHD3 polymorphisms with major depressive disorder. | Wang L et al. | β | 2014 | β |
| The genetics of major depression. | Flint J et al. | β | 2014 | β |
| The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: a diffusion tensor imaging study. | Dietsche B et al. | β | 2014 | β |
| Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity. | Albert PR et al. | β | 2014 | β |
| A genome-wide association study of depressive symptoms. | Hek K et al. | β | 2013 | β |
| A mega-analysis of genome-wide association studies for major depressive disorder. | Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium et al. | β | 2013 | β |
| Biosynthesis and function of chondroitin sulfate. | Mikami T et al. | β | 2013 | β |
| Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review. | Digangi J et al. | β | 2013 | β |
| FMR1, circadian genes and depression: suggestive associations or false discovery? | Kripke DF et al. | β | 2013 | β |
| From genotype to phenotype in human atherosclerosis--recent findings. | Holdt LM et al. | β | 2013 | β |
| Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder. | Power RA et al. | β | 2013 | β |
| Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. | Sulkava S et al. | β | 2013 | β |
| Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycans. | Mizumoto S et al. | β | 2013 | β |
| Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. | Han S et al. | β | 2013 | β |
| Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder. | Malki K et al. | β | 2013 | β |
| Mood disorders in individuals with distal 18q deletions. | Daviss WB et al. | β | 2013 | β |
| Neurogenetics of depression: a focus on reward processing and stress sensitivity. | Bogdan R et al. | β | 2013 | β |
| No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis. | Gyekis JP et al. | β | 2013 | β |
| Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression. | Stevens D et al. | β | 2013 | β |
| Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. | Ji B et al. | β | 2013 | β |
| Protein tyrosine phosphatases in health and disease. | Hendriks WJ et al. | β | 2013 | β |
| Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities. | Hendriks WJ et al. | β | 2013 | β |
| Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis. | FustΓ© M et al. | β | 2013 | β |
| Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. | Minelli A et al. | β | 2013 | β |
| The current state of play on the molecular genetics of depression. | Cohen-Woods S et al. | β | 2013 | β |
| The genetic basis of depression. | Hodgson K et al. | β | 2013 | β |
| The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. | Samaan Z et al. | β | 2013 | β |
| Toward an integration of cognitive and genetic models of risk for depression. | Gibb BE et al. | β | 2013 | β |
| Using the high-risk family design to identify biomarkers for major depression. | Talati A et al. | β | 2013 | β |
| A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. | Verbeek EC et al. | β | 2012 | β |
| Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. | Chen P et al. | β | 2012 | β |
| Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. | Degenhardt F et al. | β | 2012 | β |
| A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder. | Shi C et al. | β | 2012 | β |
| Basing psychiatric classification on scientific foundation: problems and prospects. | Uher R et al. | β | 2012 | β |
| Behavioral genetics of affective and anxiety disorders. | Domschke K et al. | β | 2012 | β |
| CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. | Bhat S et al. | β | 2012 | β |
| Copy number variation in subjects with major depressive disorder who attempted suicide. | Perlis RH et al. | β | 2012 | β |
| Depression in adolescence. | Thapar A et al. | β | 2012 | β |
| Different gene sets contribute to different symptom dimensions of depression and anxiety. | van Veen T et al. | β | 2012 | β |
| Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression. | Pajer K et al. | β | 2012 | β |
| Dissecting the genetic heterogeneity of depression through age at onset. | Power RA et al. | β | 2012 | β |
| Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals. | Hori H et al. | β | 2012 | β |
| Enriched pathways for major depressive disorder identified from a genome-wide association study. | Kao CF et al. | β | 2012 | β |
| Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. | Visscher PM et al. | β | 2012 | β |
| Gene-environment interaction in major depression and antidepressant treatment response. | Keers R et al. | β | 2012 | β |
| Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. | Wray NR et al. | β | 2012 | β |
| Genome-wide association uncovers shared genetic effects among personality traits and mood states. | Luciano M et al. | β | 2012 | β |
| Genomic structural variation in psychiatric disorders. | Rucker JJ et al. | β | 2012 | β |
| High dimensional endophenotype ranking in the search for major depression risk genes. | Glahn DC et al. | β | 2012 | β |
| Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants. | Lewis G et al. | β | 2012 | β |
| MK4MDD: a multi-level knowledge base and analysis platform for major depressive disorder. | Guo L et al. | β | 2012 | β |
| Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. | Lee PH et al. | β | 2012 | β |
| PCLO gene: its role in vulnerability to major depressive disorder. | Minelli A et al. | β | 2012 | β |
| The role of phenotype in gene discovery in the whole genome sequencing era. | Almasy L | β | 2012 | β |
| A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. | Pergadia ML et al. | β | 2011 | β |
| [A critical appraisal of genome-wide association studies of psychiatric disorders: unmet expectations]. | Hebebrand J | β | 2011 | β |
| A new, blue gene highlights glutamate and hippocampus in depression. | Tost H et al. | β | 2011 | β |
| A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3. | Hamilton SP | β | 2011 | β |
| Genes, environment, and individual differences in responding to treatment for depression. | Uher R | β | 2011 | β |
| Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. | Aragam N et al. | β | 2011 | β |
| Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. | Shyn SI et al. | β | 2011 | β |
| Polymorphisms in melatonin synthesis pathways: possible influences on depression. | Kripke DF et al. | β | 2011 | β |
| Prioritization and evaluation of depression candidate genes by combining multidimensional data resources. | Kao CF et al. | β | 2011 | β |
| Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. | Uher R et al. | β | 2011 | β |
| The genetic blueprint of major depressive disorder: contributions of imaging genetics studies. | Scharinger C et al. | β | 2011 | β |
| The neuronal transporter gene SLC6A15 confers risk to major depression. | Kohli MA et al. | β | 2011 | β |
| The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects: control by depolarization and lithium. | Pinacho R et al. | β | 2011 | β |
| Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. | Shen X et al. | β | 2011 | β |
| Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. | Dao DT et al. | β | 2010 | β |
| Overview of the genetics of major depressive disorder. | Lohoff FW | β | 2010 | β |
| Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. | Zhou X et al. | β | 2010 | β |
| The genetics of major depression: moving beyond the monoamine hypothesis. | Shyn SI et al. | β | 2010 | β |
| Genome-wide linkage and follow-up association study of postpartum mood symptoms. | Mahon PB et al. | β | 2009 | β |