Genetics of psychiatric disorders methods: molecular approaches.

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Authors: Avramopoulos, Dimitrios
Year: 2010
Journal: The Psychiatric clinics of North America
PMID: 20159337
DOI: 10.1016/j.psc.2009.12.006
PMCID: PMC2843402

#	Section	Preview
0	The genome and genetic variation	The human genome project was launched by the National Institutes of Health, the Department of Energy…
1	The genome and genetic variation	One of the first things that became apparent in the study of complex disorders was that the practice…
2	The genome and genetic variation	Fortunately, the first studies that performed high throughput genotyping showed that determining the…
3	The genome and genetic variation	increasing distance and with increasing phylogenetic age of the variant. Further, due to the…
4	The genome and genetic variation	Analysis of LD in the genome has made it clear that the correlations of genotypes are often so…
5	The genome and genetic variation	The sequencing of the human genome and the high throughput technologies that emerged in part as a…
6	The genome and genetic variation	In 2003 the ENCODE project was launched (http://www.genome.gov/10005107) with the ambitious goal to…
7	The genome and genetic variation	Today, less than 10 years after from the completion of the Human Genome Project, technological…
8	Linkage analyses	We mentioned above that linkage analysis led to the identification of most genes causing Mendelian…
9	Linkage analyses	When linkage was first applied to complex disorders it was performed using the established methods…
10	Linkage analyses	in each genomic location between affected relatives compared to the expected allele sharing for each…
11	Linkage analyses	Just one year later, in a paper that had a very strong influence in the field of complex disease…
12	Linkage analyses	in the exploration of complex disorders. The few linkage studies that are now performed use SNP…
13	Genome-Wide Association Studies	The concept of GWAS was formed in the 1990’s and supported by theoretical work such as that of…
14	Genome-Wide Association Studies	have led to hundreds of associations of common DNA variants with over 80 diseases and traits (17)…
15	Genome-Wide Association Studies	Despite the tremendous success of GWAS in the last few years there remain skeptics of the value of…
16	Genome-Wide Association Studies	a phenomenon that has triggered much discussion about the underlying reasons, which might include a…
17	Genome-Wide Association Studies	mellitus are relatively weak, with odds ratios below 1.2 (23), PPAR gamma is the target of…
18	Genome-Wide Association Studies	The insights from GWAS specific to psychiatric disorders are similar, but they include some…
19	Genome wide gene expression (GWGE) studies	Microarray technologies provided a strong push forward for high-throughput genotyping, however they…

Name	Type
1000 Genomes Project	cohort
5 kb gene promoter regions local	variant
alcohol	phenotype
alcohol dependence	phenotype
attention deficit hyperactivity disorder	phenotype
autism	phenotype
bipolar disorder	phenotype
brain	anatomy
cancer	phenotype
cases	cohort
common DNA variant local	variant
common variants	cohort
complex diseases	phenotype
COMPLEX_DISORDER local	phenotype
complex disorders	phenotype
controls	cohort
copy number variation	variant
copy number variations	variant
diabetes	phenotype
diet	drug
disease	phenotype
disease locus local	gene
DNA	drug
DNA variants	cohort
drugs	drug
dyslipidemia	phenotype
ENCODE project	cohort
Epigenetic modifications	phenotype
epigenetic variation local	drug
eQTLGen Consortium	cohort
gene	gene
genes with very small effects local	gene
GTEx project	cohort
HapMap	cohort
histone	drug
Human Genome Project	cohort
interferon	drug
International schizophrenia Consortium	cohort
LDLR	gene
major depressive disorder	phenotype
medication	drug
Mendelian genetic disorders local	phenotype
mutations	variant
neurodegenerative disorders	phenotype
neuroticism	phenotype
non-synonymous coding variants local	variant
nucleosome	drug
Oral antidiabetic agents local	drug
PPARG	gene
protein	drug
psychiatric disorders	phenotype
rare CNVs	variant
rare disease risk alleles local	variant
regulatory variant	variant
RNA	drug
RNA-seq	drug
SAGE	cohort
schizophrenia	phenotype
small effect variants local	variant
smoking behavior	phenotype
SNP	cohort
statins	drug
thiazolidinediones	drug
transcription factor	drug

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Genetics of psychiatric disorders methods: molecular approaches.

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