Relationships between impulsivity and subjective response in an IV ethanol paradigm.
- Authors
- Leeman, Robert F; Ralevski, Elizabeth; Limoncelli, Diana; Pittman, Brian; O'Malley, Stephanie S; Petrakis, Ismene L
- Year
- 2014
- Journal
- Psychopharmacology
- PMID
- 24553574
- DOI
- 10.1007/s00213-014-3458-9
- PMCID
- PMC4101083
RATIONALE: Impulsivity and individual differences in subjective response to alcohol are risk factors for alcohol problems and possibly endophenotypes for alcohol dependence. Few prior studies have addressed relationships between the two constructs. OBJECTIVES: To predict subjective responses to ethanol, we tested self-reported impulsiveness, ethanol dose condition (high dose, low dose, or placebo), and time (seven time points) along with interactions among these variables. METHODS: The present study is a secondary analysis of data from a within-subject, placebo-controlled, dose-ranging ethanol administration study using IV infusion with a clamping technique to maintain steady-state breath alcohol concentration. The sample consisted of healthy, non-alcohol dependent social alcohol drinkers between the ages of 21 and 30 (N=105). Participants at varying levels of impulsivity were compared with regard to stimulant and subjective responses to three ethanol dose conditions over time. RESULTS: Individuals with higher impulsivity reported elavated stimulant and dampened sedative response to alcohol, particularly at the higher dose. Higher impulsivity was associated with a steeper increase in stimulant effects during the first half of clamped ethanol infusion with the higher dose. CONCLUSIONS: These results suggest that impulsive individuals may experience enhanced reinforcing, stimulant effects, and relatively muted aversive sedative effects from alcohol. These subjective responses may relate to enhanced risk of alcohol problems among more impulsive individuals.
Stimulant subjective response to IV ethanol by dose condition over time among participants at the lowest (1a) and highest (1b) quartile for self-reported impulsivity. Timepoints are with respect to the time at which steady state BrAC was first reached using a clamping procedure, which required approximately 20 minutes. Ethanol infusion occurred during the +10, +30 timepoints and +60 timepoints and ended after the +60 timepoint, which is indicated with a vertical line after the +60 timepoint. Equal spacing of timepoints was for parsimony and thus is not to scale.
Sedative subjective response to IV ethanol by dose condition over time among participants at the lowest (2a) and highest (2b) quartile for self-reported impulsivity. Timepoints are with respect to the time at which steady state BrAC was first reached using a clamping procedure, which required approximately 20 minutes. Ethanol infusion occurred during the +10 and +30 timepoints and +60 timepoints and ended after the +60 timepoint, which is indicated with a vertical line after the +60 timepoint. Equal spacing of timepoints was for parsimony and thus is not to scale.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A pilot study of impulsivity and subjective alcohol response in the lab and moment. | Stamates AL et al. | — | 2025 | → |
| Interplay of cultural beliefs, psychological disposition, and social milieu during childhood on development of substance use disorder by early adulthood. | Kirisci L et al. | — | 2025 | → |
| Nucleus accumbens functional connectivity changes underlying alcohol expectancies in bipolar disorder and prospective alcohol outcomes: a within-subject randomized placebo-controlled alcohol administration fMRI study. | Lippard ETC et al. | — | 2025 | → |
| A randomized trial of the effects of COMT inhibition on subjective response to alcohol: Moderation by baseline COMT activity and mediation of alcohol self-administration. | Schacht JP et al. | — | 2024 | → |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | — | 2024 | → |
| The Relationship Between Men's Sociosexuality, Drinking Intake, and Blackouts. | Moran JB et al. | — | 2024 | → |
| Differential effects of UPPS-P impulsivity on subjective alcohol response and craving: An experimental test of acquired preparedness. | Waddell JT et al. | — | 2023 | → |
| Planned versus unplanned drinking and cannabis use: Do facets of trait impulsivity influence daily risk? | Waddell JT et al. | — | 2023 | → |
| Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study. | Lippard ETC et al. | — | 2023 | → |
| Moderators of subjective response to alcohol in the human laboratory. | Nieto SJ et al. | — | 2022 | → |
| Impulsivity and the effects of alcohol in women with a history of childhood sexual abuse: A pilot study. | Evans SM et al. | — | 2021 | → |
| Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol. | Weafer J et al. | — | 2021 | → |
| Rewarding Subjective Effects of the NMDAR Antagonist Nitrous Oxide (Laughing Gas) Are Moderated by Impulsivity and Depressive Symptoms in Healthy Volunteers. | Kamboj SK et al. | — | 2021 | → |
| Subjective response to alcohol: Associated alcohol use and orbitofrontal gray matter volume in bipolar disorder. | Tretyak V et al. | — | 2021 | → |
| An Evaluation of Alcohol Sensitivity in the Context of the Acquired Preparedness Model. | Heath LM et al. | — | 2020 | → |
| Intoxicated aggression: Do alcohol and stimulants cause dose-related aggression? A review. | Kuypers K et al. | — | 2020 | → |
| Poor inhibitory control is associated with greater stimulation and less sedation following alcohol. | Weafer J et al. | — | 2020 | → |
| To Infuse or Ingest in Human Laboratory Alcohol Research. | Cyders MA et al. | — | 2020 | → |
| Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? | Berey BL et al. | — | 2019 | → |
| Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration. | Berey BL et al. | — | 2019 | → |
| The relationship between impaired control, impulsivity, and alcohol self-administration in nondependent drinkers. | Vaughan CL et al. | — | 2019 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity. | Weafer J et al. | — | 2017 | → |
| Exposure-Response Relationships during Free-Access Intravenous Alcohol Self-Administration in Nondependent Drinkers: Influence of Alcohol Expectancies and Impulsivity. | Stangl BL et al. | — | 2017 | → |
| Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals. | Westman JG et al. | — | 2017 | → |
| Relationships of Impulsivity and Subjective Response to Alcohol Use and Related Problems. | Berey BL et al. | — | 2017 | → |
| Acute subjective response to alcohol as a function of reward and punishment sensitivity. | Morris DH et al. | — | 2016 | → |
| Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study. | Khemiri L et al. | — | 2016 | → |
| Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats. | King CP et al. | — | 2016 | → |
| Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence. | Hendershot CS et al. | — | 2015 | → |
| A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial. | Wardle MC et al. | — | 2015 | → |
| The effects of the monoamine stabilizer (-)-OSU6162 on craving in alcohol dependent individuals: A human laboratory study. | Khemiri L et al. | — | 2015 | → |