Fetal Alcohol Spectrum Disorders: Recent Neuroimaging Findings.
paper
Cited
Public
- Authors
- Moore, Eileen M; Migliorini, Robyn; Infante, M Alejandra; Riley, Edward P
- Year
- 2014
- Journal
- Current developmental disorders reports
- PMID
- 25346882
- DOI
- 10.1007/s40474-014-0020-8
- PMCID
- PMC4207054
Since the identification of Fetal Alcohol Syndrome over 40 years ago, much has been learned about the detrimental effects of prenatal alcohol exposure on the developing brain. This review highlights recent neuroimaging studies, within the context of previous work. Structural magnetic resonance imaging has described morphological differences in the brain and their relationships to cognitive deficits and measures of facial dysmorphology. Diffusion tensor imaging has elaborated on the relationship between white matter microstructure and behavior. Atypical neuromaturation across childhood and adolescence has been observed in longitudinal neuroimaging studies. Functional imaging has revealed differences in neural activation patterns underlying sensory processing, cognition and behavioral deficits. A recent functional connectivity analysis demonstrates reductions in global network efficiency. Despite this progress much remains unknown about the impact of prenatal alcohol exposure on the brain, and continued research efforts are essential.
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| Name | Type |
|---|---|
| ADHD | phenotype |
| ADHD children local | cohort |
| adolescents | cohort |
| adolescents with FASD local | cohort |
| Adverse life outcomes local | phenotype |
| alcohol | phenotype |
| alcohol dosage local | drug |
| Alcohol-exposed children local | cohort |
| alcohol-exposed children not meeting FAS criteria local | cohort |
| Alcohol-exposed individuals local | cohort |
| alcohol-exposed subjects with facial dysmorphism local | cohort |
| alcohol-exposed youth local | cohort |
| Alcohol-exposed youth local | cohort |
| Alcohol Exposure | phenotype |
| Alcohol Related Neurodevelopmental Disorder | phenotype |
| Alcohol Usage local | phenotype |
| ARND | phenotype |
| ARND cohort (children and adolescents) local | cohort |
| attention deficit hyperactivity disorder | phenotype |
| auditory cortex | anatomy |
| Auditory processing | anatomy |
| Autopsy studies local | cohort |
| Banks of the superior temporal local | anatomy |
| behavioral deficits | phenotype |
| behavioral disruption | phenotype |
| bilateral caudate local | anatomy |
| bilateral inferior parietal/perisylvian areas local | anatomy |
| Bilateral postcentral region local | anatomy |
| Bilateral precentral region local | anatomy |
| Bilateral Thalami local | anatomy |
| binge drinking | phenotype |
| Blunted Cortical Volume Change Over Time local | phenotype |
| Blunted grey matter volume change local | phenotype |
| brain | anatomy |
| Brain activation local | anatomy |
| Brain chemistry local | phenotype |
| brain development | phenotype |
| brain morphology | anatomy |
| Brain physiology local | phenotype |
| brain structure | anatomy |
| Broca's area | anatomy |
| caudate nuclei local | anatomy |
| Caudate nuclei local | anatomy |
| caudate nucleus | anatomy |
| caudate volume local | phenotype |
| Central nervous system anomalies local | phenotype |
| cerebellum | anatomy |
| Cerebral folding local | phenotype |
| children | cohort |
| children and adolescents with FASD local | cohort |
| children with FASD | cohort |
| children with heavy prenatal alcohol exposure local | cohort |
| Children with heavy prenatal alcohol exposure local | cohort |
| children with prenatal alcohol exposure local | cohort |
| Children with prenatal alcohol exposure local | cohort |
| cognition | phenotype |
| cognitive disruption local | phenotype |
| Control-like facial features local | phenotype |
| controls | cohort |
| corpus callosum | anatomy |
| Corpus Callosum (Anterior Third) local | anatomy |
| cortex | anatomy |
| cortical folding local | phenotype |
| cortical grey matter local | anatomy |
| Cortical grey matter volume local | phenotype |
| cortical thickness | phenotype |
| Cortical volume loss local | phenotype |
| default mode network | anatomy |
| Delayed myelination local | phenotype |
| Developing embryo local | phenotype |
| diagnostic severity local | phenotype |
| Diffusion abnormalities local | phenotype |
| Distinct facial characteristics local | phenotype |
| dorsolateral prefrontal cortex | anatomy |
| Environmental experience local | phenotype |
| executive functioning | phenotype |
| FA | phenotype |
| facial dysmorphology | phenotype |
| FA in cerebellum local | phenotype |
| FA in genu of corpus callosum local | phenotype |
| FA in inferior longitudinal fasciculus local | phenotype |
| FA in right corpus callosum local | phenotype |
| Family History Positive for Alcoholism local | phenotype |
| FAS | phenotype |
| FASD phenotype local | phenotype |
| FAS-like facial features local | phenotype |
| FAS/partial-FAS local | phenotype |
| Fetal Alcohol Spectrum Disorder | phenotype |
| Fetal alcohol spectrum disorders | phenotype |
| fetal alcohol syndrome | phenotype |
| Fetus local | phenotype |
| Fold opening distance local | phenotype |
| fractional anisotropy | phenotype |
| frontal cortex | anatomy |
| fronto-striatal network | anatomy |
| Full-Scale IQ Score local | phenotype |
| Functional Brain Changes local | phenotype |
| functional connectivity | phenotype |
| Functional plasticity local | phenotype |
| gamma oscillations | phenotype |
| Greater change in white matter integrity local | phenotype |
| Greater Dysmorphism of Facial Features local | phenotype |
| Greater neural activation during response inhibition local | phenotype |
| groups diagnosed with FAS local | cohort |
| growth retardation | phenotype |
| healthy controls | cohort |
| heavily exposed nonsyndromal children local | cohort |
| heavy drinking | phenotype |
| Heavy Prenatal Alcohol Exposure local | cohort |
| Higher Philtrum Lipometer Score local | phenotype |
| Hippocampal volume | anatomy |
| hippocampus | anatomy |
| Immediate memory capacity local | phenotype |
| Increased MD local | phenotype |
| Inferior-fronto-occipital local | anatomy |
| inferior longitudinal fasciculus | anatomy |
| inferior parietal lobe | anatomy |
| inferior parietal lobules local | anatomy |
| inhibitory control | phenotype |
| insula | anatomy |
| language ability | phenotype |
| left hemisphere orbitofrontal cortex local | anatomy |
| left inferior frontal gyrus | anatomy |
| Left lateral occipital local | anatomy |
| left middle cerebellar peduncle local | anatomy |
| Left postcentral gyrus local | anatomy |
| left precentral gyrus | anatomy |
| Left temporal/occipital clusters local | anatomy |
| left temporal/occipital cortex local | anatomy |
| lentiform nucleus | anatomy |
| Limited enrichment local | phenotype |
| lingual gyri local | anatomy |
| lissencephaly local | phenotype |
| M100 peak latency local | phenotype |
| malnutrition | phenotype |
| Maternal Proclivity towards Alcohol Consumption local | phenotype |
| MD | phenotype |
| mean diffusivity | phenotype |
| Medial frontal eye field region local | anatomy |
| medial prefrontal cortex | anatomy |
| medial temporal regions | anatomy |
| microcephaly | phenotype |
| More conservative response bias local | phenotype |
| Motor control | phenotype |
| Neurobehavioral assessment performance local | phenotype |
| Neurobehavioral disruption local | phenotype |
| Neuroimaging studies local | cohort |
| neuronal activity | phenotype |
| neuronal migration disorders local | phenotype |
| non-dysmorphic alcohol-exposed subjects local | cohort |
| Non-exposed children with ADHD local | cohort |
| non-exposed controls local | cohort |
| Nonsyndromal heavily exposed children local | cohort |
| occipital cortex | anatomy |
| Oculomotor control local | phenotype |
| PAE cohort local | cohort |
| pallidum | anatomy |
| parietal cortex | anatomy |
| pars opercularis local | anatomy |
| polymicrogyria local | phenotype |
| Poorer go response accuracy local | phenotype |
| Poorer microstructural integrity local | phenotype |
| postcentral region local | anatomy |
| posterior cingulate cortex | anatomy |
| posterior region | anatomy |
| Postnatal stages local | phenotype |
| precentral region local | anatomy |
| precuneus | anatomy |
| pregnancy | phenotype |
| pregnant women | cohort |
| Prenatal alcohol exposed youths local | cohort |
| prenatal alcohol exposure | phenotype |
| Prenatal alcohol exposure local | cohort |
| primary visual cortex | anatomy |
| reaction time during antisaccades local | phenotype |
| reaction time during prosaccades local | phenotype |
| Reduced activation in left postcentral gyrus local | phenotype |
| Reduced activation in left precentral gyrus local | phenotype |
| reduced FA | phenotype |
| right caudate tail local | anatomy |
| right corpus callosum local | anatomy |
| Right frontal clusters local | anatomy |
| right frontal cortex | anatomy |
| right hippocampus head local | anatomy |
| Right Inferior Frontal Cortex local | anatomy |
| right middle frontal gyrus | anatomy |
| Right parietal clusters local | anatomy |
| right parietal cortex | anatomy |
| Right postcentral local | anatomy |
| shape variation local | phenotype |
| Small palpebral fissures | phenotype |
| smooth philtrum | phenotype |
| spatial recall local | phenotype |
| Specific brain structures local | anatomy |
| splenium | anatomy |
| Steeper reduction in MD local | phenotype |
| stressors | phenotype |
| Structural plasticity local | phenotype |
| Superior fronto-occipital local | anatomy |
| Superior longitudinal fasciculi local | anatomy |
| superior parietal cortex | anatomy |
| surface area | phenotype |
| temporal cortex | anatomy |
| Thin Vermillion local | phenotype |
| total brain volume | anatomy |
| typically developing controls local | cohort |
| Typically developing controls local | cohort |
| United States | cohort |
| Ventral Diencephalon local | anatomy |
| verbal learning and recall deficits local | phenotype |
| visual processing | phenotype |
| Visual stimulus processing local | phenotype |
| volumetric reductions local | phenotype |
| white matter | anatomy |
| whole brain | anatomy |
| women with high alcohol consumption local | cohort |
| Young adults prenatally exposed to alcohol local | cohort |
| young adults with FASD local | cohort |
| young children with FASD local | cohort |
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure. | Long X et al. | — | 2026 | → |
| Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model. | Dominguez ZM et al. | — | 2025 | → |
| Neural activity is altered by childhood trauma exposure and varied by sex in typically developing youths during sustained attention-to-response tasks (SART). | Pervin Z et al. | — | 2025 | → |
| Normative modeling of brain MRI data identifies small subcortical volumes and associations with cognitive function in youth with fetal alcohol spectrum disorder (FASD). | Gimbel BA et al. | — | 2025 | → |
| Properties of the prefrontal tracts and cingulum bundle in children with prenatal alcohol exposure. | Aghamohammadi-Sereshki A et al. | — | 2025 | → |
| The impact of prenatal alcohol and tobacco exposure on white matter integrity in 8-12-year-old children. | Roos A et al. | — | 2025 | → |
| Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration. | Amin S et al. | — | 2025 | → |
| Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders-A Life-Course Examination. | Yasoda-Mohan A et al. | — | 2024 | → |
| Subcortical volume in middle-aged adults with fetal alcohol spectrum disorders. | Bischoff-Grethe A et al. | — | 2024 | → |
| Delayed cortical thinning in children and adolescents with prenatal alcohol exposure. | Gimbel BA et al. | — | 2023 | → |
| Distinctive neural correlates of phonological and reading impairment in fetal alcohol-exposed adolescents with and without facial dysmorphology. | Yu X et al. | — | 2022 | → |
| Effects of prenatal alcohol exposure on neurobehavioural development and volume of rostral cingulate cortex subregions. | Aghamohammadi-Sereshki A et al. | — | 2022 | → |
| Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure. | Long X et al. | — | 2022 | → |
| Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes. | Gimbel BA et al. | — | 2022 | → |
| Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses. | Marguet F et al. | — | 2022 | → |
| Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder. | Ernst AM et al. | — | 2022 | → |
| School-aged children diagnosed with an FASD exhibit visuo-cortical network disturbance: A magnetoencephalography (MEG) study. | Pervin Z et al. | — | 2022 | → |
| The impact of prenatal alcohol and/or tobacco exposure on brain structure in a large sample of children from a South African birth cohort. | Marshall AT et al. | — | 2022 | → |
| An fMRI investigation of neural activation predicting memory formation in children with fetal alcohol spectrum disorders. | Lewis CE et al. | — | 2021 | → |
| Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. | Chivero ET et al. | — | 2021 | → |
| Cross-Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure. | Moore EM et al. | — | 2021 | → |
| Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period. | Kable JA et al. | — | 2021 | → |
| Mechanisms of context conditioning in the developing rat. | Stanton ME et al. | — | 2021 | → |
| Neurodevelopmental Trajectories Following Prenatal Alcohol Exposure. | Moore EM et al. | — | 2021 | → |
| Prenatal Exposure to Tobacco and Alcohol Alters Development of the Neonatal Auditory System. | Sininger YS et al. | — | 2021 | → |
| Alcohol use in pregnancy and its impact on the mother and child. | Oei JL | — | 2020 | → |
| Altered brain white matter connectome in children and adolescents with prenatal alcohol exposure. | Long X et al. | — | 2020 | → |
| Extracellular Vesicles in CNS Developmental Disorders. | Gomes AR et al. | — | 2020 | → |
| [Fetal alcohol spectrum disorders in adults]. | Wagner JC et al. | — | 2020 | → |
| Incontinence in persons with fetal alcohol spectrum disorders: a polish cohort. | Roozen S et al. | — | 2020 | → |
| Increased Notching of the Corpus Callosum in Fetal Alcohol Spectrum Disorder: A Callosal Misunderstanding? | Schneble E et al. | — | 2020 | → |
| Radiological Findings on Structural Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorders and Healthy Controls. | Treit S et al. | — | 2020 | → |
| Alcohol Modulates the Biogenesis and Composition of Microglia-Derived Exosomes. | Crenshaw BJ et al. | — | 2019 | → |
| Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats. | Heroux NA et al. | — | 2019 | → |
| Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. | Buckley DM et al. | — | 2019 | → |
| Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure. | Mattson SN et al. | — | 2019 | → |
| Global DNA Methylation and Histone Posttranslational Modifications in Human and Nonhuman Primate Brain in Association with Prenatal Alcohol Exposure. | Jarmasz JS et al. | — | 2019 | → |
| Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats. | Heroux NA et al. | — | 2019 | → |
| The brain's functional connectome in young children with prenatal alcohol exposure. | Long X et al. | — | 2019 | → |
| The effects of alcohol and cannabinoid exposure during the brain growth spurt on behavioral development in rats. | Breit KR et al. | — | 2019 | → |
| The Effects of Alcohol and Cannabinoid Exposure during the Brain Growth Spurt on Behavioral Development in Rats | Breit KR et al. | — | 2019 | — |
| Altered brain functional connectivity and behaviour in a mouse model of maternal alcohol binge-drinking. | Cantacorps L et al. | — | 2018 | → |
| An investigation of intra-individual variability in children with fetal alcohol spectrum disorder (FASD). | Ali S et al. | — | 2018 | → |
| Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data. | Uban KA et al. | — | 2018 | → |
| Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children. | Bakhireva LN et al. | — | 2018 | → |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | — | 2018 | → |
| Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. | Gross LA et al. | — | 2018 | → |
| Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure. | Comasco E et al. | — | 2018 | → |
| Sex-specific deficits in biochemical but not behavioral responses to delay fear conditioning in prenatal alcohol exposure mice. | Caldwell KK et al. | — | 2018 | → |
| Speech Impairment in Boys With Fetal Alcohol Spectrum Disorders. | Terband H et al. | — | 2018 | → |
| Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure. | Hendrickson TJ et al. | — | 2018 | → |
| Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates. | Glass L et al. | — | 2017 | → |
| Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder. | Newville J et al. | — | 2017 | → |
| Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure. | Infante MA et al. | — | 2017 | → |
| Correlation between morphological MRI findings and specific diagnostic categories in fetal alcohol spectrum disorders. | Boronat S et al. | — | 2017 | → |
| Cortical gyrification is abnormal in children with prenatal alcohol exposure. | Hendrickson TJ et al. | — | 2017 | → |
| Deficits in spatial learning and memory in adult mice following acute, low or moderate levels of prenatal ethanol exposure during gastrulation or neurulation. | Schambra UB et al. | — | 2017 | → |
| Dietary choline levels modify the effects of prenatal alcohol exposure in rats. | Idrus NM et al. | — | 2017 | → |
| Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology. | Sharma VK et al. | — | 2017 | → |
| Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder. | Jarmasz JS et al. | — | 2017 | → |
| Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study. | Kable JA et al. | — | 2017 | → |
| TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders. | Pascual M et al. | — | 2017 | → |
| Alcohol exposure in utero is associated with decreased gray matter volume in neonates. | Donald KA et al. | — | 2016 | → |
| Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs. | Birch SM et al. | — | 2016 | → |
| Neural Mechanisms and Children's Intellectual Development: Multiple Impacts of Environmental Factors. | Takeuchi H et al. | — | 2016 | → |
| Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis. | Kable JA et al. | — | 2016 | → |
| Soft neurological signs and prenatal alcohol exposure: a population-based study in remote Australia. | Lucas BR et al. | — | 2016 | → |
| Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. | Murawski NJ et al. | — | 2015 | → |
| Positive Behavioral Interventions and Family Support for Fetal Alcohol Spectrum Disorders. | Petrenko CL | — | 2015 | → |
| The neuronal nitric oxide synthase (nNOS) gene and neuroprotection against alcohol toxicity. | Karaçay B et al. | — | 2015 | → |