Fetal Alcohol Spectrum Disorders: Recent Neuroimaging Findings.
paper
Cited
Public
- Authors
- Moore, Eileen M; Migliorini, Robyn; Infante, M Alejandra; Riley, Edward P
- Year
- 2014
- Journal
- Current developmental disorders reports
- PMID
- 25346882
- DOI
- 10.1007/s40474-014-0020-8
- PMCID
- PMC4207054
Since the identification of Fetal Alcohol Syndrome over 40 years ago, much has been learned about the detrimental effects of prenatal alcohol exposure on the developing brain. This review highlights recent neuroimaging studies, within the context of previous work. Structural magnetic resonance imaging has described morphological differences in the brain and their relationships to cognitive deficits and measures of facial dysmorphology. Diffusion tensor imaging has elaborated on the relationship between white matter microstructure and behavior. Atypical neuromaturation across childhood and adolescence has been observed in longitudinal neuroimaging studies. Functional imaging has revealed differences in neural activation patterns underlying sensory processing, cognition and behavioral deficits. A recent functional connectivity analysis demonstrates reductions in global network efficiency. Despite this progress much remains unknown about the impact of prenatal alcohol exposure on the brain, and continued research efforts are essential.
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| Name | Type |
|---|---|
| ADHD | phenotype |
| ADHD children local | cohort |
| adolescents | cohort |
| adolescents with FASD local | cohort |
| Adverse life outcomes local | phenotype |
| alcohol | phenotype |
| alcohol dosage local | drug |
| Alcohol-exposed children local | cohort |
| alcohol-exposed children not meeting FAS criteria local | cohort |
| Alcohol-exposed individuals local | cohort |
| alcohol-exposed subjects with facial dysmorphism local | cohort |
| alcohol-exposed youth local | cohort |
| Alcohol-exposed youth local | cohort |
| Alcohol Exposure | phenotype |
| Alcohol Related Neurodevelopmental Disorder | phenotype |
| Alcohol Usage local | phenotype |
| ARND | phenotype |
| ARND cohort (children and adolescents) local | cohort |
| attention deficit hyperactivity disorder | phenotype |
| auditory cortex | anatomy |
| Auditory processing | anatomy |
| Autopsy studies local | cohort |
| Banks of the superior temporal local | anatomy |
| behavioral deficits | phenotype |
| behavioral disruption | phenotype |
| bilateral caudate local | anatomy |
| bilateral inferior parietal/perisylvian areas local | anatomy |
| Bilateral postcentral region local | anatomy |
| Bilateral precentral region local | anatomy |
| Bilateral Thalami local | anatomy |
| binge drinking | phenotype |
| Blunted Cortical Volume Change Over Time local | phenotype |
| Blunted grey matter volume change local | phenotype |
| brain | anatomy |
| Brain activation local | anatomy |
| Brain chemistry local | phenotype |
| brain development | phenotype |
| brain morphology | anatomy |
| Brain physiology local | phenotype |
| brain structure | anatomy |
| Broca's area | anatomy |
| caudate nuclei local | anatomy |
| Caudate nuclei local | anatomy |
| caudate nucleus | anatomy |
| caudate volume local | phenotype |
| Central nervous system anomalies local | phenotype |
| cerebellum | anatomy |
| Cerebral folding local | phenotype |
| children | cohort |
| children and adolescents with FASD local | cohort |
| children with FASD | cohort |
| children with heavy prenatal alcohol exposure local | cohort |
| Children with heavy prenatal alcohol exposure local | cohort |
| children with prenatal alcohol exposure local | cohort |
| Children with prenatal alcohol exposure local | cohort |
| cognition | phenotype |
| cognitive disruption local | phenotype |
| Control-like facial features local | phenotype |
| controls | cohort |
| corpus callosum | anatomy |
| Corpus Callosum (Anterior Third) local | anatomy |
| cortex | anatomy |
| cortical folding local | phenotype |
| cortical grey matter local | anatomy |
| Cortical grey matter volume local | phenotype |
| cortical thickness | phenotype |
| Cortical volume loss local | phenotype |
| default mode network | anatomy |
| Delayed myelination local | phenotype |
| Developing embryo local | phenotype |
| diagnostic severity local | phenotype |
| Diffusion abnormalities local | phenotype |
| Distinct facial characteristics local | phenotype |
| dorsolateral prefrontal cortex | anatomy |
| Environmental experience local | phenotype |
| executive functioning | phenotype |
| FA | phenotype |
| facial dysmorphology | phenotype |
| FA in cerebellum local | phenotype |
| FA in genu of corpus callosum local | phenotype |
| FA in inferior longitudinal fasciculus local | phenotype |
| FA in right corpus callosum local | phenotype |
| Family History Positive for Alcoholism local | phenotype |
| FAS | phenotype |
| FASD phenotype local | phenotype |
| FAS-like facial features local | phenotype |
| FAS/partial-FAS local | phenotype |
| Fetal Alcohol Spectrum Disorder | phenotype |
| Fetal alcohol spectrum disorders | phenotype |
| fetal alcohol syndrome | phenotype |
| Fetus local | phenotype |
| Fold opening distance local | phenotype |
| fractional anisotropy | phenotype |
| frontal cortex | anatomy |
| fronto-striatal network | anatomy |
| Full-Scale IQ Score local | phenotype |
| Functional Brain Changes local | phenotype |
| functional connectivity | phenotype |
| Functional plasticity local | phenotype |
| gamma oscillations | phenotype |
| Greater change in white matter integrity local | phenotype |
| Greater Dysmorphism of Facial Features local | phenotype |
| Greater neural activation during response inhibition local | phenotype |
| groups diagnosed with FAS local | cohort |
| growth retardation | phenotype |
| healthy controls | cohort |
| heavily exposed nonsyndromal children local | cohort |
| heavy drinking | phenotype |
| Heavy Prenatal Alcohol Exposure local | cohort |
| Higher Philtrum Lipometer Score local | phenotype |
| Hippocampal volume | anatomy |
| hippocampus | anatomy |
| Immediate memory capacity local | phenotype |
| Increased MD local | phenotype |
| Inferior-fronto-occipital local | anatomy |
| inferior longitudinal fasciculus | anatomy |
| inferior parietal lobe | anatomy |
| inferior parietal lobules local | anatomy |
| inhibitory control | phenotype |
| insula | anatomy |
| language ability | phenotype |
| left hemisphere orbitofrontal cortex local | anatomy |
| left inferior frontal gyrus | anatomy |
| Left lateral occipital local | anatomy |
| left middle cerebellar peduncle local | anatomy |
| Left postcentral gyrus local | anatomy |
| left precentral gyrus | anatomy |
| Left temporal/occipital clusters local | anatomy |
| left temporal/occipital cortex local | anatomy |
| lentiform nucleus | anatomy |
| Limited enrichment local | phenotype |
| lingual gyri local | anatomy |
| lissencephaly local | phenotype |
| M100 peak latency local | phenotype |
| malnutrition | phenotype |
| Maternal Proclivity towards Alcohol Consumption local | phenotype |
| MD | phenotype |
| mean diffusivity | phenotype |
| Medial frontal eye field region local | anatomy |
| medial prefrontal cortex | anatomy |
| medial temporal regions | anatomy |
| microcephaly | phenotype |
| More conservative response bias local | phenotype |
| Motor control | phenotype |
| Neurobehavioral assessment performance local | phenotype |
| Neurobehavioral disruption local | phenotype |
| Neuroimaging studies local | cohort |
| neuronal activity | phenotype |
| neuronal migration disorders local | phenotype |
| non-dysmorphic alcohol-exposed subjects local | cohort |
| Non-exposed children with ADHD local | cohort |
| non-exposed controls local | cohort |
| Nonsyndromal heavily exposed children local | cohort |
| occipital cortex | anatomy |
| Oculomotor control local | phenotype |
| PAE cohort local | cohort |
| pallidum | anatomy |
| parietal cortex | anatomy |
| pars opercularis local | anatomy |
| polymicrogyria local | phenotype |
| Poorer go response accuracy local | phenotype |
| Poorer microstructural integrity local | phenotype |
| postcentral region local | anatomy |
| posterior cingulate cortex | anatomy |
| posterior region | anatomy |
| Postnatal stages local | phenotype |
| precentral region local | anatomy |
| precuneus | anatomy |
| pregnancy | phenotype |
| pregnant women | cohort |
| Prenatal alcohol exposed youths local | cohort |
| prenatal alcohol exposure | phenotype |
| Prenatal alcohol exposure local | cohort |
| primary visual cortex | anatomy |
| reaction time during antisaccades local | phenotype |
| reaction time during prosaccades local | phenotype |
| Reduced activation in left postcentral gyrus local | phenotype |
| Reduced activation in left precentral gyrus local | phenotype |
| reduced FA | phenotype |
| right caudate tail local | anatomy |
| right corpus callosum local | anatomy |
| Right frontal clusters local | anatomy |
| right frontal cortex | anatomy |
| right hippocampus head local | anatomy |
| Right Inferior Frontal Cortex local | anatomy |
| right middle frontal gyrus | anatomy |
| Right parietal clusters local | anatomy |
| right parietal cortex | anatomy |
| Right postcentral local | anatomy |
| shape variation local | phenotype |
| Small palpebral fissures | phenotype |
| smooth philtrum | phenotype |
| spatial recall local | phenotype |
| Specific brain structures local | anatomy |
| splenium | anatomy |
| Steeper reduction in MD local | phenotype |
| stressors | phenotype |
| Structural plasticity local | phenotype |
| Superior fronto-occipital local | anatomy |
| Superior longitudinal fasciculi local | anatomy |
| superior parietal cortex | anatomy |
| surface area | phenotype |
| temporal cortex | anatomy |
| Thin Vermillion local | phenotype |
| total brain volume | anatomy |
| typically developing controls local | cohort |
| Typically developing controls local | cohort |
| United States | cohort |
| Ventral Diencephalon local | anatomy |
| verbal learning and recall deficits local | phenotype |
| visual processing | phenotype |
| Visual stimulus processing local | phenotype |
| volumetric reductions local | phenotype |
| white matter | anatomy |
| whole brain | anatomy |
| women with high alcohol consumption local | cohort |
| Young adults prenatally exposed to alcohol local | cohort |
| young adults with FASD local | cohort |
| young children with FASD local | cohort |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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