Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.

paper Cited Public

Authors: Chartier, Karen G; Karriker-Jaffe, Katherine J; Cummings, Cory R; Kendler, Kenneth S
Year: 2017
Journal: The American journal on addictions
PMID: 28117924
DOI: 10.1111/ajad.12478
PMCID: PMC5695556

#	Section	Preview
0	1. Introduction	There is a recognizable shortage of genetic studies of alcohol consumption and related phenotypes in…
1	1. Introduction	We conceptualize G–E relationships from an integrated perspective, to mean that genetic and…
2	1. Introduction	The study of GxE relationships has garnered attention and excitement, but also caution and…
3	1. Introduction	This report begins with a presentation of two theoretical mechanisms for conceptualizing…
4	2. Theoretical mechanisms	We use the term environment to broadly refer to community- or societal-level factors like per capita…
5	2. Theoretical mechanisms	GxE studies. Earlier literature (e.g. Dick & Kendler10, Shanahan & Hofer11, and Sher et al.12)…
6	2. Theoretical mechanisms — Social control	Elements of social control include both protective and risk environments that primarily operate to…
7	2. Theoretical mechanisms — Social control	birth cohorts drinking much more heavily than others14,15; however, corresponding studies in U.S.…
8	2. Theoretical mechanisms — Social trigger	By contrast, adverse environmental conditions may act as social stressors that trigger or strengthen…
9	2. Theoretical mechanisms — Social trigger	et al.20 and Sartor et al.21 reported, respectively, an enhanced association of the ADH1B risk…
10	3. Studies of joint G–E effects in U.S. ethnic minority populations	We conducted a focused survey of the peer-reviewed, published literature for measured gene and…
11	3. Studies of joint G–E effects in U.S. ethnic minority populations — Population groups, phenotypes, and genetic variants covered	There were a limited number of studies addressing this topic, but even among those identified some…
12	3. Studies of joint G–E effects in U.S. ethnic minority populations — Population groups, phenotypes, and genetic variants covered	Due to the relative paucity of research in this area, the scope of the literature review was…
13	3. Studies of joint G–E effects in U.S. ethnic minority populations — Population groups, phenotypes, and genetic variants covered	Studies of GxE relationships face a number of limitations to which the identified studies are…
14	3. Studies of joint G–E effects in U.S. ethnic minority populations — Population groups, phenotypes, and genetic variants covered	in the phenotypic measures utilized across studies, which would allow for the harmonization of…
15	3. Studies of joint G–E effects in U.S. ethnic minority populations — Population groups, phenotypes, and genetic variants covered	Additionally, these studies relied almost exclusively on a candidate gene approach. Examples of the…
16	3. Studies of joint G–E effects in U.S. ethnic minority populations — Environmental influences	The environmental influences examined across these studies were considered, based on our…
17	3. Studies of joint G–E effects in U.S. ethnic minority populations — Environmental influences — Social networks	There was considerable attention given to the most proximate social network influences, as both…
18	3. Studies of joint G–E effects in U.S. ethnic minority populations — Environmental influences — Social networks	Social-network level variables also focused on other family relationships35,36,39,46, including…
19	3. Studies of joint G–E effects in U.S. ethnic minority populations — Environmental influences — Social networks	Adverse life events were a prominent environmental (triggering) variable across many of the…

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In this knowledge base

Title	Year	PMID
Intersection of familial risk and environmental social control on high-risk drinking and alcohol dependence in a US national sample of adults.	2021	33045642
Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps.	2017	28745446
Introduction: Special issue on genetic research of alcohol use disorder in diverse racial/ethnic populations.	2017	28672076

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Effects of Polygenic Risk and Perceived Friends' Drinking and Disruptive Behavior on Development of Alcohol Use Across Adolescence.	Zaso MJ et al.	—	2020	→
Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.	Bares CB et al.	—	2020	→
Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.	Williams PT	—	2020	→
Recent advances in genetic studies of alcohol use disorders.	Gupta I et al.	—	2020	→
Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents.	Compton KS et al.	—	2019	→
Linking Delay Discounting and Substance Use Disorders: Genotypes and Phenotypes.	Mitchell SH	—	2019	→
Neighborhood alcohol outlet density and genetic influences on alcohol use: evidence for gene-environment interaction.	Slutske WS et al.	—	2019	→
Neighborhood density of alcohol outlets moderates genetic and environmental influences on alcohol problems.	Slutske WS et al.	—	2019	→
The paucity of genetic studies of alcohol phenotypes in diverse populations: what are the consequences and opportunities?	Chartier KG	—	2019	→
A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.	Kim J et al.	—	2018	→
Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students.	Su J et al.	—	2018	→
The Future of Research on Alcohol-Related Disparities Across U.S. Racial/Ethnic Groups: A Plan of Attack.	Zemore SE et al.	—	2018	→
Commentary: Perspectives on alcohol-related gene and environment interplay in diverse populations.	Scott MS	—	2017	→
Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps.	Chartier KG et al.	—	2017	→
Introduction: Special issue on genetic research of alcohol use disorder in diverse racial/ethnic populations.	Chartier KG et al.	—	2017	→