Association of variants in MANEA with cocaine-related behaviors.

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Authors: Farrer, Lindsay A; Kranzler, Henry R; Yu, Yi; Weiss, Roger D; Brady, Kathleen T; Anton, Raymond; Cubells, Joseph F; Gelernter, Joel
Year: 2009
Journal: Archives of general psychiatry
PMID: 19255376
DOI: 10.1001/archgenpsychiatry.2008.538
PMCID: PMC2758158

#	Section	Preview
0	METHODS — SUBJECTS	Subjects were recruited from Yale University School of Medicine (APT Foundation, New Haven,…
1	METHODS — SUBJECTS	All subjects were interviewed using the Semi-Structured Assessment for Drug Dependence and…
2	METHODS — SUBJECTS	Subjects gave informed consent as approved by the institutional review board at each clinical site.…
3	METHODS — SNP SELECTION AND GENOTYPING	Eleven SNPs spanning 83 kilobases (kb) upstream of the MANEA promoter to downstream of the MANEA…
4	METHODS — POPULATION CLASSIFICATION	Subjects in the family-based sample were classified as AA or EA based on a Bayesian model-based…
5	METHODS — STATISTICAL ANALYSIS	Consistency with Hardy-Weinberg equilibrium expectations for each SNP was examined with the χ2 test…
6	METHODS — STATISTICAL ANALYSIS	FBAT using the expectation-maximum algorithm. In the case-control samples, a χ2 test was used to…
7	RESULTS — FAMILY-BASED ANALYSES	In the EA family sample, 6 of the 11 markers, including rs1133503 from the genome scan,24 showed at…
8	RESULTS — FAMILY-BASED ANALYSES	Haplotype analysis was conducted in the family samples to help narrow the location of a CIP…
9	RESULTS — FAMILY-BASED ANALYSES	the potentially uniquely important information from each linkage distribution block spanning the…
10	RESULTS — CASE-CONTROL ANALYSIS	We evaluated the panel of MANEA SNPs in the EA and AA case-control samples in an attempt to…
11	RESULTS — CASE-CONTROL ANALYSIS	with CD compared with controls in the AA replication sample. Although the results of analyses of…
12	COMMENT	We observed that several polymorphic markers in the MANEA gene region are associated with…
13	COMMENT	The results for association of MANEA with CD were substantially weaker in the discovery…
14	COMMENT	associated with both CD and paranoia. It is also possible that MANEA is more strongly associated…
15	COMMENT	α-Endomannosidase (MANEA), encoded by the MANEA gene on chromosome 6q16.1, is an enzyme that…
16	COMMENT	Given MANEA's role in carbohydrate metabolism and its relatively minor expression in brain,…
17	COMMENT	There are 44 markers in MANEA with appreciable frequency in 1 or more populations…
18	COMMENT	We acknowledge several limitations to our study. First, our discovery sample, which was ascertained…
19	COMMENT	in the discovery phase and the assignment of nearly all subjects to genetically matched groups based…

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Association of variants in MANEA with cocaine-related behaviors.

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