Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.

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Authors: Ashenhurst, James R; Harden, K Paige; Corbin, William R; Fromme, Kim
Year: 2016
Journal: Journal of abnormal psychology
PMID: 27505405
DOI: 10.1037/abn0000194
PMCID: PMC5061610

#	Section	Preview
40	Results — Enrichment Analyses	Finally, we sought to determine the proportion of variance (R2) in persistent externalizing…
41	Results — Enrichment Analyses	We used the PRSice package (Euesden, Lewis, & O’Reilly, 2015) in order to determine the p-value…
42	Discussion	This study tested for an enrichment of associations between SNPs in an independently assembled set…
43	Discussion — A Common Factor Model of Externalizing Behavior and Personality	A single, higher-order factor captured persistent involvement in externalizing behaviors and…
44	Discussion — A Common Factor Model of Externalizing Behavior and Personality	Including both clinically relevant behaviors in combination with disinhibited personality traits in…
45	Discussion — A Common Factor Model of Externalizing Behavior and Personality	Dick et al., 2010; Hittner & Swickert, 2006) and previous evidence from twin studies that much of…
46	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	Within a non-Hispanic White sample, this gene set (see Supplement for list of genes) showed an…
47	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	The five genes containing the strongest SNP hits of association with the Persistent Externalizing…
48	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	Furthermore, all of these genes have shown some degree of association with externalizing phenotypes…
49	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	& Schiöth, 2015), as is MARCH1 (Lee et al., 2016). Lastly, there is preliminary evidence of…
50	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	It is important to note that this is not a definitive set of genes regulating these behaviors, as…
51	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	limited to those with genetic risk for specific clinical manifestations of externalizing. Further…
52	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	The shared phenotypic variability and shared genetic etiology for externalizing behavior and traits…
53	Discussion — An Enrichment of Associations Implies Shared Genetic Etiology	involved in self-regulation, motivation, affect, and reward processing, including the prefrontal…
54	Discussion — Improving Genetic Signal Detection for Complex Traits	Researchers interested in the genetic causes and correlates of complex phenotypes like externalizing…
55	Discussion — Improving Genetic Signal Detection for Complex Traits	Our method also provides advantages for genetic discovery by leveraging the posterior-probabilities…
56	Discussion — Limitations and Conclusions	Our results must be weighed with respect to the study’s strengths and limitations. One important…
57	Discussion — Limitations and Conclusions	original set could not be included, nor could potential rare causal variants not present on the…
58	Discussion — Limitations and Conclusions	These results provide further evidence that variation in this set of 104 genes is associated with…

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Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.

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