Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse.

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Authors: Oni, Eileen N; Hart, Ronald P
Year: 2016
Journal: Current pharmacology reports
PMID: 27774408
DOI: 10.1007/s40495-016-0065-y
PMCID: PMC5070667

#	Section	Preview
20	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of methylation in DRG NSC	As a second approach, probe level analysis was used to observe higher-resolution methylation…
21	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of methylation in DRG NSC	A complementary method was used to validate selected differentially methylated genes. A set of…
22	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of methylation in DRG NSC	The Sequenom protocol validated 12 genes of the 26 predicted to be differentially methylated by…
23	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of methylation in DRG NSC	This study, while relying on the less-precise 5mC immunoprecipitation method for detecting DMRs,…
24	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	A study by Khalid and coworkers (2014) used the differentiation of human embryonic stem cells…
25	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	The goal of the study was to determine how ethanol affects both DNA methylation and gene expression…
26	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	for this is to align with two separate C→U or G→A substituted genome sequences, one to model…
27	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	Weighted gene co-expression network analysis was used to identify genes that are affected by ethanol…
28	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	Aggregating the genes with reduced mRNA expression and increased methylation of promoters or CpG…
29	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	Affected genes were screened as targets of regulation by specific transcription factors. Results…
30	Analysis of DNA methylation in models of fetal alcohol exposure — Use of hESC as model of early development	The use of bisulfite modification coupled with deep genome sequencing appears to be a step forward…
31	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	An article by Liyanage and colleagues (2015) attempted to shed light on the discrepancies between…
32	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	Binge-, chronic- and withdrawal-like ethanol conditions were used to study effects of ethanol…
33	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	To establish whether MeCP2 upstream regulatory elements (termed R1-R3) or intron 1 (R4-R6) are…
34	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	enriched DNA fragments (hMeDIP) or 5mC-specific MeDIP. 5hmC levels were enriched in R1,R3 and R5 in…
35	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	The effects on global 5mC and 5hmC DNA methylation during ethanol exposure and withdrawal were…
36	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	Since MeCP2 is relatively highly expressed in neurons and since it has been associated with…
37	Analysis of DNA methylation in models of fetal alcohol exposure — Ethanol regulation of MeCP2	This study relied upon a targeted analysis of CpG-rich sequences known to regulate a specific gene.…
38	Recommendations and Future Directions	Upon review of these recent technologies for assessing effects of ethanol on the methylome, it is…

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