Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.
- Authors
- Caspi, Avshalom; Hariri, Ahmad R; Holmes, Andrew; Uher, Rudolf; Moffitt, Terrie E
- Year
- 2010
- Journal
- The American journal of psychiatry
- PMID
- 20231323
- DOI
- 10.1176/appi.ajp.2010.09101452
- PMCID
- PMC2943341
Evidence of marked variability in response among people exposed to the same environmental risk implies that individual differences in genetic susceptibility might be at work. The study of such Gene-by-Environment (GxE) interactions has gained momentum. In this article, the authors review research about one of the most extensive areas of inquiry: variation in the promoter region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to stress sensitivity. Research in this area has both advanced basic science and generated broader lessons for studying complex diseases and traits. The authors evaluate four lines of evidence about the 5-HTT stress-sensitivity hypothesis: 1) observational studies about the serotonin transporter linked polymorphic region (5-HTTLPR), stress sensitivity, and depression in humans; 2) experimental neuroscience studies about the 5-HTTLPR and biological phenotypes relevant to the human stress response; 3) studies of 5-HTT variation and stress sensitivity in nonhuman primates; and 4) studies of stress sensitivity and genetically engineered 5-HTT mutations in rodents. The authors then dispel some misconceptions and offer recommendations for GxE research. The authors discuss how GxE interaction hypotheses can be tested with large and small samples, how GxE research can be carried out before as well as after replicated gene discovery, the uses of GxE research as a tool for gene discovery, the importance of construct validation in evaluating GxE research, and the contribution of GxE research to the public understanding of genetic science.
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| Association between serotonin transporter promoter polymorphisms and psychological distress in a diabetic population. | Wilhelm K et al. | — | 2012 | → |
| Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women. | Stoltenberg SF et al. | — | 2012 | → |
| Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. | Kenna GA et al. | — | 2012 | → |
| Associations of cytokine gene polymorphisms with post-stroke depression. | Kim JM et al. | — | 2012 | → |
| A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms. | Subaran RL et al. | — | 2012 | → |
| BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. | Gerritsen L et al. | — | 2012 | → |
| Behavioral resilience in the post-genomic era: emerging models linking genes with environment. | Rende R | — | 2012 | → |
| Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats. | Nonkes LJ et al. | — | 2012 | → |
| Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system. | Duffy A et al. | — | 2012 | → |
| Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. | Agrawal A et al. | — | 2012 | → |
| Childhood trauma in multiple sclerosis: a case-control study. | Spitzer C et al. | — | 2012 | → |
| Circadian rhythmicity in serotonin transporter knockout mice. | Pang RD et al. | — | 2012 | → |
| Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. | Miller GE et al. | — | 2012 | → |
| Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood. | Conway CC et al. | — | 2012 | → |
| Commentary: Replication, replication, replication: the continued need to substantiate GxE effects in child psychopathology--a response to Laucht et al. (2012). | Asherson P et al. | — | 2012 | → |
| Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. | Vrieze SI et al. | — | 2012 | → |
| Connectomic intermediate phenotypes for psychiatric disorders. | Fornito A et al. | — | 2012 | → |
| Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. | Heim C et al. | — | 2012 | → |
| Determining gene moderation of environmental risk factors for a mental disorder: a "perfect storm" of methodological problems. | Kraemer HC | — | 2012 | → |
| Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. | Guidotti G et al. | — | 2012 | → |
| Diethylstilbestrol and risk of psychiatric disorders: a critical review and new insights. | Kebir O et al. | — | 2012 | → |
| Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells. | Singh YS et al. | — | 2012 | → |
| Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes. | Sturge-Apple ML et al. | — | 2012 | → |
| Diversity in pathways to common childhood disruptive behavior disorders. | Martel MM et al. | — | 2012 | → |
| Don't throw the bathwater in with the baby. | Lichtenstein P | — | 2012 | → |
| Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders. | Groleau P et al. | — | 2012 | → |
| Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review. | Beard C et al. | — | 2012 | → |
| Emerging risk factors for postpartum depression: serotonin transporter genotype and omega-3 fatty acid status. | Shapiro GD et al. | — | 2012 | → |
| Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers. | Naudts KH et al. | — | 2012 | → |
| Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children. | Belsky DW et al. | — | 2012 | → |
| Future directions in vulnerability to depression among youth: integrating risk factors and processes across multiple levels of analysis. | Hankin BL | — | 2012 | → |
| Gene × Environment interaction and resilience: effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes. | Cicchetti D et al. | — | 2012 | → |
| Gene × environment interaction models in psychiatric genetics. | Karg K et al. | — | 2012 | → |
| Gene × environment vulnerability factors for PTSD: the HPA-axis. | Mehta D et al. | — | 2012 | → |
| Genetic and caregiving-based contributions to infant attachment: unique associations with distress reactivity and attachment security. | Raby KL et al. | — | 2012 | → |
| Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype × testosterone interaction. | Josephs RA et al. | — | 2012 | → |
| Genetic polymorphisms influence recovery from traumatic brain injury. | Weaver SM et al. | — | 2012 | → |
| Genetic sensitivity to the caregiving context: the influence of 5httlpr and BDNF val66met on indiscriminate social behavior. | Drury SS et al. | — | 2012 | → |
| Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes. | Camp MC et al. | — | 2012 | → |
| Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle. | Klumpers F et al. | — | 2012 | → |
| Genomic sciences for developmentalists: the current state of affairs. | Grigorenko EL et al. | — | 2012 | → |
| Infant development in family context: call for a genetically informed approach. | Parade SH et al. | — | 2012 | → |
| Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms. | Petersen IT et al. | — | 2012 | → |
| Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis. | Li JJ et al. | — | 2012 | → |
| Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance. | Sulik MJ et al. | — | 2012 | → |
| Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning? | Aas M et al. | — | 2012 | → |
| Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: a longitudinal, multilevel, mediated moderation analysis. | Brody GH et al. | — | 2012 | → |
| Linking variability in brain chemistry and circuit function through multimodal human neuroimaging. | Fisher PM et al. | — | 2012 | → |
| Maternal prenatal smoking and offspring emotional problems: no moderating effect of maternal or child 5-HTTLPR genotype. | Geels LM et al. | — | 2012 | → |
| Maternal smoking during pregnancy and child emotional problems: the relevance of maternal and child 5-HTTLPR genotype. | Cents RA et al. | — | 2012 | → |
| Mismatch or cumulative stress: toward an integrated hypothesis of programming effects. | Nederhof E et al. | — | 2012 | → |
| Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample. | Grabe HJ et al. | — | 2012 | → |
| Mouse models of the 5-HTTLPR × stress risk factor for depression. | Carola V et al. | — | 2012 | → |
| Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. | Drabant EM et al. | — | 2012 | → |
| Neurobiology of resilience. | Russo SJ et al. | — | 2012 | → |
| Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice. | Ihne JL et al. | — | 2012 | → |
| Physiological and affective reactivity to a 35% CO₂ inhalation challenge in individuals differing in the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | — | 2012 | → |
| Potential biomarkers in psychiatry: focus on the cholesterol system. | Woods AG et al. | — | 2012 | → |
| Prognostic factors, course, and outcome of depression among older primary care patients: the PROSPECT study. | Bogner HR et al. | — | 2012 | → |
| Quantitative and molecular genetics of ADHD. | Asherson P et al. | — | 2012 | → |
| Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. | Tromp DP et al. | — | 2012 | → |
| Resilience and measured gene-environment interactions. | Kim-Cohen J et al. | — | 2012 | → |
| Resilience as a dynamic concept. | Rutter M | — | 2012 | → |
| Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit. | Linnman C et al. | — | 2012 | → |
| Searching for genetic clues at the interface of sleep and mood. | Goel N | — | 2012 | → |
| Sensory processing sensitivity: a review in the light of the evolution of biological responsivity. | Aron EN et al. | — | 2012 | → |
| Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer. | Kim JM et al. | — | 2012 | → |
| Serotonergic modulation of conditioned fear. | Homberg JR | — | 2012 | → |
| Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception. | Lindstedt F et al. | — | 2012 | → |
| Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner. | Stoltenberg SF et al. | — | 2012 | → |
| Serotonin transporter gene as a predictor of stress generation in depression. | Starr LR et al. | — | 2012 | → |
| Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders. | Aas M et al. | — | 2012 | → |
| Serotonin transporter gene promoter polymorphism and alexithymia. | Kano M et al. | — | 2012 | → |
| Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients. | Savas S et al. | — | 2012 | → |
| Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. | Jasinska AJ et al. | — | 2012 | → |
| Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers. | Roiser JP et al. | — | 2012 | → |
| Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition. | Nonkes LJ et al. | — | 2012 | → |
| Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge. | Stephens MA et al. | — | 2012 | → |
| Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. | Hartley CA et al. | — | 2012 | → |
| Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression. | Fisher HL et al. | — | 2012 | → |
| Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis. | van Eekelen JA et al. | — | 2012 | → |
| Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. | Daskalakis NP et al. | — | 2012 | → |
| The 5-HTTLPR polymorphism moderates the effect of stressful life events on drinking behavior in college students of African descent. | Kranzler HR et al. | — | 2012 | → |
| The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptoms. | Mehta D et al. | — | 2012 | → |
| The canid genome: behavioral geneticists' best friend? | Hall NJ et al. | — | 2012 | → |
| The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. | Cicchetti D et al. | — | 2012 | → |
| The epigenetic code in depression: implications for treatment. | Schroeder M et al. | — | 2012 | → |
| The gene in its natural habitat: the importance of gene-trait interactions. | DeYoung CG et al. | — | 2012 | → |
| The Generation R Study: a review of design, findings to date, and a study of the 5-HTTLPR by environmental interaction from fetal life onward. | Tiemeier H et al. | — | 2012 | → |
| The genetic basis of mood and anxiety disorders - changing paradigms. | Binder EB | — | 2012 | → |
| The impact of serotonin transporter (5-HTTLPR) genotype on the development of resting-state functional connectivity in children and adolescents: a preliminary report. | Wiggins JL et al. | — | 2012 | → |
| The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. | Vrieze SI et al. | — | 2012 | → |
| The moderating effect of alcohol-specific parental rule-setting on the relation between the dopamine D2 receptor gene (DRD2), the μ-opioid receptor gene (OPRM1) and alcohol use in young adolescents. | Pieters S et al. | — | 2012 | → |
| The need for complex ideas in anorexia nervosa: why biology, environment, and psyche all matter, why therapists make mistakes, and why clinical benchmarks are needed for managing weight correction. | Strober M et al. | — | 2012 | → |
| The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features. | Naismith SL et al. | — | 2012 | → |
| Therapygenetics: moving towards personalized psychotherapy treatment. | Beevers CG et al. | — | 2012 | → |
| The reciprocal interaction between serotonin and social behaviour. | Kiser D et al. | — | 2012 | → |
| The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits. | Arias B et al. | — | 2012 | → |
| The science of resilience: implications for the prevention and treatment of depression. | Southwick SM et al. | — | 2012 | → |
| The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span. | Homberg JR et al. | — | 2012 | → |
| The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: potential roles in genetic selection and gene × environment interactions. | Lindell SG et al. | — | 2012 | → |
| The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques. | Spinelli S et al. | — | 2012 | → |
| The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. | Jonassaint CR et al. | — | 2012 | → |
| The stress-coping (mis)match hypothesis for nature × nurture interactions. | Homberg JR | — | 2012 | → |
| Translating epidemiology in psychiatry: the future is here. | Weissman M | — | 2012 | → |
| Treatment- and population-dependent activity patterns of behavioral and expression QTLs. | Ziebarth JD et al. | — | 2012 | → |
| Variations in the promoter region of the serotonin transporter gene and biased attention for emotional information: a meta-analysis. | Pergamin-Hight L et al. | — | 2012 | → |
| 5-HT and depression: is the glass half-full? | Sharp T et al. | — | 2011 | → |
| 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. | Clasen PC et al. | — | 2011 | → |
| 5-HTTLPR moderates the relation between changes in depressive and bulimic symptoms in adolescent girls: a longitudinal study. | Mata J et al. | — | 2011 | → |
| A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. | Duncan LE et al. | — | 2011 | → |
| Affective and neuroendocrine stress reactivity to an academic examination: influence of the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | — | 2011 | → |
| All (C57BL/6) Mice are not Created Equal. | Kiselycznyk C et al. | — | 2011 | → |
| A mouse model to address unresolved antidepressant issues. | Homberg JR | — | 2011 | → |
| A new interaction between SLC6A4 variation and child abuse is associated with resting heart rate. | Shinozaki G et al. | — | 2011 | → |
| Animal model and neurobiology of suicide. | Preti A | — | 2011 | → |
| Animal models of depression and anxiety: What do they tell us about human condition? | Neumann ID et al. | — | 2011 | → |
| Animal models of human anxiety disorders: reappraisal from a developmental psychopathology vantage point. | Lampis V et al. | — | 2011 | → |
| An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses. | Witt SH et al. | — | 2011 | → |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | — | 2011 | → |
| Annual Research Review: Developmental considerations of gene by environment interactions. | Lenroot RK et al. | — | 2011 | → |
| A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques. | Cirulli F et al. | — | 2011 | → |
| An update on psychogenic movement disorders. | Ellenstein A et al. | — | 2011 | → |
| Association between 5-HTTLPR and Borderline Personality Disorder Traits among Youth. | Hankin BL et al. | — | 2011 | → |
| Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample. | Blom RM et al. | — | 2011 | → |
| Behavioral and molecular genetics of dissociation: the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR). | Pieper S et al. | — | 2011 | → |
| Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. | Carver CS et al. | — | 2011 | → |
| Children's 5-HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger. | Gibb BE et al. | — | 2011 | → |
| Community attitudes to genetic susceptibility-based mental health interventions for healthy people in a large national sample. | Wilde A et al. | — | 2011 | → |
| Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. | Lindstedt F et al. | — | 2011 | → |
| CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters. | Moberg T et al. | — | 2011 | → |
| Decreased regional gray matter volume in S' allele carriers of the 5-HTTLPR triallelic polymorphism. | Selvaraj S et al. | — | 2011 | → |
| Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. | Claessens SE et al. | — | 2011 | → |
| Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions. | van den Hove DL et al. | — | 2011 | → |
| Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'. | Hankin BL et al. | — | 2011 | → |
| Discovering imaging endophenotypes for major depression. | Hasler G et al. | — | 2011 | → |
| Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. | Holmboe K et al. | — | 2011 | → |
| Effects of acute psychosocial stress exposure on endocrine and affective reactivity in college students differing in the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | — | 2011 | → |
| Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. | Fairbanks LA et al. | — | 2011 | → |
| Epigenetics in Developmental Disorder: ADHD and Endophenotypes. | Archer T et al. | — | 2011 | → |
| Excess of serotonin affects neocortical pyramidal neuron migration. | Riccio O et al. | — | 2011 | → |
| Experimental models for anxiolytic drug discovery in the era of omes and omics. | Stewart A et al. | — | 2011 | → |
| Gene-environment interaction in anorexia nervosa: relevance of non-shared environment and the serotonin transporter gene. | Karwautz AF et al. | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Gene-environment interaction in the etiology of mathematical ability using SNP sets. | Docherty SJ et al. | — | 2011 | → |
| Gene-environment interactions between CRHR1 variants and physical assault in suicide attempts. | Ben-Efraim YJ et al. | — | 2011 | → |
| Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. | Nugent NR et al. | — | 2011 | → |
| Gene-environment interactions in geriatric depression. | Lotrich FE | — | 2011 | → |
| Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop. | Bookman EB et al. | — | 2011 | → |
| Gene expression and methylation signatures of MAN2C1 are associated with PTSD. | Uddin M et al. | — | 2011 | → |
| Genes, environment, and individual differences in responding to treatment for depression. | Uher R | — | 2011 | → |
| Genetics in psychiatry: are the promises met? | Bondy B | — | 2011 | → |
| Genetics of emotion. | Bevilacqua L et al. | — | 2011 | → |
| Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. | Murphy DL et al. | — | 2011 | → |
| Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. | Sugawara H et al. | — | 2011 | → |
| Inside the prison black box: toward a life course importation model of inmate behavior. | Delisi M et al. | — | 2011 | → |
| Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design. | Hankin BL et al. | — | 2011 | → |
| Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. | Cicchetti D et al. | — | 2011 | → |
| Is depression an inflammatory disorder? | Raison CL et al. | — | 2011 | → |
| Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study. | Fergusson DM et al. | — | 2011 | → |
| Life stressors and 5-HTTLPR interaction in relation to midpregnancy depressive symptoms among African-American women. | Scheid JM et al. | — | 2011 | → |
| Looking on the bright side of serotonin transporter gene variation. | Homberg JR et al. | — | 2011 | → |
| Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice. | Pang RD et al. | — | 2011 | → |
| Memory, autonoetic consciousness, and the self. | Markowitsch HJ et al. | — | 2011 | → |
| Mood and personality effects in healthy participants after chronic administration of sertraline. | Simmons JG et al. | — | 2011 | → |
| Neuroscience, neuroimaging and the law. | Markowitsch HJ et al. | — | 2011 | → |
| Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. | Daws LC et al. | — | 2011 | → |
| Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems. | Brody GH et al. | — | 2011 | → |
| Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. | Hyde LW et al. | — | 2011 | → |
| Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. | Lindstedt F et al. | — | 2011 | → |
| Personalized medicine can pave the way for the safe use of CB₁ receptor antagonists. | Lazary J et al. | — | 2011 | → |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | — | 2011 | → |
| Pharmacogenetics of antidepressant response. | Keers R et al. | — | 2011 | → |
| Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress. | Wagner KV et al. | — | 2011 | → |
| Predicting cortisol stress responses in older individuals: influence of serotonin receptor 1A gene (HTR1A) and stressful life events. | Armbruster D et al. | — | 2011 | → |
| Psychopathology, trauma and delinquency: subtypes of aggression and their relevance for understanding young offenders. | Steiner H et al. | — | 2011 | → |
| Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research. | Dunn EC et al. | — | 2011 | → |
| Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains. | Lederle L et al. | — | 2011 | → |
| Role of mother's genes and environment in postpartum depression. | Mitchell C et al. | — | 2011 | → |
| Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making. | Stoltenberg SF et al. | — | 2011 | → |
| Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity. | Klauke B et al. | — | 2011 | → |
| Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. | Uher R et al. | — | 2011 | → |
| Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? | Margoob MA et al. | — | 2011 | → |
| Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. | Morey RA et al. | — | 2011 | → |
| Serotonin transporter genotype (5-HTTLPR) predicts utilitarian moral judgments. | Marsh AA et al. | — | 2011 | → |
| Serotonin transporter genotype moderates the link between children's reports of overprotective parenting and their behavioral inhibition. | Burkhouse KL et al. | — | 2011 | → |
| Serotonin transporter genotype x construction stress interaction in rats. | Schipper P et al. | — | 2011 | → |
| Serotonin transporter polymorphism interacts with childhood adversity to predict aspects of impulsivity. | Carver CS et al. | — | 2011 | → |
| Social constraints, genetic vulnerability, and mental health following collective stress. | Holman EA et al. | — | 2011 | → |
| Strain-specific cognitive deficits in adult mice exposed to early life stress. | Mehta M et al. | — | 2011 | → |
| Stress controversies: post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration*. | Fink G | — | 2011 | → |
| Stressful life events at onset of obsessive-compulsive disorder are associated with a distinct clinical pattern. | Real E et al. | — | 2011 | → |
| Suicidal ideation during antidepressant treatment: do genetic predictors exist? | Perroud N | — | 2011 | → |
| The Biological Implausibility of the Nature-Nurture Dichotomy & What It Means for the Study of Infancy. | Lewkowicz DJ | — | 2011 | → |
| The clinical implications of mouse models of enhanced anxiety. | Sartori SB et al. | — | 2011 | → |
| The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. | Juhasz G et al. | — | 2011 | → |
| The effects of allostatic load on neural systems subserving motivation, mood regulation, and social affiliation. | Beauchaine TP et al. | — | 2011 | → |
| The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. | Cicchetti D et al. | — | 2011 | → |
| The end of the primary outcome measure: a research agenda for constructing its replacement. | De Los Reyes A et al. | — | 2011 | → |
| The genetic blueprint of major depressive disorder: contributions of imaging genetics studies. | Scharinger C et al. | — | 2011 | → |
| The genetics of eating disorders. | Helder SG et al. | — | 2011 | → |
| The HTR1A and HTR1B receptor genes influence stress-related information processing. | Mekli K et al. | — | 2011 | → |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | — | 2011 | → |
| The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. | Minelli A et al. | — | 2011 | → |
| The other allele: exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: a review of the parallels in findings. | Glenn AL | — | 2011 | → |
| The role of early life stress as a predictor for alcohol and drug dependence. | Enoch MA | — | 2011 | → |
| The serotonin transporter and emotionality: risk, resilience, and new therapeutic opportunities. | Murrough JW et al. | — | 2011 | → |
| The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene. | Fox E et al. | — | 2011 | → |
| The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces. | von dem Hagen EA et al. | — | 2011 | → |
| The Serotonin Transporter Polymorphism (5-HTTLPR) and Alcohol Problems in Heavy Drinkers: Moderation by Depressive Symptoms. | Tartter MA et al. | — | 2011 | → |
| The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. | Karg K et al. | — | 2011 | → |
| The social environment and IL-6 in rats and humans. | Saxton KB et al. | — | 2011 | → |
| The truth about genetic variation in the serotonin transporter gene and response to stress and medication. | McGuffin P et al. | — | 2011 | → |
| The urban environment and mental disorders: Epigenetic links. | Galea S et al. | — | 2011 | → |
| The use of the zebrafish model in stress research. | Steenbergen PJ et al. | — | 2011 | → |
| Translational epidemiology in psychiatry: linking population to clinical and basic sciences. | Weissman MM et al. | — | 2011 | → |
| Translational research approach to biological and modifiable risk factors of psychosis and affective disorders. | Baune BT et al. | — | 2011 | → |
| Understanding risk for psychopathology through imaging gene-environment interactions. | Hyde LW et al. | — | 2011 | → |
| Using gene-environment interactions to target personalized treatment in mood disorder. | Klengel T et al. | — | 2011 | → |
| Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice. | Dadomo H et al. | — | 2011 | → |
| Adolescence: what do transmission, transition, and translation have to do with it? | Casey BJ et al. | — | 2010 | → |
| A longitudinal study of epigenetic variation in twins. | Wong CC et al. | — | 2010 | → |
| Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. | Grabe HJ et al. | — | 2010 | → |
| Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression? | Wankerl M et al. | — | 2010 | → |
| Early institutionalization: neurobiological consequences and genetic modifiers. | Sheridan M et al. | — | 2010 | → |
| From predisposition to illness: genetically sensitive intermediate pathways to mood disorders. | Duffy A | — | 2010 | → |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | — | 2010 | → |
| Genetic Thinking in the Study of Social Relationships: Five Points of Entry. | Reiss D | — | 2010 | → |
| Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. | Raison CL et al. | — | 2010 | → |
| Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression. | Conway CC et al. | — | 2010 | → |
| Interpretation of interactions: guide for the perplexed. | Kendler KS et al. | — | 2010 | → |
| Introduction to the Special Issue: Genetics, Personalized Medicine, and Behavioral Intervention-Can This Combination Improve Patient Care? | Reiss D | — | 2010 | → |
| Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. | Jennings KA et al. | — | 2010 | → |
| Overview of the genetics of major depressive disorder. | Lohoff FW | — | 2010 | → |
| Reconciling specific and unspecific risk factors: the interplay between theory and data. | Buitelaar JK | — | 2010 | → |
| Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction. | Wankerl M et al. | — | 2010 | → |
| Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability. | Mozhui K et al. | — | 2010 | → |
| Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis. | Mehta PH et al. | — | 2010 | → |
| Theory and methods in cultural neuroscience. | Chiao JY et al. | — | 2010 | → |
| The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. | Middeldorp CM et al. | — | 2010 | → |