Early adolescent aggression predicts antisocial personality disorder in young adults: a population-based study.
- Authors
- Whipp, Alyce M; Korhonen, Tellervo; Raevuori, Anu; Heikkilä, Kauko; Pulkkinen, Lea; Rose, Richard J; Kaprio, Jaakko; Vuoksimaa, Eero
- Year
- 2019
- Journal
- European child & adolescent psychiatry
- PMID
- 30019148
- DOI
- 10.1007/s00787-018-1198-9
- PMCID
- PMC6407741
Modestly prevalent in the general population (~ 4%), but highly prevalent in prison populations (> 40%), the diagnosis of antisocial personality disorder (ASPD) involves aggression as one of several possible criteria. Using multiple informants, we aimed to determine if general aggression, as well as direct and indirect subtypes, assessed in early adolescence (ages 12, 14) predict young adulthood ASPD in a population-based sample. Using data from a Finnish population-based longitudinal twin cohort study with psychiatric interviews available at age 22 (N = 1347), we obtained DSM-IV-based ASPD diagnoses. Aggression measures from ages 12 (parental and teacher ratings) and 14 (teacher, self, and co-twin ratings) were used to calculate odds ratios (OR) of ASPD from logistic regression models and the area under the curve (AUC) from receiver operating characteristic curve analysis. Analyses were adjusted for sex, age, and family structure. All informants' aggression ratings were significant (p < 0.05) predictors of ASPD (OR range 1.3-1.8; AUC range 0.65-0.72). Correlations between informants ranged from 0.13 to 0.33. Models including two or more aggression ratings, particularly age 14 teacher and self ratings, more accurately predicted ASPD (AUC: 0.80; 95% confidence interval 0.73-0.87). Direct aggression rated by all informants significantly predicted ASPD (OR range 1.4-1.9), whereas only self-rated indirect aggression was significantly associated with ASPD (OR = 1.4). Across different informants, general and direct aggression at ages 12 and 14 predicted ASPD in a population-based sample. Psychiatric, social, and parenting interventions for ASPD prevention should focus on children and adolescents with high aggression levels, with an aim to gather information from multiple informants.
a-dReceiver operating characteristic (ROC) curves of select total aggression score logistic models. a Parent rating (12) only model. b Self rating (14) only model. c All 5 ratings (parent-12, teacher-12, teacher-14, self-14, co-twin-14) model. d Teacher (14) and self (14) model
| Name | Type |
|---|---|
| ACTION consortium local | cohort |
| adjustment local | phenotype |
| adolescent prison population local | phenotype |
| adolescents | cohort |
| Adult psychiatric disorders | phenotype |
| Age 14 self aggression rating local | phenotype |
| Age 14 teacher aggression rating local | phenotype |
| aggression | phenotype |
| Aggression levels local | phenotype |
| Aggression subscores local | phenotype |
| alcohol | phenotype |
| Alcohol Problems | phenotype |
| antisocial personality disorder | phenotype |
| ASPD | phenotype |
| At-risk families local | cohort |
| behavioral development | phenotype |
| behavior problems | phenotype |
| Birth cohort of 3-year-old children local | cohort |
| callousness local | phenotype |
| Childhood and adolescent psychiatric disorders local | phenotype |
| clinical samples | cohort |
| conduct disorder | phenotype |
| Co-Twin informant local | cohort |
| co-twin rating age 14 local | phenotype |
| crime | phenotype |
| deceitfulness | phenotype |
| depression | phenotype |
| direct aggression local | phenotype |
| Direct aggression local | phenotype |
| Direct Aggression local | phenotype |
| Direct aggression residual score local | phenotype |
| Direct aggression scores local | phenotype |
| Direct aggression subtype local | phenotype |
| emotional and behavioral problems | phenotype |
| externalizing disorders | phenotype |
| Final Sample (n=1347) local | cohort |
| Finland | cohort |
| Finnish Central Population Registry local | cohort |
| Finnish cohort | cohort |
| Finnish twins | cohort |
| Finntwin12 | cohort |
| FinnTwin12 study local | cohort |
| General aggression local | phenotype |
| general population | cohort |
| General pre- and early adolescent population local | cohort |
| health habits local | phenotype |
| hostility | phenotype |
| impulsivity | phenotype |
| impulsivity-hyperactivity local | phenotype |
| inattention | phenotype |
| Indirect aggression residual score local | phenotype |
| Indirect aggression scores local | phenotype |
| informant local | cohort |
| intensively studied subsample local | cohort |
| Intensively studied subsample local | cohort |
| internalizing disorders | phenotype |
| irresponsibility local | phenotype |
| large population-based sample local | cohort |
| Modified definitions of ASPD local | phenotype |
| MPNI aggression ratings local | phenotype |
| negative outcomes | phenotype |
| non-ASPD local | phenotype |
| parental aggression rating local | phenotype |
| Parental informant local | cohort |
| Parent informant local | cohort |
| Parent rating local | phenotype |
| parent rating age 12 local | phenotype |
| population-based sample | cohort |
| PR local | cohort |
| prison-based samples local | cohort |
| Prison population local | cohort |
| risk taking | phenotype |
| rule-breaking behavior | phenotype |
| Self aggression rating local | phenotype |
| Self informant local | cohort |
| Self informant (age 14) local | cohort |
| Self rating local | phenotype |
| self rating age 14 local | phenotype |
| sex | phenotype |
| social anxiety | phenotype |
| Social anxiety ratings local | phenotype |
| SR local | cohort |
| substance abuse | phenotype |
| substance use | phenotype |
| teacher aggression rating local | phenotype |
| Teacher aggression rating local | phenotype |
| Teacher informant local | cohort |
| Teacher informant (age 14) local | cohort |
| Teacher rating local | phenotype |
| teacher rating age 12 local | phenotype |
| teacher rating age 14 local | phenotype |
| total aggression local | phenotype |
| Total aggression local | phenotype |
| Total aggression rating (all informants) local | cohort |
| total aggression score local | phenotype |
| Total aggression scores local | phenotype |
| TR local | cohort |
| Twin cohort | cohort |
| TWR local | cohort |
| young adults | cohort |
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In this knowledge base
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|---|---|---|
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