C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation.
paper
Cited
Public
- Authors
- Li, Ying; Wright, Gary L; Peterson, Jonathan M
- Year
- 2017
- Journal
- Comprehensive Physiology
- PMID
- 28640446
- DOI
- 10.1002/cphy.c160044
- PMCID
- PMC5756469
As the largest endocrine organ, adipose tissue secretes many bioactive molecules that circulate in blood, collectively termed adipokines. Efforts to identify such metabolic regulators have led to the discovery of a family of secreted proteins, designated as C1q tumor necrosis factor (TNF)-related proteins (CTRPs). The CTRP proteins, adiponectin, TNF-alpha, as well as other proteins with the distinct C1q domain are collectively grouped together as the C1q/TNF superfamily. Reflecting profound biological potency, the initial characterization of these adipose tissue-derived CTRP factors finds wide-ranging effects upon metabolism, inflammation, and survival-signaling in multiple tissue types. CTRP3 (also known as CORS26, cartducin, or cartonectin) is a unique member of this adipokine family. In this review we provide a comprehensive overview of the research concerning the expression, regulation, and physiological function of CTRP3. © 2017 American Physiological Society. Compr Physiol 7:863-878, 2017.
Structural overview of CTRP3. (A) Two splice variants were identified and designated as CTRP3A and CTRP3B. (B) Organization of the CTRP3A and CTRP3B genes and proteins. The human CTRP3A gene is 25.3 kb in size, consists of six exons and five introns, and is located on chromosome 5p13. Exons 1, 2, 3, 4, 5, and 6 of the CTRP3A gene are 171, 112, 155, 130, 100, and 2885 bp in size, respectively. The size of each intron is also indicated. Exon 1B (gray square) contains a 219-nucleotide sequence found in CTRP3B cDNA, coding for an extra 73 amino acid residues. A potential Nlinked glycosylation site is circled. The consensus splice donors are shown in italic type. This figure was originally published in The Journal of Biological Chemistry (51) and image reproduced according to the copyright policy of the ASBMB. © the American Society for Biochemistry and Molecular Biology.
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|---|---|---|
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | 2019 | 29568101 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association between circulating plasma CTRP3 levels and acute ischemic stroke: a systematic review and meta-analysis. | Niu Q et al. | — | 2025 | → |
| CTRP3 attenuates myocardial lipotoxicity via suppression of lipid accumulation, inflammation, apoptosis, and mitochondrial oxidative stress. | Wang Q et al. | — | 2025 | → |
| Evaluation of the serum level of CTRP-3 and CTRP-6 in patients with Hashimoto's disease and correlation with thyroid hormones and lipid profile. | Al-Abboody RS et al. | — | 2025 | → |
| Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients. | Han P et al. | — | 2025 | → |
| Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases. | Wang QP et al. | — | 2025 | → |
| Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies. | Ren Y et al. | — | 2025 | → |
| Unveiling the roles of CTRP family in cardiac remodeling. | Zhao S et al. | — | 2025 | → |
| An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging. | Melendez J et al. | — | 2024 | → |
| Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients. | Schmid A et al. | — | 2024 | → |
| Decreased Serum CTRP3 level was associated with connective tissue diseases. | Ma L et al. | — | 2024 | → |
| Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adipose Tissue of Mice. | Wenderoth T et al. | — | 2024 | → |
| gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice. | Zhang X et al. | — | 2024 | → |
| Lower serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetic patients | Han P et al. | — | 2024 | — |
| Obesity alters adipose tissue response to fasting and refeeding in women: A study on lipolytic and endocrine dynamics and acute insulin resistance. | Rossmeislová L et al. | — | 2024 | → |
| Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates. | Rekler D et al. | — | 2024 | → |
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| The effect of immunotherapy PD-1 blockade on acute bone cancer pain: Insights from transcriptomic and microbiomic profiling. | Ding R et al. | — | 2024 | → |
| The relationships between biological novel biomarkers Lp-PLA<sub>2</sub> and CTRP-3 and CVD in patients with type 2 diabetes mellitus. | Chen Y et al. | — | 2024 | → |
| Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling. | Yu H et al. | — | 2023 | → |
| Association of serum 25-hydroxyvitamin D3, fibroblast growth factor-23, and C1q/tumor necrosis factor-related protein-3 with coronary artery calcification in nondialysis chronic kidney disease patients. | Zhu Y et al. | — | 2023 | → |
| Bone marrow-mesenchymal stem cells alleviate microglial Pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3. | Wang Q et al. | — | 2023 | → |
| C1q and central nervous system disorders. | Zhang W et al. | — | 2023 | → |
| Circulating Levels of C1q/TNF-Related Protein 3 (CTRP3) and CTRP9 in Gestational Diabetes and Their Association with Insulin Resistance and Inflammatory Cytokines. | Fadaei R et al. | — | 2023 | → |
| Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis. | Uçar IMB et al. | — | 2023 | → |
| CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication. | Zhang H et al. | — | 2023 | → |
| Keloid Core Factor CTRP3 Overexpression Significantly Controlled TGF-<i>β</i>1-Induced Propagation and Migration in Keloid Fibroblasts. | He L et al. | — | 2023 | → |
| Advances in the functions of CTRP6 in the development and progression of the malignancy. | Hu B et al. | — | 2022 | → |
| African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3. | Lv C et al. | — | 2022 | → |
| Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers. | Mohamed MK et al. | — | 2022 | → |
| C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization. | Micallef P et al. | — | 2022 | → |
| C1q/tumor necrosis factor-related protein-3 improves microvascular endothelial function in diabetes through the AMPK/eNOS/NO· signaling pathway. | Yan Z et al. | — | 2022 | → |
| Genome-wide association study on milk production and somatic cell score for Thai dairy cattle using weighted single-step approach with random regression test-day model. | Buaban S et al. | — | 2022 | → |
| Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma. | Karapetyan L et al. | — | 2022 | → |
| Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice. | Thomas KL et al. | — | 2022 | → |
| C1q-like 1 is frequently up-regulated in lung adenocarcinoma and contributes to the proliferation and invasion of tumor cells. | Gao YJ et al. | — | 2021 | → |
| CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress. | Zhang J et al. | — | 2021 | → |
| CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition. | Cho Y et al. | — | 2021 | → |
| CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells. | Mei M et al. | — | 2021 | → |
| CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway. | Ding H et al. | — | 2021 | → |
| Effects of non-vascularized adipose tissue transplantation on its genetic profile. | Schreiter JS et al. | — | 2021 | → |
| Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6. | Sanaei R et al. | — | 2021 | → |
| The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. | Tang X et al. | — | 2021 | → |
| The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. | Myngbay A et al. | — | 2021 | → |
| C1QTNF6 Overexpression Acts as a Predictor of Poor Prognosis in Bladder Cancer Patients. | Zhu X et al. | — | 2020 | → |
| CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. | Gao J et al. | — | 2020 | → |
| CTRP3 and serum triglycerides in children aged 7-10 years. | Alamian A et al. | — | 2020 | → |
| CTRP3 induces an intermediate switch of CD14<sup>++</sup>CD16<sup>+</sup> monocyte subset with anti-inflammatory phenotype. | Zhu H et al. | — | 2020 | → |
| CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. | Youngstrom DW et al. | — | 2020 | → |
| Deficiency of C1q/TNF-related protein 3 (CTRP3) decreases adipose tissue weight in diet-induced obesity mice. | Maeda T et al. | — | 2020 | → |
| Increased mRNA Expression of CTRP3 and CTRP9 in Adipose Tissue from Obese Women: Is it Linked to Obesity-Related Parameters and mRNA Expression of Inflammatory Cytokines? | Masoodian SM et al. | — | 2020 | → |
| Plasma Proteome Responses in Salmonid Fish Following Immunization. | Bakke FK et al. | — | 2020 | → |
| The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: Focus on type 2 diabetes and cardiovascular diseases. | Shanaki M et al. | — | 2020 | → |
| Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication. | Funcke JB et al. | — | 2019 | → |
| Blubber transcriptome responses to repeated ACTH administration in a marine mammal. | Deyarmin JS et al. | — | 2019 | → |
| C1QTNF6 as a novel biomarker regulates cellular behaviors in A549 cells and exacerbates the outcome of lung adenocarcinoma patients. | Han M et al. | — | 2019 | → |
| C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction. | Zhang Z et al. | — | 2019 | → |
| Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy. | Komosinska-Vassev K et al. | — | 2019 | → |
| CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. | Zhang J et al. | — | 2019 | → |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | — | 2019 | → |
| Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients. | Yagmur E et al. | — | 2019 | → |
| High molecular weight, but not total, CTRP3 levels are associated with serum triglyceride levels. | Trogen G et al. | — | 2019 | → |
| Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery. | Brock J et al. | — | 2019 | → |
| Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function. | Chen T et al. | — | 2019 | → |
| Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function. | Moradi N et al. | — | 2019 | → |
| The cartonectin levels at different stages of chronic kidney disease and related factors. | Yavuz YC et al. | — | 2019 | → |
| The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. | Loosen SH et al. | — | 2019 | → |
| Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. | Li X et al. | — | 2018 | → |
| Serum CTRP3 level is inversely associated with nonalcoholic fatty liver disease: A 3-y longitudinal study. | Zhou W et al. | — | 2018 | → |
| The sex specific effect of alcohol consumption on circulating levels of CTRP3. | DeGroat AR et al. | — | 2018 | → |