Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.

paper Cited Public

Authors: Criado, J R; Ehlers, C L
Year: 2009
Journal: Neuroscience
PMID: 19540906
DOI: 10.1016/j.neuroscience.2009.06.039
PMCID: PMC2741167

Mouse models have been developed to simulate several relevant human traits associated with alcohol use and dependence. However, the neurophysiological substrates regulating these traits remain to be completely elucidated. We have previously demonstrated that differences in the event-related potential (ERP) responses can be found that distinguish high-alcohol preferring from low alcohol preferring mice that resemble differences seen in human studies of individuals with high and low risk for alcohol dependence. Recently, evidence of genes that affect event-related oscillations (EROs) and the risk for alcohol dependence has emerged, however, to date EROs have not been evaluated in genetic mouse models of high and low alcohol preference. Therefore, the objective of the present study was to characterize EROs in mouse models of high (C57BL/6 [B6] and high alcohol preference 1 [HAP-1] mice) and low (DBA/2J [D2] and low alcohol preference-1 [LAP-1] mice) alcohol preference. A time-frequency representation method was used to determine delta, theta and alpha/beta ERO energy and the degree of phase variation in these mouse models. The present results suggest that the decrease in P3 amplitudes previously shown in B6 mice, compared to D2 mice, is related to reductions in evoked delta ERO energy and delta and theta phase locking. In contrast, the increase in P1 amplitudes reported in HAP-1 mice, compared to LAP-1 mice, is associated with increases in evoked theta ERO energy. These studies suggest that differences in delta and theta ERO measures in mice mirror changes observed between groups at high- and low-risk for alcoholism where changes in EROs were found to be more significant than group differences in P3 amplitudes, further suggesting that ERO measures are more stable endophenotypes in the study of alcohol dependence. Further studies are needed to determine the relationship between expression of these neurophysiological endophenotypes and the genetic profile of these mouse models.

#	Section	Preview
0	EXPERIMENTAL PROCEDURES — Animals	In the first study, 66 male mice, 29 of the C57BL/6 strain (B6) and 37 of DBA/2 strain (D2) were…
1	EXPERIMENTAL PROCEDURES — Animals	libitum for the duration of the study. Detailed description of the environmental conditions of mice…
2	EXPERIMENTAL PROCEDURES — Surgical procedure	Mice were implanted with stainless steel screws (Small Parts, Miami Lakes, FL; size: 000 × 120 ×…
3	EXPERIMENTAL PROCEDURES — Electrophysiological recording procedures	Electroencephalograms (EEG) and ERPs were recorded using Microtech™ recording cables. ERPs were…
4	EXPERIMENTAL PROCEDURES — General procedures	EEG and ERP recordings were collected in one recording session in a sound-attenuated and…
5	EXPERIMENTAL PROCEDURES — Event-related oscillations (ERO) and phase locking index (PLI) analyses	ERO and PLI analyses were accomplished from the same datasets that were used to generate the ERP…
6	EXPERIMENTAL PROCEDURES — Event-related oscillations (ERO) and phase locking index (PLI) analyses	The S-transform resembles a continuous wavelet but it uses scaled Gaussian windows which are not,…
7	EXPERIMENTAL PROCEDURES — Event-related oscillations (ERO) and phase locking index (PLI) analyses	The PLI was calculated to measure phase variability in relation to stimulus onset, as previously…
8	EXPERIMENTAL PROCEDURES — Event-related oscillations (ERO) and phase locking index (PLI) analyses	Implicit in this and related methods is the assumption that the trial being analyzed is preceded by…
9	EXPERIMENTAL PROCEDURES — Event-related oscillations (ERO) and phase locking index (PLI) analyses	et al., 2004). Baseline corrected post-stimulus activity (900 ms) was calculated by subtracting…
10	EXPERIMENTAL PROCEDURES — Statistical Analysis	Statistical analyses were performed by using SPSS for the Macintosh (SPSS, Inc., Chicago, IL). Brain…
11	RESULTS	The present study extended our initial analyses of neurophysiological endophenotypes in genetic…
12	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — Effect of tone type on ERO energy and PLI	Fig. 1A–D illustrates a grand mean S-transform time-frequency representation of the rare auditory…
13	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — Effect of tone type on ERO energy and PLI	Two-way repeated measures ANOVA with ERO energy as dependent variable revealed a significant main…
14	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — Effect of tone type on ERO energy and PLI	1). Lower ERO energy in the parietal delta and theta bands (50–350 ms and 350–800 ms time…
15	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — Effect of tone type on ERO energy and PLI	Two-way repeated measures ANOVA with PLI as dependent variable revealed a significant main effect of…
16	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: Baseline activity	No differences were observed in baseline ERO mean energy in the frontal delta and theta bands…
17	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy and PLI in the 0–50 ms window — ERO Energy	Significant Group × Tone interaction was observed in the delta band in the parietal cortex [F(1.8,…
18	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy and PLI in the 0–50 ms window — ERO Energy	Group × Tone interaction in the theta band was significant in the frontal cortex [F(1.7, 108.8) =…
19	RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy and PLI in the 0–50 ms window — ERO Energy	band in response to standard [F(1,65) = 57.5; P < 0.001] and rare [F(1,65) = 18.4; P < 0.001] tones…

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In this knowledge base

Title	Year	PMID
Endophenotype best practices.	2017	27473600
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	2015	26236574
Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.	2014	24819672
Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders?	2014	24656843
Ethanol reduces the phase locking of neural activity in human and rodent brain.	2012	22410292
Event-Related Oscillations in Alcoholism Research: A Review.	2012	24273686
Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP).	2010	20598842

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Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP).	Criado JR et al.	—	2010	→