Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.
- Authors
- Criado, J R; Ehlers, C L
- Year
- 2009
- Journal
- Neuroscience
- PMID
- 19540906
- DOI
- 10.1016/j.neuroscience.2009.06.039
- PMCID
- PMC2741167
Mouse models have been developed to simulate several relevant human traits associated with alcohol use and dependence. However, the neurophysiological substrates regulating these traits remain to be completely elucidated. We have previously demonstrated that differences in the event-related potential (ERP) responses can be found that distinguish high-alcohol preferring from low alcohol preferring mice that resemble differences seen in human studies of individuals with high and low risk for alcohol dependence. Recently, evidence of genes that affect event-related oscillations (EROs) and the risk for alcohol dependence has emerged, however, to date EROs have not been evaluated in genetic mouse models of high and low alcohol preference. Therefore, the objective of the present study was to characterize EROs in mouse models of high (C57BL/6 [B6] and high alcohol preference 1 [HAP-1] mice) and low (DBA/2J [D2] and low alcohol preference-1 [LAP-1] mice) alcohol preference. A time-frequency representation method was used to determine delta, theta and alpha/beta ERO energy and the degree of phase variation in these mouse models. The present results suggest that the decrease in P3 amplitudes previously shown in B6 mice, compared to D2 mice, is related to reductions in evoked delta ERO energy and delta and theta phase locking. In contrast, the increase in P1 amplitudes reported in HAP-1 mice, compared to LAP-1 mice, is associated with increases in evoked theta ERO energy. These studies suggest that differences in delta and theta ERO measures in mice mirror changes observed between groups at high- and low-risk for alcoholism where changes in EROs were found to be more significant than group differences in P3 amplitudes, further suggesting that ERO measures are more stable endophenotypes in the study of alcohol dependence. Further studies are needed to determine the relationship between expression of these neurophysiological endophenotypes and the genetic profile of these mouse models.
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| 20 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy and PLI in the 0–50 ms window — PLI | Significant Group × Tone interaction was observed in the delta and theta bands in the frontal and… |
| 21 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 50–350 ms window — ERO Energy | Significant Group × Tone interaction was observed in the delta band in the parietal cortex [F(1.6,… |
| 22 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 50–350 ms window — ERO Energy | Group × Tone interaction in the theta band was not significant in the frontal and parietal… |
| 23 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 50–350 ms window — PLI | Significant Group × Tone interaction was observed in the delta and theta band in the parietal, but… |
| 24 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 350–800 ms window — ERO Energy | Group × Tone interaction in the delta band was significant in the parietal cortex [F(1.9, 120.4) =… |
| 25 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 350–800 ms window — ERO Energy | Significant Group × Tone interaction was found in the alpha/beta band in the parietal cortex… |
| 26 | RESULTS — ERO mean energy and phase locking in B6 and D2 mice — ERO differences between B6 and D2 mice: ERO energy in the 350–800 ms window — PLI | Significant Group × Tone interaction was observed in the delta and theta bands in the parietal and… |
| 27 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — Effect of tone type on ERO energy and PLI | Fig. 5A–C illustrates a grand mean S-transform time-frequency representation of the rare auditory… |
| 28 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — Effect of tone type on ERO energy and PLI | ms, 50–350 ms and 350–800 ms time windows), theta (0–50 ms and 350–800 ms time windows) and… |
| 29 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — Effect of tone type on ERO energy and PLI | Two-way repeated measures ANOVA with PLI as dependent variable revealed a significant main effect of… |
| 30 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences among HAP-1, LAP-1 and HS/Ibg mice: Baseline activity | No differences were observed in baseline ERO mean energy in the frontal and parietal delta, theta… |
| 31 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 0–50 ms window — ERO Energy | Group × Tone interaction in the delta, theta and alpha/beta bands in the 0 to 50 ms time window… |
| 32 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 0–50 ms window — PLI | Significant Group × Tone interaction was observed in the theta band in the frontal [F(3.3, 80.4) =… |
| 33 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 50–350 ms window — ERO Energy | Group × Tone interaction in the delta and alpha/beta bands were not significant in the frontal and… |
| 34 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 50–350 ms window — PLI | Significant Group × Tone interaction was observed in the delta band in the frontal (Table 4), but… |
| 35 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 350–800 ms window — ERO Energy | Group × Tone interaction in the delta, theta and alpha/beta bands in the 0 to 50 ms time window… |
| 36 | RESULTS — ERO mean energy and phase locking in HAP-1, LAP-1 and HS/Ibg mice — ERO differences between HAP-1, LAP-1 and HS/Ibg mice: ERO energy and PLI in the 350–800 ms window — PLI | Significant Group × Tone interaction was observed in the delta band in the frontal [F(3.0, 73.6) =… |
| 37 | DISCUSSION | Substantial evidence has emerged to suggest that brain oscillations represent neurophysiological… |
| 38 | DISCUSSION | Recent research efforts have focused on studying genes that may regulate EROs associated with… |
| 39 | DISCUSSION — Effects of a passive three-tone auditory ‘oddball’ paradigm on ERO energy and PLI | Several laboratories have provided ample evidence to suggest that ERP components, including a late… |
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