Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.

paper Cited Public

Authors: Criado, J R; Ehlers, C L
Year: 2009
Journal: Neuroscience
PMID: 19540906
DOI: 10.1016/j.neuroscience.2009.06.039
PMCID: PMC2741167

Mouse models have been developed to simulate several relevant human traits associated with alcohol use and dependence. However, the neurophysiological substrates regulating these traits remain to be completely elucidated. We have previously demonstrated that differences in the event-related potential (ERP) responses can be found that distinguish high-alcohol preferring from low alcohol preferring mice that resemble differences seen in human studies of individuals with high and low risk for alcohol dependence. Recently, evidence of genes that affect event-related oscillations (EROs) and the risk for alcohol dependence has emerged, however, to date EROs have not been evaluated in genetic mouse models of high and low alcohol preference. Therefore, the objective of the present study was to characterize EROs in mouse models of high (C57BL/6 [B6] and high alcohol preference 1 [HAP-1] mice) and low (DBA/2J [D2] and low alcohol preference-1 [LAP-1] mice) alcohol preference. A time-frequency representation method was used to determine delta, theta and alpha/beta ERO energy and the degree of phase variation in these mouse models. The present results suggest that the decrease in P3 amplitudes previously shown in B6 mice, compared to D2 mice, is related to reductions in evoked delta ERO energy and delta and theta phase locking. In contrast, the increase in P1 amplitudes reported in HAP-1 mice, compared to LAP-1 mice, is associated with increases in evoked theta ERO energy. These studies suggest that differences in delta and theta ERO measures in mice mirror changes observed between groups at high- and low-risk for alcoholism where changes in EROs were found to be more significant than group differences in P3 amplitudes, further suggesting that ERO measures are more stable endophenotypes in the study of alcohol dependence. Further studies are needed to determine the relationship between expression of these neurophysiological endophenotypes and the genetic profile of these mouse models.

#	Section	Preview
40	DISCUSSION — Effects of a passive three-tone auditory ‘oddball’ paradigm on ERO energy and PLI — B6 and D2 mice	While ERPs have been successfully recorded in a number of animal species the use of ERO technology…
41	DISCUSSION — Effects of a passive three-tone auditory ‘oddball’ paradigm on ERO energy and PLI — B6 and D2 mice	Our previous studies in B6 and D2 mice showed that the mouse P3 and N1 amplitudes were significantly…
42	DISCUSSION — Effects of a passive three-tone auditory ‘oddball’ paradigm on ERO energy and PLI — HAP-1, LAP-1 and HS/Ibg mice	We previously showed that, collapsed across lines, frontal N1a and N1b amplitudes increased as a…
43	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	We previously demonstrated that B6 and D2 strains did not differ in overall EEG amplitudes (Ehlers…
44	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	energy in the 0 to 50 ms time window, in response to standard and rare tones, may mediate the…
45	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	B6 mice also exhibited reduced delta ERO energy in the 50 to 350 ms time window in the parietal…
46	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	Genetic sensitivity to convulsants during alcohol withdrawal has been studied in different mouse…
47	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	The present study did not test whether deficits in GABAergic receptor function are responsible for…
48	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	4 and beta oscillations (Porjesz et al., 2002). Moreover, a GABAA receptor gene encoding the alpha-2…
49	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	B6 mice have been also shown to be less susceptible than D2 mice to the proconvulsant effects of the…
50	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	Previous studies using the taste conditioning procedure have shown that B6 and D2 mice also differ…
51	DISCUSSION — ERO and PLI analyses in B6 and D2 mice	Findings from the present study showed that baseline ERO energy in the frontal alpha/beta band and…
52	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	Studies have shown that while HAP-1 mice consume two to three times more alcohol than LAP-1 mice…
53	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	in the 2–4 Hz and 8–16 Hz EEG bands of the frontal cortex, compared to HAP-1 mice (Slawecki et…
54	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	greater in HAP-1 mice than in LAP-1 and HS/Ibg mice (Slawecki et al., 2003). In contrast, the…
55	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	The amplitude of the P1 component has been associated with increased arousal and attention (Coull,…
56	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	Previous studies have shown behavioral differences between HAP-1 and LAP-1 mice (Grahame et al.,…
57	DISCUSSION — ERO and PLI analyses in HAP-1, LAP-1 and HS/Ibg mice	chromosome 9 near the gene that encodes the dopamine D2 receptor, Drd2 (Bice et al., 2006). More…
58	CONCLUSION	Considerable progress has been made to develop mouse and rat models that simulate several relevant…
59	CONCLUSION	suggest that the increase in P1 amplitudes reported in HAP-1 mice, compared to LAP mice, is…

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In this knowledge base

Title	Year	PMID
Endophenotype best practices.	2017	27473600
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	2015	26236574
Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.	2014	24819672
Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders?	2014	24656843
Ethanol reduces the phase locking of neural activity in human and rodent brain.	2012	22410292
Event-Related Oscillations in Alcoholism Research: A Review.	2012	24273686
Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP).	2010	20598842

External

Title	Authors	Journal	Year	Link
Advancements and Applications of EEG in Gustatory Perception.	Yang L et al.	—	2025	→
Biomarkers and neuromodulation techniques in substance use disorders.	Habelt B et al.	—	2020	→
Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk.	Ehlers CL et al.	—	2020	→
Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents.	Amodeo LR et al.	—	2017	→
Binge drinking affects brain oscillations linked to motor inhibition and execution.	López-Caneda E et al.	—	2017	→
Endophenotype best practices.	Iacono WG et al.	—	2017	→
Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis.	Sanchez-Alavez M et al.	—	2016	→
Review of evoked and event-related delta responses in the human brain.	Güntekin B et al.	—	2016	→
EEG biomarkers of target engagement, therapeutic effect, and disease process.	Featherstone RE et al.	—	2015	→
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	Salvatore JE et al.	—	2015	→
Cholinergic modulation of event-related oscillations (ERO).	Sanchez-Alavez M et al.	—	2014	→
Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.	Ehlers CL et al.	—	2014	→
Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders?	Burwell SJ et al.	—	2014	→
EEG delta oscillations as a correlate of basic homeostatic and motivational processes.	Knyazev GG	—	2012	→
Ethanol reduces the phase locking of neural activity in human and rodent brain.	Ehlers CL et al.	—	2012	→
Event-Related Oscillations in Alcoholism Research: A Review.	Pandey AK et al.	—	2012	→
Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats.	Criado JR et al.	—	2010	→
Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP).	Criado JR et al.	—	2010	→