Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

paper Cited Public

Authors: Pardiñas, Antonio F; Holmans, Peter; Pocklington, Andrew J; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H; McCarroll, Steven A; Baune, Bernhard T; Breen, Gerome; Byrne, Enda M; Dannlowski, Udo; Eley, Thalia C; Hayward, Caroline; Martin, Nicholas G; McIntosh, Andrew M; Plomin, Robert; Porteous, David J; Wray, Naomi R; Caballero, Armando; Geschwind, Daniel H; Huckins, Laura M; Ruderfer, Douglas M; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A; Won, Hyejung; Agerbo, Esben; Als, Thomas D; Andreassen, Ole A; Bækvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bøcker; Børglum, Anders D; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giørtz; Golimbet, Vera; Grove, Jakob; Hougaard, David M; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Søholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; GERAD1 Consortium; CRESTAR Consortium; Collier, David A; Rujescu, Dan; Kirov, George; Owen, Michael J; O'Donovan, Michael C; Walters, James T R
Year: 2018
Journal: Nature genetics
PMID: 29483656
DOI: 10.1038/s41588-018-0059-2
PMCID: PMC5918692

Fig. 1

Manhattan plot of schizophrenia GWAS associationsAssociations are shown from the meta-analysis of CLOZUK and an independent PGC dataset (n = 105,318; 40,675 cases and 64,643 controls). The 145 genome-wide significant loci are highlighted in green. The red horizontal line indicates the genome-wide statistical significance threshold (P = 5×10−8).

LLM interpretation

This is a Manhattan plot showing schizophrenia GWAS associations across 23 chromosomes. The y-axis represents the $-\log_{10}(P)$ value, with a red horizontal line marking the genome-wide significance threshold at $P = 5 \times 10^{-8}$. Numerous significant loci are highlighted in green, with a prominent, high-magnitude peak visible on chromosome 6.

Fig. 2

Partitioned heritability analysis of gene sets in schizophreniaa, Heritability of genomic partitions and the six conditionally independent (‘significant’) gene sets (Table 2). The radius of each segment indicates the degree of enrichment, while the arc (angle of each slice) indicates the percentage of total SNP-based heritability explained. No relative enrichment (enrichment = 1) is shown by the dashed red line (and depletion equates to enrichment <1, inside red line). b, Heritability of the significant CNS gene sets dissected by their overlap with LoF-intolerant genes. Whiskers represent heritability or enrichment standard errors. Asterisks indicate the significance of each heritability enrichment (*P≤0.05, **P≤0.01, ***P≤0.001).

LLM interpretation

This figure presents a partitioned heritability analysis for schizophrenia. Panel **a** is a polar plot where the radius represents heritability enrichment and the arc angle represents the percentage of total SNP-based heritability explained, showing significant enrichment for CNS-related gene sets (blue segments) extending beyond the red dashed line (enrichment = 1). Panel **b** consists of two bar charts comparing the proportion of genic heritability explained and the heritability enrichment across six gene sets, further dissected by their overlap with loss-of-function (LoF) intolerant genes, with significance markers (*P≤0.05 to ***P≤0.001) indicating enrichment levels.

#	Section	Preview
20	Results — Identifying likely candidates within associated loci	To identify SNPs and genes that might be causally linked to the genome-wide significant…
21	Results — Identifying likely candidates within associated loci	through chromosome conformation analysis performed in tissue from the developing brain using Hi-C41…
22	Results — Identifying likely candidates within associated loci	We also applied Summary-data-based Mendelian Randomization (SMR) analysis43 to the data in concert…
23	Results — Identifying likely candidates within associated loci	In total, the combination of FINEMAP, Hi-C and SMR analyses assigned potentially causal genes at 33…
24	Discussion	In the largest genetic study of schizophrenia thus far, we explore the genomic architecture of and…
25	Discussion	Given that mutation intolerance is due to high selection pressure21,23,24, our finding that…
26	Discussion	We did not find enrichment for any measure of positive selection or Neanderthal introgression. A…
27	Methods	Methods, including statements of data availability and any associated accession codes and…
28	Methods — GWAS and reporting of independently associated regions	Details of sample collection and genotype quality control are given in the Supplementary Note. The…
29	Methods — GWAS and reporting of independently associated regions	To identify independent signals among the regression results, signals were amalgamated into putative…
30	Methods — Meta-analysis with PGC	A total of 6,040 cases and 5,719 controls from CLOZUK were included in the recent PGC study5. We…
31	Methods — Replication of new GWAS loci	To validate the association signals from the CLOZUK + PGC meta-analysis, we amalgamated data…
32	Methods — Estimation and assessment of a polygenic signal	Association signals caused by the vast polygenicity underlying complex traits can be hard to…
33	Methods — Estimation and assessment of a polygenic signal	For the CLOZUK + PGC meta-analysis, the LD score intercept was 1.075 ± 0.014 (mean χ2 = 1.960),…
34	Methods — Estimation and assessment of a polygenic signal	The LDSR framework allowed us to compare the genetic architecture of CLOZUK and INDEPENDENT PGC, by…
35	Methods — Estimation and assessment of a polygenic signal	1,160 SNPs with an association P value less than 1 × 10−4 in the INDEPENDENT PGC sample, 82%…
36	Methods — Estimation and assessment of a polygenic signal	We went on to conduct polygenic risk score analysis. Polygenic scores for CLOZUK were generated from…
37	Methods — Estimation and assessment of a polygenic signal	(P < 1 × 10−300, Nagelkerke r2 = 0.12; Supplementary Table 2), confirming the validity of…
38	Methods — Gene set analysis	To assess the enrichment of sets of functionally related genes, we used MAGMA v1.0320 on the CLOZUK…
39	Methods — Gene set analysis	We performed sequential analyses using the following approaches: LoF-intolerant genes. We tested the…

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Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation.	Durairaj P et al.	—	2025	→
Brain region and cell type-specific DNA methylation profiles in association with ADHD.	Meijer M et al.	—	2025	→
Candidate Genetic Markers of Schizophrenia Based on Exome Sequencing Data and Its Relation to Immunological, Clinical, and Morphometric Changes in the Russian Population.	Rastorguev SM et al.	—	2025	→
Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders.	Poggi G et al.	—	2025	→
Characterization of cardiac autonomic dysfunction in acute Schizophrenia: a cluster analysis of heart rate variability parameters.	Refisch A et al.	—	2025	→
Characterizing selection on complex traits through conditional frequency spectra.	Patel RA et al.	—	2025	→
Clozapine's Molecular Signature: Selective 5-HT2A Receptor Downregulation and Signalling in Rat Brain Cortical Regions.	Kedracka-Krok S et al.	—	2025	→
Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell-derived microglia.	Moura S et al.	—	2025	→
Comprehensive transcriptome analysis and lncRNA-miRNA-mRNA establishment of schizophrenia based on induced pluripotent stem cells.	Jia N et al.	—	2025	→
Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression.	Ouellet-Morin I et al.	—	2025	→
Deletion of the Voltage-Gated Calcium Channel Gene, Ca<sub>V</sub>1.3, Reduces Purkinje Cell Dendritic Complexity Without Altering Cerebellar-Mediated Eyeblink Conditioning.	Klomp A et al.	—	2025	→
Dermatoglyphics and schizophrenia: A comprehensive review of neurodevelopmental biomarkers.	Bou Farah E et al.	—	2025	→
Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study.	Lin BD et al.	—	2025	→
Dissecting Schizophrenia Biology Using Pleiotropy With Cognitive Genomics.	Bhattacharyya U et al.	—	2025	→
Dysfunction of cortical GABAergic projection neurons as a major hallmark in a model of neuropsychiatric syndrome.	Asenjo-Martinez A et al.	—	2025	→
Early developmental origins of cortical disorders modeled in human neural stem cells.	Mato-Blanco X et al.	—	2025	→
Early establishment and life course stability of sex biases in the human brain transcriptome.	Benoit-Pilven C et al.	—	2025	→
Exploring the bidirectional causal relationship between Autism Spectrum Disorder and Schizophrenia using Mendelian randomization.	Jiang Z et al.	—	2025	→
Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank.	Lin BD et al.	—	2025	→
Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.	Dang X et al.	—	2025	→
Genome-Wide 5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Analysis of Plasma Cell-Free DNA in Schizophrenia.	Xue G et al.	—	2025	→
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.	Strom NI et al.	—	2025	→
Genome-wide association study unravels mechanisms of brain glymphatic activity.	Huang SY et al.	—	2025	→
GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases.	Li X et al.	—	2025	→
High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes	Yildiz U et al.	—	2025	—
Identification of Schizophrenia-Risk Regulatory Variant rs1399178 in the Non-coding Region With Its Impact on NRF1 Binding.	Ji L et al.	—	2025	→
Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.	Liang Q et al.	—	2025	→
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.	Seah C et al.	—	2025	→
Integrating brain imaging features and genomic profiles for the subtyping of major depression.	Yin L et al.	—	2025	→
Integrating genetic regulation and schizophrenia-specific splicing quantitative expression with GWAS prioritizes novel risk genes for schizophrenia.	Li X et al.	—	2025	→
Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression.	Torok D et al.	—	2025	→
Investigating Connectivity Gradients in Schizophrenia: Integrating Functional, Structural, and Genetic Perspectives.	Xiang J et al.	—	2025	→
Investigating the causal and genetic relationship between migraine and Parkinson's disease.	Deng MG et al.	—	2025	→
Just a SNP away: The future of <i>in vivo</i> massively parallel reporter assay.	Degner KN et al.	—	2025	→
Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain.	De Paoli-Iseppi R et al.	—	2025	→
Lower density of calretinin-immunopositive neurons in the putamen of subjects with schizophrenia.	Kelmer P et al.	—	2025	→
Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics.	Abe H et al.	—	2025	→
Mapping the cellular etiology of schizophrenia and complex brain phenotypes.	Duncan LE et al.	—	2025	→
Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity.	Kosicki M et al.	—	2025	→
Mendelian Randomization Reveals Causalities Between DNA Methylation and Schizophrenia.	Wang D et al.	—	2025	→
Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression.	Crouse JJ et al.	—	2025	→
Molecular Signatures of Schizophrenia and Insights into Potential Biological Convergence.	Saada M et al.	—	2025	→
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.	Bentley AR et al.	—	2025	→
Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.	Rodriguez V et al.	—	2025	→
Polygenic enrichment analysis in multi-omics levels identifies cell/tissue specific associations with schizophrenia based on single-cell RNA sequencing data.	Cheng B et al.	—	2025	→
Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation.	Shen T et al.	—	2025	→
Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications.	Bigdeli TB et al.	—	2025	→
Recommendations for defining treatment outcomes in major psychiatric disorders using real-world data.	Koch E et al.	—	2025	→
Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells.	Kurishev AO et al.	—	2025	→
SCRIPT: Predicting Single-Cell Long-Range Cis-Regulation Based on Pretrained Graph Attention Networks.	Zhang Y et al.	—	2025	→
Seminal Contributions of Timothy J. Crow.	Palaniyappan L et al.	—	2025	→
Shared genetic architecture and causal relationship between frailty and schizophrenia.	Deng MG et al.	—	2025	→
Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis.	Li G et al.	—	2025	→
Sociodemographic Characteristics, Dementia, and Familial Risk in Patients With Paraphrenia: A Danish Register-Based Cohort Study.	Wium-Andersen IK et al.	—	2025	→
Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank.	Kamp M et al.	—	2025	→
Somatic Mosaicism in Brain Disorders.	Corrigan RR et al.	—	2025	→
Structure of a polymorphic repeat at the <i>CACNA1C</i> schizophrenia locus.	Moya R et al.	—	2025	→
TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling.	Ma W et al.	—	2025	→
Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits.	Yan Y et al.	—	2025	→
The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach.	Papassotiropoulos A et al.	—	2025	→
The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes.	Gui Y et al.	—	2025	→
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans.	Byrne RAJ et al.	—	2025	→
The X chromosome's influences on the human brain.	Jiang Z et al.	—	2025	→
Transcriptomic divergence of network hubs in the prenatal human brain.	Oldham S et al.	—	2025	→
Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.	Capatina TF et al.	—	2025	→
Understanding the Emergence of Schizophrenia in the Light of Human Evolution: New Perspectives in Genetics.	Sandroni V et al.	—	2025	→
Whole-exome sequencing analysis identifies risk genes for schizophrenia.	Chick SL et al.	—	2025	→
Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders.	González-Peñas J et al.	—	2024	→
Accurate identification of genes associated with brain disorders by integrating heterogeneous genomic data into a Bayesian framework.	He D et al.	—	2024	→
Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits.	Zhao S et al.	—	2024	→
'Almost nothing is firmly established': A History of Heredity and Genetics in Mental Health Science.	Chaney S et al.	—	2024	→
Altered Rbfox1-Vamp1 pathway and prefrontal cortical dysfunction in schizophrenia.	Chung Y et al.	—	2024	→
An evolutionary perspective on complex neuropsychiatric disease.	McClellan JM et al.	—	2024	→
An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment.	Méndez-Albelo NM et al.	—	2024	→
A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.	Hess JL et al.	—	2024	→
A preliminary metabolomics study of the database for biological samples of schizophrenia among Chinese ethnic minorities.	Ye J et al.	—	2024	→
Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection.	Chen S et al.	—	2024	→
Association of clinical parameters and polygenic risk scores for body mass index, schizophrenia, and diabetes with antipsychotic-induced weight gain.	Franz M et al.	—	2024	→
Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics.	Yap CX et al.	—	2024	→
Breaking down causes, consequences, and mediating effects of telomere length variation on human health.	Moix S et al.	—	2024	→
Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.	Gao Y et al.	—	2024	→
Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment.	Shin M et al.	—	2024	→
Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.	Aranda S et al.	—	2024	→
Copy number variant risk loci for schizophrenia converge on the BDNF pathway.	Ehrhart F et al.	—	2024	→
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.	Bigdeli TB et al.	—	2024	→
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders.	Zhou B et al.	—	2024	→
Discovery of 3-((4-Benzylpyridin-2-yl)amino)benzamides as Potent GPR52 G Protein-Biased Agonists.	Murphy RE et al.	—	2024	→
Discrimination between healthy participants and people with panic disorder based on polygenic scores for psychiatric disorders and for intermediate phenotypes using machine learning.	Ohi K et al.	—	2024	→
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings.	Pauly R et al.	—	2024	→
Enrichment of the Local Synaptic Translatome for Genetic Risk Associated With Schizophrenia and Autism Spectrum Disorder.	Clifton NE et al.	—	2024	→
Ensemble Learning for Higher Diagnostic Precision in Schizophrenia Using Peripheral Blood Gene Expression Profile.	Wagh VV et al.	—	2024	→
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate.	Mack TM et al.	—	2024	→
Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data.	Dai R et al.	—	2024	→
Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits.	Mize TJ et al.	—	2024	→
Exploring the intersection of polygenic risk scores and prenatal alcohol exposure: Unraveling the mental health equation.	Gerlikhman L et al.	—	2024	→
Eye-brain connections revealed by multimodal retinal and brain imaging genetics.	Zhao B et al.	—	2024	→
FMR1 genetically interacts with DISC1 to regulate glutamatergic synaptogenesis.	Honda T et al.	—	2024	→
Functional classes of SNPs related to psychiatric disorders and behavioral traits contrast with those related to neurological disorders.	Reimers MA et al.	—	2024	→
Genetic and Phenotypic Features of Schizophrenia in the UK Biobank.	Legge SE et al.	—	2024	→
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.	Ge YJ et al.	—	2024	→
Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.	Ning C et al.	—	2024	→
Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders.	Kämpe A et al.	—	2024	→
Genetic correlation and causal associations between psychiatric disorders and lung cancer risk.	Shi J et al.	—	2024	→
Genetic effects of sequence-conserved enhancer-like elements on human complex traits.	Zhu X et al.	—	2024	→
Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?	Iakunchykova O et al.	—	2024	→
Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders.	Luo J et al.	—	2024	→
Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis.	Aygün N et al.	—	2024	→
Genome-wide association study and polygenic risk score analysis for schizophrenia in a Korean population.	Lee D et al.	—	2024	→
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.	Morey RA et al.	—	2024	→
Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review.	Santarriaga S et al.	—	2024	→
Identification of important gene signatures in schizophrenia through feature fusion and genetic algorithm.	Chen Z et al.	—	2024	→
Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics.	Dai J et al.	—	2024	→
Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia.	Amerio A et al.	—	2024	→
Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction.	Zhuang Y et al.	—	2024	→
Influence of antipsychotic drugs on microRNA expression in schizophrenia patients - A systematic review.	Xavier G et al.	—	2024	→
Interpretation of SNP combination effects on schizophrenia etiology based on stepwise deep learning with multi-precision data.	Jo Y et al.	—	2024	→
Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types.	Kim SS et al.	—	2024	→
Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.	Jameei H et al.	—	2024	→
Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts.	Gillespie AL et al.	—	2024	→
Meta-analysis of set-based multiple phenotype association test based on GWAS summary statistics from different cohorts.	Zhu L et al.	—	2024	→
Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.	Muhtaseb AW et al.	—	2024	→
Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.	Primak A et al.	—	2024	→
Network propagation for GWAS analysis: a practical guide to leveraging molecular networks for disease gene discovery.	Visonà G et al.	—	2024	→
Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk.	Borcuk C et al.	—	2024	→
NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.	Almodóvar-Payá C et al.	—	2024	→
Orphan GPR52 as an emerging neurotherapeutic target.	Ali S et al.	—	2024	→
Parkinson's disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes.	Karunakaran KB et al.	—	2024	→
Parvalbumin interneuron deficits in schizophrenia.	Marín O	—	2024	→
Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.	Crouse JJ et al.	—	2024	→
Phenotypic and Genetic Associations Between Preschool Fine Motor Skills and Later Neurodevelopment, Psychopathology, and Educational Achievement.	Bowler A et al.	—	2024	→
Predicting cell population-specific gene expression from genomic sequence.	Michielsen L et al.	—	2024	→
Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms.	Aranda S et al.	—	2024	→
Progress in the mechanisms of pain associated with neurodegenerative diseases.	Tian Z et al.	—	2024	→
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes.	Peall KJ et al.	—	2024	→
Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia.	Kappel DB et al.	—	2024	→
Reported race-associated differences in control and schizophrenia post-mortem brain transcriptomes implicate stress-related and neuroimmune pathways.	Simmons S et al.	—	2024	→
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus.	Benjamin KJM et al.	—	2024	→
Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour.	Bosworth ML et al.	—	2024	→
Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions.	Casazza W et al.	—	2024	→
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.	Jiang JC et al.	—	2024	→
SnapHiC-G: identifying long-range enhancer-promoter interactions from single-cell Hi-C data via a global background model.	Liu W et al.	—	2024	→
Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.	Maury EA et al.	—	2024	→
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease.	Miyoshi E et al.	—	2024	→
Stress, Environment and Early Psychosis.	Xenaki LA et al.	—	2024	→
Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study.	Liu Y et al.	—	2024	→
Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder.	Arakelyan A et al.	—	2024	→
The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis.	Wellard NL et al.	—	2024	→
The cliff edge model of the evolution of schizophrenia: Mathematical, epidemiological, and genetic evidence.	Mitteroecker P et al.	—	2024	→
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.	Alameda L et al.	—	2024	→
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease.	Manuello J et al.	—	2024	→
The FXR1 network acts as a signaling scaffold for actomyosin remodeling.	Chen X et al.	—	2024	→
The genetic architecture of substance use and its diverse correlations with mental health traits.	Wormington B et al.	—	2024	→
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders.	Chen SD et al.	—	2024	→
The genetic landscape of basal ganglia and implications for common brain disorders.	Bahrami S et al.	—	2024	→
The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications.	Gillespie B et al.	—	2024	→
The Risk Genes for Neuropsychiatric Disorders <i>negr1</i> and <i>opcml</i> Are Expressed throughout Zebrafish Brain Development.	Habicher J et al.	—	2024	→
The role and molecular mechanisms of the early growth response 3 gene in schizophrenia.	He Q et al.	—	2024	→
The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease.	Clarin JD et al.	—	2024	→
The structure of psychiatric comorbidity without selection and assortative mating.	Ayorech Z et al.	—	2024	→
Transcriptomics : Approaches to Quantifying Gene Expression and Their Application to Studying the Human Brain.	Liharska L et al.	—	2024	→
Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans.	Kamboj S et al.	—	2024	→
Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach.	Zhang C et al.	—	2024	→
xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data.	Luo L et al.	—	2024	→
150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.	Wu Y et al.	—	2023	→
Advances in the pathophysiology of bipolar disorder.	Wartchow KM et al.	—	2023	→
Altered Sphingolipid Hydrolase Activities and Alpha-Synuclein Level in Late-Onset Schizophrenia.	Usenko T et al.	—	2023	→
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders.	Cui Y et al.	—	2023	→
[An analysis of the relationship between genetic factors and the risk of schizophrenia].	Shmakova AA et al.	—	2023	→
Annotating genetic variants to target genes using H-MAGMA.	Sey NYA et al.	—	2023	→
An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder.	da Silva BS et al.	—	2023	→
A rare case of schizophrenia coexistence with antiphospholipid syndrome, β-thalassemia, and monoclonal gammopathy of undetermined significance.	Jin Y et al.	—	2023	→
A resource of induced pluripotent stem cell (iPSC) lines including clinical, genomic, and cellular data from genetically isolated families with mood and psychotic disorders.	Detera-Wadleigh SD et al.	—	2023	→
A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark.	Laugesen K et al.	—	2023	→
Associated Genetics and Connectomic Circuitry in Schizophrenia and Bipolar Disorder.	Wei Y et al.	—	2023	→
Association Between Human Blood Metabolome and the Risk of Psychiatric Disorders.	Jia Y et al.	—	2023	→
Associations between brain gene expression perturbations implicated by COVID-19 and psychiatric disorders.	Gao Y et al.	—	2023	→
Associations of common genetic risk variants of the muscarinic acetylcholine receptor M2 with cardiac autonomic dysfunction in patients with schizophrenia.	Refisch A et al.	—	2023	→
A Systematic Review of the Human Accelerated Regions in Schizophrenia and Related Disorders: Where the Evolutionary and Neurodevelopmental Hypotheses Converge.	Guardiola-Ripoll M et al.	—	2023	→
Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions.	Moreau CA et al.	—	2023	→
Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.	Zhang C et al.	—	2023	→
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.	Hou K et al.	—	2023	→
Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses.	Lee AJ et al.	—	2023	→
Characterization of loss of chromosome Y in peripheral blood cells in male Han Chinese patients with schizophrenia.	Jiang L et al.	—	2023	→
Clinical utility of polygenic risk scores: a critical 2023 appraisal.	Koch S et al.	—	2023	→
Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive Disorder.	Ardesch DJ et al.	—	2023	→
Copy Number Variations in Neuropsychiatric Disorders.	Büki G et al.	—	2023	→
Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls.	Gas C et al.	—	2023	→
Cross species review of the physiological role of D-serine in translationally relevant behaviors.	Arizanovska D et al.	—	2023	→
Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders.	Hindley G et al.	—	2023	→
Cryptic mutations of PLC family members in brain disorders: recent discoveries and a deep-learning-based approach.	Lim KH et al.	—	2023	→
Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics.	Batista-Brito R et al.	—	2023	→
Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.	Falkai P et al.	—	2023	→
DRAGON-Data: a platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts.	Lynham AJ et al.	—	2023	→
Dysfunction of cAMP-Protein Kinase A-Calcium Signaling Axis in Striatal Medium Spiny Neurons: A Role in Schizophrenia and Huntington's Disease Neuropathology.	Fjodorova M et al.	—	2023	→
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Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders.	Koller D et al.	—	2023	→
eQTL colocalization analysis highlights novel susceptibility genes in Autism Spectrum Disorders (ASD).	Dominguez-Alonso S et al.	—	2023	→
Exploratory factor analysis of shared and specific genetic associations in depression and anxiety.	Li C et al.	—	2023	→
Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data.	Quintero Reis A et al.	—	2023	→
Functional connectivity signatures of NMDAR dysfunction in schizophrenia-integrating findings from imaging genetics and pharmaco-fMRI.	Gaebler AJ et al.	—	2023	→
Gene-environment correlations and genetic confounding underlying the association between media use and mental health.	Ayorech Z et al.	—	2023	→
Gene expression profiling of monocytes in recent-onset schizophrenia.	Kübler R et al.	—	2023	→
Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.	Pingault JB et al.	—	2023	→
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.	Hughes DE et al.	—	2023	→
Genetic susceptibility for schizophrenia after adjustment by genetic susceptibility for smoking: implications in identification of risk genes and genetic correlation with related traits.	Al-Soufi L et al.	—	2023	→
Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.	Kember RL et al.	—	2023	→
Genetic variations in DOCK4 contribute to schizophrenia susceptibility in a Chinese cohort: A genetic neuroimaging study.	Xu X et al.	—	2023	→
Genome-scale copy number variant analysis in schizophrenia patients and controls from South India.	Singh M et al.	—	2023	→
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.	Demontis D et al.	—	2023	→
Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa.	Bang L et al.	—	2023	→
Genome-wide association study meta-analysis of suicide death and suicidal behavior.	Li QS et al.	—	2023	→
Genome-wide association study of cerebellar white matter microstructure and genetic overlap with common brain disorders.	Wu BS et al.	—	2023	→
Genome-wide copy number variant screening of Saudi schizophrenia patients reveals larger deletions in cases versus controls.	Abumadini MS et al.	—	2023	→
Genomic findings in schizophrenia and their implications.	Owen MJ et al.	—	2023	→
Genomic insights into schizophrenia.	Owen MJ	—	2023	→
Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores.	Kappel DB et al.	—	2023	→
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.	Zhao B et al.	—	2023	→
Human microglia maturation is underpinned by specific gene regulatory networks.	Han CZ et al.	—	2023	→
Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia.	Guardiola-Ripoll M et al.	—	2023	→
Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study.	Wei W et al.	—	2023	→
Identification of Personality-Related Candidate Genes in Thoroughbred Racehorses Using a Bioinformatics-Based Approach Involving Functionally Annotated Human Genes.	Yokomori T et al.	—	2023	→
Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information.	Gedik H et al.	—	2023	→
Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci.	Alfimova MV et al.	—	2023	→
Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.	Elkrief L et al.	—	2023	→
Inferring cell-type-specific causal gene regulatory networks during human neurogenesis.	Aygün N et al.	—	2023	→
Interhemispheric differences of pyramidal cells in the primary motor cortices of schizophrenia patients investigated postmortem.	Szocsics P et al.	—	2023	→
Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders.	Chen M et al.	—	2023	→
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.	Johnson EC et al.	—	2023	→
Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes.	Wu Y et al.	—	2023	→
Lessons Learned From Parsing Genetic Risk for Schizophrenia Into Biological Pathways.	Pergola G et al.	—	2023	→
Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.	Jung K et al.	—	2023	→
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases.	Reynolds RH et al.	—	2023	→
Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants.	Rummel CK et al.	—	2023	→
Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects.	Ayorech Z et al.	—	2023	→
Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count.	Lock SK et al.	—	2023	→
Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns.	Oliva V et al.	—	2023	→
Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Identifies Novel Risk Genes for Schizophrenia.	Dang X et al.	—	2023	→
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression.	Sokolov AV et al.	—	2023	→
Microglia at the Tripartite Synapse during Postnatal Development: Implications for Autism Spectrum Disorders and Schizophrenia.	Ferrucci L et al.	—	2023	→
Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia.	Win PW et al.	—	2023	→
Modeling psychotic disorders: Environment x environment interaction.	Murlanova K et al.	—	2023	→
Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.	Scammell BH et al.	—	2023	→
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.	Hernandez LM et al.	—	2023	→
Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons.	Zhang S et al.	—	2023	→
Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia.	Medina AM et al.	—	2023	→
Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells.	Hong Y et al.	—	2023	→
Perturbed iron biology in the prefrontal cortex of people with schizophrenia.	Lotan A et al.	—	2023	→
Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study.	Gomez L et al.	—	2023	→
Polygenic risk scores for schizophrenia and treatment resistance: New data, systematic review and meta-analysis.	Facal F et al.	—	2023	→
Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes.	Coors A et al.	—	2023	→
Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents.	Zwicker A et al.	—	2023	→
Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort.	Duncan L et al.	—	2023	→
Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.	Osimo EF et al.	—	2023	→
Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.	Wang B et al.	—	2023	→
Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.	González-Peñas J et al.	—	2023	→
Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system.	Lona-Durazo F et al.	—	2023	→
Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.	Gong W et al.	—	2023	→
Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank.	Roelfs D et al.	—	2023	→
Shared genetics of psychiatric disorders and type 2 diabetes:a large-scale genome-wide cross-trait analysis.	Ding H et al.	—	2023	→
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.	Piwecka M et al.	—	2023	→
Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific <i>cis</i>-regulatory elements.	Anderson AG et al.	—	2023	→
Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders.	Seah C et al.	—	2023	→
Symptom dimensions of major depression in a large community-based cohort.	Wainberg M et al.	—	2023	→
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants.	McAfee JC et al.	—	2023	→
The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases.	Chen Z et al.	—	2023	→
The first genome-wide association study of internet addiction; Revealed substantial shared risk factors with neurodevelopmental psychiatric disorders.	Haghighatfard A et al.	—	2023	→
The functional and evolutionary impacts of human-specific deletions in conserved elements.	Xue JR et al.	—	2023	→
The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders.	Ou YN et al.	—	2023	→
The genetic architecture of human amygdala volumes and their overlap with common brain disorders.	Ou YN et al.	—	2023	→
The genetic architecture of schizophrenia: review of large-scale genetic studies.	Kato H et al.	—	2023	→
The genetic relationships between brain structure and schizophrenia.	Stauffer EM et al.	—	2023	→
The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research.	Nakamura T et al.	—	2023	→
The neural signatures of psychoses in Alzheimer's disease: a neuroimaging genetics approach.	Manca R et al.	—	2023	→
The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia.	Clifton NE et al.	—	2023	→
The relationship between technology addictions and schizotypal traits: mediating roles of depression, anxiety, and stress.	Fekih-Romdhane F et al.	—	2023	→
The Role of IgLON Cell Adhesion Molecules in Neurodegenerative Diseases.	Salluzzo M et al.	—	2023	→
The shared genetic architecture of smoking behaviours and psychiatric disorders: evidence from a population-based longitudinal study in England.	Ajnakina O et al.	—	2023	→
Treatment resistance NMDA receptor pathway polygenic score is associated with brain glutamate in schizophrenia.	Griffiths K et al.	—	2023	→
Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.	Martin E et al.	—	2023	→
Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders.	Malik MA et al.	—	2023	→
Using allele scores to identify confounding by reverse causation: studies of alcohol consumption as an exemplar.	Sallis HM et al.	—	2023	→
Whole transcriptome analysis reveals dysregulation of molecular networks in schizophrenia.	Yang J et al.	—	2023	→
Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.	Zhao X et al.	—	2022	→
A functional neuroimaging association study on the interplay between two schizophrenia genome-wide associated genes (CACNA1C and ZNF804A).	Guardiola-Ripoll M et al.	—	2022	→
A genome-wide association study of outcome from traumatic brain injury.	Kals M et al.	—	2022	→
A Local Genetic Correlation Analysis Provides Biological Insights Into the Shared Genetic Architecture of Psychiatric and Substance Use Phenotypes.	Gerring ZF et al.	—	2022	→
Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.	Zhu MH et al.	—	2022	→
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data.	Zhang CY et al.	—	2022	→
Analysis of <i>CACNA1C</i> and <i>KCNH2</i> Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia.	Refisch A et al.	—	2022	→
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.	Bae T et al.	—	2022	→
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes.	Benjamin KJM et al.	—	2022	→
An association study of the HSPA8 gene polymorphisms with schizophrenia in a Polish population.	Kowalczyk M et al.	—	2022	→
An atlas of genetic correlations between gestational age and common psychiatric disorders.	Yao Y et al.	—	2022	→
Ancestry-inclusive dog genomics challenges popular breed stereotypes.	Morrill K et al.	—	2022	→
Annotating functional effects of non-coding variants in neuropsychiatric cell types by deep transfer learning.	Lai B et al.	—	2022	→
A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution.	Zhu T et al.	—	2022	→
A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.	D'Ambrosio E et al.	—	2022	→
A Polymorphism in the <i>BDNF</i> Gene (rs11030101) is Associated With Negative Symptoms in Chinese Han Patients With Schizophrenia.	Ping J et al.	—	2022	→
Assessment of Bidirectional Relationships between Leisure Sedentary Behaviors and Neuropsychiatric Disorders: A Two-Sample Mendelian Randomization Study.	He Q et al.	—	2022	→
Association analysis of risk genes identified by SCHEMA with schizophrenia in the Chinese Han population.	Guo A et al.	—	2022	→
Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank.	O'Connell KS et al.	—	2022	→
Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort.	Newbury JB et al.	—	2022	→
Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants.	Schilling C et al.	—	2022	→
Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia.	Deng M et al.	—	2022	→
A tool for translating polygenic scores onto the absolute scale using summary statistics.	Pain O et al.	—	2022	→
Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells.	Bhat A et al.	—	2022	→
Bioinformatics and network-based approaches for determining pathways, signature molecules, and drug substances connected to genetic basis of schizophrenia etiology.	Khan U et al.	—	2022	→
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.	Fass DM et al.	—	2022	→
Brain vasculature disturbance in schizophrenia.	Puvogel S et al.	—	2022	→
Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.	Gandal MJ et al.	—	2022	→
Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis.	Chen R et al.	—	2022	→
[Cellular and supracellular models in the study of molecular mechanisms associated with schizophrenia].	Karpov DS et al.	—	2022	→
Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults.	Marchi M et al.	—	2022	→
Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia.	Guardiola-Ripoll M et al.	—	2022	→
Common variants contribute to intrinsic human brain functional networks.	Zhao B et al.	—	2022	→
Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene.	Zhang C et al.	—	2022	→
Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders.	Cabana-Domínguez J et al.	—	2022	→
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease.	Uellendahl-Werth F et al.	—	2022	→
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.	Dubonyte U et al.	—	2022	→
Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells.	Li Z et al.	—	2022	→
Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations.	Koller D et al.	—	2022	→
Deregulation of complement components C4A and CSMD1 peripheral expression in first-episode psychosis and links to cognitive ability.	Hatzimanolis A et al.	—	2022	→
Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network.	Qi S et al.	—	2022	→
Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function.	Clifton NE et al.	—	2022	→
Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.	Chohan MO et al.	—	2022	→
Dissecting the association between psychiatric disorders and neurological proteins: a genetic correlation and two-sample bidirectional Mendelian randomization study.	Huang H et al.	—	2022	→
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.	Birey F et al.	—	2022	→
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.	Mullins N et al.	—	2022	→
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.	Bahrami S et al.	—	2022	→
Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders.	Bahrami S et al.	—	2022	→
Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months.	Riglin L et al.	—	2022	→
Effects of polygenic risk for major mental disorders and cross-disorder on cortical complexity.	Schmitt S et al.	—	2022	→
Emerging evidence for astrocyte dysfunction in schizophrenia.	de Oliveira Figueiredo EC et al.	—	2022	→
Endosomal trafficking in schizophrenia.	Plooster M et al.	—	2022	→
EPIC: Inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing.	Wang R et al.	—	2022	→
Epigenome-wide association study of alcohol use disorder in five brain regions.	Zillich L et al.	—	2022	→
Evaluating brain structure traits as endophenotypes using polygenicity and discoverability.	Matoba N et al.	—	2022	→
Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses.	Perry BI et al.	—	2022	→
Evidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway.	Hettwer MD et al.	—	2022	→
Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective.	Zug R et al.	—	2022	→
Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.	Jones HJ et al.	—	2022	→
Expansion of Schizophrenia Gene Network Knowledge Using Machine Learning Selected Signals From Dorsolateral Prefrontal Cortex and Amygdala RNA-seq Data.	Liu Y et al.	—	2022	→
Exploring Lead loci shared between schizophrenia and Cardiometabolic traits.	He Q et al.	—	2022	→
Expression of actin- and oxidative phosphorylation-related transcripts across the cortical visuospatial working memory network in unaffected comparison and schizophrenia subjects.	Kimoto S et al.	—	2022	→
Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells.	Coleman JRI	—	2022	→
Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development.	Washer SJ et al.	—	2022	→
Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1.	Wang J et al.	—	2022	→
Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.	Abdullah A et al.	—	2022	→
Gene-based association tests using GWAS summary statistics and incorporating eQTL.	Cao X et al.	—	2022	→
Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients.	Rodríguez N et al.	—	2022	→
Gene expression changes following chronic antipsychotic exposure in single cells from mouse striatum.	Abrantes A et al.	—	2022	→
Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis.	Pistis G et al.	—	2022	→
Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank.	Chambers T et al.	—	2022	→
Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder.	Jang SK et al.	—	2022	→
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.	Hautakangas H et al.	—	2022	→
Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci.	Wiström ED et al.	—	2022	→
Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders.	Okhuijsen-Pfeifer C et al.	—	2022	→
Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort.	Yao Y et al.	—	2022	→
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.	Deak JD et al.	—	2022	→
Genome-wide association study of musical beat synchronization demonstrates high polygenicity.	Niarchou M et al.	—	2022	→
Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders.	Gunturkun MH et al.	—	2022	→
Genome-wide identification of the shared genetic basis of cannabis and cigarette smoking and schizophrenia implicates NCAM1 and neuronal abnormality.	Song W et al.	—	2022	→
Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.	Deak JD et al.	—	2022	→
[Genotype - phenotype relationships in view of recent advances in the understanding of genetic causes of schizophrenia].	Golimbet VE et al.	—	2022	→
GSK3β and mTORC1 Represent 2 Distinct Signaling Markers in Peripheral Blood Mononuclear Cells of Drug-Naive, First Episode of Psychosis Patients.	Petrikis P et al.	—	2022	→
How does genetic variation modify ND-CNV phenotypes?	Dinneen TJ et al.	—	2022	→
How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia.	Kasap M et al.	—	2022	→
HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population.	Kowalczyk M et al.	—	2022	→
Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.	Marballi KK et al.	—	2022	→
Identification of potential biomarkers and their correlation with immune infiltration cells in schizophrenia using combinative bioinformatics strategy.	Li Z et al.	—	2022	→
Identification of potential blood biomarkers for early diagnosis of schizophrenia through RNA sequencing analysis.	Li Z et al.	—	2022	→
Identifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies.	Casella AM et al.	—	2022	→
Identifying pleiotropic genes for major psychiatric disorders with GWAS summary statistics using multivariate adaptive association tests.	Wang Y et al.	—	2022	→
Identifying the Common Genetic Basis of Antidepressant Response.	Pain O et al.	—	2022	→
Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex.	Liu S et al.	—	2022	→
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development.	Liu D et al.	—	2022	→
Incorporating regulatory interactions into gene-set analyses for GWAS data: A controlled analysis with the MAGMA tool.	Groenewoud D et al.	—	2022	→
Influences on the Genetic Relationship Between Cannabis Use and Schizophrenia: The Role of the Externalizing Spectrum.	Wormington B et al.	—	2022	→
<i>NRN1</i> Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.	Almodóvar-Payá C et al.	—	2022	→
Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery.	Ji Y et al.	—	2022	→
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.	Pardiñas AF et al.	—	2022	→
Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness.	Luykx JJ et al.	—	2022	→
Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling.	Lim KX et al.	—	2022	→
Joint-Tissue Integrative Analysis Identified Hundreds of Schizophrenia Risk Genes.	Wu Y et al.	—	2022	→
Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia.	Vassos E et al.	—	2022	→
Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia.	Alver M et al.	—	2022	→
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.	Liang W et al.	—	2022	→
Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK biobank.	Bracher-Smith M et al.	—	2022	→
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.	Trubetskoy V et al.	—	2022	→
Maternal immune activation induces methylation changes in schizophrenia genes.	Johnson T et al.	—	2022	→
Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring.	Rasile M et al.	—	2022	→
Mendelian Randomization and GWAS Meta Analysis Revealed the Risk-Increasing Effect of Schizophrenia on Cancers.	Yuan K et al.	—	2022	→
Mendelian randomization study on the effect of tumor necrosis factor on schizophrenia.	Ma N et al.	—	2022	→
MicroRNA binding site variation is enriched in psychiatric disorders.	Geaghan MP et al.	—	2022	→
Motivation and Cognitive Abilities as Mediators Between Polygenic Scores and Psychopathology in Children.	Pat N et al.	—	2022	→
Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits.	Zeng B et al.	—	2022	→
Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain.	Fan CC et al.	—	2022	→
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities.	Mallard TT et al.	—	2022	→
Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes.	Dannemann M et al.	—	2022	→
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.	Hawe JS et al.	—	2022	→
Neurobiology of Psychosis and Schizophrenia 2021: Nottingham Meeting.	Sami MB et al.	—	2022	→
New insights of the role of the KCNH2 gene in schizophrenia: An fMRI case-control study.	Guardiola-Ripoll M et al.	—	2022	→
Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants: Exposome-Wide Analysis and Mendelian Randomization Analysis.	Lin BD et al.	—	2022	→
Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder.	Erady C et al.	—	2022	→
Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review.	Murillo-García N et al.	—	2022	→
Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.	Cullen MBR et al.	—	2022	→
Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.	Kiewa J et al.	—	2022	→
Perinatal iron deficiency as an early risk factor for schizophrenia.	Maxwell AM et al.	—	2022	→
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.	Andreu-Bernabeu Á et al.	—	2022	→
Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.	Restuadi R et al.	—	2022	→
Polygenic scores: prediction versus explanation.	Plomin R et al.	—	2022	→
Potential diagnostic biomarkers for schizophrenia.	Yue W et al.	—	2022	→
Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood.	Rammos A et al.	—	2022	→
Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.	Wainberg M et al.	—	2022	→
Prediction of transition to psychosis from an at-risk mental state using structural neuroimaging, genetic, and environmental data.	Tavares V et al.	—	2022	→
Preliminary studies on apparent mendelian psychotic disorders in consanguineous families.	Kanwal A et al.	—	2022	→
Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated.	Elhaik E	—	2022	→
Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice.	Brown JEH et al.	—	2022	→
Putting Genetics to Work in the Psychiatric Clinic.	McMahon FJ	—	2022	→
Rare copy number variation in posttraumatic stress disorder.	Maihofer AX et al.	—	2022	→
Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression.	Li Y et al.	—	2022	→
Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression.	Li S et al.	—	2022	→
Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes.	Pingault JB et al.	—	2022	→
Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis.	Garcia-Mondragon L et al.	—	2022	→
Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth.	Birmaher B et al.	—	2022	→
scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies.	Jia P et al.	—	2022	→
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk.	McKinney BC et al.	—	2022	→
Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.	Woolway GE et al.	—	2022	→
Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer's Disease.	Zheng D et al.	—	2022	→
Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2.	Pass R et al.	—	2022	→
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.	Blokland GAM et al.	—	2022	→
Shared genetic influences on resting-state functional networks of the brain.	P O F T Guimarães J et al.	—	2022	→
Stratification of individuals with lifetime depression and low wellbeing in the UK Biobank.	Fabbri C et al.	—	2022	→
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.	Larivière S et al.	—	2022	→
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types.	Wen J et al.	—	2022	→
Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders.	Akingbuwa WA et al.	—	2022	→
Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells.	Zhang W et al.	—	2022	→
Ten challenges for clinical translation in psychiatric genetics.	Derks EM et al.	—	2022	→
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.	Nehme R et al.	—	2022	→
The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes.	Mitchell BL et al.	—	2022	→
The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders.	Alkelai A et al.	—	2022	→
The consequences of a year of the COVID-19 pandemic for the mental health of young adult twins in England and Wales.	Rimfeld K et al.	—	2022	→
The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study.	Yu J et al.	—	2022	→
The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study.	Song J et al.	—	2022	→
The Latent Structure of Negative Symptoms in the General Population in Adolescence and Emerging Adulthood.	Havers L et al.	—	2022	→
The nature of schizophrenia: As broad as it is long.	Owen MJ et al.	—	2022	→
The next 10 years of behavioural genomic research.	Plomin R	—	2022	→
The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.	Paternoster V et al.	—	2022	→
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density.	Li S et al.	—	2022	→
The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.	Hindley G et al.	—	2022	→
Thirteen Independent Genetic Loci Associated with Preserved Processing Speed in a Study of Cognitive Resilience in 330,097 Individuals in the UK Biobank.	Fitzgerald J et al.	—	2022	→
Three legs of the missing heritability problem.	Matthews LJ et al.	—	2022	→
Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics.	Leng K et al.	—	2022	→
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.	Sanders B et al.	—	2022	→
Treatment Response and GWAS Risk Allele rs2514218 (C) of the Dopamine D2 Receptor Gene in Inpatients with Schizophrenia.	Morozova MA et al.	—	2022	→
TVAR: assessing tissue-specific functional effects of non-coding variants with deep learning.	Yang H et al.	—	2022	→
Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia.	Akingbuwa WA et al.	—	2022	→
Ultrarare Coding Variants and Cognitive Function in Schizophrenia-Unraveling the Enduring Mysteries of Neuropsychiatric Genetics.	Braff DL et al.	—	2022	→
Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank.	Cresswell M et al.	—	2022	→
Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization.	Liu W et al.	—	2022	→
Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia.	Arnsten AFT et al.	—	2022	→
Upper cortical layer-driven network impairment in schizophrenia.	Batiuk MY et al.	—	2022	→
Using DNA to predict behaviour problems from preschool to adulthood.	Gidziela A et al.	—	2022	→
Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment.	Harper J et al.	—	2022	→
Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain Disease.	Brennand KJ	—	2022	→
Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype.	Shaqiri A et al.	—	2022	→
A candidate biological network formed by genes from genomic and hypothesis-free scans of suicide.	Sokolowski M et al.	—	2021	→
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.	Ni G et al.	—	2021	→
A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders.	Song W et al.	—	2021	→
A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disorders.	Doostparast Torshizi A et al.	—	2021	→
Adolescent cannabis use and adult psychoticism: A longitudinal co-twin control analysis using data from two cohorts.	Schaefer JD et al.	—	2021	→
A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia.	Levchenko A et al.	—	2021	→
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.	Szabo A et al.	—	2021	→
Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function.	Vanderplow AM et al.	—	2021	→
Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function.	Li Q et al.	—	2021	→
A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.	Gassó P et al.	—	2021	→
Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects.	Ohi K et al.	—	2021	→
A machine learning case-control classifier for schizophrenia based on DNA methylation in blood.	Gunasekara CJ et al.	—	2021	→
A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression.	Li Y et al.	—	2021	→
Analysis framework and experimental design for evaluating synergy-driving gene expression.	Schrode N et al.	—	2021	→
Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.	Rao S et al.	—	2021	→
Analysis of whole exome sequencing in severe mental illness hints at selection of brain development and immune related genes.	Mahadevan J et al.	—	2021	→
A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia.	De Berardis D et al.	—	2021	→
An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt.	Russell AE et al.	—	2021	→
A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia.	Mahmood T et al.	—	2021	→
Are psychiatric disorders risk factors for COVID-19 susceptibility and severity? a two-sample, bidirectional, univariable, and multivariable Mendelian Randomization study.	Luykx JJ et al.	—	2021	→
A selection pressure landscape for 870 human polygenic traits.	Song W et al.	—	2021	→
Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia.	Fu Y et al.	—	2021	→
Association Between Genetic Risk for Psychiatric Disorders and the Probability of Living in Urban Settings.	Maxwell JM et al.	—	2021	→
Association between Human Genetic Variants and the Vaginal Bacteriome of Pregnant Women.	Fan W et al.	—	2021	→
Association Between Physical Activity and Schizophrenia: Results of a 2-Sample Mendelian Randomization Analysis.	Papiol S et al.	—	2021	→
Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study.	Chauquet S et al.	—	2021	→
Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study.	Perry BI et al.	—	2021	→
Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results.	Nolasco-Rosales GA et al.	—	2021	→
Association Study of Polymorphisms in Neuronal Nicotinic Acetylcholine Receptor Subunit Genes With Schizophrenia in the Han Chinese Population.	Li YY et al.	—	2021	→
Astrocyte Bioenergetics and Major Psychiatric Disorders.	Maly IV et al.	—	2021	→
A systematic review of gene-by-intervention studies of alcohol and other substance use.	Neale ZE et al.	—	2021	→
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.	Kim M et al.	—	2021	→
Brain regionalization by Polycomb-group proteins and chromatin accessibility.	Eto H et al.	—	2021	→
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.	Aygün N et al.	—	2021	→
Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank.	Wainberg M et al.	—	2021	→
Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants.	Ng B et al.	—	2021	→
Case Report: The Emerging Role of Ring Chromosome 22 in Phelan-McDermid Syndrome With Atypical Teratoid/Rhabdoid Tumor: The First Child Treated With Growth Hormone.	Crocco M et al.	—	2021	→
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.	Liang D et al.	—	2021	→
Cell-Type-Specific Gene Modules Related to the Regional Homogeneity of Spontaneous Brain Activity and Their Associations With Common Brain Disorders.	Shen J et al.	—	2021	→
Cellular Models in Schizophrenia Research.	Abashkin DA et al.	—	2021	→
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations.	Panyard DJ et al.	—	2021	→
Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking.	Hindley G et al.	—	2021	→
Characterizing the effect of background selection on the polygenicity of brain-related traits.	Wendt FR et al.	—	2021	→
Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism.	Warrier V et al.	—	2021	→
Chromatin interactions in differentiating keratinocytes reveal novel atopic dermatitis- and psoriasis-associated genes.	Sahlén P et al.	—	2021	→
Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders.	Hall LS et al.	—	2021	→
Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia.	Willcocks IR et al.	—	2021	→
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.	Hartl CL et al.	—	2021	→
Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain.	Muntané G et al.	—	2021	→
Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia.	Zahova SK et al.	—	2021	→
Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.	Yousefi S et al.	—	2021	→
Contribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation.	Orri M et al.	—	2021	→
Convergence and Divergence in the Genetics of Psychiatric Disorders From Pathways to Developmental Stages.	Shohat S et al.	—	2021	→
Convergent lines of evidence support <i>NOTCH4</i> as a schizophrenia risk gene.	Zhang Y et al.	—	2021	→
Cortical cellular diversity and development in schizophrenia.	Price AJ et al.	—	2021	→
Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.	Murray GK et al.	—	2021	→
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived <i>NRXN1</i>-mutant neurons.	Pak C et al.	—	2021	→
Current findings and perspectives on aberrant neural oscillations in schizophrenia.	Hirano Y et al.	—	2021	→
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders.	Akula N et al.	—	2021	→
De novo variation in bipolar disorder.	Goes FS et al.	—	2021	→
Detecting local genetic correlations with scan statistics.	Guo H et al.	—	2021	→
Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes.	Priol AC et al.	—	2021	→
Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity.	Clifton NE et al.	—	2021	→
Discriminating bipolar depression from major depressive disorder with polygenic risk scores.	Liebers DT et al.	—	2021	→
Dissecting autism and schizophrenia through neuroimaging genomics.	Moreau CA et al.	—	2021	→
Distinct effect of prenatal and postnatal brain expression across 20 brain disorders and anthropometric social traits: a systematic study of spatiotemporal modularity.	Jia P et al.	—	2021	→
Distinct genetic patterns of shared and unique genes across four neurodevelopmental disorders.	Zhang Y et al.	—	2021	→
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.	Ahanger SH et al.	—	2021	→
DNA methylation differences in cortical grey and white matter in schizophrenia.	Berdenis van Berlekom A et al.	—	2021	→
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia.	Hannon E et al.	—	2021	→
Downregulation by CNNM2 of ATP5MD expression in the 10q24.32 schizophrenia-associated locus involved in impaired ATP production and neurodevelopment.	Wang Z et al.	—	2021	→
Effect of selection bias on two sample summary data based Mendelian randomization.	Wang K et al.	—	2021	→
Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank.	Caseras X et al.	—	2021	→
E-MAGMA: an eQTL-informed method to identify risk genes using genome-wide association study summary statistics.	Gerring ZF et al.	—	2021	→
Epigenetic Age Acceleration Was Delayed in Schizophrenia.	Wu X et al.	—	2021	→
Ethnicity-dependent effects of Zinc finger 804A variant on schizophrenia: a systematic review and meta-analysis.	Wang D et al.	—	2021	→
Examining the Causal Inference of Leptin and Soluble Plasma Leptin Receptor Levels on Schizophrenia: A Mendelian Randomization Study.	Chen G et al.	—	2021	→
Exploring the Diverse Functional and Regulatory Consequences of Alternative Splicing in Development and Disease.	Titus MB et al.	—	2021	→
Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing.	Leung SK et al.	—	2021	→
Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness.	Bonneau M et al.	—	2021	→
Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus.	Chang H et al.	—	2021	→
Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis.	Li S et al.	—	2021	→
FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors.	Shen M et al.	—	2021	→
Gene-expression correlates of the oscillatory signatures supporting human episodic memory encoding.	Berto S et al.	—	2021	→
Generation of Neural Stem Cells from Pluripotent Stem Cells for Characterization of Early Neuronal Development.	Jung M et al.	—	2021	→
Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons.	Cosgrove D et al.	—	2021	→
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts.	Fabbri C et al.	—	2021	→
Genetic architecture of schizophrenia: a review of major advancements.	Legge SE et al.	—	2021	→
Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.	Cheng W et al.	—	2021	→
Genetic association of FMRP targets with psychiatric disorders.	Clifton NE et al.	—	2021	→
Genetic contributions to bipolar disorder: current status and future directions.	O'Connell KS et al.	—	2021	→
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.	Cleynen I et al.	—	2021	→
Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.	Sallis HM et al.	—	2021	→
Genetic overlap and causal associations between smoking behaviours and mental health.	Barkhuizen W et al.	—	2021	→
Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk.	Dimitriadis SI et al.	—	2021	→
Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene.	Gonda X et al.	—	2021	→
Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis.	Hederih J et al.	—	2021	→
Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium.	Peterson RE et al.	—	2021	→
Genome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese.	Shen L et al.	—	2021	→
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.	DeMichele-Sweet MAA et al.	—	2021	→
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans.	Bigdeli TB et al.	—	2021	→
Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia.	Liu J et al.	—	2021	→
Genome wide association study identifies four loci for early onset schizophrenia.	Guo S et al.	—	2021	→
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.	Mullins N et al.	—	2021	→
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.	Clements CC et al.	—	2021	→
Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk.	Park CY et al.	—	2021	→
Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk.	Perzel Mandell KA et al.	—	2021	→
Genomic perspectives on the circadian clock hypothesis of psychiatric disorders.	von Schantz M et al.	—	2021	→
Grey and white matter microstructure is associated with polygenic risk for schizophrenia.	Stauffer EM et al.	—	2021	→
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.	Wu Y et al.	—	2021	→
Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms.	Haan N et al.	—	2021	→
Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection.	Novo I et al.	—	2021	→
Human genetic analyses of organelles highlight the nucleus in age-related trait heritability.	Gupta R et al.	—	2021	→
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.	Chen Z et al.	—	2021	→
Identification of a Risk Locus at 7p22.3 for Schizophrenia and Bipolar Disorder in East Asian Populations.	Li W et al.	—	2021	→
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.	Kia DA et al.	—	2021	→
Identification of pleiotropy at the gene level between psychiatric disorders and related traits.	Polushina T et al.	—	2021	→
Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning.	Pelin H et al.	—	2021	→
Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS.	Peyrot WJ et al.	—	2021	→
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia.	Corsi-Zuelli F et al.	—	2021	→
Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors.	Chen W et al.	—	2021	→
Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.	Paternoster V et al.	—	2021	→
Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.	Li W et al.	—	2021	→
Infections, antibiotic treatment and the Microbiome in relation to schizophrenia.	Klein-Petersen AW et al.	—	2021	→
Inflammation and JNK's Role in Niacin-GPR109A Diminished Flushed Effect in Microglial and Neuronal Cells With Relevance to Schizophrenia.	Ansarey SH	—	2021	→
Inherited L1 Retrotransposon Insertions Associated With Risk for Schizophrenia and Bipolar Disorder.	Reiner BC et al.	—	2021	→
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease.	Volpato V	—	2021	→
Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates.	Konuma T et al.	—	2021	→
Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene.	Wang JY et al.	—	2021	→
Integrative Analysis Identified Key Schizophrenia Risk Factors from an Abnormal Behavior Mouse Gene Set.	Chen M et al.	—	2021	→
Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.	Yao X et al.	—	2021	→
Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease.	Gerring ZF et al.	—	2021	→
Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?	Riglin L et al.	—	2021	→
Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.	Jia X et al.	—	2021	→
Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa.	Adams DM et al.	—	2021	→
Is there a shared genetic basis and causal relationship between polycystic ovary syndrome and psychiatric disorders: evidence from a comprehensive genetic analysis.	Jiang X et al.	—	2021	→
KALRN: A central regulator of synaptic function and synaptopathies.	Parnell E et al.	—	2021	→
Limited Association between Schizophrenia Genetic Risk Factors and Transcriptomic Features.	Yu AW et al.	—	2021	→
Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia.	Kim MH et al.	—	2021	→
<i>SCFD1</i> expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed.	Iacoangeli A et al.	—	2021	→
Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters.	Liu Y et al.	—	2021	→
Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.	Mulvey B et al.	—	2021	→
Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder.	Yang H et al.	—	2021	→
Meta-Analysis of Brain Gene Expression Data from Mouse Model Studies of Maternal Immune Activation Using Poly(I:C).	Laighneach A et al.	—	2021	→
Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls.	Corley E et al.	—	2021	→
Molecular characterization of the stress network in individuals at risk for schizophrenia.	Meijer M et al.	—	2021	→
Molecular signaling pathways underlying schizophrenia.	Tiihonen J et al.	—	2021	→
Multi-omics analyses of cognitive traits and psychiatric disorders highlights brain-dependent mechanisms.	Korologou-Linden R et al.	—	2021	→
Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis.	Gregory MD et al.	—	2021	→
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.	Hu B et al.	—	2021	→
Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction.	León A et al.	—	2021	→
Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.	Tigaret CM et al.	—	2021	→
nMAGMA: a network-enhanced method for inferring risk genes from GWAS summary statistics and its application to schizophrenia.	Yang A et al.	—	2021	→
Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals: A Genome-Wide Association Study and Meta-analysis.	Li HJ et al.	—	2021	→
Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.	Lencz T et al.	—	2021	→
Obstetric Complications and Polygenic Risk Score: Which Role in Predicting a Severe Short-Term Outcome in Psychosis?	Tosato S et al.	—	2021	→
Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome.	Powell SK et al.	—	2021	→
Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities.	Silberstein M et al.	—	2021	→
Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review.	Wagh VV et al.	—	2021	→
Phenotypically independent profiles relevant to mental health are genetically correlated.	Roelfs D et al.	—	2021	→
Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.	Lee PH et al.	—	2021	→
Polygenic risk scores differentiate schizophrenia patients with toxoplasma gondii compared to toxoplasma seronegative patients.	Lori A et al.	—	2021	→
Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study.	Ohi K et al.	—	2021	→
Population-specific causal disease effect sizes in functionally important regions impacted by selection.	Shi H et al.	—	2021	→
Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores.	Di Florio A et al.	—	2021	→
Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes.	Ma S et al.	—	2021	→
Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations.	Pei G et al.	—	2021	→
Prioritization of disease genes from GWAS using ensemble-based positive-unlabeled learning.	Kolosov N et al.	—	2021	→
Prioritization of schizophrenia risk genes from GWAS results by integrating multi-omics data.	He D et al.	—	2021	→
Probability of Alzheimer's disease based on common and rare genetic variants.	Escott-Price V et al.	—	2021	→
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia.	Dobrindt K et al.	—	2021	→
Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia.	Hubbard L et al.	—	2021	→
Rare germline variants in individuals diagnosed with schizophrenia within multiplex families.	Li S et al.	—	2021	→
Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families.	Fatima A et al.	—	2021	→
RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes.	Brownstein CA et al.	—	2021	→
Revisiting Schizophrenia from an Evolutionary Perspective: An Association Study of Recent Evolutionary Markers and Schizophrenia.	Bhattacharyya U et al.	—	2021	→
SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes.	Feurle P et al.	—	2021	→
scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks.	Jin T et al.	—	2021	→
Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults.	Bartsch U et al.	—	2021	→
Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons.	Plooster M et al.	—	2021	→
Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning.	Crouse JJ et al.	—	2021	→
Schizophrenia risk alleles often affect the expression of many genes and each gene may have a different effect on the risk: A mediation analysis.	Peng X et al.	—	2021	→
Shaping the Trans-Scale Properties of Schizophrenia <i>via</i> Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions.	Zhao SW et al.	—	2021	→
Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.	Ohi K et al.	—	2021	→
Single-cell epigenomics reveals mechanisms of human cortical development.	Ziffra RS et al.	—	2021	→
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease.	Morabito S et al.	—	2021	→
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain.	Tran MN et al.	—	2021	→
SnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data.	Yu M et al.	—	2021	→
SNX29, a new susceptibility gene shared with major mental disorders in Han Chinese population.	Chen JH et al.	—	2021	→
Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.	Ren H et al.	—	2021	→
Spatiotemporal 22q11.21 Protein Network Implicates DGCR8-Dependent MicroRNA Biogenesis as a Risk for Late-Fetal Cortical Development in Psychiatric Diseases.	Chen L et al.	—	2021	→
Spatiotemporal 7q11.23 protein network analysis implicates the role of DNA repair pathway during human brain development.	Chen L et al.	—	2021	→
Studying the virome in psychiatric disease.	Yolken RH et al.	—	2021	→
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits.	Zhang Y et al.	—	2021	→
Synaptic processes and immune-related pathways implicated in Tourette syndrome.	Tsetsos F et al.	—	2021	→
Systematic discovery of signaling pathways linking immune activation to schizophrenia.	Gao Y et al.	—	2021	→
Targeting synaptic plasticity in schizophrenia: insights from genomic studies.	Mould AW et al.	—	2021	→
The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study.	Huang P et al.	—	2021	→
The contribution of X-linked coding variation to severe developmental disorders.	Martin HC et al.	—	2021	→
The impact of parenting a child with serious mental illness: Accounting for the parent's genetic vulnerability to mental illness.	Greenberg J et al.	—	2021	→
The MIR137 VNTR rs58335419 Is Associated With Cognitive Impairment in Schizophrenia and Altered Cortical Morphology.	Mahmoudi E et al.	—	2021	→
The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons.	Lee D et al.	—	2021	→
The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study.	Perry BI et al.	—	2021	→
The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls.	Jansen AG et al.	—	2021	→
The state of the science in psychiatric genomics.	Sullivan PF et al.	—	2021	→
Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment.	Lisoway AJ et al.	—	2021	→
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.	Maynard KR et al.	—	2021	→
Transcriptome-wide association study identifies new susceptibility genes and pathways for depression.	Li X et al.	—	2021	→
Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety.	Su X et al.	—	2021	→
Transcriptome-wide association study reveals two genes that influence mismatch negativity.	Bhat A et al.	—	2021	→
Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.	Hernandez LM et al.	—	2021	→
Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations.	Gordon A et al.	—	2021	→
Unveiling the Pathogenesis of Psychiatric Disorders Using Network Models.	Zuo Y et al.	—	2021	→
Variations and expression features of CYP2D6 contribute to schizophrenia risk.	Ma L et al.	—	2021	→
Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population.	Zhang L et al.	—	2021	→
What Have We Learned About the Genetics of Obsessive-Compulsive and Related Disorders in Recent Years?	Mattheisen M et al.	—	2021	→
A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons.	Espeso-Gil S et al.	—	2020	→
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.	Sey NYA et al.	—	2020	→
Age dependent association of inbreeding with risk for schizophrenia in Egypt.	McClain L et al.	—	2020	→
A large-scale genome-wide association study meta-analysis of cannabis use disorder.	Johnson EC et al.	—	2020	→
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.	Flynn M et al.	—	2020	→
A modified protocol of Capture-C allows affordable and flexible high-resolution promoter interactome analysis.	Golov AK et al.	—	2020	→
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain.	Schmidt-Kastner R et al.	—	2020	→
An Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings: The PsyCourse Study.	Dwyer DB et al.	—	2020	→
A powerful fine-mapping method for transcriptome-wide association studies.	Wu C et al.	—	2020	→
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.	Zimmerman AJ et al.	—	2020	→
A randomised clinical trial of methotrexate points to possible efficacy and adaptive immune dysfunction in psychosis.	Chaudhry IB et al.	—	2020	→
Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects.	Punchaichira TJ et al.	—	2020	→
Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls.	Lyngstad SH et al.	—	2020	→
A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.	Habtewold TD et al.	—	2020	→
A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia.	Hall LS et al.	—	2020	→
Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.	Li X et al.	—	2020	→
Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli.	Moon AL et al.	—	2020	→
Cell-type-specific 3D epigenomes in the developing human cortex.	Song M et al.	—	2020	→
Cell Type-Specific Annotation and Fine Mapping of Variants Associated With Brain Disorders.	Doostparast Torshizi A et al.	—	2020	→
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes.	Torshizi AD et al.	—	2020	→
Clinical indicators of treatment-resistant psychosis.	Legge SE et al.	—	2020	→
Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders.	Jia Z et al.	—	2020	→
Cognitive Genomics: Recent Advances and Current Challenges.	Fitzgerald J et al.	—	2020	→
Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism.	Matoba N et al.	—	2020	→
Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.	Spies M et al.	—	2020	→
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Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics.	Koromina M et al.	—	2020	→
De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia.	Rees E et al.	—	2020	→
Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning.	Arbab M et al.	—	2020	→
Disrupted Sleep and Circadian Rhythms in Schizophrenia and Their Interaction With Dopamine Signaling.	Ashton A et al.	—	2020	→
Distinct subnetworks of the thalamic reticular nucleus.	Li Y et al.	—	2020	→
Do AKT1, COMT and FAAH influence reports of acute cannabis intoxication experiences in patients with first episode psychosis, controls and young adult cannabis users?	Hindocha C et al.	—	2020	→
Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?	Marsman A et al.	—	2020	→
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.	Mencacci NE et al.	—	2020	→
Effects of complement gene-set polygenic risk score on brain volume and cortical measures in patients with psychotic disorders and healthy controls.	Holland JF et al.	—	2020	→
Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers.	Khavari B et al.	—	2020	→
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.	Wootton RE et al.	—	2020	→
Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.	Adorjan I et al.	—	2020	→
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.	Pries LK et al.	—	2020	→
Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization.	Wang K et al.	—	2020	→
Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study.	Tunset ME et al.	—	2020	→
FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability.	Clifton NE et al.	—	2020	→
Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders.	Hoffmann A et al.	—	2020	→
Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease.	Wamsley B et al.	—	2020	→
Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.	Li HJ et al.	—	2020	→
Genes regulated by BCL11B during T-cell development are enriched for de novo mutations found in schizophrenia patients.	Fahey L et al.	—	2020	→
Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament.	Costilla R et al.	—	2020	→
Genetic feedback for psychiatric conditions: Where are we now and where are we going.	Driver MN et al.	—	2020	→
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.	Bryois J et al.	—	2020	→
Genetic Intersections of Language and Neuropsychiatric Conditions.	Koomar T et al.	—	2020	→
Genetic liability in individuals at ultra-high risk of psychosis: A comparison study of 9 psychiatric traits.	Lim K et al.	—	2020	→
Genetic variability of serotonin pathway associated with schizophrenia onset, progression, and treatment.	Hrovatin K et al.	—	2020	→
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.	Revez JA et al.	—	2020	→
Genome-wide Association Study of Creativity Reveals Genetic Overlap With Psychiatric Disorders, Risk Tolerance, and Risky Behaviors.	Li H et al.	—	2020	→
Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.	Docherty AR et al.	—	2020	→
Genome-Wide Search for SNP Interactions in GWAS Data: Algorithm, Feasibility, Replication Using Schizophrenia Datasets.	Lee KY et al.	—	2020	→
Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples.	Esteller-Cucala P et al.	—	2020	→
Genomic Chaos Begets Psychiatric Disorder.	Dwyer DS	—	2020	→
Genomics at cellular resolution: insights into cognitive disorders and their evolution.	Berto S et al.	—	2020	→
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective.	Wendt FR et al.	—	2020	→
Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci.	Liu W et al.	—	2020	→
Identification of a functional SNP rs7304782 at schizophrenia risk locus 12q24.31 and validation of its association with schiz ophrenia in Chinese populations.	Ma C et al.	—	2020	→
Identification of rare and common variants in BNIP3L: a schizophrenia susceptibility gene.	Zhou J et al.	—	2020	→
Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study.	Kendall KM et al.	—	2020	→
Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia.	Halvorsen M et al.	—	2020	→
Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems.	Rehbach K et al.	—	2020	→
Integration analysis of methylation quantitative trait loci and GWAS identify three schizophrenia risk variants.	Yu H et al.	—	2020	→
Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics.	Matos MR et al.	—	2020	→
Integration of GWAS Summary Statistics and Gene Expression Reveals Target Cell Types Underlying Kidney Function Traits.	Li Y et al.	—	2020	→
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease.	Morabito S et al.	—	2020	→
Integrative In Silico Analysis of Genome-Wide DNA Methylation Profiles in Schizophrenia.	Forero DA et al.	—	2020	→
Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.	Warre-Cornish K et al.	—	2020	→
Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.	Powell SK et al.	—	2020	→
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.	Sieberts SK et al.	—	2020	→
Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophrenia.	Hook PW et al.	—	2020	→
Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability.	Cattaneo A et al.	—	2020	→
Loss-of-function Mutations of CUL3, a High Confidence Gene for Psychiatric Disorders, Lead to Aberrant Neurodevelopment In Human Induced Pluripotent Stem Cells.	Fischer S et al.	—	2020	→
Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.	Vawter MP et al.	—	2020	→
Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders.	Bach S et al.	—	2020	→
Modeling Psychiatric Disorder Biology with Stem Cells.	Das D et al.	—	2020	→
Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4.	Badowska DM et al.	—	2020	→
Molecular mechanisms of psychiatric diseases.	Blokhin IO et al.	—	2020	→
Multiparametric Assays for Accelerating Early Drug Discovery.	Herholt A et al.	—	2020	→
Multivariable G-E interplay in the prediction of educational achievement.	Allegrini AG et al.	—	2020	→
NetCore: a network propagation approach using node coreness.	Barel G et al.	—	2020	→
Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders.	Shi L et al.	—	2020	→
Neurocognitive and neurophysiological endophenotypes in schizophrenia: An overview.	Donati FL et al.	—	2020	→
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.	Khan TA et al.	—	2020	→
No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.	Yao Y et al.	—	2020	→
Novel Approaches for Identifying the Molecular Background of Schizophrenia.	Golov AK et al.	—	2020	→
On the diagnostic and neurobiological origins of bipolar disorder.	Charney AW et al.	—	2020	→
Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia.	Shaw AD et al.	—	2020	→
Overdispersed gene expression in schizophrenia.	Huang G et al.	—	2020	→
Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders.	Khavari B et al.	—	2020	→
Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations.	Reay WR et al.	—	2020	→
Peripheral Blood Leukocyte RNA-Seq Identifies a Set of Genes Related to Abnormal Psychomotor Behavior Characteristics in Patients with Schizophrenia.	Zhang Y et al.	—	2020	→
Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives, and Healthy Participants.	Ohi K et al.	—	2020	→
Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.	Pries LK et al.	—	2020	→
Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort.	Grama S et al.	—	2020	→
Polygenic risk scores for late smoking initiation associated with the risk of schizophrenia.	Ohi K et al.	—	2020	→
Polygenic Scores in Developmental Psychology: Invite Genetics In, Leave Biodeterminism Behind.	Raffington L et al.	—	2020	→
Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia.	Singh SM et al.	—	2020	→
Prenatal Origins of ASD: The When, What, and How of ASD Development.	Courchesne E et al.	—	2020	→
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.	Jaffe AE et al.	—	2020	→
Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex.	Pishva E et al.	—	2020	→
PsyCoP - A Platform for Systematic Semi-Automated Behavioral and Cognitive Profiling Reveals Gene and Environment Dependent Impairments of Tcf4 Transgenic Mice Subjected to Social Defeat.	Volkmann P et al.	—	2020	→
Quantifying genetic effects on disease mediated by assayed gene expression levels.	Yao DW et al.	—	2020	→
Rare and common variants analysis of the EMB gene in patients with schizophrenia.	Zhou J et al.	—	2020	→
Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.	Rajkumar AP et al.	—	2020	→
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.	Guelfi S et al.	—	2020	→
Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.	Montagnese M et al.	—	2020	→
[Structure of schizotypal traits in the Russian population].	Alfimova MV et al.	—	2020	→
SZDB2.0: an updated comprehensive resource for schizophrenia research.	Wu Y et al.	—	2020	→
Telomere length and human hippocampal neurogenesis.	Palmos AB et al.	—	2020	→
The Genetic Control of Stoichiometry Underlying Autism.	Darnell RB	—	2020	→
The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine.	Yang Z et al.	—	2020	→
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders.	Denomme MM et al.	—	2020	→
The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.	Smeland OB et al.	—	2020	→
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia.	Richards AL et al.	—	2020	→
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases.	Flaherty E et al.	—	2020	→
The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study.	Peters T et al.	—	2020	→
The role of the retinoids in schizophrenia: genomic and clinical perspectives.	Reay WR et al.	—	2020	→
Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes.	Etemadikhah M et al.	—	2020	→
Transcriptome-wide association analysis offers novel opportunities for clinical translation of genetic discoveries on mental disorders.	Derks EM et al.	—	2020	→
Translating insights from neuropsychiatric genetics and genomics for precision psychiatry.	Rees E et al.	—	2020	→
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.	Davies RW et al.	—	2020	→
Using Genetics to Examine a General Liability to Childhood Psychopathology.	Riglin L et al.	—	2020	→
Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia.	Liang W et al.	—	2020	→
Zebrafish as a tool to study schizophrenia-associated copy number variants.	Campbell PD et al.	—	2020	→
Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia.	Horsdal HT et al.	—	2019	→
Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.	Legge SE et al.	—	2019	→
Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia.	Morozova A et al.	—	2019	→
Comparative genetic architectures of schizophrenia in East Asian and European populations.	Lam M et al.	—	2019	→
Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities.	Koromina M et al.	—	2019	→
Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.	Wendt FR et al.	—	2019	→
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.	Zhao B et al.	—	2019	→
Informing disease modelling with brain-relevant functional genomic annotations.	Reynolds RH et al.	—	2019	→
Manganese homeostasis: from rare single-gene disorders to complex phenotypes and diseases.	Katz N et al.	—	2019	→
Oligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interaction.	Raabe FJ et al.	—	2019	→
Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients.	Papiol S et al.	—	2019	→
Predicting novel genomic regions linked to genetic disorders using GWAS and chromosome conformation data - a case study of schizophrenia.	Buxton DS et al.	—	2019	→
Schizophrenia-associated MicroRNA-Gene Interactions in the Dorsolateral Prefrontal Cortex.	Santarelli DM et al.	—	2019	→
The Fate of Deleterious Variants in a Barley Genomic Prediction Population.	Kono TJY et al.	—	2019	→
The great hairball gambit.	Flint J et al.	—	2019	→