DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.
paper
Cited
Public
- Authors
- Cotto, Kelsy C; Wagner, Alex H; Feng, Yang-Yang; Kiwala, Susanna; Coffman, Adam C; Spies, Gregory; Wollam, Alex; Spies, Nicholas C; Griffith, Obi L; Griffith, Malachi
- Year
- 2018
- Journal
- Nucleic acids research
- PMID
- 29156001
- DOI
- 10.1093/nar/gkx1143
- PMCID
- PMC5888642
The drug-gene interaction database (DGIdb, www.dgidb.org) consolidates, organizes and presents drug-gene interactions and gene druggability information from papers, databases and web resources. DGIdb normalizes content from 30 disparate sources and allows for user-friendly advanced browsing, searching and filtering for ease of access through an intuitive web user interface, application programming interface (API) and public cloud-based server image. DGIdb v3.0 represents a major update of the database. Nine of the previously included 24 sources were updated. Six new resources were added, bringing the total number of sources to 30. These updates and additions of sources have cumulatively resulted in 56 309 interaction claims. This has also substantially expanded the comprehensive catalogue of druggable genes and anti-neoplastic drug-gene interactions included in the DGIdb. Along with these content updates, v3.0 has received a major overhaul of its codebase, including an updated user interface, preset interaction search filters, consolidation of interaction information into interaction groups, greatly improved search response times and upgrading the underlying web application framework. In addition, the expanded API features new endpoints which allow users to extract more detailed information about queried drugs, genes and drug-gene interactions, including listings of PubMed IDs, interaction type and other interaction metadata.
DGIdb 3.0 content by source. The number of drugβgene interaction claims (first panel) and druggable gene categories (second panel) are separated into three categories: sources that existed in the DGIdb previously, sources that existed in the DGIdb previously but have been updated for 3.0 or sources that are entirely new to the DGIdb. Abbreviations: CF: Clearity Foundation; CGI = Cancer genome interpreter, CKB = JAX-Clinical Knowledgebase, CMI = Caris Molecular Intelligence, FO = Foundation One, GTP = Guide to pharmacology, MCG = My cancer genome, OncoKB = Precision Oncology Knowledge Base, TALC = Targeted agents in lung cancer, TTD = Therapeutic Target Database, TEND = Trends in the exploration of novel drug targets, GO = Gene Ontology and MSK = Memorial Sloan Kettering.
Comparison of the DGIdb 2.0 and 3.0 response time by search and result size. The left panel summarizes observed response times (n = 100) for searches of various sizes (1, 2, 3, 4, 5, 10, 15, 20 and 25) of randomly selected genes. The right panel summarizes observed response times for the corresponding interaction search result sizes.
The DGIdb interaction search interface. (A) A search field accepts drug or gene identifiers, depending on which tab is selected and provides auto-completion suggestions for search terms. (B) Preset options are provided to filter search results based on the attributes of mapped interactors. (C) Advanced filters allow the user to further filter based on source database, gene category or interaction type. (D) The interaction search results (Unique Matches) view shows results for search terms that were matched within the DGIdb. (E) The interaction search results (Ambiguous or Unmatched) view shows search terms that were either ambiguously matched or unmatched within the DGIdb. (F) Additional side panels provide a brief summary of unmatched and ambiguously matched terms.
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| BentoA.P., GaultonA., HerseyA., BellisL.J., ChambersJ., DaviesM., KrΓΌgerF.A., LightY., MakL., McGlincheyS. The ChEMBL bioactivity database: an update. Nucleic Acids Res.2014; 42:D1083βD1090.2421496510.1093/nar/gkt1031PMC3965067 | β | β | β |
| BrownG.R., HemV., KatzK.S., OvetskyM., WallinC., ErmolaevaO., TolstoyI., TatusovaT., PruittK.D., MaglottD.R. Gene: a gene-centered information resource at NCBI. Nucleic Acids Res.2015; 43:D36βD42.2535551510.1093/nar/gku1055PMC4383897 | β | β | β |
| ChakravartyD., GaoJ., PhillipsS., KundraR., ZhangH., WangJ., RudolphJ.E., YaegerR., SoumeraiT., NissanM.H. OncoKB: a precision oncology knowledge base. JCO Precis. Oncol.2017; 1, doi:10.1200/PO.17.00011.10.1200/PO.17.00011PMC558654028890946 | β | β | β |
| ChengD.T., MitchellT.N., ZehirA., ShahR.H., BenayedR., SyedA., ChandramohanR., LiuZ.Y., WonH.H., ScottS.N. Memorial sloan kettering-integrated mutation profiling of actionable cancer targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology. J. Mol. Diagn.2015; 17:251β264.2580182110.1016/j.jmoldx.2014.12.006PMC5808190 | β | β | β |
| EdwardsA.M., IsserlinR., BaderG.D., FryeS.V., WillsonT.M., YuF.H. Too many roads not taken. Nature. 2011; 470:163β165.2130791310.1038/470163a | β | β | β |
| FinanC., GaultonA., KrugerF.A., LumbersR.T., ShahT., EngmannJ., GalverL., KelleyR., KarlssonA., SantosR. The druggable genome and support for target identification and validation in drug development. Sci. Transl. Med.2017; 9:eaag1166.2835650810.1126/scitranslmed.aag1166PMC6321762 | β | β | β |
| FischK.M., MeiΓnerT., GioiaL., DucomJ.-C., CarlandT.M., LoguercioS., SuA.I. Omics Pipe: a community-based framework for reproducible multi-omics data analysis. Bioinformatics. 2015; 31:1724β1728.2563756010.1093/bioinformatics/btv061PMC4443682 | β | β | β |
| Gene Ontology Consortium Gene Ontology Consortium: going forward. Nucleic Acids Res.2015; 43:D1049βD1056.2542836910.1093/nar/gku1179PMC4383973 | β | β | β |
| GriffithM., GriffithO.L., CoffmanA.C., WeibleJ.V., McMichaelJ.F., SpiesN.C., KovalJ., DasI., CallawayM.B., EldredJ.M. DGIdbβmining the druggable genome. Nat. Methods. 2013; 10:1209β1210.2412204110.1038/nmeth.2689PMC3851581 | β | β | β |
| GriffithM., SpiesN.C., KrysiakK., McMichaelJ.F., CoffmanA.C., DanosA.M., AinscoughB.J., RamirezC.A., RiekeD.T., KujanL. CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. Nat. Genet.2017; 49:170β174.2813815310.1038/ng.3774PMC5367263 | β | β | β |
| HartS.N., MooreR.M., ZimmermannM.T., OliverG.R., EganJ.B., BryceA.H., KocherJ.-P.A. PANDA: pathway and annotation explorer for visualizing and interpreting gene-centric data. PeerJ. 2015; 3:e970.2603872510.7717/peerj.970PMC4451017 | β | β | β |
| HopkinsA.L., GroomC.R. The druggable genome. Nat. Rev. Drug Discov.2002; 1:727β730.1220915210.1038/nrd892 | β | β | β |
| KimS., ThiessenP.A., BoltonE.E., ChenJ., FuG., GindulyteA., HanL., HeJ., HeS., ShoemakerB.A. PubChem substance and compound databases. Nucleic Acids Res.2016; 44:D1202βD1213.2640017510.1093/nar/gkv951PMC4702940 | β | β | β |
| KumarR.D., ChangL.-W., EllisM.J., BoseR. Prioritizing potentially druggable mutations with dGene: an annotation tool for cancer genome sequencing data. PLoS One. 2013; 8:e67980.2382635010.1371/journal.pone.0067980PMC3694871 | β | β | β |
| LawV., KnoxC., DjoumbouY., JewisonT., GuoA.C., LiuY., MaciejewskiA., ArndtD., WilsonM., NeveuV. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res.2014; 42:D1091βD1097.2420371110.1093/nar/gkt1068PMC3965102 | β | β | β |
| MockA., MurphyS., MorrisJ., MarassF., RosenfeldN., MassieC. CVE: an R package for interactive variant prioritisation in precision oncology. BMC Med. Genomics. 2017; 10:37.2854546310.1186/s12920-017-0261-6PMC5445311 | β | β | β |
| PailaU., ChapmanB.A., KirchnerR., QuinlanA.R. GEMINI: integrative exploration of genetic variation and genome annotations. PLoS Comput. Biol.2013; 9:e1003153.2387419110.1371/journal.pcbi.1003153PMC3715403 | β | β | β |
| PattersonS.E., LiuR., StatzC.M., DurkinD., LakshminarayanaA., MockusS.M. The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies. Hum. Genomics. 2016; 10:4.2677274110.1186/s40246-016-0061-7PMC4715272 | β | β | β |
| RussA.P., LampelS. The druggable genome: an update. Drug Discov. Today. 2005; 10:1607β1610.1637682010.1016/S1359-6446(05)03666-4 | β | β | β |
| SimonG.R., SomaiahN. A tabulated summary of targeted and biologic therapies for non-small-cell lung cancer. Clin. Lung Cancer. 2014; 15:21β51.2437774310.1016/j.cllc.2013.11.009 | β | β | β |
| SouthanC., SharmanJ.L., BensonH.E., FaccendaE., PawsonA.J., AlexanderS.P.H., BunemanO.P., DavenportA.P., McGrathJ.C., PetersJ.A. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res.2016; 44:D1054βD1068.2646443810.1093/nar/gkv1037PMC4702778 | β | β | β |
| ThurnherrT., SingerF., StekhovenD.J., BeerenwinkelN. Genomic variant annotation workflow for clinical applications [version 2; referees: 2 approved]. F1000Research. 2016; 5:1963.2799026010.12688/f1000research.9357.1PMC5130070 | β | β | β |
| WagnerA.H., CoffmanA.C., AinscoughB.J., SpiesN.C., SkidmoreZ.L., CampbellK.M., KrysiakK., PanD., McMichaelJ.F., EldredJ.M. DGIdb 2.0: mining clinically relevant drugβgene interactions. Nucleic Acids Res.2016; 44:D1036βD1044.2653182410.1093/nar/gkv1165PMC4702839 | β | β | β |
| WuC., OrozcoC., BoyerJ., LegliseM., GoodaleJ., BatalovS., HodgeC.L., HaaseJ., JanesJ., HussJ.W. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol.2009; 10:R130.1991968210.1186/gb-2009-10-11-r130PMC3091323 | β | β | β |
| YehP., ChenH., AndrewsJ., NaserR., PaoW., HornL. DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy. Clin. Cancer Res.2013; 19:1894β1901.2334426410.1158/1078-0432.CCR-12-1894PMC4121886 | β | β | β |
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| PMAIP1, a novel diagnostic and potential therapeutic biomarker in osteoporosis. | Li T et al. | β | 2024 | β |
| Potential Drug Synergy Through the ERBB2 Pathway in HER2+ Breast Tumors. | Rojas-Salazar Y et al. | β | 2024 | β |
| Potential mechanisms and drug prediction of Rheumatoid Arthritis and primary SjΓΆgren's Syndrome: A public databases-based study. | Wu L et al. | β | 2024 | β |
| Preliminary Analysis of Aging-Related Genes in Intracerebral Hemorrhage by Integration of Bulk and Single-Cell RNA Sequencing Technology. | Li Q et al. | β | 2024 | β |
| Profiling Kinase Activities for Precision Oncology in Diffuse Gastric Cancer. | Singh S et al. | β | 2024 | β |
| Pyroptosis is involved in the immune microenvironment regulation of unexplained recurrent miscarriage. | Wang J et al. | β | 2024 | β |
| Ribonucleotide reductase inhibition improves the symptoms of a Caenorhabditis elegans model of Alzheimer's disease. | Brokate-Llanos AM et al. | β | 2024 | β |
| S100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps. | Khayer N et al. | β | 2024 | β |
| Searching for Essential Genes and Targeted Drugs Common to Breast Cancer and Osteoarthritis. | Guo L et al. | β | 2024 | β |
| Sex differences in shared genetic determinants between severe mental disorders and metabolic traits. | Pisanu C et al. | β | 2024 | β |
| Single nucleotide polymorphisms conferring susceptibility to leukemia and oral mucositis: a multi-center pilot study of patients prior to conditioning therapy for hematopoietic cell transplant. | Mougeot JC et al. | β | 2024 | β |
| Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns. | Xiang Y et al. | β | 2024 | β |
| The diagnostic value investigation of programmed cell death genes in heart failure. | Chen Q et al. | β | 2024 | β |
| The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data. | Zheng J et al. | β | 2024 | β |
| The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program. | Fagnan A et al. | β | 2024 | β |
| The landscape of the methodology in drug repurposing using human genomic data: a systematic review. | Wang L et al. | β | 2024 | β |
| Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation. | Zhao X et al. | β | 2024 | β |
| Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis. | Mao G et al. | β | 2024 | β |
| Validation of new immune and inflammation-related diagnostic biomarkers for RA. | Bao X | β | 2024 | β |
| ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and Predicts Prognosis in Osteosarcoma. | Wang J et al. | β | 2023 | β |
| A molecular classification system for estimating radiotherapy response and anticancer immunity for individual breast cancer patients. | Zhang J et al. | β | 2023 | β |
| An Omics Strategy for Translational Bioinformatics and Rapid COVID-19 Drug Repurposing. | Revikumar A | β | 2023 | β |
| A pan-cancer landscape of pathogenic somatic copy number variations. | Becchi T et al. | β | 2023 | β |
| A Phase II Exploratory Study to Identify Biomarkers Predictive of Clinical Response to Regorafenib in Patients with Metastatic Colorectal Cancer Who Have Failed First-Line Therapy. | Gambaro K et al. | β | 2023 | β |
| Atlas of interactions between SARS-CoV-2 macromolecules and host proteins. | Li G et al. | β | 2023 | β |
| CHDbase: A Comprehensive Knowledgebase for Congenital Heart Disease-related Genes and Clinical Manifestations. | Zhou WZ et al. | β | 2023 | β |
| Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of chronic obstructive pulmonary disease and atrial fibrillation. | Sun Z et al. | β | 2023 | β |
| Comprehensive analyses identify potential biomarkers for encephalitis in HIV infection. | Wang S et al. | β | 2023 | β |
| Comprehensive bioinformatics analysis revealed potential key genes and pathways underlying abdominal aortic aneurysm. | Zhang K et al. | β | 2023 | β |
| Consensus cluster analysis of apoptosis-related genes in patients with osteoarthritis and their correlation with immune cell infiltration. | Yu E et al. | β | 2023 | β |
| COVID-19: A novel holistic systems biology approach to predict its molecular mechanisms (in vitro) and repurpose drugs. | Sameni M et al. | β | 2023 | β |
| COVID-19 of differing severity: from bulk to single-cell expression data analysis. | Tian L et al. | β | 2023 | β |
| DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine. | Liu X et al. | β | 2023 | β |
| Deciphering molecular mechanisms of SARS-CoV-2 pathogenesis and drug repurposing through GRN motifs: a comprehensive systems biology study. | Sameni M et al. | β | 2023 | β |
| Decoding Systems Biology of Inflammation Signatures in Cancer Pathogenesis: Pan-Cancer Insights from 12 Common Cancers. | Turanli B | β | 2023 | β |
| Demystifying the impact of prenatal tobacco exposure on the placental immune microenvironment: Avoiding the tragedy of mending the fold after death. | Zhao X et al. | β | 2023 | β |
| Diagnostic and predictive values of pyroptosis-related genes in sepsis. | Wang X et al. | β | 2023 | β |
| EGCG identified as an autophagy inducer for rosacea therapy. | Zhou L et al. | β | 2023 | β |
| ESCCdb: A comprehensive database and key regulator exploring platform based on cross dataset comparisons for esophageal squamous cell carcinoma. | Yang J et al. | β | 2023 | β |
| Establishment of comorbidity target pools and prediction of drugs candidate for multiple sclerosis and autoimmune thyroid diseases based on GWAS and transcriptome data. | Wang X et al. | β | 2023 | β |
| Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM. | Tian S et al. | β | 2023 | β |
| Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapies. | Jiang Y et al. | β | 2023 | β |
| Gene-network based analysis of human placental trophoblast subtypes identifies critical genes as potential targets of therapeutic drugs. | Lackner AI et al. | β | 2023 | β |
| Genome-wide identification of murine interferon genes in microglial-mediated neuroinflammation in Alzheimer's disease. | Shippy DC et al. | β | 2023 | β |
| Genomic landscape and actionable mutations of brain metastases derived from non-small cell lung cancer: A systematic review. | Andrews LJ et al. | β | 2023 | β |
| HighAltitudeOmicsDB, an integrated resource for high-altitude associated genes and proteins, networks and semantic-similarities. | Gupta A et al. | β | 2023 | β |
| <i>CD40LG</i> and <i>GZMB</i> were correlated with adipose tissue macrophage infiltration and involved in obstructive sleep apnea related metabolic dysregulation: Evidence from bioinformatics analysis. | Ming X et al. | β | 2023 | β |
| <i>De novo</i> identification of complex traits associated with asthma. | Zaied RE et al. | β | 2023 | β |
| Identification and validation of autophagy-related genes in Kawasaki disease. | Zhu H et al. | β | 2023 | β |
| Identification and validation of oxidative stress and immune-related hub genes in Alzheimer's disease through bioinformatics analysis. | Li S et al. | β | 2023 | β |
| Identification and validation of potential diagnostic signature and immune cell infiltration for NAFLD based on cuproptosis-related genes by bioinformatics analysis and machine learning. | Ouyang G et al. | β | 2023 | β |
| Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. | Yang ZH et al. | β | 2023 | β |
| Identification of asthma-related genes using asthmatic blood eQTLs of Korean patients. | Kim DJ et al. | β | 2023 | β |
| Identification of druggable hub genes and key pathways associated with cervical cancer by protein-protein interaction analysis: An in silico study. | Asadzadeh A et al. | β | 2023 | β |
| Identification of key biomarkers related to epithelial-mesenchymal transition and immune infiltration in ameloblastoma using integrated bioinformatics analysis. | Zhang Z et al. | β | 2023 | β |
| Identification of key signaling pathways and hub genes related to immune infiltration in Kawasaki disease with resistance to intravenous immunoglobulin based on weighted gene co-expression network analysis. | Wang Y et al. | β | 2023 | β |
| Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis. | Tang T et al. | β | 2023 | β |
| Identification of novel potential drugs and miRNAs biomarkers in lung cancer based on gene co-expression network analysis. | Hajipour S et al. | β | 2023 | β |
| Identification of oxidative stress-related genes differentially expressed in Alzheimer's disease and construction of a hub gene-based diagnostic model. | Zhang Y et al. | β | 2023 | β |
| Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction. | Huang B et al. | β | 2023 | β |
| Identifying repurposed drugs with moderate anti-influenza virus activity through computational prioritization of drug-target pairs | Taye B et al. | β | 2023 | β |
| Integrated analysis of C3AR1 and CD163 associated with immune infiltration in intracranial aneurysms pathogenesis. | Li S et al. | β | 2023 | β |
| Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Diabetic Kidney Disease. | Wang J et al. | β | 2023 | β |
| Integrated Bioinformatic Analysis of the Correlation of HOXA10 Expression with Survival and Immune Cell Infiltration in Lower Grade Glioma. | Wang T et al. | β | 2023 | β |
| Integrated bioinformatics analysis of differentially expressed genes in the temporomandibular joint internal derangement. | Yang J | β | 2023 | β |
| Integrating Computational Methods in Network Pharmacology and <i>In Silico</i> Screening to Uncover Multi-targeting Phytochemicals against Aberrant Protein Glycosylation in Lung Cancer. | Grijaldo SJB et al. | β | 2023 | β |
| Integration of transcriptomics reveals ferroptosis-related signatures and immune cell infiltration in bronchopulmonary dysplasia. | Hu Z et al. | β | 2023 | β |
| Lipid metabolism transcriptomics of murine microglia in Alzheimer's disease and neuroinflammation. | Shippy DC et al. | β | 2023 | β |
| Molecular markers of type II alveolar epithelial cells in acute lung injury by bioinformatics analysis. | Yang X et al. | β | 2023 | β |
| Molecular mechanism and diagnostic marker investigation of endoplasmic reticulum stress on periodontitis. | Sun Q et al. | β | 2023 | β |
| Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population. | Su Y et al. | β | 2023 | β |
| Multi-scale systems genomics analysis predicts pathways, cell types, and drug targets involved in normative variation in peri-adolescent human cognition. | Pai S et al. | β | 2023 | β |
| myCMIE: My cancer molecular information exchange. | Xu Q et al. | β | 2023 | β |
| Prioritization of New Candidate Genes for Rare Genetic Diseases by a Disease-Aware Evaluation of Heterogeneous Molecular Networks. | de la Fuente L et al. | β | 2023 | β |
| Proteogenomic characterization of ferroptosis regulators reveals therapeutic potential in glioblastoma. | Wang X et al. | β | 2023 | β |
| Revolutionizing Biological Science: The Synergy of Genomics in Health, Bioinformatics, Agriculture, and Artificial Intelligence. | Biswas A et al. | β | 2023 | β |
| Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases. | Ratajczak F et al. | β | 2023 | β |
| SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients. | Barik SK et al. | β | 2023 | β |
| The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma. | Wang D et al. | β | 2023 | β |
| The molecular link between obstructive sleep apnea and osteoarthritis: based on bioinformatics analysis and experimental validation. | Ren XS et al. | β | 2023 | β |
| Using reported pathogenic variants to identify therapeutic opportunities for genetic diseases. | Ressler AK et al. | β | 2023 | β |
| A computational approach to drug repurposing using graph neural networks. | Doshi S et al. | β | 2022 | β |
| A Multimodal Framework for Improving in Silico Drug Repositioning With the Prior Knowledge From Knowledge Graphs. | Xiong Z et al. | β | 2022 | β |
| Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury. | Wang Z et al. | β | 2022 | β |
| A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis and Treatment of Glioma. | Yang Z et al. | β | 2022 | β |
| Application of Transcriptomics for Predicting Protein Interaction Networks, Drug Targets and Drug Candidates. | Kankanige D et al. | β | 2022 | β |
| A systematic review and functional bioinformatics analysis of genes associated with Crohn's disease identify more than 120 related genes. | Garza-Hernandez D et al. | β | 2022 | β |
| Bioinformatics analysis of candidate genes and potential therapeutic drugs targeting adipose tissue in obesity. | Yu Y et al. | β | 2022 | β |
| Bioinformatics Analysis of the MicroRNA-Metabolic Gene Regulatory Network in Neuropathic Pain and Prediction of Corresponding Potential Therapeutics. | Zhang HG et al. | β | 2022 | β |
| Bioinformatics roadmap for therapy selection in cancer genomics. | JimΓ©nez-Santos MJ et al. | β | 2022 | β |
| Candidate Drugs Screening for Behcet's Disease Based on Bioinformatics Analysis and Mouse Experiments. | Xia Q et al. | β | 2022 | β |
| Comprehensive analyses of the microRNA-messenger RNA-transcription factor regulatory network in mouse and human renal fibrosis. | Deng L et al. | β | 2022 | β |
| Comprehensive analysis and validation of novel immune and vascular remodeling related genes signature associated with drug interactions in pulmonary arterial hypertension. | Wang J et al. | β | 2022 | β |
| Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy. | Fang Y et al. | β | 2022 | β |
| Comprehensive Analysis of Prognostic and immune infiltrates for FOXPs Transcription Factors in Human Breast Cancer. | Yi J et al. | β | 2022 | β |
| Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis. | He Y et al. | β | 2022 | β |
| Deciphering the involvement of iron targets in colorectal cancer: a network biology approach. | Khan AA et al. | β | 2022 | β |
| Disulfiram in glioma: Literature review of drug repurposing. | Zhong S et al. | β | 2022 | β |
| Drug Repositioning Based on the Enhanced Message Passing and Hypergraph Convolutional Networks. | Huang W et al. | β | 2022 | β |
| Drug repurposing for rheumatoid arthritis: Identification of new drug candidates <i>via</i> bioinformatics and text mining analysis. | Unal U et al. | β | 2022 | β |
| Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. | Ma WF et al. | β | 2022 | β |
| Enhancer methylation dynamics drive core transcriptional regulatory circuitry in pan-cancer. | Pan X et al. | β | 2022 | β |
| Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype Ontology. | Peng J et al. | β | 2022 | β |
| Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network analysis. | Nomiri S et al. | β | 2022 | β |
| Exploration of Hub Genes in Retinopathy of Prematurity Based on Bioinformatics Analysis of the Oxygen-Induced Retinopathy Model. | Xiong Q et al. | β | 2022 | β |
| Exploring Potential Biomarkers, Ferroptosis Mechanisms, and Therapeutic Targets Associated with Cutaneous Squamous Cell Carcinoma via Integrated Transcriptomic Analysis. | Su W et al. | β | 2022 | β |
| Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective. | Meng Q et al. | β | 2022 | β |
| Exploring the Mystery of Osteoarthritis using Bioinformatics Analysis of Cartilage Tissue. | Wang B et al. | β | 2022 | β |
| Exploring the zinc-related transcriptional landscape in Alzheimer's disease. | Shippy DC et al. | β | 2022 | β |
| Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms. | Mathieu S et al. | β | 2022 | β |
| Genetic effect of ischemia-reperfusion injury upon primary graft dysfunction and chronic lung allograft dysfunction in lung transplantation: evidence based on transcriptome data. | Zheng XY et al. | β | 2022 | β |
| Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir. | Dai W et al. | β | 2022 | β |
| Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation. | Xu JJ et al. | β | 2022 | β |
| Genotype-protein phenotype characterization of <i>NOD2</i> and <i>IL23R</i> missense variants associated with inflammatory bowel disease: A paradigm from molecular modelling, dynamics, and docking simulations. | Nasser KK et al. | β | 2022 | β |
| Graph neural network approaches for drug-target interactions. | Zhang Z et al. | β | 2022 | β |
| GuiltyTargets: Prioritization of Novel Therapeutic Targets With Network Representation Learning. | Muslu O et al. | β | 2022 | β |
| High-content analysis of microRNAs involved in the phenotype regulation of vascular smooth muscle cells. | Zhang J et al. | β | 2022 | β |
| Identification and characterization of four immune-related signatures in keloid. | Wang X et al. | β | 2022 | β |
| Identification and Experimental Validation of Marker Genes between Diabetes and Alzheimer's Disease. | Huang C et al. | β | 2022 | β |
| Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative. | Wu ATH et al. | β | 2022 | β |
| Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia-reperfusion acute kidney injury at an early stage by bioinformatics methods. | You R et al. | β | 2022 | β |
| Identification of Biomarkers in Intracranial Aneurysm and Their Immune Infiltration Characteristics. | Huang C et al. | β | 2022 | β |
| Identification of Candidate Therapeutic Genes for More Precise Treatment of Esophageal Squamous Cell Carcinoma and Adenocarcinoma. | Polewko-Klim A et al. | β | 2022 | β |
| Identification of common susceptibility genes and drug target genes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis and its value to guide clinical treatment. | Liu Y et al. | β | 2022 | β |
| Identification of Core Genes and Screening of Potential Targets in Intervertebral Disc Degeneration Using Integrated Bioinformatics Analysis. | Li J et al. | β | 2022 | β |
| Identification of Inflammation-Related Genes and Exploration of Regulatory Mechanisms in Patients with Osteonecrosis of the Femoral Head. | Li T et al. | β | 2022 | β |
| Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics Analyses. | Shu J et al. | β | 2022 | β |
| Identification of pyroptosis-related immune signature and drugs for ischemic stroke. | Shi S et al. | β | 2022 | β |
| Identification of the Key Genes and Potential Therapeutic Compounds for Abdominal Aortic Aneurysm Based on a Weighted Correlation Network Analysis. | Li L et al. | β | 2022 | β |
| Identifying Potential Mitochondrial Proteome Signatures Associated with the Pathogenesis of Pulmonary Arterial Hypertension in the Rat Model. | Wang J et al. | β | 2022 | β |
| Identifying significant genes and functionally enriched pathways in familial hypercholesterolemia using integrated gene co-expression network analysis. | Awan Z et al. | β | 2022 | β |
| Identifying the tumor location-associated candidate genes in development of new drugs for colorectal cancer using machine-learning-based approach. | Bayrak T et al. | β | 2022 | β |
| Immune-Related Biomarkers Associated with Lung Metastasis from the Colorectal Cancer Microenvironment. | Da W et al. | β | 2022 | β |
| In silico bioinformatics analysis for identification of differentially expressed genes and therapeutic drug molecules in Glucocorticoid-resistant Multiple myeloma. | Ghosal S et al. | β | 2022 | β |
| Integrated Analysis of miRNA and mRNA Expression Profiles Reveals the Molecular Mechanism of Posttraumatic Stress Disorder and Therapeutic Drugs. | Gan C et al. | β | 2022 | β |
| Integrated bioinformatic analysis to understand the association between phthalate exposure and breast cancer progression. | Khan NG et al. | β | 2022 | β |
| Integrated Bioinformatics and Clinical Correlation Analysis of Key Genes, Pathways, and Potential Therapeutic Agents Related to Diabetic Nephropathy. | Chen S et al. | β | 2022 | β |
| Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19. | Ma Y et al. | β | 2022 | β |
| Integrative Analyses of Genes Associated With Otologic Disorders in Turner Syndrome. | Xue R et al. | β | 2022 | β |
| Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer. | Liu Y et al. | β | 2022 | β |
| Investigating the potential molecular players and therapeutic drug molecules in carfilzomib resistant multiple myeloma by comprehensive bioinformatics analysis. | Ghosal S et al. | β | 2022 | β |
| Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation. | Kamali Z et al. | β | 2022 | β |
| Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities. | Cosgrove N et al. | β | 2022 | β |
| Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review. | Wang YX et al. | β | 2022 | β |
| Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses. | Kim SC et al. | β | 2022 | β |
| Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses. | Jeong N et al. | β | 2022 | β |
| Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. | Gaddis N et al. | β | 2022 | β |
| Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine. | ZΓ‘topkovΓ‘ M et al. | β | 2022 | β |
| Natural Language Processing-Assisted Literature Retrieval and Analysis for Combination Therapy in Cancer. | Zeng J et al. | β | 2022 | β |
| NETISCE: a network-based tool for cell fate reprogramming. | Marazzi L et al. | β | 2022 | β |
| Network-based approach for targeting human kinases commonly associated with amyotrophic lateral sclerosis and cancer. | Khatoon F et al. | β | 2022 | β |
| Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia. | Binder M et al. | β | 2022 | β |
| PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics. | Ma WF et al. | β | 2022 | β |
| Promoter/enhancer-based controllability of regulatory networks. | Devkota P et al. | β | 2022 | β |
| Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma. | Dong L et al. | β | 2022 | β |
| Proteomic Analyses Identify Therapeutic Targets in Hepatocellular Carcinoma. | Elmas A et al. | β | 2022 | β |
| Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis. | Wu Y et al. | β | 2022 | β |
| Rational drug repositioning for coronavirus-associated diseases using directional mapping and side-effect inference. | Wang J et al. | β | 2022 | β |
| RNA-seq based integrative analysis of potential crucial genes and pathways associated with patellar instability. | Xu C et al. | β | 2022 | β |
| scAmpi-A versatile pipeline for single-cell RNA-seq analysis from basics to clinics. | Bertolini A et al. | β | 2022 | β |
| Screening and identification of immune-related genes for immunotherapy and prognostic assessment in colorectal cancer patients. | Wang S et al. | β | 2022 | β |
| Sequence-based prediction of protein binding regions and drug-target interactions. | Lee I et al. | β | 2022 | β |
| Single-cell co-expression analysis using computational machine learning reveals oxidative, immunopathologic, and myocardial responses for multi-organ failure in COVID-19. | Zhang C et al. | β | 2022 | β |
| Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. | Wu LMN et al. | β | 2022 | β |
| Systematic illumination of druggable genes in cancer genomes. | Jiang J et al. | β | 2022 | β |
| The commonness in immune infiltration of rheumatoid arthritis and atherosclerosis: Screening for central targets <i>via</i> microarray data analysis. | Wang Z et al. | β | 2022 | β |
| Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis. | Moita MR et al. | β | 2022 | β |
| Transcriptomic profiling of Indian breast cancer patients revealed subtype-specific mRNA and lncRNA signatures. | Manjunath M et al. | β | 2022 | β |
| Universal and cross-cancer prognostic biomarkers for predicting survival risk of cancer patients from expression profile of apoptotic pathway genes. | Arora C et al. | β | 2022 | β |
| Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. | Navare AT et al. | β | 2022 | β |
| A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer's Disease. | Jing Q et al. | β | 2021 | β |
| A Computational Exploration of the Molecular Network Associated to Neuroinflammation in Alzheimer's Disease. | El Idrissi F et al. | β | 2021 | β |
| A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses. | Li Z et al. | β | 2021 | β |
| A multiple network-based bioinformatics pipeline for the study of molecular mechanisms in oncological diseases for personalized medicine. | Dotolo S et al. | β | 2021 | β |
| An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX. | Magavern EF et al. | β | 2021 | β |
| Analysis of Communal Molecular Mechanism and Potential Therapeutic Targets in Heart Failure and Type 2 Diabetes Mellitus. | Wang Z et al. | β | 2021 | β |
| Analysis of GABRG2 C588T polymorphism in genetic epilepsy and evaluation of GABRG2 in drug treatment. | Wang S et al. | β | 2021 | β |
| Analysis of Nuclear Encoded Mitochondrial Gene Networks in Cervical Cancer. | Meneur C et al. | β | 2021 | β |
| Analysis of Serum miRNAs in Alzheimer's Disease. | Lu L et al. | β | 2021 | β |
| An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. | Souilmi Y et al. | β | 2021 | β |
| An ensemble learning approach for modeling the systems biology of drug-induced injury. | Aguirre-Plans J et al. | β | 2021 | β |
| A Network Medicine Approach for Drug Repurposing in Duchenne Muscular Dystrophy. | Lombardo SD et al. | β | 2021 | β |
| An Integrated Bioinformatics Analysis of the Potential Regulatory Effects of miR-21 on T-cell Related Target Genes in Multiple Sclerosis. | Manian M et al. | β | 2021 | β |
| An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma. | Reggiani F et al. | β | 2021 | β |
| A Non-Coding RNA Network Involved in KSHV Tumorigenesis. | Naipauer J et al. | β | 2021 | β |
| An Open Access Database of Licensed Cancer Drugs. | Pantziarka P et al. | β | 2021 | β |
| A showcase study on personalized in silico drug response prediction based on the genetic landscape of muscle invasive bladder cancer. | Krentel F et al. | β | 2021 | β |
| Association of Pericardiac Adipose Tissue With Coronary Artery Disease. | Li M et al. | β | 2021 | β |
| A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases. | Perrot N et al. | β | 2021 | β |
| Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer. | Lopes-Santos G et al. | β | 2021 | β |
| Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea. | Zhang H et al. | β | 2021 | β |
| Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke. | Zhou S et al. | β | 2021 | β |
| Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19. | Prasad K et al. | β | 2021 | β |
| Candidate pharmacological treatments for substance use disorder and suicide identified by gene co-expression network-based drug repositioning. | Cabrera-Mendoza B et al. | β | 2021 | β |
| CaNDis: a web server for investigation of causal relationships between diseases, drugs and drug targets. | Ε krlj B et al. | β | 2021 | β |
| CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium. | Lv Y et al. | β | 2021 | β |
| Clinical-grade whole-genome sequencing and 3' transcriptome analysis of colorectal cancer patients. | Stodolna A et al. | β | 2021 | β |
| Clotting in COVID-19: Is It All in the Genes? | Hernandez Cordero AI et al. | β | 2021 | β |
| CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data. | Molendijk J et al. | β | 2021 | β |
| Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia. | Heliste J et al. | β | 2021 | β |
| Common Genes Involved in Autophagy, Cellular Senescence and the Inflammatory Response in AMD and Drug Discovery Identified via Biomedical Databases. | Wang S et al. | β | 2021 | β |
| Common genetic associations between age-related diseases. | DΓΆnertaΕ HM et al. | β | 2021 | β |
| Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins. | Shoily SS et al. | β | 2021 | β |
| Community Detection in Large-Scale Bipartite Biological Networks. | Calderer G et al. | β | 2021 | β |
| Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma. | Vinel C et al. | β | 2021 | β |
| Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID-19. | Mo S et al. | β | 2021 | β |
| Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib. | Lee CJ et al. | β | 2021 | β |
| Contraceptive and Infertility Target DataBase: a contraceptive drug development tool for targeting and analysis of human reproductive specific tissuesβ . | Sinha S et al. | β | 2021 | β |
| Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer. | Gambaro K et al. | β | 2021 | β |
| CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via inΒ vivo dependency mapping. | Naert T et al. | β | 2021 | β |
| Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain. | Barowsky S et al. | β | 2021 | β |
| CSNK1A1, KDM2A, and LTB4R2 Are New Druggable Vulnerabilities in Lung Cancer. | Sauta E et al. | β | 2021 | β |
| Differential expression analysis in ovarian cancer: A functional genomics and systems biology approach. | Zhang Y et al. | β | 2021 | β |
| Druggable genome and precision medicine in cancer: current challenges. | Dupont CA et al. | β | 2021 | β |
| Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. | Hegvik TA et al. | β | 2021 | β |
| Drug repositioning for treatment-resistant depression: Hypotheses from a pharmacogenomic study. | Fabbri C et al. | β | 2021 | β |
| Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro. | Orr-Burks N et al. | β | 2021 | β |
| Drug Repurposing for Alzheimer's Disease Based on Protein-Protein Interaction Network. | Soleimani Zakeri NS et al. | β | 2021 | β |
| Drug-Target Interaction Prediction Based on Adversarial Bayesian Personalized Ranking. | Ye Y et al. | β | 2021 | β |
| Elucidating the Molecular Mechanism of Ischemic Stroke Using Integrated Analysis of miRNA, mRNA, and lncRNA Expression Profiles. | Sun Y et al. | β | 2021 | β |
| Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. | Xiang X et al. | β | 2021 | β |
| Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome. | Unterman I et al. | β | 2021 | β |
| Explainable drug sensitivity prediction through cancer pathway enrichment. | Tang YC et al. | β | 2021 | β |
| Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation. | Li Y et al. | β | 2021 | β |
| Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge. | Xu X et al. | β | 2021 | β |
| Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations. | Fedrizzi T et al. | β | 2021 | β |
| Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action. | Karatzas E et al. | β | 2021 | β |
| FIREWORKS: a bottom-up approach to integrative coessentiality network analysis. | Amici DR et al. | β | 2021 | β |
| Gene correlation network analysis to identify regulatory factors in sciatic nerve injury. | Li L et al. | β | 2021 | β |
| Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function. | Reay WR et al. | β | 2021 | β |
| Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies. | Traylor M et al. | β | 2021 | β |
| Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. | Stein MB et al. | β | 2021 | β |
| Genome-wide prioritization reveals novel gene signatures associated with cardiotoxic effects of tyrosine kinase inhibitors. | Li Y et al. | β | 2021 | β |
| Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection. | Kamel W et al. | β | 2021 | β |
| GPCards: An integrated database of genotype-phenotype correlations in human genetic diseases. | Li B et al. | β | 2021 | β |
| Harnessing the paradoxical phenotypes of APOE Ι2 and APOE Ι4 to identify genetic modifiers in Alzheimer's disease. | Kim YW et al. | β | 2021 | β |
| IBDDB: a manually curated and text-mining-enhanced database of genes involved in inflammatory bowel disease. | Khan F et al. | β | 2021 | β |
| Identification and Validation of Prognostic Factors of Lipid Metabolism in Obstructive Sleep Apnea. | Peng L et al. | β | 2021 | β |
| Identification and Verification of Five Potential Biomarkers Related to Skin and Thermal Injury Using Weighted Gene Co-Expression Network Analysis. | Yang R et al. | β | 2021 | β |
| Identification of 37 Heterogeneous Drug Candidates for Treatment of COVID-19 via a Rational Transcriptomics-Based Drug Repurposing Approach. | GelemanoviΔ A et al. | β | 2021 | β |
| Identification of Conserved Pappalysin 1-Derived Circular RNA-Mediated Competing Endogenous RNA in Osteosarcoma. | Ming GF et al. | β | 2021 | β |
| Identification of hub genes and candidate drugs in hepatocellular carcinoma by integrated bioinformatics analysis. | Chen X et al. | β | 2021 | β |
| Identification of Hub Genes Related to Liver Metastasis of Colorectal Cancer by Integrative Analysis. | Liu S et al. | β | 2021 | β |
| Identification of Independent and Communal Differentially Expressed Genes as Well as Potential Therapeutic Targets in Ischemic Heart Failure and Non-Ischemic Heart Failure. | Wang Z et al. | β | 2021 | β |
| Identification of key genes and pathways associated with resting mast cells in meningioma. | Xie H et al. | β | 2021 | β |
| Identification of Key Genes and Pathways in Persistent Hyperplastic Primary Vitreous of the Eye Using Bioinformatic Analysis. | Thomas DM et al. | β | 2021 | β |
| Identification of key genes and pathways in scleral extracellular matrix remodeling in glaucoma: Potential therapeutic agents discovered using bioinformatics analysis. | Hu D et al. | β | 2021 | β |
| Identification of Pivotal MicroRNAs and Target Genes Associated with Persistent Atrial Fibrillation Based on Bioinformatics Analysis. | Xiao S et al. | β | 2021 | β |
| Identification of Potential Key Genes and Regulatory Markers in Essential Thrombocythemia Through Integrated Bioinformatics Analysis and Clinical Validation. | Wang J et al. | β | 2021 | β |
| Identification of Repurpose Drugs by Computational Analysis of Disease-Gene-Drug Associations. | Gopal J et al. | β | 2021 | β |
| Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. | Daniloski Z et al. | β | 2021 | β |
| Identifying Hub Genes, Key Pathways and Immune Cell Infiltration Characteristics in Pediatric and Adult Ulcerative Colitis by Integrated Bioinformatic Analysis. | Xiu MX et al. | β | 2021 | β |
| IGF2BP1, a Conserved Regulator of RNA Turnover in Cancer. | GlaΓ M et al. | β | 2021 | β |
| <i>In-silico</i> network-based analysis of drugs used against COVID-19: Human well-being study. | Attique Z et al. | β | 2021 | β |
| Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines. | Han T et al. | β | 2021 | β |
| In silico drug repurposing for the treatment of heart diseases using gene expression data and molecular docking techniques. | Aalikhani M et al. | β | 2021 | β |
| Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019. | Wang T et al. | β | 2021 | β |
| Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance. | Tung KL et al. | β | 2021 | β |
| Integration of <i>Immunome</i> With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies. | Devaprasad A et al. | β | 2021 | β |
| Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. | Freshour SL et al. | β | 2021 | β |
| Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma. | Zhang Y et al. | β | 2021 | β |
| Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease. | Gerring ZF et al. | β | 2021 | β |
| Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages. | Zhang Q et al. | β | 2021 | β |
| Investigation of genetic loci shared between bipolar disorder and risk-taking propensity: potential implications for pharmacological interventions. | Pisanu C et al. | β | 2021 | β |
| ISPRF: a machine learning model to predict the immune subtype of kidney cancer samples by four genes. | Wang Z et al. | β | 2021 | β |
| Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways. | Schierding W et al. | β | 2021 | β |
| Machine learning approaches and databases for prediction of drug-target interaction: a survey paper. | Bagherian M et al. | β | 2021 | β |
| Machine learning integrated ensemble of feature selection methods followed by survival analysis for predicting breast cancer subtype specific miRNA biomarkers. | Sarkar JP et al. | β | 2021 | β |
| Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors. | Jiang B et al. | β | 2021 | β |
| Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics. | Swanzey E et al. | β | 2021 | β |
| Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19. | Tomazou M et al. | β | 2021 | β |
| MUSTARD-a comprehensive resource of mutation-specific therapies in cancer. | Mittal G et al. | β | 2021 | β |
| Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia. | Sayyab S et al. | β | 2021 | β |
| Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia. | Ding YY et al. | β | 2021 | β |
| Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. | Gocho Y et al. | β | 2021 | β |
| OncoGEMINI: software for investigating tumor variants from multiple biopsies with integrated cancer annotations. | Nicholas TJ et al. | β | 2021 | β |
| OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. | Wang T et al. | β | 2021 | β |
| Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets. | Elmas A et al. | β | 2021 | β |
| Patient-tailored design for selective co-inhibition of leukemic cell subpopulations. | Ianevski A et al. | β | 2021 | β |
| Potential Drug Prediction of Glioblastoma Based on Drug Perturbation-Induced Gene Expression Signatures. | Zhu B et al. | β | 2021 | β |
| Potential drugs against COVID-19 revealed by gene expression profile, molecular docking and molecular dynamic simulation. | Cava C et al. | β | 2021 | β |
| Potential Molecular Mechanism of TNF Superfamily-Related Genes in Glioblastoma Multiforme Based on Transcriptome and Epigenome. | Xie H et al. | β | 2021 | β |
| Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank. | Valette K et al. | β | 2021 | β |
| Prognostic Biomarkers and Immunotherapeutic Targets Among CXC Chemokines in Pancreatic Adenocarcinoma. | Huang J et al. | β | 2021 | β |
| Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson's disease. | Bonte MA et al. | β | 2021 | β |
| Proteogenomic and metabolomic characterization of human glioblastoma. | Wang LB et al. | β | 2021 | β |
| Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets. | DaSilva NA et al. | β | 2021 | β |
| Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis. | Tan S et al. | β | 2021 | β |
| Screening of Hub Genes Associated with Pulmonary Arterial Hypertension by Integrated Bioinformatic Analysis. | Zeng Y et al. | β | 2021 | β |
| Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks. | Chung SS et al. | β | 2021 | β |
| Simultaneous Inhibition of SARS-CoV-2 Entry Pathways by Cyclosporine. | Prasad K et al. | β | 2021 | β |
| Synergistic efficacy of curcumin and anti-programmed cell death-1 in hepatocellular carcinoma. | Guo L et al. | β | 2021 | β |
| Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma. | Chen Q et al. | β | 2021 | β |
| Systematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Several Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma. | Mohr T et al. | β | 2021 | β |
| Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations. | Prasad K et al. | β | 2021 | β |
| Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution. | Ong EZ et al. | β | 2021 | β |
| Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer. | Zhou L et al. | β | 2021 | β |
| The SARS-CoV-2 RNA-protein interactome in infected human cells. | Schmidt N et al. | β | 2021 | β |
| Transcriptome-Based Molecular Networks Uncovered Interplay Between Druggable Genes of CD8<sup>+</sup> T Cells and Changes in Immune Cell Landscape in Patients With Pulmonary Tuberculosis. | Alsulaimany FA et al. | β | 2021 | β |
| Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis. | Hoefflin R et al. | β | 2021 | β |
| Unbiased Proteomic and Phosphoproteomic Analysis Identifies Response Signatures and Novel Susceptibilities After Combined MEK and mTOR Inhibition in BRAF<sup>V600E</sup> Mutant Glioma. | Maxwell MJ et al. | β | 2021 | β |
| Unravelling the Shared Genetic Mechanisms Underlying 18 Autoimmune Diseases Using a Systems Approach. | Gokuladhas S et al. | β | 2021 | β |
| Using interpretable deep learning to model cancer dependencies. | Lin CH et al. | β | 2021 | β |
| Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine. | Bainomugisa CK et al. | β | 2021 | β |
| virusMED: an atlas of hotspots of viral proteins. | Zhang H et al. | β | 2021 | β |
| Web-based transcriptome analysis determines a sixteen-gene signature and associated drugs on hearing loss patients: A bioinformatics approach. | Lei M et al. | β | 2021 | β |
| Weighted Gene Co-Expression Network Analysis Reveals Key Genes and Potential Drugs in Abdominal Aortic Aneurysm. | Kan KJ et al. | β | 2021 | β |
| Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits. | Patel K et al. | β | 2021 | β |
| Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. | Cade BE et al. | β | 2021 | β |
| ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. | Arabzade A et al. | β | 2021 | β |
| ACE2 Co-evolutionary Pattern Suggests Targets for Pharmaceutical Intervention in the COVID-19 Pandemic. | Braun M et al. | β | 2020 | β |
| A comprehensive map of disease networks and molecular drug discoveries for glaucoma. | Wang H et al. | β | 2020 | β |
| ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis. | Charmsaz S et al. | β | 2020 | β |
| ADH7, miR-3065 and LINC01133 are associated with cervical cancer progression in different age groups. | Ding S et al. | β | 2020 | β |
| Advances in Genomics for Drug Development. | Spreafico R et al. | β | 2020 | β |
| A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. | Wang L et al. | β | 2020 | β |
| A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare Diseases. | Sosa DN et al. | β | 2020 | β |
| An omics perspective on drug target discovery platforms. | Paananen J et al. | β | 2020 | β |
| A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers. | Ren J et al. | β | 2020 | β |
| An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation. | Vo AH et al. | β | 2020 | β |
| A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants. | Kanders SH et al. | β | 2020 | β |
| A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction. | Ray PR et al. | β | 2020 | β |
| Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning. | Mohammadi E et al. | β | 2020 | β |
| Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. | Kim H et al. | β | 2020 | β |
| Association of microbiota-derived propionic acid and Alzheimer's disease; bioinformatics analysis. | Aliashrafi M et al. | β | 2020 | β |
| A systems approach to infectious disease. | Eckhardt M et al. | β | 2020 | β |
| Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis. | Su W et al. | β | 2020 | β |
| Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma. | Hu W et al. | β | 2020 | β |
| Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data analysis. | Kim HY et al. | β | 2020 | β |
| CancerTracer: a curated database for intrapatient tumor heterogeneity. | Wang C et al. | β | 2020 | β |
| Case report: 16-yr life history and genomic evolution of an ER<sup>+</sup> HER2<sup>-</sup> breast cancer. | Xu B et al. | β | 2020 | β |
| Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics. | Herr P et al. | β | 2020 | β |
| CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19. | Verstraete N et al. | β | 2020 | β |
| CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma. | Li Z et al. | β | 2020 | β |
| dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. | Huang M et al. | β | 2020 | β |
| Deciphering the co-adaptation of codon usage between respiratory coronaviruses and their human host uncovers candidate therapeutics for COVID-19. | Nambou K et al. | β | 2020 | β |
| Designing custom CRISPR libraries for hypothesis-driven drug target discovery. | Iyer VS et al. | β | 2020 | β |
| Discovery of Selenocysteine as aΒ Potential Nanomedicine Promotes Cartilage Regeneration With Enhanced Immune Response by Text Mining and Biomedical Databases. | Ye J et al. | β | 2020 | β |
| Diverse types of genomic evidence converge on alcohol use disorder risk genes. | Dai Y et al. | β | 2020 | β |
| DriverSubNet: A Novel Algorithm for Identifying Cancer Driver Genes by Subnetwork Enrichment Analysis. | Zhang D et al. | β | 2020 | β |
| Drug discovery strategies for the identification of novel regulators of uterine contractility. | Siricilla S et al. | β | 2020 | β |
| Exploring Integrative Analysis Using the BioMedical Evidence Graph. | Struck A et al. | β | 2020 | β |
| Functional Dependency Analysis Identifies Potential Druggable Targets in Acute Myeloid Leukemia. | Zhou Y et al. | β | 2020 | β |
| Gastric Cancer Heterogeneity and Clinical Outcomes. | Sexton RE et al. | β | 2020 | β |
| Gene4Denovo: an integrated database and analytic platform for de novo mutations in humans. | Zhao G et al. | β | 2020 | β |
| Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer. | Choi J et al. | β | 2020 | β |
| Genes, pathways and vulvar carcinoma - New insights from next-generation sequencing studies. | ZiΔba S et al. | β | 2020 | β |
| Genetic drug target validation using Mendelian randomisation. | Schmidt AF et al. | β | 2020 | β |
| Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology. | Bazaga A et al. | β | 2020 | β |
| Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. | Zhou H et al. | β | 2020 | β |
| Genomic landscape of the immune microenvironments of brain metastases in breast cancer. | Lu WC et al. | β | 2020 | β |
| Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies. | Groisberg R et al. | β | 2020 | β |
| GMIEC: a shiny application for the identification of gene-targeted drugs for precision medicine. | Malagoli Tagliazucchi G et al. | β | 2020 | β |
| GWAS SNPs Impact Shared Regulatory Pathways Amongst Multimorbid Psychiatric Disorders and Cognitive Functioning. | Golovina E et al. | β | 2020 | β |
| Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing. | Fang J et al. | β | 2020 | β |
| H-RACS: a handy tool to rank anti-cancer synergistic drugs. | Yan X et al. | β | 2020 | β |
| Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures. | Pfeil J et al. | β | 2020 | β |
| Identification and classification of differentially expressed genes reveal potential molecular signature associated with SARS-CoV-2 infection in lung adenocarcinomal cells. | Soremekun OS et al. | β | 2020 | β |
| Identification of Biomarkers Associated with Septic Cardiomyopathy Based on Bioinformatics Analyses. | Chen M et al. | β | 2020 | β |
| Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis. | Maghsoudloo M et al. | β | 2020 | β |
| Identification of hub genes and small molecule therapeutic drugs related to breast cancer with comprehensive bioinformatics analysis. | Hao M et al. | β | 2020 | β |
| Identification of Osteosarcoma Metastasis-Associated Gene Biomarkers and Potentially Targeted Drugs Based on Bioinformatic and Experimental Analysis. | Cao MD et al. | β | 2020 | β |
| Identification of potential gene drivers of cutaneous squamous cell carcinoma: Analysis of microarray data. | Zheng Y et al. | β | 2020 | β |
| Identification of Potential Gene Signatures Related to Sleep Deprivation. | Ruan SS et al. | β | 2020 | β |
| Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophrenia. | Rodriguez-LΓ³pez J et al. | β | 2020 | β |
| Identifying drug candidates for hepatocellular carcinoma based on differentially expressed genes. | Xing J et al. | β | 2020 | β |
| IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis. | Politano G et al. | β | 2020 | β |
| In silico analysis of alternative splicing on drug-target gene interactions. | Ji Y et al. | β | 2020 | β |
| In Silico Discovery of Candidate Drugs against Covid-19. | Cava C et al. | β | 2020 | β |
| Integrated Analysis of Key Pathways and Drug Targets Associated With Vogt-Koyanagi-Harada Disease. | Chen Z et al. | β | 2020 | β |
| Integration and Comparison of Transcriptomic and Proteomic Data for Meningioma. | Dunn J et al. | β | 2020 | β |
| Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery. | Liu Y et al. | β | 2020 | β |
| Interactome overlap between schizophrenia and cognition. | Koch E et al. | β | 2020 | β |
| Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer. | Bradfield A et al. | β | 2020 | β |
| Learning to encode cellular responses to systematic perturbations with deep generative models. | Xue Y et al. | β | 2020 | β |
| Mapping the Multi-Organ miRNA-mRNA Regulatory Network in LPS-Mediated Endotoxemic Mice: Exploring the Shared Underlying Key Genes and Mechanisms. | Zhang C et al. | β | 2020 | β |
| MEXCOwalk: mutual exclusion and coverage based random walk to identify cancer modules. | Ahmed R et al. | β | 2020 | β |
| Mexican <i>Ganoderma Lucidum</i> Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet. | Romero-CΓ³rdoba SL et al. | β | 2020 | β |
| Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders. | Zilocchi M et al. | β | 2020 | β |
| Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis. | Andronis C et al. | β | 2020 | β |
| Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types. | Bao R et al. | β | 2020 | β |
| Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs. | Chen XF et al. | β | 2020 | β |
| Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort. | Mangalaparthi KK et al. | β | 2020 | β |
| Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. | Hee E et al. | β | 2020 | β |
| Optimisation of cancer classification by machine learning generates an enriched list of candidate drug targets and biomarkers. | Ramroach S et al. | β | 2020 | β |
| Pathway and network embedding methods for prioritizing psychiatric drugs. | Pershad Y et al. | β | 2020 | β |
| Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses. | de Witte CJ et al. | β | 2020 | β |
| Pharmacological enrichment of polygenic risk for precision medicine in complex disorders. | Reay WR et al. | β | 2020 | β |
| Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis. | Wang M et al. | β | 2020 | β |
| PRODIGY: personalized prioritization of driver genes. | Dinstag G et al. | β | 2020 | β |
| Proteogenomic Characterization of Endometrial Carcinoma. | Dou Y et al. | β | 2020 | β |
| Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma. | Gillette MA et al. | β | 2020 | β |
| Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. | Krug K et al. | β | 2020 | β |
| Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression. | Chen YJ et al. | β | 2020 | β |
| Reconstructing the blood metabolome and genotype using long-range chromatin interactions. | Fadason T et al. | β | 2020 | β |
| Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches. | Treveil A et al. | β | 2020 | β |
| Screening and identification of key regulatory connections and immune cell infiltration characteristics for lung transplant rejection using mucosal biopsies. | Xiu MX et al. | β | 2020 | β |
| Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders. | Gokuladhas S et al. | β | 2020 | β |
| Significance of tumor mutation burden combined with immune infiltrates in the progression and prognosis of ovarian cancer. | Bi F et al. | β | 2020 | β |
| Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. | Gojo J et al. | β | 2020 | β |
| TargetDB: A target information aggregation tool and tractability predictor. | De Cesco S et al. | β | 2020 | β |
| The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community. | Kiel DP et al. | β | 2020 | β |
| The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. | Brueffer C et al. | β | 2020 | β |
| The Role of Gene Expression Changes in ceRNA Network Underlying Ossification of Ligamentum Flavum Development. | Wu W et al. | β | 2020 | β |
| The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs. | Cui H et al. | β | 2020 | β |
| Toward heterogeneous information fusion: bipartite graph convolutional networks for in silico drug repurposing. | Wang Z et al. | β | 2020 | β |
| Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. | von der Heyde B et al. | β | 2020 | β |
| Turning genome-wide association study findings into opportunities for drug repositioning. | Lau A et al. | β | 2020 | β |
| Understanding of Zaire ebolavirus-human protein interaction for drug repurposing. | Muthaiyan M et al. | β | 2020 | β |
| Using Informatics Tools to Identify Opportunities for Precision Medicine in Diffuse Large B-cell Lymphoma. | Patel SP et al. | β | 2020 | β |
| Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data. | Pulley JM et al. | β | 2020 | β |
| Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma. | Dutta M et al. | β | 2020 | β |
| Alterations in DNA Damage Repair Genes in Primary Liver Cancer. | Lin J et al. | β | 2019 | β |
| Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer. | Xi Y et al. | β | 2019 | β |
| An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer. | Long NP et al. | β | 2019 | β |
| A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria. | Karatzas E et al. | β | 2019 | β |
| Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. | Mack SC et al. | β | 2019 | β |
| Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017. | Uitdehaag JCM et al. | β | 2019 | β |
| Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis. | BΓΆsl K et al. | β | 2019 | β |
| Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery. | Siricilla S et al. | β | 2019 | β |
| Computational drug repurposing for inflammatory bowel disease using genetic information. | Grenier L et al. | β | 2019 | β |
| Computational resources associating diseases with genotypes, phenotypes and exposures. | Zhang W et al. | β | 2019 | β |
| Epigenome-wide association study of depression symptomatology in elderly monozygotic twins. | Starnawska A et al. | β | 2019 | β |
| Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. | Mordaunt CE et al. | β | 2019 | β |
| Evaluating the consistency of large-scale pharmacogenomic studies. | Rahman R et al. | β | 2019 | β |
| Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost. | Ji X et al. | β | 2019 | β |
| Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer. | Tong Z et al. | β | 2019 | β |
| FXYD5 (Dysadherin) upregulation predicts shorter survival and reveals platinum resistance in high-grade serous ovarian cancer patients. | Tassi RA et al. | β | 2019 | β |
| Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy. | Winters BR et al. | β | 2019 | β |
| GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum. | Bradley MW et al. | β | 2019 | β |
| Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies. | PΓΆlΓΆnen P et al. | β | 2019 | β |
| Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with <i>MLL</i> gene rearrangement. | Zhang H et al. | β | 2019 | β |
| Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy. | Yang W et al. | β | 2019 | β |
| Identification of novel candidate indicators for assessing zinc status during pregnancy in mice from microarray data. | Xu W et al. | β | 2019 | β |
| Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen. | Shortt K et al. | β | 2019 | β |
| Identification of Transcriptional Markers and microRNA-mRNA Regulatory Networks in Colon Cancer by Integrative Analysis of mRNA and microRNA Expression Profiles in Colon Tumor Stroma. | Uddin MN et al. | β | 2019 | β |
| Insights into Impact of DNA Copy Number Alteration and Methylation on the Proteogenomic Landscape of Human Ovarian Cancer via a Multi-omics Integrative Analysis. | Song X et al. | β | 2019 | β |
| Integration of target discovery, drug discovery and drug delivery: A review on computational strategies. | Duarte Y et al. | β | 2019 | β |
| Ion Channel Contributions to Wing Development in <i>Drosophila melanogaster</i>. | George LF et al. | β | 2019 | β |
| MECoRank: cancer driver genes discovery simultaneously evaluating the impact of SNVs and differential expression on transcriptional networks. | Hui Y et al. | β | 2019 | β |
| Novel drug candidate for the treatment of several softβtissue sarcoma histologic subtypes: A computational method using survivalβassociated gene signatures for drug repurposing. | Yang X et al. | β | 2019 | β |
| OCTANE: Oncology Clinical Trial Annotation Engine. | Zeng J et al. | β | 2019 | β |
| 'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. | Politano G et al. | β | 2019 | β |
| Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response. | Das S et al. | β | 2019 | β |
| Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types. | Izzi V et al. | β | 2019 | β |
| Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs. | Zolotovskaia MA et al. | β | 2019 | β |
| Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms. | Keine D et al. | β | 2019 | β |
| Potential therapeutic drugs for ischemic stroke based on bioinformatics analysis. | Zhou L et al. | β | 2019 | β |
| Precision oncology for gallbladder cancer: insights from genetic alterations and clinical practice. | Lin J et al. | β | 2019 | β |
| Regulostat Inferelator: a novel network biology platform to uncover molecular devices that predetermine cellular response phenotypes. | Ung CY et al. | β | 2019 | β |
| SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment. | Deng X et al. | β | 2019 | β |
| Standard operating procedure for curation and clinical interpretation of variants in cancer. | Danos AM et al. | β | 2019 | β |
| Systematic analysis of gene expression profiles reveals prognostic stratification and underlying mechanisms for muscle-invasive bladder cancer. | Zhang PB et al. | β | 2019 | β |
| Targeted sequencing aids in identifying clonality in chronic myelomonocytic leukemia. | Hwang SM et al. | β | 2019 | β |
| The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches. | Hassan M et al. | β | 2019 | β |
| The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. | Huang Y et al. | β | 2019 | β |
| The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system. | Wong D et al. | β | 2019 | β |
| The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public. | van der Spek RAA et al. | β | 2019 | β |
| The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. | Trigg RM et al. | β | 2019 | β |
| Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. | Giri A et al. | β | 2019 | β |
| Uncovering Potential Therapeutic Targets in Colorectal Cancer by Deciphering Mutational Status and Expression of Druggable Oncogenes. | Menyhart O et al. | β | 2019 | β |
| Understanding Human-Virus Protein-Protein Interactions Using a Human Protein Complex-Based Analysis Framework. | Yang S et al. | β | 2019 | β |
| VIST - a Variant-Information Search Tool for precision oncology. | Ε eva J et al. | β | 2019 | β |
| Genomics and electronic health record systems. | Ohno-Machado L et al. | β | 2018 | β |
| G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? | Sriram K et al. | β | 2018 | β |
| Hub genes in a pan-cancer co-expression network show potential for predicting drug responses. | Azuaje F et al. | β | 2018 | β |
| Identification of potential drugs for diffuse large b-cell lymphoma based on bioinformatics and Connectivity Map database. | Luo B et al. | β | 2018 | β |
| Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers. | Jung H et al. | β | 2018 | β |
| Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. | Nagel M et al. | β | 2018 | β |
| Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response. | PiΓ±ero J et al. | β | 2018 | β |
| Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience. | Hoefflin R et al. | β | 2018 | β |
| Potential Therapeutic Drugs for Parkinson's Disease Based on Data Mining and Bioinformatics Analysis. | Xu C et al. | β | 2018 | β |
| Probing the chemical-biological relationship space with the Drug Target Explorer. | Allaway RJ et al. | β | 2018 | β |
| SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics. | Singer F et al. | β | 2018 | β |
| The Role of COL5A2 in Patients With Muscle-Invasive Bladder Cancer: A Bioinformatics Analysis of Public Datasets Involving 787 Subjects and 29 Cell Lines. | Meng XY et al. | β | 2018 | β |