Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach.

paper Cited Public

Authors: Gilmore, Casey S; Malone, Stephen M; Iacono, William G
Year: 2010
Journal: Behavior genetics
PMID: 20155392
DOI: 10.1007/s10519-010-9343-3
PMCID: PMC2830280

#	Section	Preview
20	Methods — Participants	For the present report, data were collected when members of both cohorts were at a similar age,…
21	Methods — Diagnostic Assessment	For participants in each of the two cohorts, lifetime presence of DSM-III-R (American Psychiatric…
22	Methods — Diagnostic Assessment	Personality Disorder). Mothers reported on the presence of conduct disorder and substance use…
23	Methods — Diagnostic Assessment	Our measure of Externalizing consisted of the first principal component (which accounted for 59% of…
24	Methods — Psychophysiological Assessment — Resting EEG	Five minutes of resting EEG were collected while participants were instructed to relax with their…
25	Methods — Psychophysiological Assessment — ERP task	A rotated-heads visual oddball task (Begleiter et al., 1984) was used. Subjects viewed 240 stimuli…
26	Methods — Psychophysiological Assessment — Recording procedure	A Grass model 12A Neurodata Acquisition System recorded the EEG. Impedances were kept below 5 kΩ.…
27	Methods — Data processing — Resting EEG	The resting EEG data were divided into 2 s half-overlapping epochs (i.e. the first second of each…
28	Methods — Data processing — ERP	For the ERP data, blinks and other ocular artifacts were corrected using the method of Gratton,…
29	Methods — Data processing — Time-frequency PCA decomposition of ERPs	The time-frequency PCA (TF-PCA) method has been detailed in previous reports (E. M. Bernat et al.,…
30	Methods — Data processing — Time-frequency PCA decomposition of ERPs	of rotated component loadings for each TF point. Five components were retained, based upon…
31	Methods — Data Analysis	Our main approach consisted in fitting multivariate biometric models using a Cholesky…
32	Methods — Data Analysis	We freely estimated means and covariances of P3 amplitude, beta power, the time-frequency components…
33	Methods — Data Analysis	to determine whether genetic influences on the endophenotypes account for significant genetic…
34	Results	Before analyzing the data, we examined them for outliers using an R package (Fox, 2009) that…
35	Results — Stability of Time-Frequency Components	For our TF-PCA components, we first wanted to confirm that the decompositions were stable across our…
36	Results — TF Components Most Relevant for EXT	To determine which time-frequency components to include in our Cholesky model, we conducted PCA on…
37	Results — TF Components Most Relevant for EXT	and TF-PC4 (with peak energy also centered around 2.5 Hz, but occurring slightly later in time,…
38	Results — Endophenotypic Measures	For subsequent analyses, we created composite endophenotype measures. For those measures recorded…
39	Results — Endophenotypic Measures	Table 1 gives descriptive statistics for the endophenotypes and EXT. As the table indicates, MZ and…

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Title	Year	PMID
A genome wide association study of fast beta EEG in families of European ancestry.	2017	28040410
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Gender modulates the development of theta event related oscillations in adolescents and young adults.	2015	26102560
Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task.	2015	26388585
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Genetic psychophysiology: advances, problems, and future directions.	2014	24739435
Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study.	2014	25387704
Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.	2014	25387720
Event-Related Oscillations in Alcoholism Research: A Review.	2012	24273686

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Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.	Iacono WG et al.	—	2014	→
A construct-network approach to bridging diagnostic and physiological domains: application to assessment of externalizing psychopathology.	Patrick CJ et al.	—	2013	→
Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults.	Yoon HH et al.	—	2013	→
Endophenotypes in psychopathology research: where do we stand?	Miller GA et al.	—	2013	→
Genetic influences on composite neural activations supporting visual target identification.	Ethridge LE et al.	—	2013	→
Clarifying domains of internalizing psychopathology using neurophysiology.	Vaidyanathan U et al.	—	2012	→
Event-Related Oscillations in Alcoholism Research: A Review.	Pandey AK et al.	—	2012	→
Do resting brain dynamics predict oddball evoked-potential?	Lee TW et al.	—	2011	→
Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.	Tye C et al.	—	2011	→
P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis.	Szuromi B et al.	—	2011	→
Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies.	Hicks BM et al.	—	2011	→