Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents.

paper Cited Public

Authors: Spadoni, Andrea D; Norman, Andria L; Schweinsburg, Alecia D; Tapert, Susan F
Year: 2008
Journal: Alcoholism, clinical and experimental research
PMID: 18540914
DOI: 10.1111/j.1530-0277.2008.00694.x
PMCID: PMC2532854

#	Section	Preview
20	RESULTS — Motion	The maximum values of rotation and displacement were modest (roll = 0.18°, pitch = 1.28°, yaw =…
21	RESULTS — SWM Activation and Family History	Across participants, the pattern of SWM relative to vigilance was consistent with existing…
22	RESULTS — Follow-Up Analyses	To clarify this pattern of activation, 2 single-sample t-tests in AFNI compared SWM relative to…
23	RESULTS — Follow-Up Analyses	the fixation condition, showed a trend-level negative relationship between BOLD response to…
24	DISCUSSION	The goal of this study was to explore the relationship between FH of AUD and brain response to SWM…
25	DISCUSSION	Midline structures such as the posterior cingulate cortex, medial frontal gyri, and anterior…
26	DISCUSSION	more fixation-related BOLD response and less vigilance response in the cingulate. Potentially, this…
27	DISCUSSION	Previous work investigating the utility of the default network suggests that activation in midline…
28	DISCUSSION	of connectivity in the default network, and proposed that lateral prefrontal regions may actively…
29	DISCUSSION	In FH dense adolescents, compromised neural regulation of midline regions may have direct behavioral…
30	DISCUSSION	Our findings have potentially interesting implications for the interpretation of anomalous…
31	DISCUSSION	in GABA receptor genes affect neural inhibition and thus the level of neural excitability, thereby…
32	DISCUSSION	Additional data support the link between substance use risk and activation of structures involved in…
33	DISCUSSION	This study has several limitations. First, participant motion, although relatively modest, was…
34	DISCUSSION	The current investigation suggests that functional neuroimaging may be useful for identifying…

Name	Type
academic performance	phenotype
Accuracy (SWM) local	phenotype
Accuracy (vigilance) local	phenotype
Adolescent cohort (12-14 years) local	cohort
adolescents	cohort
Adolescents at risk for Alcohol Use Disorder local	cohort
Adolescents with dense FH local	cohort
adolescents with denser FH local	cohort
age	phenotype
alcohol	phenotype
alcohol dependence	phenotype
alcoholism	phenotype
Alcohol Use Disorder	phenotype
anterior cingulate cortex	anatomy
antisocial personality disorder	phenotype
anxiety	phenotype
AUD	phenotype
axis I disorder	phenotype
behavioral disinhibition	phenotype
behavioral inhibition	phenotype
bipolar I disorder	phenotype
Block Design local	phenotype
BOLD activation	phenotype
BOLD response	phenotype
BOLD response to vigilance local	phenotype
Bulk motion local	phenotype
Bulk Motion local	phenotype
CBCL scores local	phenotype
Cerebellar Tonsil local	anatomy
children of alcoholics	cohort
cingulate cortex	anatomy
cingulate/medial frontal gyral region local	anatomy
CNS disinhibition	phenotype
CNS disinhibitory related behaviors local	phenotype
cognition	phenotype
conduct disorder	phenotype
Conduct disorder diagnosis local	phenotype
default mode network	anatomy
default network	anatomy
Default network regions local	anatomy
Demography local	phenotype
depression	phenotype
Disinhibitory disorders	phenotype
dorsolateral prefrontal cortex	anatomy
drugs	drug
Edinburgh Handedness Inventory local	phenotype
event-related potential	phenotype
familial AUD local	phenotype
Familial density of AUD local	phenotype
family history density	phenotype
Family History Negative youth local	cohort
family history of alcoholism	phenotype
family history positive	phenotype
FH	cohort
FH dense adolescents local	cohort
FH Density Scores local	phenotype
FHN youth local	cohort
FHP adolescents local	cohort
FHP youth	cohort
fixation local	phenotype
fixation-related BOLD response local	phenotype
GABA	phenotype
GABA receptor genes	gene
GABA subunits local	gene
Head injury	phenotype
higher-order cortical regions local	anatomy
Hollingshead scale local	drug
impulsivity	phenotype
Increased resting beta frequency local	phenotype
inferior area local	anatomy
inferior cingulate local	anatomy
Intra-individual consistency in behavioral performance local	phenotype
Late puberty local	phenotype
lateral prefrontal cortex	anatomy
learning disabilities	phenotype
Left-handedness	phenotype
Maternal years of education local	phenotype
Matrices local	phenotype
medial frontal cortex	anatomy
midline regions	anatomy
midline structures local	anatomy
Midline Structures local	anatomy
Mid-puberty local	phenotype
mind wandering local	phenotype
mood disorders	phenotype
Mothers' Education local	phenotype
Neural inhibition local	phenotype
Neurocognitive deficits	phenotype
Neurological problems local	phenotype
neuronal excitability	phenotype
neuropsychological test performance	phenotype
nicotine	drug
Nondrinking FHP individuals local	cohort
oppositional defiant disorder	phenotype
other drugs	drug
other drug use	phenotype
P300 amplitude	phenotype
P300 measures	phenotype
paracentral lobule	anatomy
parietal cortex	anatomy
participant motion local	phenotype
participants	cohort
positive family histories local	phenotype
posterior cingulate cortex	anatomy
Posterior cingulate gyri local	anatomy
Precentral Motor Cortex local	anatomy
preterm birth	phenotype
problematic alcohol use	phenotype
psychopathological syndromes local	phenotype
psychosis	phenotype
Pubertal development scores local	phenotype
Pubertal staging local	phenotype
Reaction time (vigilance condition) local	phenotype
relapse	phenotype
right cerebellar tonsil local	anatomy
San Diego area middle school students local	cohort
Secondary sex characteristic development local	phenotype
sex	phenotype
Similarities local	phenotype
Simple Vigilance Baseline Condition local	phenotype
spatial working memory	phenotype
stimulant dependent adults local	cohort
stimulus independent thought local	phenotype
substance use	phenotype
Superior Medial Region local	anatomy
SWM	phenotype
SWM condition local	phenotype
SWM response local	phenotype
Tanner staging local	phenotype
Task-correlated Motion local	phenotype
Task-correlated motion (roll rotation) local	phenotype
Task-correlated motion (yaw rotation) local	phenotype
task difficulty	phenotype
vigilance	phenotype
Vigilance condition local	phenotype
vigilance-related activation local	phenotype
vigilance response local	phenotype
vocabulary	phenotype
Wechsler Abbreviated Scale of Intelligence	drug
working memory	phenotype
Youth at risk for substance problems	cohort
youths at risk for AUD local	cohort
Youth without risk factors for AUD local	cohort
Youth with risk factors for AUD local	cohort

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External

Title	Authors	Journal	Year	Link
Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.	Schilling L et al.	—	2025	→
Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder.	Schmid F et al.	—	2024	→
Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us.	Tapert SF et al.	—	2022	→
Maternal drinking behaviour and co-exposure from smoking during and after pregnancy in relation to the neurocognitive function of school-children in the rural Western Cape.	Chetty-Mhlanga S et al.	—	2022	→
The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.	Courtney KE et al.	—	2019	→
Cognitive and behavioural dispositions in offspring at high risk for alcoholism.	Kumar R et al.	—	2018	→
Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder.	Henderson KE et al.	—	2018	→
Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use.	Brown-Rice KA et al.	—	2018	→
Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.	Hu S et al.	—	2016	→
Neurobiological phenotypes associated with a family history of alcoholism.	Cservenka A	—	2016	→
Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism.	Peraza J et al.	—	2015	→
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	Salvatore JE et al.	—	2015	→
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task.	Acheson A et al.	—	2015	→
Anomalous temporoparietal activity in individuals with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project.	Acheson A et al.	—	2014	→
Contributions of magnetic resonance spectroscopy to understanding development: potential applications in the study of adolescent alcohol use and abuse.	Cohen-Gilbert JE et al.	—	2014	→
fMRI response during figural memory task performance in college drinkers.	Dager AD et al.	—	2014	→
GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.	Silveri MM	—	2014	→
<i>Considering Cannabis</i>: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults.	Lisdahl KM et al.	—	2014	→
Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.	Acheson A et al.	—	2014	→
Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence.	Charlet K et al.	—	2014	→
The effect of alcohol use on human adolescent brain structures and systems.	Squeglia LM et al.	—	2014	→
Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence.	Cheetham A et al.	—	2014	→
White matter integrity in alcohol-naive youth with a family history of alcohol use disorders.	Squeglia LM et al.	—	2014	→
A functional magnetic resonance imaging study of spatial working memory in children with prenatal alcohol exposure: contribution of familial history of alcohol use disorders.	Norman AL et al.	—	2013	→
Amygdala Volume in Offspring from Multiplex for Alcohol Dependence Families: The Moderating Influence of Childhood Environment and 5-HTTLPR Variation.	Hill SY et al.	—	2013	→
Atypical neural activity during inhibitory processing in substance-naïve youth who later experience alcohol-induced blackouts.	Wetherill RR et al.	—	2013	→
Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism.	Mackiewicz Seghete KL et al.	—	2013	→
Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.	Lisdahl KM et al.	—	2013	→
Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders.	Sjoerds Z et al.	—	2013	→
Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents.	Spadoni AD et al.	—	2013	→
Neurotoxic effects of alcohol in adolescence.	Jacobus J et al.	—	2013	→
White matter microstructure, alcohol exposure, and familial risk for alcohol dependence.	Hill SY et al.	—	2013	→
Acute alcohol effects on contextual memory BOLD response: differences based on fragmentary blackout history.	Wetherill RR et al.	—	2012	→
Adolescent brain development and underage drinking in the United States: identifying risks of alcohol use in college populations.	Silveri MM	—	2012	→
Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism.	Cservenka A et al.	—	2012	→
Brain response to working memory over three years of adolescence: influence of initiating heavy drinking.	Squeglia LM et al.	—	2012	→
Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism.	Wetherill RR et al.	—	2012	→
Increased marijuana use and gender predict poorer cognitive functioning in adolescents and emerging adults.	Lisdahl KM et al.	—	2012	→
Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.	Weiland BJ et al.	—	2012	→
Risky decision-making: an FMRI study of youth at high risk for alcoholism.	Cservenka A et al.	—	2012	→
Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance.	Silveri MM et al.	—	2011	→
Do executive and reactive disinhibition mediate the effects of familial substance use disorders on adolescent externalizing outcomes?	Handley ED et al.	—	2011	→
Neural activation during inhibition predicts initiation of substance use in adolescence.	Norman AL et al.	—	2011	→
Alcohol cue reactivity task development.	Pulido C et al.	—	2010	→
Neural circuitry associated with risk for alcohol use disorders.	Tessner KD et al.	—	2010	→
Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholics.	Heitzeg MM et al.	—	2010	→
Family history of alcohol-use disorders and spatial working memory: effects on adolescent alcohol expectancies.	Pulido C et al.	—	2009	→