Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential.
paper
Cited
Public
- Authors
- Iacono, William G; Malone, Stephen M
- Year
- 2011
- Journal
- Child development perspectives
- PMID
- 22247735
- DOI
- 10.1111/j.1750-8606.2011.00205.x
- PMCID
- PMC3254094
Although substance use disorders are heritable, their complexity has made identifying genes underlying their development challenging. Endophenotypes, biologically informed quantitative measures that index genetic risk for a disorder, are being recognized for their potential to assist the search for disorder relevant genes. After outlining criteria for an endophenotype that includes developmental considerations, we review how the brain P300 response serves as an index of genetic risk for substance abuse and related externalizing disorders. The P300 response is highly heritable and associated broadly with characteristics of externalizing disorder, including childhood disruptive disorders, antisociality, and precocious expression of deviant behavior. This association appears to be mediated by shared genetic influences. Prospective studies confirm that reduced P300 amplitude present in youth prior to significant exposure to addictive substances is associated with the subsequent development of substance use disorders. Despite pronounced change in mean level over the course of development, P300 amplitude shows strong rank order stability with repeated assessment through young adulthood. In addition, P300 developmental trajectories based on multiple assessments show very high heritability and may be especially informative as measures of genetic risk. Collectively, these findings provide strong support that P300 amplitude and its change through development reflect genetic vulnerability to substance abuse and related externalizing psychopathology.
No figures extracted from this document.
← Prev
21–27 of 27
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Clarifying the place of p300 in the empirical structure of psychopathology over development. | Perkins ER et al. | — | 2024 | → |
| Electrophysiological biomarkers in dual pathology. | Rojas Bernal LA et al. | — | 2024 | → |
| Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. | Brislin SJ et al. | — | 2024 | → |
| How can (or could) biology inform more effective parenting interventions for childhood aggression? | Perkins ER et al. | — | 2024 | → |
| Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder. | Pandey G et al. | — | 2023 | → |
| Effects of binge drinking and depression on cognitive-control processes during an emotional Go/No-Go task in emerging adults. | Magee KE et al. | — | 2023 | → |
| Longitudinal stability and change in time-frequency measures from an oddball task during adolescence and early adulthood. | Malone SM et al. | — | 2023 | → |
| Physical inactivity during adolescence heightens risk for cannabis use disorder in adulthood. | Tarter RE et al. | — | 2023 | → |
| The relevant research of adverse childhood experiences and "risky drinking" in children of alcoholics in China. | Sun G et al. | — | 2023 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
| Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment. | Harper J et al. | — | 2022 | → |
| Event-related potential (ERP) measures of error processing as biomarkers of externalizing disorders: A narrative review. | Lutz MC et al. | — | 2021 | → |
| Incentive sensitization in binge behaviors: A mini review on electrophysiological evidence. | Werle D et al. | — | 2021 | → |
| Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use. | Harper J et al. | — | 2021 | → |
| In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD. | Miranda P et al. | — | 2020 | → |
| The association between early life mental health and alcohol use behaviours in adulthood: A systematic review. | Ning K et al. | — | 2020 | → |
| Using a co-twin control design to evaluate alternative trait measures as indices of liability for substance use disorders. | Joyner KJ et al. | — | 2020 | → |
| A meta-analytic evaluation of the N2 component as an endophenotype of response inhibition and externalizing psychopathology in childhood. | Hoyniak CP et al. | — | 2019 | → |
| Reduced premovement positivity during the stimulus-response interval precedes errors: Using single-trial and regression ERPs to understand performance deficits in ADHD. | Burwell SJ et al. | — | 2019 | → |
| Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use. | Harper J et al. | — | 2019 | → |
| A longitudinal, within-person investigation of the association between the P3 ERP component and externalizing behavior problems in young children. | Petersen IT et al. | — | 2018 | → |
| Effects of depression and past-year binge drinking on cognitive control processes during a flanker task in college-aged adults. | Connell AM et al. | — | 2018 | → |
| Reduced Medial Frontal Positivity During the Stimulus-Response Interval Precedes Action Errors and Explains Task Deficits in Attention-Deficit Hyperactivity Disorder | Burwell SJ et al. | — | 2018 | — |
| Children's brain activation during risky decision-making: A contributor to substance problems? | Crowley TJ et al. | — | 2017 | → |
| Comparing Self-Regulation-Associated Event Related Potentials in Preschool Children with and without High Levels of Disruptive Behavior. | Grabell AS et al. | — | 2017 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2017 | → |
| Sustained dysfunctional information processing in patients with Internet gaming disorder: 6-month follow-up ERP study. | Park M et al. | — | 2017 | → |
| Theta- and delta-band EEG network dynamics during a novelty oddball task. | Harper J et al. | — | 2017 | → |
| What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude? | Malone SM et al. | — | 2017 | → |
| One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study. | Burwell SJ et al. | — | 2016 | → |
| Quantitative magnetic resonance imaging traits as endophenotypes for genetic mapping in epilepsy. | Alhusaini S et al. | — | 2016 | → |
| Altered corpus callosum morphology associated with autism over the first 2 years of life. | Wolff JJ et al. | — | 2015 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2015 | → |
| How does reactivity to frustrative non-reward increase risk for externalizing symptoms? | Gatzke-Kopp LM et al. | — | 2015 | → |
| Implications of ongoing neural development for the measurement of the error-related negativity in childhood. | DuPuis D et al. | — | 2015 | → |
| Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. | Yoon HH et al. | — | 2015 | → |
| Psychopathy, attention, and oddball target detection: New insights from PCL-R facet scores. | Anderson NE et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward. | Vaidyanathan U et al. | — | 2015 | → |
| A general population twin study of conduct problems and the auditory P300 waveform. | Bertoletti E et al. | — | 2014 | → |
| Decomposing P300 to identify its genetic basis. | Ford JM | — | 2014 | → |
| Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders? | Burwell SJ et al. | — | 2014 | → |
| Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview. | Iacono WG et al. | — | 2014 | → |
| Heritability and molecular genetic basis of acoustic startle eye blink and affectively modulated startle response: a genome-wide association study. | Vaidyanathan U et al. | — | 2014 | → |
| Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study. | Vaidyanathan U et al. | — | 2014 | → |
| Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study. | Vaidyanathan U et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| In search of biomarkers in psychiatry: EEG-based measures of brain function. | McLoughlin G et al. | — | 2014 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Endophenotypes in psychopathology research: where do we stand? | Miller GA et al. | — | 2013 | → |
| Multifactorial determinants of target and novelty-evoked P300 amplitudes in children of addicted parents. | Euser AS et al. | — | 2013 | → |
| P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents. | Perlman G et al. | — | 2013 | → |
| Role of murine models in psychiatric illness drug discovery: a dimensional view. | Hoffman KL | — | 2013 | → |
| Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. | Vrieze SI et al. | — | 2012 | → |
| Examining electrodermal hyporeactivity as a marker of externalizing psychopathology: a twin study. | Isen JD et al. | — | 2012 | → |
| Lexical decision as an endophenotype for reading comprehension: an exploration of an association. | Naples A et al. | — | 2012 | → |
| Parsing the Undercontrol/Disinhibition Pathway to Substance Use Disorders: A Multilevel Developmental Problem. | Zucker RA et al. | — | 2011 | → |
| The Contributions of Developmental Science to the Study of Substance Use and Disorder: Introduction to a Special Section of <i>Child Development Perspectives.</i> | Hussong AM | — | 2011 | → |