Peer substance involvement modifies genetic influences on regular substance involvement in young women.
paper
Cited
Public
- Authors
- Agrawal, Arpana; Balasubramanian, Sumitra; Smith, Emily K; Madden, Pamela A F; Bucholz, Kathleen K; Heath, Andrew C; Lynskey, Michael T
- Year
- 2010
- Journal
- Addiction (Abingdon, England)
- PMID
- 20569232
- DOI
- 10.1111/j.1360-0443.2010.02993.x
- PMCID
- PMC3046802
AIMS: Peer substance involvement (PSI) is a robust correlate of adolescent substance use. A small number of genetically informative studies suggest that shared genetic and environmental factors contribute to this association. We examine mechanisms by which PSI influences the etiology of regular substance involvement (RSI), particularly in women. DESIGN: Population-based cohort study of twin women from the US Midwest. PARTICIPANTS: 2176 twin women. MEASUREMENTS: To examine the relationship between self-reported PSI during adolescence and a composite RSI representing regular tobacco, alcohol and cannabis use during young adulthood, using genetically informative correlation, moderation and joint correlation-moderation models. FINDINGS: There was evidence for a significant additive genetic X environment interaction. PSI was moderately heritable (h(2) = 0.25). Genetic, shared and non-shared influences on RSI overlapped with influences on PSI (genetic correlation of 0.43). Even after controlling for these shared genetic influences, RSI was more heritable in those reporting greater PSI. CONCLUSIONS: While young women may select peers based on certain dispositional traits (e.g. permissiveness towards substance use), the social milieu constructed by PSI does modify the architecture of increased RSI in those individuals with increasing levels of PSI being associated with stronger expression of heritable influences.
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| Name | Type |
|---|---|
| A local | phenotype |
| additive genetic factors local | phenotype |
| African-Americans | cohort |
| age | phenotype |
| age 14-16 years local | cohort |
| age 16-17 years local | cohort |
| age 18-20 years local | cohort |
| age 21+ years local | cohort |
| alcohol | phenotype |
| Alcohol Use | phenotype |
| cannabis use | phenotype |
| cigarettes | phenotype |
| cocaine | phenotype |
| crack cocaine | phenotype |
| dependence | phenotype |
| drinks per week | phenotype |
| European-American women local | cohort |
| female same-sex twin pairs local | cohort |
| Five-year follow-up interview local | cohort |
| genetic liability for substance use | phenotype |
| hashish | drug |
| heavy drinking | phenotype |
| inhalants | drug |
| marijuana | phenotype |
| men | cohort |
| MOAFTS | cohort |
| non-shared environmental factors local | phenotype |
| peer alcohol use | phenotype |
| peer delinquency | phenotype |
| peer deviance | phenotype |
| peer substance use | phenotype |
| permissiveness towards substance use local | phenotype |
| Positive peer assortment local | phenotype |
| problematic substance involvement local | phenotype |
| PSI local | phenotype |
| recent alcohol and tobacco use local | phenotype |
| Recent alcohol and tobacco use local | phenotype |
| regular alcohol use | phenotype |
| regular cannabis use local | phenotype |
| regular/repeated substance use local | phenotype |
| regular smoking | phenotype |
| RSI local | phenotype |
| shared environmental influence | phenotype |
| smokeless tobacco | phenotype |
| substance abuse | phenotype |
| substance use | phenotype |
| Substance Use Measure local | phenotype |
| substance using peers local | phenotype |
| substance-using peers local | drug |
| Substance using peers local | phenotype |
| tobacco use | phenotype |
| Twin cohort | cohort |
| Twin respondents local | cohort |
| unique environmental influences | phenotype |
| women | cohort |
| young adult female sample local | cohort |
| young women | cohort |
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