Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology.
paper
Cited
Public
- Authors
- Carlson, Scott R; Iacono, William G
- Year
- 2008
- Journal
- Journal of abnormal psychology
- PMID
- 19025236
- DOI
- 10.1037/a0013443
- PMCID
- PMC2701667
Boys at risk for alcoholism show deviant P300 amplitude development. Genetic influences on P300, however, are related to a range of externalizing disorders. This study examined whether P300 development from adolescence to early adulthood differed between groups varying in severity of paternal externalizing. Parietal P300 was assessed during the "rotated heads" task on up to 3 times between the ages of 17 and 24 years. Participants were divided into 3 paternal externalizing groups: (a) severe (father has adult antisocial behavior), (b) intermediate (father has alcohol dependence but not a more severe disorder), and (c) low (father has no externalizing disorders or substance treatment and is not extreme in alcohol use). Mixed models were used to evaluate linear change in amplitude. P300 decreased with age. The severe-risk group had smaller P300 initially and changed less with time than did the low-risk group. The intermediate-risk group did not differ significantly from the low-risk group, but differed marginally from the severe-risk males. Externalizing and early-onset substance disorders in the sons were associated with smaller initial values of P300. Measures of deviant P300 development may be vulnerability markers for externalizing psychopathology.
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| 40 | Discussion — Conclusion | P300 amplitude decreased with age from mid-adolescence to early adulthood. Rather than reflecting a… |
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| Name | Type |
|---|---|
| AAB | cohort |
| Abstinent adults with alcoholism local | cohort |
| ADHD | phenotype |
| adolescents | cohort |
| adult antisocial behavior | phenotype |
| Adult antisocial men local | cohort |
| Affected participants local | cohort |
| age | phenotype |
| age at first drink | phenotype |
| Age at first drink without parental permission local | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| alcoholism | phenotype |
| alcoholism risk | phenotype |
| alcohol or drug treatment local | phenotype |
| Alcohol Use Disorder | phenotype |
| anterior sites local | anatomy |
| antisocial personality disorder | phenotype |
| at-risk groups | phenotype |
| beer | drug |
| Biological fathers local | cohort |
| CD | phenotype |
| central nervous system | anatomy |
| conduct disorder | phenotype |
| Disinhibited behavior disorders local | phenotype |
| disinhibited personality characteristics local | phenotype |
| disorder | phenotype |
| drug | drug |
| drug dependence | phenotype |
| DSM–III–R | phenotype |
| earlier age at first alcohol use local | phenotype |
| Earlier onset substance disorder local | phenotype |
| Early-onset substance disorder local | phenotype |
| early-onset substance problems local | phenotype |
| educational attainment | phenotype |
| EEG | phenotype |
| EOG local | phenotype |
| externalizing disorders | phenotype |
| Externalizing groups local | phenotype |
| externalizing low-risk group local | cohort |
| externalizing risk groups local | cohort |
| Familial externalizing local | phenotype |
| families | cohort |
| fathers | cohort |
| frontal cortex | anatomy |
| frontally influenced cognitive processes local | phenotype |
| Frontally influenced cognitive processes local | phenotype |
| frontal P300 generators local | anatomy |
| Gender × Risk Status interaction local | phenotype |
| heavy substance involvement local | phenotype |
| High paternal risk group local | cohort |
| high-risk children | cohort |
| high-risk girls local | cohort |
| high-risk young men local | cohort |
| high-risk young women local | cohort |
| Hill et al. (1999) local | cohort |
| illicit drug dependence | phenotype |
| illicit drugs | phenotype |
| illicit drug use | phenotype |
| intercept | phenotype |
| intermediate externalizing risk group local | cohort |
| Intermediate paternal externalizing risk group local | cohort |
| intermediate paternal risk local | cohort |
| intermediate paternal risk local | phenotype |
| intermediate paternal risk group local | phenotype |
| intermediate-risk fathers local | cohort |
| intermediate-risk group local | cohort |
| Intermediate risk group local | cohort |
| Intermediate-risk group local | cohort |
| liquor | drug |
| low paternal risk local | cohort |
| low paternal risk local | phenotype |
| low paternal risk group local | cohort |
| Low paternal risk group local | cohort |
| low risk local | cohort |
| low-risk children local | cohort |
| low-risk fathers local | cohort |
| low-risk group | cohort |
| low-risk group local | phenotype |
| low-risk participants local | cohort |
| Low-risk trajectory group local | cohort |
| maximum consumption measure local | phenotype |
| Maximum number of alcoholic drinks consumed in a 24-hr period local | phenotype |
| maximum number of drinks in a 24-hr period local | phenotype |
| Men with disorder local | cohort |
| Men without disorder local | cohort |
| Minnesota Twin Family Study (MTFS) local | cohort |
| mixed drink | drug |
| MTFS | cohort |
| MTFS participants | cohort |
| MTFS youths local | cohort |
| neutral nontarget stimulus amplitude local | phenotype |
| neutral P300 amplitude local | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| nicotine use disorder | phenotype |
| nonpsychiatric sample local | cohort |
| nontarget P300 amplitude local | phenotype |
| ODD | phenotype |
| offspring diagnoses local | phenotype |
| offspring IQ local | phenotype |
| P300 amplitude | phenotype |
| P300 measure local | phenotype |
| P300 measures | phenotype |
| parietal cortex | anatomy |
| parietal P300 generators local | anatomy |
| participants | cohort |
| paternal AAB local | cohort |
| paternal AAB local | phenotype |
| Paternal AAB local | phenotype |
| paternal AAB group local | cohort |
| paternal AAB group local | phenotype |
| Paternal AAB group local | cohort |
| paternal AAB groups local | cohort |
| paternal AAB risk group local | phenotype |
| paternal alcohol use measures local | phenotype |
| paternal history of Alcohol Abuse local | phenotype |
| Paternal history of alcohol dependence local | phenotype |
| paternal history of externalizing problems local | phenotype |
| Paternal low-risk group local | cohort |
| Paternal risk group local | cohort |
| paternal risk groups local | cohort |
| Paternal risk groups local | cohort |
| posterior sites | anatomy |
| prefrontal cortex | anatomy |
| Pz | anatomy |
| Reduced gray matter local | phenotype |
| severe externalizing risk group local | cohort |
| Severe paternal externalizing psychopathology local | phenotype |
| severe paternal risk local | cohort |
| severe-risk fathers local | cohort |
| severe-risk group local | cohort |
| Severe-risk trajectory group local | cohort |
| slope | phenotype |
| Sons of fathers with AAB local | cohort |
| sons with heightened risk local | cohort |
| substance use | phenotype |
| target amplitude local | phenotype |
| target P300 amplitude local | phenotype |
| Twin cohort | cohort |
| visual P300 amplitude local | phenotype |
| Visual P300 amplitude local | phenotype |
| vulnerable children local | cohort |
| wine | drug |
| Working memory systems local | anatomy |
| young men | cohort |
| young men at risk for externalizing problems local | cohort |
| young people with conduct problems local | cohort |
| young people without conduct problems local | cohort |
| young women | cohort |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review. | Feeney K et al. | — | 2024 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
| P300 development from infancy to adolescence. | Riggins T et al. | — | 2020 | → |
| Relationships Among Emerging Adult Psychological Problems, Maltreatment, and Parental Psychopathology: Moderation by Parent-Child Relationship Quality. | Steele EH et al. | — | 2020 | → |
| Remnants and changes in facial emotion processing in women with remitted borderline personality disorder: an EEG study. | Schneider I et al. | — | 2018 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2015 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Endophenotypes in psychopathology research: where do we stand? | Miller GA et al. | — | 2013 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| P3a amplitude predicts successful treatment program completion in substance-dependent individuals. | Anderson NE et al. | — | 2011 | → |
| For distinguished contributions to psychophysiology: William G. Iacono. | Miller GA | — | 2010 | → |