Childhood or adolescent parental divorce/separation, parental history of alcohol problems, and offspring lifetime alcohol dependence.
paper
Cited
Public
- Authors
- Thompson, Ronald G; Lizardi, Dana; Keyes, Katherine M; Hasin, Deborah S
- Year
- 2008
- Journal
- Drug and alcohol dependence
- PMID
- 18757141
- DOI
- 10.1016/j.drugalcdep.2008.06.011
- PMCID
- PMC3818521
BACKGROUND: This study examined whether the experiences of childhood or adolescent parental divorce/separation and parental alcohol problems affected the likelihood of offspring DSM-IV lifetime alcohol dependence, controlling for parental history of drug, depression, and antisocial behavior problems. METHOD: Data were drawn from the 2001-2002 National Epidemiological Survey on Alcohol and Related Conditions (NESARC), a nationally representative United States survey of 43,093 civilian non-institutionalized participants aged 18 and older, interviewed in person. Logistic regression models were used to calculate the main and interaction effects of childhood or adolescent parental divorce/separation and parental history of alcohol problems on offspring lifetime alcohol dependence, after adjusting for parental history of drug, depression, and antisocial behavior problems. RESULTS: Childhood or adolescent parental divorce/separation and parental history of alcohol problems were significantly related to offspring lifetime alcohol dependence, after adjusting for parental history of drug, depression, and antisocial behavior problems. Experiencing parental divorce/separation during childhood, even in the absence of parental history of alcohol problems, remained a significant predictor of lifetime alcohol dependence. Experiencing both childhood or adolescent parental divorce/separation and parental alcohol problems had a significantly stronger impact on the risk for DSM-IV alcohol dependence than the risk incurred by either parental risk factor alone. CONCLUSIONS: Further research is needed to better identify the factors that increase the risk for lifetime alcohol dependence among those who experience childhood or adolescent parental divorce/separation.
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| Name | Type |
|---|---|
| 5-HTTLPR | variant |
| Academic problems local | phenotype |
| Age 18β29 years local | phenotype |
| Age 30β44 years local | phenotype |
| Age 45β64 years local | phenotype |
| Age 65+ years local | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol expectancy and beliefs local | phenotype |
| alcoholism | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use Disorder | phenotype |
| antisocial alcoholism | phenotype |
| antisocial personality disorder | phenotype |
| Asian | cohort |
| AUDADIS-IV | drug |
| Australia | cohort |
| behavior problems | phenotype |
| Black | phenotype |
| British birth cohort local | cohort |
| Canada | cohort |
| Children of divorced parents local | cohort |
| Children raised in intact two-parent families local | cohort |
| combined parental divorce/separation and parental history of alcohol problems local | phenotype |
| delinquency | phenotype |
| depression | phenotype |
| divorce rate local | phenotype |
| drinking | phenotype |
| drug | drug |
| Drug abuse disorders local | phenotype |
| drug dependence | phenotype |
| drugs | drug |
| DSM-IV | phenotype |
| DSM-IV alcohol disorders local | phenotype |
| early alcohol use | phenotype |
| educational attainment | phenotype |
| emotional and behavioral problems | phenotype |
| excessive alcohol consumption | phenotype |
| family dysfunction | phenotype |
| full sample | cohort |
| Germany | cohort |
| High school education local | phenotype |
| Hispanic | phenotype |
| HMO members cohort local | cohort |
| Household substance use local | phenotype |
| Inadequate parenting local | phenotype |
| Income $0β19,999 local | phenotype |
| Income $20,000β34,999 local | phenotype |
| Income $35,000β69,999 local | phenotype |
| Income $70,000+ local | phenotype |
| Less than high school education | phenotype |
| lifetime alcohol use | phenotype |
| Lower earnings local | phenotype |
| Maladaptive coping and cognitive styles local | phenotype |
| Maladaptive parental behaviors local | phenotype |
| MAOA | gene |
| MAOA-LPR low-activity variant local | variant |
| marital satisfaction | phenotype |
| marital status | phenotype |
| Maternal problems local | phenotype |
| National Epidemiologic Survey on Alcohol and Related Conditions | cohort |
| nationally representative sample | cohort |
| Native Americans | cohort |
| NESARC | cohort |
| Offspring of divorced/separated parents local | cohort |
| Parental Alcohol Disorder local | phenotype |
| parental alcoholism | phenotype |
| Parental antisocial behavior problems local | phenotype |
| parental depression | phenotype |
| parental divorce rate local | phenotype |
| parental divorce/separation | phenotype |
| Parental divorce/separation (childhood or adolescent) local | phenotype |
| parental drug problems | phenotype |
| Parental history of alcohol local | phenotype |
| Parental History of Alcohol local | phenotype |
| Parental History of Antisocial Behavior local | phenotype |
| parental history of antisocial behavior problems local | phenotype |
| Parental history of antisocial behavior problems local | phenotype |
| parental history of depression local | phenotype |
| Parental history of depression local | phenotype |
| Parental History of Depression local | phenotype |
| Parental History of Drug local | phenotype |
| parental history of drug problems local | phenotype |
| Parental history of drug problems local | phenotype |
| Parental Other Disorders local | phenotype |
| Paternal problems local | phenotype |
| Permanent separation local | phenotype |
| physical abuse | phenotype |
| psychological problems | phenotype |
| respondents | cohort |
| Russian Federation local | cohort |
| sex | phenotype |
| SLC6A4 | gene |
| social problems | phenotype |
| Some college local | phenotype |
| study cohort | cohort |
| Terrorism exposure local | phenotype |
| United Kingdom | cohort |
| United States | cohort |
| US civilian population | cohort |
| U.S. national divorce rate local | phenotype |
| U.S. population survey local | cohort |
| Welfare dependency local | phenotype |
| White | phenotype |
| Widowed/separated/divorced local | phenotype |
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