Environmental adversity and increasing genetic risk for externalizing disorders.
paper
Cited
Public
- Authors
- Hicks, Brian M; South, Susan C; Dirago, Ana C; Iacono, William G; McGue, Matt
- Year
- 2009
- Journal
- Archives of general psychiatry
- PMID
- 19487629
- DOI
- 10.1001/archgenpsychiatry.2008.554
- PMCID
- PMC2717707
CONTEXT: Studies of gene-environment interplay in the development of psychiatric and substance use disorders are rapidly accumulating. However, few attempts have been made to integrate findings and to articulate general mechanisms of gene-environment influence in the emergence of psychopathology. OBJECTIVE: To identify patterns of gene-environment interplay between externalizing disorders (antisocial behavior and substance use) and several environmental risk factors. DESIGN: We used quantitative genetic models to examine how genetic and environmental risk for externalizing disorders changes as a function of environmental context. SETTING: Participants were recruited from the community and took part in a daylong assessment at a university laboratory. PARTICIPANTS: The sample consisted of 1315 male and female twin pairs participating in the assessment of the Minnesota Twin Family Study at age 17 years. MAIN OUTCOME MEASURES: Multiple measures and informants were used to construct a composite of externalizing disorders and composite measures of 6 environmental risk factors, including academic achievement and engagement, antisocial and prosocial peer affiliations, mother-child and father-child relationship problems, and stressful life events. RESULTS: A significant gene x environment interaction was detected between each environmental risk factor and externalizing such that greater environmental adversity was associated with increased genetic risk for externalizing. CONCLUSIONS: In the context of environmental adversity, genetic factors become more important in the etiology of externalizing disorders. The consistency of the results further suggests a general mechanism of environmental influence on externalizing disorders regardless of the specific form of the environmental risk.
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|---|---|---|---|---|
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| A common neural signature between genetic and environmental risk for mental illness. | Vedechkina M et al. | — | 2025 | → |
| Associations of polygenic scores and developmental trajectories of externalizing behaviors. | Sasia AB et al. | — | 2025 | → |
| Gene-Environment Interplay Between Perceived Stress and ADHD Symptoms in Adults. | Hur YM | — | 2025 | → |
| Shedding Light on Antisocial Behavior Through Genetically Informed Research. | Pezzoli P et al. | — | 2025 | → |
| Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect. | Bruins S et al. | — | 2024 | → |
| Family history of psychiatric conditions and development of siblings of children with autism. | Bellia G et al. | — | 2024 | → |
| Gene-environment interaction between gaming addiction and perceived stress in late adolescents and young adults: A twin study. | Hur YM | — | 2024 | → |
| Gene-environment transactions between peer cigarette use, parental supervision, and Chinese adolescent cigarette smoking initiation. | Meyer Z et al. | — | 2024 | → |
| Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth. | Dash GF et al. | — | 2023 | → |
| Gene-environment interplay linking perceived parental supervision and peer drunkenness with Chinese adolescent alcohol initiation. | Zheng Y et al. | — | 2023 | → |
| Genetics and epigenetics of human aggression. | Odintsova VV et al. | — | 2023 | → |
| Frontal Alpha Asymmetry in Response to Stressor Moderates the Relation Between Parenting Hassles and Child Externalizing Problems. | Mulligan DJ et al. | — | 2022 | → |
| Parenting moderates the etiology of callous-unemotional traits in middle childhood. | Tomlinson RC et al. | — | 2022 | → |
| The Genetic, Environmental, and Cultural Forces Influencing Youth Antisocial Behavior Are Tightly Intertwined. | Burt SA | — | 2022 | → |
| Are Different Individuals Sensitive to Different Environments? Individual Differences in Sensitivity to the Effects of the Parent, Peer and School Environment on Externalizing Behavior and its Genetic and Environmental Etiology. | Markovitch N et al. | — | 2021 | → |
| Developmental disabilities across the world: A scientometric review from 1936 to 2020. | Carollo A et al. | — | 2021 | → |
| Marital Satisfaction as a Moderator of Molecular Genetic Influences on Mental Health. | South SC et al. | — | 2021 | → |
| Maternal Parenting Behaviors Amplify Environmental Influences on Developmental Trajectories of Alcohol Use During Adolescence. | Zheng Y et al. | — | 2021 | → |
| Respiratory sinus arrhythmia as a moderator of early maltreatment effects on later externalizing problems. | Tabachnick AR et al. | — | 2021 | → |
| Understanding the Effects of the COVID-19 Pandemic on Youth Psychopathology: Genotype-Environment Interplay. | Carroll SL et al. | — | 2021 | → |
| Child Antisocial Behavior Is more Environmental in Origin in Disadvantaged Neighborhoods: Evidence Across Residents' Perceptions and Geographic Scales in Two Samples. | Burt SA et al. | — | 2020 | → |
| Do neighborhood social processes moderate the etiology of youth conduct problems? | Burt SA et al. | — | 2020 | → |
| Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use. | Bares CB et al. | — | 2020 | → |
| Gene-Environment Interplay Between Physical Exercise and Fitness and Depression Symptomatology. | Johnson W et al. | — | 2020 | → |
| Neurocognitive Deficits in Attention-Deficit/Hyperactivity Disorder With and Without Comorbid Oppositional Defiant Disorder. | Noordermeer SDS et al. | — | 2020 | → |
| Personality, romantic relationships, and alcohol use disorder symptoms in adolescence and young adulthood: An evaluation of personality × social context interplay. | Samek DR et al. | — | 2020 | → |
| The (Broad-Sense) Genetic Correlations Among Four Measures of Inattention and Hyperactivity in 12 Year Olds. | Dolan CV et al. | — | 2020 | → |
| Blunted Reward Sensitivity and Trait Disinhibition Interact to Predict Substance Use Problems. | Joyner KJ et al. | — | 2019 | → |
| Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. | Odintsova VV et al. | — | 2019 | → |
| Alcohol family history moderates the association between evening substance-free reinforcement and alcohol problems. | Joyner KJ et al. | — | 2018 | → |
| Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: a unitary trend? | Grucza RA et al. | — | 2018 | → |
| Defining the phenotype of young adults with family histories of alcohol and other substance use disorders: Studies from the family health patterns project. | Acheson A et al. | — | 2018 | → |
| Gene x environment interactions in conduct disorder: Implications for future treatments. | Holz NE et al. | — | 2018 | → |
| Intergenerational Continuity in Substance Abuse: Does Offspring's Friendship Network Make a Difference? | Henry KL et al. | — | 2018 | → |
| Investigating possible causal effects of externalizing behaviors on tobacco initiation: A Mendelian randomization analysis. | Fluharty ME et al. | — | 2018 | → |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Psychosocial functioning among regular cannabis users with and without cannabis use disorder. | Foster KT et al. | — | 2018 | → |
| The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. | Iacono WG et al. | — | 2018 | → |
| A combination test for detection of gene-environment interaction in cohort studies. | Coombes B et al. | — | 2017 | → |
| Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction. | Samek DR et al. | — | 2017 | → |
| Biometric Modeling of Gene-Environment Interplay: The Intersection of Theory and Method and Applications for Social Inequality. | South SC et al. | — | 2017 | → |
| Comparing the Developmental Genetics of Cognition and Personality over the Life Span. | Briley DA et al. | — | 2017 | → |
| Etiology of Triarchic Psychopathy Dimensions in Chimpanzees (<i>Pan troglodytes</i>). | Latzman RD et al. | — | 2017 | → |
| Genetic and environmental sources of covariation between early drinking and adult functioning. | Waldron JS et al. | — | 2017 | → |
| Parental involvement as an etiological moderator of middle childhood oppositional defiant disorder. | Li I et al. | — | 2017 | → |
| Parent and peer influences on emerging adult substance use disorder: A genetically informed study. | Bountress K et al. | — | 2017 | → |
| Risk factors for comorbid oppositional defiant disorder in attention-deficit/hyperactivity disorder. | Noordermeer SDS et al. | — | 2017 | → |
| Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition. | Richards JS et al. | — | 2017 | → |
| The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence. | Jarnecke AM et al. | — | 2017 | → |
| Adolescent behavioral and neural reward sensitivity: a test of the differential susceptibility theory. | Richards JS et al. | — | 2016 | → |
| Antisocial peer affiliation and externalizing disorders in the transition from adolescence to young adulthood: Selection versus socialization effects. | Samek DR et al. | — | 2016 | → |
| Dependence of Gene-by-Environment Interactions (GxE) on Scaling: Comparing the Use of Sum Scores, Transformed Sum Scores and IRT Scores for the Phenotype in Tests of GxE. | Murray AL et al. | — | 2016 | → |
| Developmentally Sensitive Interaction Effects of Genes and the Social Environment on Total and Subcortical Brain Volumes. | Richards JS et al. | — | 2016 | → |
| Effects of the MAOA gene and levels of exposure to violence on antisocial outcomes. | Ouellet-Morin I et al. | — | 2016 | → |
| Genetic influences on adolescent behavior. | Dick DM et al. | — | 2016 | → |
| Genetics of aggressive behavior: An overview. | Veroude K et al. | — | 2016 | → |
| Parental monitoring and knowledge: Testing bidirectional associations with youths' antisocial behavior. | Wertz J et al. | — | 2016 | → |
| Polygenic Risk for Externalizing Psychopathology and Executive Dysfunction in Trauma-Exposed Veterans. | Sadeh N et al. | — | 2016 | → |
| Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes. | Li Y et al. | — | 2016 | → |
| Sensation seeking, peer deviance, and genetic influences on adolescent delinquency: Evidence for person-environment correlation and interaction. | Mann FD et al. | — | 2016 | → |
| A critical assessment of the equal-environment assumption of the twin method for schizophrenia. | Fosse R et al. | — | 2015 | → |
| A double-edged sword: advantages and disadvantages to the current emphasis on biogenetic causes of child psychopathology. | Burt SA | — | 2015 | → |
| Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype × Environment Interaction. | Molenaar D et al. | — | 2015 | → |
| Behavioral problems after early life stress: contributions of the hippocampus and amygdala. | Hanson JL et al. | — | 2015 | → |
| Gene-Environment Interaction Effects of Peer Deviance, Parental Knowledge and Stressful Life Events on Adolescent Alcohol Use. | Cooke ME et al. | — | 2015 | → |
| Gene-environment interplay between parent-child relationship problems and externalizing disorders in adolescence and young adulthood. | Samek DR et al. | — | 2015 | → |
| Gene-Environment Interplay: Where We Are, Where We Are Going. | Salvatore JE et al. | — | 2015 | → |
| Genetic and Environmental Influences on Adult Mental Health: Evidence for Gene-Environment Interplay as a Function of Maternal and Paternal Discipline and Affection. | South SC et al. | — | 2015 | → |
| High School Sports Involvement Diminishes the Association Between Childhood Conduct Disorder and Adult Antisocial Behavior. | Samek DR et al. | — | 2015 | → |
| Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. | Salvatore JE et al. | — | 2015 | → |
| Investigating genetic and environmental contributions to adolescent externalizing behavior in a collectivistic culture: a multi-informant twin study. | Chen J et al. | — | 2015 | → |
| Parental involvement moderates etiological influences on attention deficit hyperactivity disorder behaviors in child twins. | Nikolas MA et al. | — | 2015 | → |
| Parent-child conflict and drug use in college women: a moderated mediation model of self-control and mindfulness. | Tarantino N et al. | — | 2015 | → |
| Peer Victimization and DRD4 Genotype Influence Problem Behaviors in Young Children. | DiLalla LF et al. | — | 2015 | → |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | — | 2015 | → |
| Serotonin Transporter Genotype (5HTTLPR) Moderates the Longitudinal Impact of Atypical Attachment on Externalizing Behavior. | Humphreys KL et al. | — | 2015 | → |
| The quality of the interparental relationship does not moderate the etiology of child conduct problems. | Burt SA et al. | — | 2015 | → |
| Alcohol use disorder in women: Risks and consequences of an adolescent onset and persistent course. | Foster KT et al. | — | 2014 | → |
| Child care, socio-economic status and problem behavior: a study of gene-environment interaction in young Dutch twins. | Middeldorp CM et al. | — | 2014 | → |
| Combat exposure severity as a moderator of genetic and environmental liability to post-traumatic stress disorder. | Wolf EJ et al. | — | 2014 | → |
| Delineating selection and mediation effects among childhood personality and environmental risk factors in the development of adolescent substance abuse. | Hicks BM et al. | — | 2014 | → |
| Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats. | Grotewold SK et al. | — | 2014 | → |
| Examining transactional influences between reading achievement and antisocially-behaving friends. | Hart SA et al. | — | 2014 | → |
| Externalizing Disorders and Environmental Risk: Mechanisms of Gene-Environment Interplay and Strategies for Intervention. | Samek DR et al. | — | 2014 | → |
| Genetic strategies for probing conscientiousness and its relationship to aging. | South SC et al. | — | 2014 | → |
| Genetic vulnerability interacts with parenting and early care education to predict increasing externalizing behavior. | Lipscomb ST et al. | — | 2014 | → |
| Identifying childhood characteristics that underlie premorbid risk for substance use disorders: socialization and boldness. | Hicks BM et al. | — | 2014 | → |
| Increasing phenotypic and genetic variations in hyperactivity/inattention problems from age 3 to 13 years: a cross-sectional twin study. | Hur YM | — | 2014 | → |
| Maternal pre-pregnancy risk drinking and toddler behavior problems: the Norwegian Mother and Child Cohort Study. | Knudsen AK et al. | — | 2014 | → |
| Parent-child conflict as an etiological moderator of childhood conduct problems: an example of a 'bioecological' gene-environment interaction. | Burt SA et al. | — | 2014 | → |
| Peer deviance, parental divorce, and genetic risk in the prediction of drug abuse in a nationwide Swedish sample: evidence of environment-environment and gene-environment interaction. | Kendler KS et al. | — | 2014 | → |
| Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. | Salvatore JE et al. | — | 2014 | → |
| Prosocial peer affiliation suppresses genetic influences on non-aggressive antisocial behaviors during childhood. | Burt SA et al. | — | 2014 | → |
| The adolescent origins of substance use disorders: a behavioral genetic perspective. | McGue M et al. | — | 2014 | → |
| The association between adult mortality risk and family history of longevity: the moderating effects of socioeconomic status. | Temby OF et al. | — | 2014 | → |
| The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins. | Otowa T et al. | — | 2014 | → |
| Violence among people with schizophrenia: phenotypes and neurobiology. | Hodgins S et al. | — | 2014 | → |
| Behavior genetics: past, present, future. | Jaffee SR et al. | — | 2013 | → |
| Behind the wheel and on the map: Genetic and environmental associations between drunk driving and other externalizing behaviors. | Quinn PD et al. | — | 2013 | → |
| Child maltreatment and mediating influences of childhood personality types on the development of adolescent psychopathology. | Oshri A et al. | — | 2013 | → |
| Delinquent peer affiliation as an etiological moderator of childhood delinquency. | Burt SA et al. | — | 2013 | → |
| Gene-environment correlation in the development of adolescent substance abuse: selection effects of child personality and mediation via contextual risk factors. | Hicks BM et al. | — | 2013 | → |
| Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. | Hicks BM et al. | — | 2013 | → |
| Marital satisfaction and physical health: evidence for an orchid effect. | South SC et al. | — | 2013 | → |
| Maternal warmth and directiveness jointly moderate the etiology of childhood conduct problems. | Alexandra Burt S et al. | — | 2013 | → |
| Prevalence and correlates of child sexual abuse: a national study. | Pérez-Fuentes G et al. | — | 2013 | → |
| Tests of a direct effect of childhood abuse on adult borderline personality disorder traits: a longitudinal discordant twin design. | Bornovalova MA et al. | — | 2013 | → |
| Addiction in developmental perspective: influence of conduct disorder severity, subtype, and attention-deficit hyperactivity disorder on problem severity and comorbidity in adults with opioid dependence. | Carpentier PJ et al. | — | 2012 | → |
| Additional evidence against shared environmental contributions to attention-deficit/hyperactivity problems. | Burt SA et al. | — | 2012 | → |
| A note on false positives and power in G × E modelling of twin data. | van der Sluis S et al. | — | 2012 | → |
| Childhood problem behavior and parental divorce: evidence for gene-environment interaction. | Robbers S et al. | — | 2012 | → |
| Child physical abuse and adult mental health: a national study. | Sugaya L et al. | — | 2012 | → |
| Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. | Vrieze SI et al. | — | 2012 | → |
| Detecting specific genotype by environment interactions using marginal maximum likelihood estimation in the classical twin design. | Molenaar D et al. | — | 2012 | → |
| Developmental genetics and psychopathology: some new feathers for a fine old hat. | Johnson W | — | 2012 | → |
| Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use. | Irons DE et al. | — | 2012 | → |
| Genetically influenced change in sensation seeking drives the rise of delinquent behavior during adolescence. | Harden KP et al. | — | 2012 | → |
| Negative emotionality and externalizing problems in toddlerhood: overreactive parenting as a moderator of genetic influences. | Lipscomb ST et al. | — | 2012 | → |
| Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. | Buckholtz JW et al. | — | 2012 | → |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | — | 2012 | → |
| The Association of Externalizing Behavior and Parent-Child Relationships: An Intergenerational Study. | Brook JS et al. | — | 2012 | → |
| The influence of gene-environment interactions on the development of alcoholism and drug dependence. | Enoch MA | — | 2012 | → |
| The Minnesota Center for Twin and Family Research genome-wide association study. | Miller MB et al. | — | 2012 | → |
| Agency versus structure: genetics, group membership, and a new twist on an old debate. | Angel RJ | — | 2011 | → |
| Genetic risk by experience interaction for childhood internalizing problems: converging evidence across multiple methods. | Vendlinski MK et al. | — | 2011 | → |
| Greater discounting of delayed rewards in young adults with family histories of alcohol and drug use disorders: studies from the Oklahoma family health patterns project. | Acheson A et al. | — | 2011 | → |
| Migration from Mexico to the United States and conduct disorder: a cross-national study. | Breslau J et al. | — | 2011 | → |
| Neurobiology of attention deficit/hyperactivity disorder. | Purper-Ouakil D et al. | — | 2011 | → |
| Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. | Kendler KS et al. | — | 2011 | → |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | — | 2011 | → |
| The role of early life stress as a predictor for alcohol and drug dependence. | Enoch MA | — | 2011 | → |
| Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature. | Gunter TD et al. | — | 2010 | → |
| Consequences of an adolescent onset and persistent course of alcohol dependence in men: adolescent risk factors and adult outcomes. | Hicks BM et al. | — | 2010 | → |
| Effects of child maltreatment and inherited liability on antisocial development: an official records study. | Jonson-Reid M et al. | — | 2010 | → |
| For distinguished contributions to psychophysiology: William G. Iacono. | Miller GA | — | 2010 | → |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | — | 2010 | → |
| Major depressive disorder with subthreshold bipolarity: exploring and managing new diagnoses. | Westermeyer J | — | 2010 | → |
| MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. | Edwards AC et al. | — | 2010 | → |
| Peer substance involvement modifies genetic influences on regular substance involvement in young women. | Agrawal A et al. | — | 2010 | → |
| Pica in an eating disordered woman with multiple sclerosis: impulse dys-control, compulsive symptom or self-medication attempt? | Ceschin L et al. | — | 2010 | → |
| The end of behavioral genetics? 2008. | McGue M | — | 2010 | → |
| The genetic epidemiology of personality disorders. | Reichborn-Kjennerud T | — | 2010 | → |
| The relationship between problem behavior and neurotransmitter deficiency in adolescents. | Song X et al. | — | 2010 | → |
| Gene-environment interplay in internalizing disorders: consistent findings across six environmental risk factors. | Hicks BM et al. | — | 2009 | → |
| Taking substance use and development seriously: Developmentally distal and proximal influences on adolescent drug use. | Schulenberg JE et al. | — | 2009 | → |
| The End of Behavioral Genetics? | McGue M | — | 2008 | → |