Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
paper
Cited
Public
- Authors
- Hyde, Craig L; Nagle, Michael W; Tian, Chao; Chen, Xing; Paciga, Sara A; Wendland, Jens R; Tung, Joyce Y; Hinds, David A; Perlis, Roy H; Winslow, Ashley R
- Year
- 2016
- Journal
- Nature genetics
- PMID
- 27479909
- DOI
- 10.1038/ng.3623
- PMCID
- PMC5706769
Despite strong evidence supporting the heritability of major depressive disorder (MDD), previous genome-wide studies were unable to identify risk loci among individuals of European descent. We used self-report data from 75,607 individuals reporting clinical diagnosis of depression and 231,747 individuals reporting no history of depression through 23andMe and carried out meta-analysis of these results with published MDD genome-wide association study results. We identified five independent variants from four regions associated with self-report of clinical diagnosis or treatment for depression. Loci with a P value <1.0 Γ 10(-5) in the meta-analysis were further analyzed in a replication data set (45,773 cases and 106,354 controls) from 23andMe. A total of 17 independent SNPs from 15 regions reached genome-wide significance after joint analysis over all three data sets. Some of these loci were also implicated in genome-wide association studies of related psychiatric traits. These studies provide evidence for large-scale consumer genomic data as a powerful and efficient complement to data collected from traditional means of ascertainment for neuropsychiatric disease genomics.
Discovery phase meta-analysis of 23andMe self-report ascertainment of major depression (75,607 cases and 231,747 controls) and PGC MDD (9,240 cases and 9,519 controls). a) Manhattan plot of Discovery phase 23andMe GWAS. LD score regression calculated intercept was used for inflation correction. The threshold for genome-wide significance (p < 5Γ10β8) is indicated by the purple line. Red dots represent SNPs with p-values smaller than the genome-wide significant threshold. Regions labeled in black denote loci that reached genome-wide significance in the join-analysis. b) Q-Q plot for the 23andMe MDD GWAS.
Regional association plots for genome-wide significant regions and secondary independent signals identified in each region. a) OLFM4 locus (rs12552), b) TMEM161B-MEF2C (rs10514299), c) MEIS2-TMCO5A locus (rs8025231), and d) NEGR1 locus (rs11209948). Secondary signals in TMEM161B-MEF2C and NEGR1 (rs454214, rs2422321 respectively) are shown. Purple diamonds represent smallest p-value for each locus.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Affective dysregulation, familial psychopathology, and suicidal behavior in transgender individuals: A structural equation model. | SΓ‘nchez-Γlvarez N | β | 2026 | β |
| A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity. | Kaas M et al. | β | 2026 | β |
| Combining Mendelian randomization and experimental approaches for the identification of miRNAs related to major depressive disorder. | Cao L et al. | β | 2026 | β |
| Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders. | Feng Y et al. | β | 2026 | β |
| Dysfunctional circular RNA network in major depressive disorder: dissecting the cell identity and potential clinical applications. | Tan L et al. | β | 2026 | β |
| Exploring the association of age at first sexual intercourse and lifetime number of sexual partners on neurological and psychiatric disorders: An observational and genetic study. | Dong Y et al. | β | 2026 | β |
| Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods. | Lei C et al. | β | 2026 | β |
| Polygenic depression risk, childhood parental substance abuse, and GΓE interaction in divergent depression trajectories from middle to late adulthood. | Chen P et al. | β | 2026 | β |
| The predicament of heritable confounders. | Cai N et al. | β | 2026 | β |
| Unraveling the neural underpinnings of major depressive disorder and pain: A mendelian randomization study and mediation analysis. | Jiang J et al. | β | 2026 | β |
| A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. | Wang J et al. | β | 2025 | β |
| Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder. | Ivanov SM et al. | β | 2025 | β |
| An Atlas of Genetic Correlations Between Thyroid Hormone Levels and Human Health-Related Traits. | Li JL et al. | β | 2025 | β |
| Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research. | Cai N et al. | β | 2025 | β |
| Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank. | Jung J et al. | β | 2025 | β |
| A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling. | Dalby A et al. | β | 2025 | β |
| Bidirectional causal relationship between depression and Type 2 diabetes: a multi-ancestry and sex stratified Mendelian Randomization analysis. | Liu HY et al. | β | 2025 | β |
| Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin. | Sirotkin AV et al. | β | 2025 | β |
| Cerebellar neurocan gene expression is a common pathogenic factor of trigeminal neuralgia and depression. | Zeng Z et al. | β | 2025 | β |
| Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression. | Li Y et al. | β | 2025 | β |
| Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation. | Phongphithakchai A et al. | β | 2025 | β |
| Early-pregnancy maternal metabolite signatures, genetic predisposition, and perinatal depressive symptom trajectories: A prospective birth cohort study. | Zhang N et al. | β | 2025 | β |
| Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction. | Zhang YQ et al. | β | 2025 | β |
| Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study. | Sun F et al. | β | 2025 | β |
| Exploring the Relationship between Polygenic Scores, Community-Shared Socioeconomic Indicators and Major Depressive Disorder Outcome. | Sepulveda DT et al. | β | 2025 | β |
| Extrahepatic and Circulating miR-122: Diagnostic Implications and Future Directions. | Royfman RS et al. | β | 2025 | β |
| Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression. | Xu MM et al. | β | 2025 | β |
| Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression. | Shorter JR et al. | β | 2025 | β |
| Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory. | Hopkins LN et al. | β | 2025 | β |
| Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program. | Raghavan S et al. | β | 2025 | β |
| Genomic risk prediction for depression in a large prospective study of older adults of European descent. | Yu C et al. | β | 2025 | β |
| Implications of the choice of method to identify major depressive disorder in large research cohorts. | Sanchez-Ruiz JA et al. | β | 2025 | β |
| Large-scale genome-wide analyses of stuttering. | Polikowsky HG et al. | β | 2025 | β |
| <i>Akkermansia muciniphila</i> reverses neuronal atrophy in <i>Negr1</i> knockout mice with depression-like phenotypes. | Hwang HG et al. | β | 2025 | β |
| Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation. | Reinsberg A et al. | β | 2025 | β |
| Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65). | Su F et al. | β | 2025 | β |
| No Evidence for a Causal Association Between Depression and Herpes Zoster or Post-Herpetic Neuralgia: A Mendelian Randomization Study. | Zhang X et al. | β | 2025 | β |
| Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression. | Odierna GL et al. | β | 2025 | β |
| Peripartum sertraline impacts maternal neurobehavioral and neurodegenerative mechanisms in pregnant and postpartum mice. | Blaine B et al. | β | 2025 | β |
| Polygenic Risk, Agent Orange Exposure, and Lymphoid Neoplasms in the Veterans Affairs Million Veteran Program. | Teng X et al. | β | 2025 | β |
| Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. | Chen Y et al. | β | 2025 | β |
| Polygenic scores for depression are associated with indices of neighborhood adversity. | Feurer C et al. | β | 2025 | β |
| PSMB4: a potential biomarker and therapeutic target for depression, perspective from integration analysis of depression GWAS data and human plasma proteome. | Liu J | β | 2025 | β |
| Serotonin 2A (5-HT<sub>2A</sub>) receptor as evolving biological target: function, structure, ligands and role in the therapy of neuropsychiatric diseases. | Fryc M et al. | β | 2025 | β |
| Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus. | Guo X et al. | β | 2025 | β |
| Shared genetic architecture and causal relationship between frailty and schizophrenia. | Deng MG et al. | β | 2025 | β |
| The genetics of severe depression. | Franklin CE et al. | β | 2025 | β |
| The Interaction Between Family Functioning and the <i>PCDH9</i> rs9540720 Polymorphism on Major Depressive Disorder in Chinese Freshmen. | Qin Y et al. | β | 2025 | β |
| The role of schemas in the experience of distress, burden, and wellbeing in parents and siblings of people with serious mental health difficulties. | Jayasinghe A et al. | β | 2025 | β |
| Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. | Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk et al. | β | 2025 | β |
| Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy. | Choi J et al. | β | 2025 | β |
| Whole exome sequencing identified six novel genes for depressive symptoms. | Li ZY et al. | β | 2025 | β |
| Women's perceptions of biological causes and potentials of genomic risk markers in postpartum depression: A qualitative study. | HΓΈgh S et al. | β | 2025 | β |
| Alcohol drinking, DNA methylation and psychiatric disorders: A multi-omics Mendelian randomization study to investigate causal pathways. | Shi X et al. | β | 2024 | β |
| Assessing the validity of a self-reported clinical diagnosis of schizophrenia. | Woolway GE et al. | β | 2024 | β |
| Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study. | Duan H et al. | β | 2024 | β |
| Cardiorespiratory fitness mediates the relationship between depressive symptomatology and cognition in older but not younger adults. | Barros C et al. | β | 2024 | β |
| Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression. | Spildrejorde M et al. | β | 2024 | β |
| Early Maladaptive Schemas and Depression in Caregivers of Individuals With Schizophrenia Spectrum and Bipolar Disorders. | Karambelas GJ et al. | β | 2024 | β |
| Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights. | Salenius K et al. | β | 2024 | β |
| Exploring the shared genetic basis of major depressive disorder and frailty. | Fu W et al. | β | 2024 | β |
| Gene expression and brain imaging association study reveals gene signatures in major depressive disorder. | Liu W et al. | β | 2024 | β |
| Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population. | Park K et al. | β | 2024 | β |
| Gray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data. | Fu X et al. | β | 2024 | β |
| Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders. | GarcΓa-MarΓn LM et al. | β | 2024 | β |
| Leveraging Random Effects in Cistrome-Wide Association Studies for Decoding the Genetic Determinants of Prostate Cancer. | Shao M et al. | β | 2024 | β |
| MEF2C Hypofunction in GABAergic Cells Alters Sociability and Prefrontal Cortex Inhibitory Synaptic Transmission in a Sex-Dependent Manner. | Cho JY et al. | β | 2024 | β |
| Micronutrients and Major Depression: A Mendelian Randomisation Study. | Carnegie RE et al. | β | 2024 | β |
| No relationship between male pubertal timing and depression - new insights from epidemiology and Mendelian randomization. | Hirtz R et al. | β | 2024 | β |
| Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine. | Eszlari N et al. | β | 2024 | β |
| Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases. | Sun W et al. | β | 2024 | β |
| Relationships between nine neuropsychiatric disorders and cervical cancer: insights from genetics, causality and shared gene expression patterns. | Li J et al. | β | 2024 | β |
| Replication of previous autism-GWAS hits suggests the association between <i>NAA1, SORCS3,</i> and <i>GSDME</i> and autism in the Han Chinese population. | Lin F et al. | β | 2024 | β |
| The burden of major depressive disorder in the Middle East and North Africa region, 1990-2019. | Safiri S et al. | β | 2024 | β |
| The causal relationship between major depression disorder and thyroid diseases: A Mendelian randomization study and mediation analysis. | Zhang X et al. | β | 2024 | β |
| The causal relationship between severe mental illness and risk of lung carcinoma. | Chen X et al. | β | 2024 | β |
| The genetic landscape of basal ganglia and implications for common brain disorders. | Bahrami S et al. | β | 2024 | β |
| The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. | Singh K et al. | β | 2024 | β |
| The Risk Genes for Neuropsychiatric Disorders <i>negr1</i> and <i>opcml</i> Are Expressed throughout Zebrafish Brain Development. | Habicher J et al. | β | 2024 | β |
| Transcriptomic decoding of regional cortical vulnerability to major depressive disorder. | Zhu J et al. | β | 2024 | β |
| Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans. | El Yacoubi M et al. | β | 2024 | β |
| Using Alternative Definitions of Controls to Increase Statistical Power in GWAS. | Benstock SE et al. | β | 2024 | β |
| Vitamin B5 is a context-dependent dietary regulator of nociception. | Hamoudi Z et al. | β | 2024 | β |
| A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity. | Baltramonaityte V et al. | β | 2023 | β |
| A sex-specific genome-wide association study of depression phenotypes in UK Biobank. | Silveira PP et al. | β | 2023 | β |
| Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization. | Palmos AB et al. | β | 2023 | β |
| Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population. | Liang P et al. | β | 2023 | β |
| Association of time spent in outdoor light and genetic risk with the incidence of depression. | Lin J et al. | β | 2023 | β |
| CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. | Sanchez-Roige S et al. | β | 2023 | β |
| Causal association of juvenile idiopathic arthritis-associated uveitis with depression and anxiety: a bidirectional Mendelian randomization study. | Zhang J et al. | β | 2023 | β |
| Cerebral blood flow changes and their genetic mechanisms in major depressive disorder: a combined neuroimaging and transcriptome study. | Sun X et al. | β | 2023 | β |
| Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management. | Berk M et al. | β | 2023 | β |
| Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics. | Morrill K et al. | β | 2023 | β |
| Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. | Als TD et al. | β | 2023 | β |
| Examining the relationship between genetic risk for depression and youth episodic stress exposure. | Harrison TJ et al. | β | 2023 | β |
| Exploring the overlap between alopecia areata and major depressive disorder: Epidemiological and genetic perspectives. | Foo JC et al. | β | 2023 | β |
| Gender differences in the association of polygenic risk and divergent depression trajectories from mid to late life: a national longitudinal study. | Chen P et al. | β | 2023 | β |
| Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers. | Singh P et al. | β | 2023 | β |
| Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank. | Li D et al. | β | 2023 | β |
| Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression. | Holen B et al. | β | 2023 | β |
| Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits. | Mocci E et al. | β | 2023 | β |
| Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants. | Alemany S et al. | β | 2023 | β |
| Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders. | Karadag N et al. | β | 2023 | β |
| Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older. | Zhou J et al. | β | 2023 | β |
| Major depressive disorder and chronic gastritis: A bidirectional two-sample Mendelian randomization study. | Li J et al. | β | 2023 | β |
| Maternal Mental Health and Children's Problem Behaviours: A Bi-directional Relationship? | Lowthian E et al. | β | 2023 | β |
| Passive and active suicidal ideation in a population-based sample of older adults: Associations with polygenic risk scores of relevance for suicidal behavior. | Zettergren A et al. | β | 2023 | β |
| Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. | Dahl A et al. | β | 2023 | β |
| Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naΓ―ve patients with major depressive disorder: A large-scale cross-sectional study. | Hu J et al. | β | 2023 | β |
| Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology. | Parker N et al. | β | 2023 | β |
| Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. | Yin MY et al. | β | 2023 | β |
| Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions. | Luo F et al. | β | 2023 | β |
| Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. | Alzuri SE et al. | β | 2023 | β |
| Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study. | Cui Y et al. | β | 2023 | β |
| Sex Differences in Depression and Anxiety. | Pavlidi P et al. | β | 2023 | β |
| Sex Significantly Impacts the Function of Major Depression-Linked Variants InΒ Vivo. | Mulvey B et al. | β | 2023 | β |
| Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis. | Tesfaye M et al. | β | 2023 | β |
| The genetic basis of major depressive disorder. | Flint J | β | 2023 | β |
| The Greater Impact of Paternal, Compared to Maternal, Hereditary Background on Depressive-Like Behavior in Wistar Kyoto Rats with Different Amino Acid Metabolism in the Pup Brain. | Ihara T et al. | β | 2023 | β |
| The Role of Genetics in the Development and Pharmacotherapy of Depression and Its Impact on Drug Discovery. | ZiΔba A et al. | β | 2023 | β |
| The Role of IgLON Cell Adhesion Molecules in Neurodegenerative Diseases. | Salluzzo M et al. | β | 2023 | β |
| The Role of MEF2 Transcription Factor Family in Neuronal Survival and Degeneration. | Lisek M et al. | β | 2023 | β |
| The Roles of Long Noncoding RNA in Depression. | Wang S et al. | β | 2023 | β |
| Towards a multilevel model of major depression: genes, immuno-metabolic function, and cortico-striatal signaling. | Paul ER et al. | β | 2023 | β |
| Age and diet shape the genetic architecture of body weight in diversity outbred mice. | Wright KM et al. | β | 2022 | β |
| A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. | Raghavan S et al. | β | 2022 | β |
| Ancestry-inclusive dog genomics challenges popular breed stereotypes. | Morrill K et al. | β | 2022 | β |
| An Elevated FIB-4 Score Is Associated with an Increased Incidence of Depression among Outpatients in Germany. | SchΓΆler D et al. | β | 2022 | β |
| A Polygenic Approach to Understanding Resilience to Peer Victimisation. | Armitage JM et al. | β | 2022 | β |
| Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations. | Feurer C et al. | β | 2022 | β |
| Beliefs and willingness towards participating in genetic testing for depression in low-income and racial/ethnic minority mothers at-risk. | Atkins R et al. | β | 2022 | β |
| Capturing large genomic contexts for accurately predicting enhancer-promoter interactions. | Chen K et al. | β | 2022 | β |
| Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study. | Hirtz R et al. | β | 2022 | β |
| Causal relationship between genetically predicted depression and cancer risk: a two-sample bi-directional mendelian randomization. | Zhu GL et al. | β | 2022 | β |
| Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US. | Dalby M et al. | β | 2022 | β |
| College Students' eMental Health Literacy and Risk of Diagnosis with Mental Health Disorders. | Cormier E et al. | β | 2022 | β |
| Common variants contribute to intrinsic human brain functional networks. | Zhao B et al. | β | 2022 | β |
| Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts. | Davies MR et al. | β | 2022 | β |
| Computational Approaches for Understanding Sequence Variation Effects on the 3D Genome Architecture. | Avdeyev P et al. | β | 2022 | β |
| Depression-Associated <i>Negr1</i> Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice. | Kaare M et al. | β | 2022 | β |
| Differential expression of MDGA1 in major depressive disorder. | Li YJ et al. | β | 2022 | β |
| Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. | Bahrami S et al. | β | 2022 | β |
| Editorial: Genome-wide Association Studies of Internalizing Symptoms: A Big Step on a Long Road. | Coleman JRI | β | 2022 | β |
| Effects of depression on employment and social outcomes: a Mendelian randomisation study. | Campbell D et al. | β | 2022 | β |
| Efficient privacy-preserving whole-genome variant queries. | AkgΓΌn M et al. | β | 2022 | β |
| Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study. | Li GH et al. | β | 2022 | β |
| Familial risk of postpartum depression. | Rasmussen MH et al. | β | 2022 | β |
| Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression. | PΓ©rez-Granado J et al. | β | 2022 | β |
| Gene-gene interaction and new onset of major depressive disorder: Findings from a Chinese freshmen nested case-control study. | Yue S et al. | β | 2022 | β |
| Genetics of common cerebral small vessel disease. | Bordes C et al. | β | 2022 | β |
| Genome-wide interaction study with major depression identifies novel variants associated with cognitive function. | Thalamuthu A et al. | β | 2022 | β |
| Identification of a Novel Functional Non-synonymous Single Nucleotide Polymorphism in Frizzled Class Receptor 6 Gene for Involvement in Depressive Symptoms. | Han H et al. | β | 2022 | β |
| Is subthreshold depression in adolescence clinically relevant? | Noyes BK et al. | β | 2022 | β |
| Major Depressive Disorder: Existing Hypotheses about Pathophysiological Mechanisms and New Genetic Findings. | Kamran M et al. | β | 2022 | β |
| Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes. | Dannemann M et al. | β | 2022 | β |
| Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36. | Yoo A et al. | β | 2022 | β |
| Phenome-Wide Association Study of <i>UMOD</i> Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank. | Akwo EA et al. | β | 2022 | β |
| Polygenic power calculator: Statistical power and polygenic prediction accuracy of genome-wide association studies of complex traits. | Wu T et al. | β | 2022 | β |
| Progress on the roles of MEF2C in neuropsychiatric diseases. | Zhang Z et al. | β | 2022 | β |
| Psychosomatic Aspects of The Development of Comorbid Pathology: A Review. | Tatayeva R et al. | β | 2022 | β |
| Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene <i>BHLHE22</i>. | Hupalo D et al. | β | 2022 | β |
| Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression. | Talishinsky A et al. | β | 2022 | β |
| Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression. | Li Y et al. | β | 2022 | β |
| Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study. | Viinikainen J et al. | β | 2022 | β |
| Self-reporting of psychiatric illness in an online patient registry is a good indicator of the existence of psychiatric illness. | Sordo Vieira L et al. | β | 2022 | β |
| Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. | Blokland GAM et al. | β | 2022 | β |
| Shared genetic liability and causal effects between major depressive disorder and insomnia. | Baranova A et al. | β | 2022 | β |
| Shared genetic loci between depression and cardiometabolic traits. | Torgersen K et al. | β | 2022 | β |
| Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development. | Dredge WH et al. | β | 2022 | β |
| "Supporting Wellness": A depression and bipolar support alliance mixed-methods investigation of lived experience perspectives and priorities for mood disorder treatment. | Morton E et al. | β | 2022 | β |
| The Influence of HLA Alleles on the Affective Distress Profile. | VicΔ ML et al. | β | 2022 | β |
| The Molecular Basis of Spinocerebellar Ataxia Type 7. | Goswami R et al. | β | 2022 | β |
| The molecular pathophysiology of depression and the new therapeutics. | Tian H et al. | β | 2022 | β |
| The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores. | Page ML et al. | β | 2022 | β |
| The Role of <i>N</i>-Glycosylation in the Intracellular Trafficking and Functionality of Neuronal Growth Regulator 1. | Sim G et al. | β | 2022 | β |
| The Role of Sex in Genetic Association Studies of Depression. | Hoth KF et al. | β | 2022 | β |
| Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank. | Cresswell M et al. | β | 2022 | β |
| Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. | Wendt FR et al. | β | 2022 | β |
| [Validation of a DSM-5-based screening test using digital phenotyping in the Russian population]. | Kasyanov ED et al. | β | 2022 | β |
| A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts. | Ni G et al. | β | 2021 | β |
| Advancing drug discovery using the power of the human genome. | Heilbron K et al. | β | 2021 | β |
| A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. | Kang Y et al. | β | 2021 | β |
| Alternative Promoter Use Governs the Expression of IgLON Cell Adhesion Molecules in Histogenetic Fields of the Embryonic Mouse Brain. | JagomΓ€e T et al. | β | 2021 | β |
| A Multiscale View of the Mechanisms Underlying Ketamine's Antidepressant Effects: An Update on Neuronal Calcium Signaling. | Kawatake-Kuno A et al. | β | 2021 | β |
| Analysis of Major Depression Risk Genes Reveals Evolutionary Conservation, Shared Phenotypes, and Extensive Genetic Interactions. | Sall S et al. | β | 2021 | β |
| A polygenic resilience score moderates the genetic risk for schizophrenia. | Hess JL et al. | β | 2021 | β |
| Are psychiatric disorders risk factors for COVID-19 susceptibility and severity? a two-sample, bidirectional, univariable, and multivariable Mendelian Randomization study. | Luykx JJ et al. | β | 2021 | β |
| Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. | Levey DF et al. | β | 2021 | β |
| Brain proteome-wide association study implicates novel proteins in depression pathogenesis. | Wingo TS et al. | β | 2021 | β |
| Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study. | Park S et al. | β | 2021 | β |
| Causal influences of neuroticism on mental health and cardiovascular disease. | Zhang F et al. | β | 2021 | β |
| Causal links between major depressive disorder and insomnia: A Mendelian randomisation study. | Cai L et al. | β | 2021 | β |
| Common genetic variation influencing human white matter microstructure. | Zhao B et al. | β | 2021 | β |
| Delineating the Genetic Component of Gene Expression in Major Depression. | Dall'Aglio L et al. | β | 2021 | β |
| Detecting local genetic correlations with scan statistics. | Guo H et al. | β | 2021 | β |
| Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression. | Wu W et al. | β | 2021 | β |
| Discriminating Heterogeneous Trajectories of Resilience and Depression After Major Life Stressors Using Polygenic Scores. | Schultebraucks K et al. | β | 2021 | β |
| Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics. | Buch AM et al. | β | 2021 | β |
| Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression. | Park HS et al. | β | 2021 | β |
| Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures. | GarcΓa-PΓ©rez R et al. | β | 2021 | β |
| Exploring the genetic heterogeneity in major depression across diagnostic criteria. | Jermy BS et al. | β | 2021 | β |
| Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. | Li S et al. | β | 2021 | β |
| Genetic and clinical analyses of psychosis spectrum symptoms in a large multiethnic youth cohort reveal significant link with ADHD. | Olde Loohuis LM et al. | β | 2021 | β |
| Genetic Architecture of Depression: Where Do We Stand Now? | Unal-Aydin P et al. | β | 2021 | β |
| Genetic Liability to Depression and Risk of Coronary Artery Disease, Myocardial Infarction, and Other Cardiovascular Outcomes. | Lu Y et al. | β | 2021 | β |
| Genetic loci shared between major depression and intelligence with mixed directions of effect. | Bahrami S et al. | β | 2021 | β |
| Genetic markers for depressive disorders with earlier age at onset. | Kang HJ et al. | β | 2021 | β |
| Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy. | Clements CC et al. | β | 2021 | β |
| Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry. | Sanchez-Roige S et al. | β | 2021 | β |
| GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways between Major Depressive Disorder and Insomnia. | Lin YS et al. | β | 2021 | β |
| High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice. | Kaare M et al. | β | 2021 | β |
| Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum. | Yang Z et al. | β | 2021 | β |
| Involvement of myocyte enhancer factor 2c in the pathogenesis of autism spectrum disorder. | Chaudhary R et al. | β | 2021 | β |
| Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons. | Schraut KG et al. | β | 2021 | β |
| Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder. | Yang H et al. | β | 2021 | β |
| Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences. | Clark SL et al. | β | 2021 | β |
| [Modern approaches to the genetics of depression: scopes and limitations]. | Kasyanov ED et al. | β | 2021 | β |
| Multi-Modal Data Analysis for Alzheimer's Disease Diagnosis: An Ensemble Model Using Imagery and Genetic Features. | Ying Q et al. | β | 2021 | β |
| Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank. | Glanville KP et al. | β | 2021 | β |
| Neuroimaging and DNA Methylation: An Innovative Approach to Study the Effects of Early Life Stress on Developmental Plasticity. | Mariani Wigley ILC et al. | β | 2021 | β |
| Polygenic Risk for Major Depression Interacts with Parental Criticism in Predicting Adolescent Depressive Symptom Development. | Nelemans SA et al. | β | 2021 | β |
| Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression. | Mitchell BL et al. | β | 2021 | β |
| Repeated episodes of transient reduction of oxygen exposure simulating aircraft cabin conditions enhance resilience to stress in mice. | Ginerete RP et al. | β | 2021 | β |
| Resource profile and user guide of the Polygenic Index Repository. | Becker J et al. | β | 2021 | β |
| Self-reported medication use as an alternate phenotyping method for anxiety and depression in the UK Biobank. | Skelton M et al. | β | 2021 | β |
| Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress. | Reshetnikov VV et al. | β | 2021 | β |
| Stress modulates Ahi1-dependent nuclear localization of ten-eleven translocation protein 2. | Zhang Q et al. | β | 2021 | β |
| Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. | Thorp JG et al. | β | 2021 | β |
| The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. | Giannakopoulou O et al. | β | 2021 | β |
| The genetic architecture of the human thalamus and its overlap with ten common brain disorders. | ElvsΓ₯shagen T et al. | β | 2021 | β |
| The genetic basis of major depression. | Kendall KM et al. | β | 2021 | β |
| The Genetics of Major Depression: Perspectives on the State of Research and Opportunities for Precision Medicine. | Peterson RE | β | 2021 | β |
| Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays. | Mulvey B et al. | β | 2021 | β |
| Transcriptome-wide association study identifies new susceptibility genes and pathways for depression. | Li X et al. | β | 2021 | β |
| Twin studies to GWAS: there and back again. | Friedman NP et al. | β | 2021 | β |
| Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity. | de Jong TV et al. | β | 2021 | β |
| 1p31.1 microdeletion including only NEGR1 gene in two patients. | Tassano E et al. | β | 2020 | β |
| A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder. | Zhang Y et al. | β | 2020 | β |
| Alcohol Induced Depression: Clinical, Biological and Genetic Features. | FarrΓ© A et al. | β | 2020 | β |
| A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. | Shen X et al. | β | 2020 | β |
| Association Between <i>FoxO1</i>, <i>A2M</i>, and <i>TGF-Ξ²1</i>, Environmental Factors, and Major Depressive Disorder. | Zhao M et al. | β | 2020 | β |
| Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. | Amare AT et al. | β | 2020 | β |
| Causes and Consequences of Diagnostic Heterogeneity in Depression: Paths to Discovering Novel Biological Depression Subtypes. | Lynch CJ et al. | β | 2020 | β |
| Depression-Associated Gene <i>Negr1-Fgfr2</i> Pathway Is Altered by Antidepressant Treatment. | Carboni L et al. | β | 2020 | β |
| Depression in multiple sclerosis patients associated with risk variant near NEGR1. | Brugger SW et al. | β | 2020 | β |
| Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis. | Lim SH et al. | β | 2020 | β |
| Disease-discordant twin structural MRI studies on affective disorders. | Delvecchio G et al. | β | 2020 | β |
| Effect of the <i>SIRT1</i> gene on regional cortical grey matter density in the Han Chinese population. | Rao S et al. | β | 2020 | β |
| Eliciting Willingness and Beliefs towards Participation in Genetic Psychiatric Testing in Black/African American Mothers at Risk for Depression. | Atkins R et al. | β | 2020 | β |
| Genetic heterogeneity in self-reported depressive symptoms identified through genetic analyses of the PHQ-9. | Thorp JG et al. | β | 2020 | β |
| Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression. | Maul S et al. | β | 2020 | β |
| Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. | Adams MJ et al. | β | 2020 | β |
| Genetic stratification of depression in UK Biobank. | Howard DM et al. | β | 2020 | β |
| Genome-wide association study and polygenic risk score analysis of esketamine treatment response. | Li QS et al. | β | 2020 | β |
| Genome-Wide Association Study of Sleep Disturbances in Depressive Disorders. | Melhuish Beaupre LM et al. | β | 2020 | β |
| Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. | Xu K et al. | β | 2020 | β |
| Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. | Coleman JRI et al. | β | 2020 | β |
| Genomic Chaos Begets Psychiatric Disorder. | Dwyer DS | β | 2020 | β |
| Genomic prediction of depression risk and resilience under stress. | Fang Y et al. | β | 2020 | β |
| Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective. | Wendt FR et al. | β | 2020 | β |
| Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes. | Venkannagari H et al. | β | 2020 | β |
| Identification of a functional SNP rs7304782 at schizophrenia risk locus 12q24.31 and validation of its association with schiz ophrenia in Chinese populations. | Ma C et al. | β | 2020 | β |
| Identifying common genome-wide risk genes for major psychiatric traits. | Liu S et al. | β | 2020 | β |
| Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder. | Wang X et al. | β | 2020 | β |
| Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. | Takahashi Y et al. | β | 2020 | β |
| MEF2C and HDAC5 regulate <i>Egr1</i> and <i>Arc</i> genes to increase dendritic spine density and complexity in early enriched environment. | Puang SJ et al. | β | 2020 | β |
| Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. | Aberg KA et al. | β | 2020 | β |
| Minimal phenotyping yields genome-wide association signals of low specificity for major depression. | Cai N et al. | β | 2020 | β |
| Molecular Connections Between Circadian Clocks and Mood-related Behaviors. | Albrecht U | β | 2020 | β |
| Orphan G Protein Coupled Receptors in Affective Disorders. | Watkins LR et al. | β | 2020 | β |
| Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. | Breton E et al. | β | 2020 | β |
| Rare variants in SLC6A4 cause susceptibility to major depressive disorder with suicidal ideation in Han Chinese adolescents and young adults. | Ran L et al. | β | 2020 | β |
| Regulatory mechanisms of major depressive disorder risk variants. | Li S et al. | β | 2020 | β |
| Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study. | Mulugeta A et al. | β | 2020 | β |
| Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies. | Cai N et al. | β | 2020 | β |
| Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases. | Lu L et al. | β | 2020 | β |
| Role of rs454214 in Personality mediated Depression and Subjective Well-being. | Hou B et al. | β | 2020 | β |
| Seeking for potential pathogenic genes of major depressive disorder in the Gene Expression Omnibus database. | Feng J et al. | β | 2020 | β |
| Sex differences in the genetic architecture of depression. | Kang HJ et al. | β | 2020 | β |
| Shared genetic etiology underlying Alzheimer's disease and major depressive disorder. | Lutz MW et al. | β | 2020 | β |
| Targeted exome sequencing identifies five novel loci at genome-wide significance for modulating antidepressant response in patients with major depressive disorder. | Xu Z et al. | β | 2020 | β |
| Targeted sequencing of the BDNF gene in young Chinese Han people with major depressive disorder. | Zhang C et al. | β | 2020 | β |
| The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms. | Dattilo V et al. | β | 2020 | β |
| The genetic architecture of human brainstem structures and their involvement in common brain disorders. | ElvsΓ₯shagen T et al. | β | 2020 | β |
| The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. | Coleman JRI et al. | β | 2020 | β |
| The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. | Ward J et al. | β | 2020 | β |
| The Relation Between Attachment and Depression in Children and Adolescents: A Multilevel Meta-Analysis. | Spruit A et al. | β | 2020 | β |
| Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect. | Krebs CE et al. | β | 2020 | β |
| A Functional Polymorphism (rs6265, G>A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study. | Iqbal MUN et al. | β | 2019 | β |
| A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression. | Gerring ZF et al. | β | 2019 | β |
| A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. | Schork AJ et al. | β | 2019 | β |
| A Longitudinal Model of Human Neuronal Differentiation for Functional Investigation of Schizophrenia Polygenic Risk. | Ori APS et al. | β | 2019 | β |
| A model of human endogenous retrovirus (HERV) activation in mental health and illness. | Canli T | β | 2019 | β |
| A single-nucleotide polymorphism influences brain morphology in drug-naΓ―ve patients with major depressive disorder. | Katsuki A et al. | β | 2019 | β |
| Association Between <i>Period 3</i> Gene Polymorphisms and Adverse Effects of Antidepressants for Major Depressive Disorder. | Xu Y et al. | β | 2019 | β |
| Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population. | Musliner KL et al. | β | 2019 | β |
| Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. | Barbu MC et al. | β | 2019 | β |
| Benefits and limitations of genome-wide association studies. | Tam V et al. | β | 2019 | β |
| Continuity of genetic and environmental influences on clinically assessed major depression from ages 18 to 45. | Torvik FA et al. | β | 2019 | β |
| Depression and obesity: evidence of shared biological mechanisms. | Milaneschi Y et al. | β | 2019 | β |
| Depression genetic risk score is associated with anhedonia-related markers across units of analysis. | Guffanti G et al. | β | 2019 | β |
| Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. | Demontis D et al. | β | 2019 | β |
| Emerging roles for MEF2 in brain development and mental disorders. | Assali A et al. | β | 2019 | β |
| Epigenetics and Depression: An Update. | Lin E et al. | β | 2019 | β |
| Established and emerging strategies to crack the genetic code of obesity. | Tam V et al. | β | 2019 | β |
| Genetic associations of perinatal pain and depression. | McClain L et al. | β | 2019 | β |
| Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms. | Kakeda S et al. | β | 2019 | β |
| Genetic variants in major depressive disorder: From pathophysiology to therapy. | Gonda X et al. | β | 2019 | β |
| Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. | Jones SE et al. | β | 2019 | β |
| Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination. | Eszlari N et al. | β | 2019 | β |
| Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. | Ikeda M et al. | β | 2019 | β |
| Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. | Koshimizu H et al. | β | 2019 | β |
| Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20Β 328 research participants of European ancestry. | Sanchez-Roige S et al. | β | 2019 | β |
| Genome-wide association study of peripheral artery disease in the Million Veteran Program. | Klarin D et al. | β | 2019 | β |
| Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. | Zhang X et al. | β | 2019 | β |
| Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. | Howard DM et al. | β | 2019 | β |
| Genomic variation in educational attainment modifies Alzheimer disease risk. | Raghavan NS et al. | β | 2019 | β |
| GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. | Heinzman JT et al. | β | 2019 | β |
| GWAS of Behavioral Traits. | Mehta D et al. | β | 2019 | β |
| Identification of common genetic risk variants for autism spectrum disorder. | Grove J et al. | β | 2019 | β |
| Inbreeding depression causes reduced fecundity in Golden Retrievers. | Chu ET et al. | β | 2019 | β |
| Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder. | Zhong J et al. | β | 2019 | β |
| Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. | Li H et al. | β | 2019 | β |
| LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels. | Leinonen JT et al. | β | 2019 | β |
| Linking migraine frequency with family history of migraine. | Pelzer N et al. | β | 2019 | β |
| Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities. | Zitnik M et al. | β | 2019 | β |
| Multivariate genome-wide analyses of the well-being spectrum. | Baselmans BML et al. | β | 2019 | β |
| Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. | Singh K et al. | β | 2019 | β |
| On the utilization of polygenic risk scores for therapeutic targeting. | Gibson G | β | 2019 | β |
| Predictors of depressive symptoms in college students: A systematic review and meta-analysis of cohort studies. | Liu Y et al. | β | 2019 | β |
| Progressing Polygenic Medicine in Psychiatry Through Electronic Health Records. | Lewis CM et al. | β | 2019 | β |
| Rediscovering the value of families for psychiatric genetics research. | Glahn DC et al. | β | 2019 | β |
| Regulation of glucose and lipid metabolism in health and disease. | Chen L et al. | β | 2019 | β |
| Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression. | MΓΌhle C et al. | β | 2019 | β |
| Sex differences in depression: Insights from clinical and preclinical studies. | Eid RS et al. | β | 2019 | β |
| The association between cardiorespiratory fitness and the incidence of common mental health disorders: A systematic review and meta-analysis. | Kandola A et al. | β | 2019 | β |
| The genetics of depression: successful genome-wide association studies introduce new challenges. | Ormel J et al. | β | 2019 | β |
| The SLC transporter in nutrient and metabolic sensing, regulation, and drug development. | Zhang Y et al. | β | 2019 | β |
| Translational medicine in the Age of Big Data. | Tatonetti NP | β | 2019 | β |
| Uncovering the Genetic Architecture of Major Depression. | McIntosh AM et al. | β | 2019 | β |
| Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies. | Schwabe I et al. | β | 2019 | β |
| Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. | Howard DM et al. | β | 2018 | β |
| A <i>DRD2/ANNK1</i>-<i>COMT</i> Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese. | Zhang K et al. | β | 2018 | β |
| Altered DNA methylation associated with a translocation linked to major mental illness. | McCartney DL et al. | β | 2018 | β |
| Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients. | Karis K et al. | β | 2018 | β |
| A rare missense variant in RCL1 segregates with depression in extended families. | Amin N et al. | β | 2018 | β |
| Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes. | Aponte JL et al. | β | 2018 | β |
| Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults. | Ciobanu LG et al. | β | 2018 | β |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | β | 2018 | β |
| Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. | Li X et al. | β | 2018 | β |
| Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. | Evans LM et al. | β | 2018 | β |
| Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. | Aberg KA et al. | β | 2018 | β |
| Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression. | Carboni L et al. | β | 2018 | β |
| DNA methylation and clinical response to antidepressant medication in major depressive disorder: A review and recommendations. | Lisoway AJ et al. | β | 2018 | β |
| DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders. | Ryan NM et al. | β | 2018 | β |
| Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. | Peyrot WJ et al. | β | 2018 | β |
| Elucidating the genetic basis of social interaction and isolation. | Day FR et al. | β | 2018 | β |
| Finding associated variants in genome-wide association studies on multiple traits. | Gai L et al. | β | 2018 | β |
| FoxO1, A2M, and TGF-Ξ²1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses. | Cattaneo A et al. | β | 2018 | β |
| From the Psychiatrist's Couch to Induced Pluripotent Stem Cells: Bipolar Disease in a Dish. | Hoffmann A et al. | β | 2018 | β |
| Genetic nature or genetic nurture? Introducing social genetic parameters to quantify bias in polygenic score analyses. | Trejo S et al. | β | 2018 | β |
| Genetics Factors in Major Depression Disease. | Shadrina M et al. | β | 2018 | β |
| Genetics of biologically based psychological differences. | Sallis H et al. | β | 2018 | β |
| Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. | Klarin D et al. | β | 2018 | β |
| Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. | Wray NR et al. | β | 2018 | β |
| Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications. | Ikeda M et al. | β | 2018 | β |
| Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. | Zhou H et al. | β | 2018 | β |
| Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. | Sanchez-Roige S et al. | β | 2018 | β |
| Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. | Howard DM et al. | β | 2018 | β |
| Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos. | Dunn EC et al. | β | 2018 | β |
| Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD. | Van der Auwera S et al. | β | 2018 | β |
| Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. | Arnau-Soler A et al. | β | 2018 | β |
| Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank. | Hall LS et al. | β | 2018 | β |
| Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom. | Mekli K et al. | β | 2018 | β |
| Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. | Nievergelt CM et al. | β | 2018 | β |
| Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence. | Holl K et al. | β | 2018 | β |
| Identification and replication of RNA-Seq gene network modules associated with depression severity. | Le TT et al. | β | 2018 | β |
| Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue. | Bhalala OG et al. | β | 2018 | β |
| Imaging genetics paradigms in depression research: Systematic review and meta-analysis. | Pereira LP et al. | β | 2018 | β |
| Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation. | de Kloet ER et al. | β | 2018 | β |
| International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets. | Caraci F et al. | β | 2018 | β |
| Investigating the genetic architecture of general and specific psychopathology in adolescence. | Jones HJ et al. | β | 2018 | β |
| Investigation of serum levels of sortilin in response to antidepressant treatment. | ButtenschΓΈn HN et al. | β | 2018 | β |
| Is familial risk for depression confounded by individual and familial socioeconomic factors and neighborhood environmental factors? A 7-year follow-up study in Sweden. | Hamano T et al. | β | 2018 | β |
| <i>SIRT1</i> Allele Frequencies in Depressed Patients of European Descent in Russia. | Aftanas LI et al. | β | 2018 | β |
| Item-level analyses reveal genetic heterogeneity in neuroticism. | Nagel M et al. | β | 2018 | β |
| <i>VRK2</i>, a Candidate Gene for Psychiatric and Neurological Disorders. | Li M et al. | β | 2018 | β |
| Lipidomics in Major Depressive Disorder. | Walther A et al. | β | 2018 | β |
| Longitudinal Relations Between Depressive Symptoms and Executive Functions From Adolescence to Early Adulthood: A Twin Study. | Friedman NP et al. | β | 2018 | β |
| Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder. | Yu C et al. | β | 2018 | β |
| Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. | Leng L et al. | β | 2018 | β |
| Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. | Nagel M et al. | β | 2018 | β |
| Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus. | Mulvey B et al. | β | 2018 | β |
| Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression. | Peterson RE et al. | β | 2018 | β |
| Molecular genetic overlap between migraine and major depressive disorder. | Yang Y et al. | β | 2018 | β |
| Multi-trait analysis of genome-wide association summary statistics using MTAG. | Turley P et al. | β | 2018 | β |
| Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated <i>Negr1</i> Gene. | Singh K et al. | β | 2018 | β |
| Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness. | HΓΆkfelt T et al. | β | 2018 | β |
| Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia. | Bryzgalov LO et al. | β | 2018 | β |
| Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study. | Wassertheil-Smoller S et al. | β | 2018 | β |
| Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. | Bogdan R et al. | β | 2018 | β |
| Precision pharmacotherapy: psychiatry's future direction in preventing, diagnosing, and treating mental disorders. | Menke A | β | 2018 | β |
| Predicting loneliness with polygenic scores of social, psychological and psychiatric traits. | Abdellaoui A et al. | β | 2018 | β |
| Psychodynamic Psychiatry, the Biopsychosocial Model, and the Difficult Patient. | Plakun EM | β | 2018 | β |
| Response to therapeutic sleep deprivation: a naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory. | Trautmann N et al. | β | 2018 | β |
| Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder. | Nishino J et al. | β | 2018 | β |
| Signatures of negative selection in the genetic architecture of human complex traits. | Zeng J et al. | β | 2018 | β |
| Significance of risk polymorphisms for depression depends on stress exposure. | Gonda X et al. | β | 2018 | β |
| Sources of Parent-Offspring Resemblance for Major Depression in a National Swedish Extended Adoption Study. | Kendler KS et al. | β | 2018 | β |
| The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. | Piel JH et al. | β | 2018 | β |
| The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder. | Xiao X et al. | β | 2018 | β |
| The Genetic Epidemiology of Treated Major Depression in Sweden. | Kendler KS et al. | β | 2018 | β |
| The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. | Ni H et al. | β | 2018 | β |
| The impact of epigenomic next-generation sequencing approaches on our understanding of neuropsychiatric disorders. | Schang AL et al. | β | 2018 | β |
| The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age. | Riglin L et al. | β | 2018 | β |
| The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence. | Muench C et al. | β | 2018 | β |
| Transition-transversion encoding and genetic relationship metric in ReliefF feature selection improves pathway enrichment in GWAS. | Arabnejad M et al. | β | 2018 | β |
| Treatment resistant depression: A multi-scale, systems biology approach. | Akil H et al. | β | 2018 | β |
| Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. | Su J et al. | β | 2018 | β |
| 11,670 whole-genome sequences representative of the Han Chinese population from the CONVERGE project. | Cai N et al. | β | 2017 | β |
| 23andMe wades further into drug discovery. | Petrone J | β | 2017 | β |
| A continuum of genetic liability for minor and major depression. | Corfield EC et al. | β | 2017 | β |
| Advancing psychiatric genetics through dissecting heterogeneity. | Hodgson K et al. | β | 2017 | β |
| A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort. | Yu C et al. | β | 2017 | β |
| A New Hope for Biological Insights Into Depression. | Hyman SE | β | 2017 | β |
| Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience. | Anderzhanova E et al. | β | 2017 | β |
| A novel strategy for clustering major depression individuals using whole-genome sequencing variant data. | Yu C et al. | β | 2017 | β |
| Anticipating the Ethical Challenges of Psychiatric Genetic Testing. | Appelbaum PS et al. | β | 2017 | β |
| Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data. | Gibson J et al. | β | 2017 | β |
| Association study of <i>MIF</i> promoter polymorphisms with suicide completers in the Japanese population. | Shimmyo N et al. | β | 2017 | β |
| Commentary: What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017). | Moore SR | β | 2017 | β |
| Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. | Xiao X et al. | β | 2017 | β |
| Copy Number Variation in Syndromic Forms of Psychiatric Illness: The Emerging Value of Clinical Genetic Testing in Psychiatry. | Bouwkamp CG et al. | β | 2017 | β |
| Copy number variation meta-analysis reveals a novel duplication at 9p24 associated with multiple neurodevelopmental disorders. | Glessner JT et al. | β | 2017 | β |
| Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. | Silveira PP et al. | β | 2017 | β |
| DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress. | Yao B et al. | β | 2017 | β |
| Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19β762), UK Biobank (n=24β048) and the English Longitudinal Study of Ageing (n=5766). | Wigmore EM et al. | β | 2017 | β |
| Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. | Hoffmann A et al. | β | 2017 | β |
| Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. | Uher R et al. | β | 2017 | β |
| Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist. | Martin J et al. | β | 2017 | β |
| Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms. | Van Assche E et al. | β | 2017 | β |
| Genetic Approaches to Understanding Psychiatric Disease. | Michaelson JJ | β | 2017 | β |
| Genetic effects influencing risk for major depressive disorder in China and Europe. | Bigdeli TB et al. | β | 2017 | β |
| Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. | Zhou H et al. | β | 2017 | β |
| Genetics of Depression: Progress at Last. | Mullins N et al. | β | 2017 | β |
| Genetics of depressive symptoms in adolescence. | Sallis H et al. | β | 2017 | β |
| Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank. | Howard DM et al. | β | 2017 | β |
| Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder. | Zeng Y et al. | β | 2017 | β |
| Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder. | Mbarek H et al. | β | 2017 | β |
| GW-SEM: A Statistical Package to Conduct Genome-Wide Structural Equation Modeling. | Verhulst B et al. | β | 2017 | β |
| Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression. | Malki K et al. | β | 2017 | β |
| Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. | Bogdan R et al. | β | 2017 | β |
| Investigation of copy number variation in subjects with major depression based on whole-genome sequencing data. | Yu C et al. | β | 2017 | β |
| Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. | Gardiner SL et al. | β | 2017 | β |
| Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies. | Xiao X et al. | β | 2017 | β |
| Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells. | Lazzerini Ospri L et al. | β | 2017 | β |
| Nature, Eco, and Adventure Therapies for Mental Health and Chronic Disease. | Buckley RC et al. | β | 2017 | β |
| Nonlinear modulation of interacting between COMT and depression on brain function. | Gong L et al. | β | 2017 | β |
| Pharmacogenetics of antidepressant response: A polygenic approach. | GarcΓa-GonzΓ‘lez J et al. | β | 2017 | β |
| Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry. | Amare AT et al. | β | 2017 | β |
| Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway. | Ehm MG et al. | β | 2017 | β |
| Polygenic loading for major depression is associated with specific medical comorbidity. | McCoy TH et al. | β | 2017 | β |
| Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. | Andersen AM et al. | β | 2017 | β |
| Prevention of Mental Health Disorders Using Internet- and Mobile-Based Interventions: A Narrative Review and Recommendations for Future Research. | Ebert DD et al. | β | 2017 | β |
| Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse. | Vanaveski T et al. | β | 2017 | β |
| Response to Infant Cry in Clinically Depressed and Non-Depressed Mothers. | Esposito G et al. | β | 2017 | β |
| Sex-specific transcriptional signatures in human depression. | LabontΓ© B et al. | β | 2017 | β |
| Summaries of plenary and selected symposia sessions at the XXIV World Congress of Psychiatric Genetics; Jerusalem, Israel; 30 October 2016-3 November 2016. | Ciobanu LG et al. | β | 2017 | β |
| Systems biology in the central nervous system: a brief perspective on essential recent advancements. | Dougherty JD et al. | β | 2017 | β |
| Testing positive for a genetic predisposition to depression magnifies retrospective memory for depressive symptoms. | Lebowitz MS et al. | β | 2017 | β |
| The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. | Amare AT et al. | β | 2017 | β |
| The PHF21B gene is associated with major depression and modulates the stress response. | Wong ML et al. | β | 2017 | β |
| The Relationship Between Mental Health, Disease Severity, and Genetic Risk for Depression in Early Rheumatoid Arthritis. | Euesden J et al. | β | 2017 | β |
| VEGF-related polymorphisms identified by GWAS and risk for major depression. | Xie T et al. | β | 2017 | β |
| Whole genome sequencing in psychiatric disorders: the WGSPD consortium. | Sanders SJ et al. | β | 2017 | β |
| Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression. | Yu C et al. | β | 2017 | β |
| Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide. | Barde S et al. | β | 2016 | β |
| Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression. | Gonda X et al. | β | 2016 | β |
| Genetic and Environmental Contribution to Major Depressive Disorder and Self-declared Depression. | Fabbri C | β | 2016 | β |
| Identification of SLC25A37 as a major depressive disorder risk gene. | Huo YX et al. | β | 2016 | β |
| Major depressive disorder. | Otte C et al. | β | 2016 | β |
| Pharmacogenetics of antidepressant response: a polygenic approach | GarcΓa-GonzΓ‘lez J et al. | β | 2016 | β |
| Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression. | Zeng Y et al. | β | 2016 | β |
| The implications of the shared genetics of psychiatric disorders. | O'Donovan MC et al. | β | 2016 | β |