Association study of 182 candidate genes in anorexia nervosa.
paper
Cited
Public
- Authors
- Pinheiro, Andrea Poyastro; Bulik, Cynthia M; Thornton, Laura M; Sullivan, Patrick F; Root, Tammy L; Bloss, Cinnamon S; Berrettini, Wade H; Schork, Nicholas J; Kaye, Walter H; Bergen, Andrew W; Magistretti, Pierre; Brandt, Harry; Crawford, Steve; Crow, Scott; Fichter, Manfred M; Goldman, David; Halmi, Katherine A; Johnson, Craig; Kaplan, Allan S; Keel, Pamela K; Klump, Kelly L; La Via, Maria; Mitchell, James E; Strober, Michael; Rotondo, Alessandro; Treasure, Janet; Woodside, D Blake
- Year
- 2010
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 20468064
- DOI
- 10.1002/ajmg.b.31082
- PMCID
- PMC2963154
We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate genes), brain expression, biological plausibility, and estrogen responsivity. We employed a case-control design that tested each SNP individually as well as haplotypes derived from these SNPs in 1,085 case individuals with AN diagnoses and 677 control individuals. We also performed separate association analyses using three increasingly restrictive case definitions for AN: all individuals with any subtype of AN (All AN: n = 1,085); individuals with AN with no binge eating behavior (AN with No Binge Eating: n = 687); and individuals with the restricting subtype of AN (Restricting AN: n = 421). After accounting for multiple comparisons, there were no statistically significant associations for any individual SNP or haplotype block with any definition of illness. These results underscore the importance of large samples to yield appropriate power to detect genotypic differences in individuals with AN and also motivate complementary approaches involving Genome-Wide Association (GWA) studies, Copy Number Variation (CNV) analyses, sequencing-based rare variant discovery assays, and pathway-based analysis in order to make up for deficiencies in traditional candidate gene approaches to AN.
No figures extracted from this document.
β Prev
21β33 of 33
| Name | Type |
|---|---|
| affected relatives local | cohort |
| Affected relatives local | cohort |
| Affected Relatives local | cohort |
| Agouti-related protein local | drug |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| All AN local | phenotype |
| All AN cohort local | cohort |
| All AN sample local | cohort |
| AN | phenotype |
| AN binge-purge local | phenotype |
| ANBN local | phenotype |
| AN cases local | cohort |
| anorexia nervosa | phenotype |
| Anorexia Nervosa Affected Relative Pair Study local | cohort |
| Anorexia Nervosa Trios Study local | cohort |
| AN Trios Study local | cohort |
| AN with No Binge Eating local | phenotype |
| AN with No Binge Eating cohort local | cohort |
| AN with No Binge Eating sample local | cohort |
| anxiety | phenotype |
| artificial sweeteners local | drug |
| axis I disorder | phenotype |
| BAN local | phenotype |
| Bdnf | gene |
| binge eating | phenotype |
| Binge-eating anorexia nervosa local | phenotype |
| binging local | phenotype |
| bipolar disorder | phenotype |
| BMI | phenotype |
| BN | phenotype |
| body mass index | phenotype |
| body weight | phenotype |
| brain | anatomy |
| brainstem | anatomy |
| breast cancer | phenotype |
| bulimia nervosa | phenotype |
| Bulimia Nervosa Affected Relative Pair Study local | cohort |
| Bulimia Nervosa (nonpurging type) local | phenotype |
| Bulimia Nervosa, non-purging type local | phenotype |
| Bulimia Nervosa (purging type) local | phenotype |
| Bulimia Nervosa, purging type local | phenotype |
| candidate genes | cohort |
| cannabinoids | drug |
| cardiovascular disease | phenotype |
| cases | cohort |
| control group | cohort |
| controls | cohort |
| Control women local | phenotype |
| Crohnβs disease | phenotype |
| dopamine | drug |
| Dorsal medial hypothalamic nucleus local | anatomy |
| drive for thinness local | phenotype |
| Eating Attitudes Test local | drug |
| Eating Attitudes Test local | phenotype |
| eating disorder | phenotype |
| eating disorder caseβcontrol dataset local | cohort |
| Eating disorder diagnoses other than AN local | phenotype |
| Eating disorder not otherwise specified local | phenotype |
| Eating Disorder Not Otherwise Specified local | phenotype |
| eating disorder participants local | cohort |
| eating disorders | phenotype |
| Epinephrine local | drug |
| estrogen | drug |
| European population | cohort |
| female participants | cohort |
| Five-nation consortium local | cohort |
| food intake | phenotype |
| full sample | cohort |
| genetic variants | cohort |
| genomic DNA | drug |
| ghrelin | drug |
| GLP2 local | drug |
| GLP2R local | gene |
| healthy control women | cohort |
| height | phenotype |
| hippocampus | anatomy |
| HTR1D local | gene |
| hypothalamic nucleus local | anatomy |
| Illumina | drug |
| Illumina Custom Infinium Genotyping Beadchips local | drug |
| KCNN3 | gene |
| KCNN3 CAG repeat length local | variant |
| leptin | drug |
| long-term potentiation | phenotype |
| Melanocortin local | drug |
| mood disorders | phenotype |
| neuropeptide Y | drug |
| nicotine addiction | phenotype |
| No Binge Eating local | phenotype |
| Non-purging BN local | phenotype |
| norepinephrine | drug |
| obsessionality local | phenotype |
| opioid | drug |
| Oprd1 | cohort |
| Other substance abuse local | phenotype |
| other substances | phenotype |
| PAH | gene |
| PAN local | phenotype |
| parents | cohort |
| phenylalanine | drug |
| phenylalanine hydroxylase local | drug |
| phenylketonuria | phenotype |
| potassium channels | drug |
| Price Foundation Genetic Studies of Eating Disorders local | cohort |
| Price Foundation Genetic Studies of Eating Disorders initiative local | cohort |
| Primary sample local | cohort |
| probands | cohort |
| prostate cancer | phenotype |
| Psychiatric Genomics Consortium | cohort |
| Psychiatric GWAS Consortium (PGC) local | cohort |
| psychosis | phenotype |
| purging local | phenotype |
| Purging anorexia nervosa local | phenotype |
| Purging Anorexia Nervosa local | phenotype |
| Purging BN local | phenotype |
| RAN local | phenotype |
| restricting AN | phenotype |
| Restricting anorexia nervosa local | phenotype |
| Restricting Anorexia Nervosa local | phenotype |
| Restricting AN sample local | cohort |
| restricting type of AN local | phenotype |
| rs4791362 local | variant |
| samples | cohort |
| schizophrenia | phenotype |
| Secondary samples local | cohort |
| serotonin | drug |
| siblings | cohort |
| SLC6A4 | gene |
| SNP | cohort |
| Somatoform disorders local | phenotype |
| Structured Clinical Interview for DSM-IV (SCID) Screen Patient Questionnaire local | phenotype |
| Subthreshold AN local | phenotype |
| Subthreshold anorexia nervosa local | phenotype |
| Sub-threshold Anorexia Nervosa local | phenotype |
| Subthreshold Anorexia Nervosa local | phenotype |
| Subthreshold BN local | phenotype |
| Sub-threshold Bulimia Nervosa local | phenotype |
| Sub-threshold Mixed Eating Disorder local | phenotype |
| T1DM local | phenotype |
| T2DM | phenotype |
| top SNPs | cohort |
| tyrosine | drug |
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | 2012 | 22064162 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| World Federation of Societies of Biological Psychiatry (WFSBP) consensus statement on candidate biomarkers for anorexia nervosa. | Himmerich H et al. | β | 2026 | β |
| From Lab to Clinic and Farm: Leveraging <i>Drosophila</i> Feeding Studies to Combat Eating Disorders and Pest Challenges. | Banu A et al. | β | 2025 | β |
| Anti-hypothalamus autoantibodies in anorexia nervosa: a possible new mechanism in neuro-physiological derangement? | Escelsior A et al. | β | 2022 | β |
| Childhood trauma determines different clinical and biological manifestations in patients with eating disorders. | RodrΓguez-Quiroga A et al. | β | 2021 | β |
| Estrogen-related Receptor Alpha (ERRΞ±) is Required for PGC-1Ξ±-dependent Gene Expression in the Mouse Brain. | McMeekin LJ et al. | β | 2021 | β |
| Is there a hypothalamic basis for anorexia nervosa? | Tolle V et al. | β | 2021 | β |
| Variants in the Obesity-Linked FTO gene locus modulates psychopathological features of patients with Anorexia Nervosa. | GonzΓ‘lez LM et al. | β | 2021 | β |
| A logical relationship for schizophrenia, bipolar, and major depressive disorder. Part 4: Evidence from chromosome 4 high-density association screen. | Tang J et al. | β | 2019 | β |
| Genetic risk factors for eating disorders: an update and insights into pathophysiology. | Himmerich H et al. | β | 2019 | β |
| Interaction between polymorphisms of the oxytocinergic system genes and emotion perception in inpatients with anorexia nervosa. | Kucharska K et al. | β | 2019 | β |
| Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics. | Breuer R et al. | β | 2018 | β |
| The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. | Thornton LM et al. | β | 2018 | β |
| A novel relationship for schizophrenia, bipolar and major depressive disorder Part 5: a hint from chromosome 5 high density association screen. | Chen X et al. | β | 2017 | β |
| Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies. | Collantoni E et al. | β | 2017 | β |
| Convergent and divergent genetic changes in the genome of Chinese and European pigs. | Wang J et al. | β | 2017 | β |
| Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study. | Sardahaee FS et al. | β | 2017 | β |
| Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. | Shih PB | β | 2017 | β |
| Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors. | Lutter M et al. | β | 2017 | β |
| The Anorexia Nervosa Genetics Initiative: Overview and Methods | Thornton LM et al. | β | 2017 | β |
| The Eating-Disorder Associated HDAC4<sup>A778T</sup> Mutation Alters Feeding Behaviors in Female Mice. | Lutter M et al. | β | 2017 | β |
| BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice. | Madra M et al. | β | 2016 | β |
| Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders. | Amorim-Barbosa T et al. | β | 2016 | β |
| Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. | Shih PB et al. | β | 2016 | β |
| Machine learning derived risk prediction of anorexia nervosa. | Guo Y et al. | β | 2016 | β |
| New Insights in Anorexia Nervosa. | Gorwood P et al. | β | 2016 | β |
| The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population. | Otowa T et al. | β | 2016 | β |
| Canonical genetic signatures of the adult human brain. | Hawrylycz M et al. | β | 2015 | β |
| Genetics and Epigenetics of Eating Disorders. | Yilmaz Z et al. | β | 2015 | β |
| Ghrelin in psychiatric disorders - A review. | Wittekind DA et al. | β | 2015 | β |
| Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders. | Gamero-Villarroel C et al. | β | 2015 | β |
| Overview of genetic research in anorexia nervosa: The past, the present and the future. | Brandys MK et al. | β | 2015 | β |
| The neurobiology of eating disorders--a clinical perspective. | von Hausswolff-Juhlin Y et al. | β | 2015 | β |
| Association of common variants in PAH and LAT1 with non-syndromic cleft lip with or without cleft palate (NSCL/P) in the Polish population. | Hozyasz KK et al. | β | 2014 | β |
| Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population. | Ando T et al. | β | 2014 | β |
| BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders. | Gamero-Villarroel C et al. | β | 2014 | β |
| Constitutional thinness and anorexia nervosa: a possible misdiagnosis? | Estour B et al. | β | 2014 | β |
| Evidence for the role of EPHX2 gene variants in anorexia nervosa. | Scott-Van Zeeland AA et al. | β | 2014 | β |
| Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. | Lohoff FW et al. | β | 2014 | β |
| Genetic neuropathology of obsessive psychiatric syndromes. | Jaffe AE et al. | β | 2014 | β |
| Interpreting genetics in the context of eating disorders: evidence of disease, not diversity. | Easter M | β | 2014 | β |
| Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. | Cui H et al. | β | 2013 | β |
| [Genomic Advances in Eating Behavior Disorders]. | Genis-Mendoza AD et al. | β | 2013 | β |
| Ghrelin gene variants and eating disorders. | Ando T | β | 2013 | β |
| Influence of dopamine polymorphisms on the risk for anorexia nervosa and associated psychopathological features. | Gervasini G et al. | β | 2013 | β |
| The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis. | Brandys MK et al. | β | 2013 | β |
| Association analysis of 94 candidate genes and schizophrenia-related endophenotypes. | Greenwood TA et al. | β | 2012 | β |
| Examining associations between disordered eating and serotonin transporter gene polymorphisms. | Munn-Chernoff MA et al. | β | 2012 | β |
| Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. | Boraska V et al. | β | 2012 | β |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | β | 2012 | β |
| "Not all my fault": genetics, stigma, and personal responsibility for women with eating disorders. | Easter MM | β | 2012 | β |
| The genetics of anorexia nervosa. | Clarke TK et al. | β | 2012 | β |
| Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes. | Jonassaint CR et al. | β | 2011 | β |
| Aetiology of anorexia nervosa: from a "psychosomatic family model" to a neuropsychiatric disorder? | Herpertz-Dahlmann B et al. | β | 2011 | β |
| Association of candidate genes with phenotypic traits relevant to anorexia nervosa. | Root TL et al. | β | 2011 | β |
| Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. | Slof-Op 't Landt MC et al. | β | 2011 | β |
| Genetic association of recovery from eating disorders: the role of GABA receptor SNPs. | Bloss CS et al. | β | 2011 | β |
| The genetics of eating disorders. | Helder SG et al. | β | 2011 | β |