Association study of 182 candidate genes in anorexia nervosa.

paper Cited Public

Authors: Pinheiro, Andrea Poyastro; Bulik, Cynthia M; Thornton, Laura M; Sullivan, Patrick F; Root, Tammy L; Bloss, Cinnamon S; Berrettini, Wade H; Schork, Nicholas J; Kaye, Walter H; Bergen, Andrew W; Magistretti, Pierre; Brandt, Harry; Crawford, Steve; Crow, Scott; Fichter, Manfred M; Goldman, David; Halmi, Katherine A; Johnson, Craig; Kaplan, Allan S; Keel, Pamela K; Klump, Kelly L; La Via, Maria; Mitchell, James E; Strober, Michael; Rotondo, Alessandro; Treasure, Janet; Woodside, D Blake
Year: 2010
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 20468064
DOI: 10.1002/ajmg.b.31082
PMCID: PMC2963154

#	Section	Preview
0	INTRODUCTION	Anorexia nervosa (AN) is a potentially chronic illness with extremely high morbidity and mortality…
1	INTRODUCTION	A previous study from our group that applied linkage analysis to affected relatives with the…
2	INTRODUCTION	Specific candidate gene approaches have targeted neurotransmitter and neuropeptide systems, and have…
3	INTRODUCTION	is likely that susceptibility to disease is comprised of multiple, relatively common genetic…
4	INTRODUCTION	Accordingly, we present herein the results of a case–control association study in a sample of…
5	MATERIALS AND METHODS — Participants	Participants of primarily European decent were from the three multisite international Price…
6	MATERIALS AND METHODS — Participants — AN affected relative pair study	The sample for this study included both probands and affected relatives. Probands met the following…
7	MATERIALS AND METHODS — Participants — AN affected relative pair study	lifetime eating disorder diagnoses of modified DSM-IV AN (again excluding amenorrhea), lifetime…
8	MATERIALS AND METHODS — Participants — BN affected relative pair study	The sample for this study included probands and affected relatives. Probands met the following…
9	MATERIALS AND METHODS — Participants — AN Trios study	The sample for this study included individuals with AN and their parents as well as a sample of…
10	MATERIALS AND METHODS — Participants — AN Trios study	In the AN Trios Study, healthy control women were recruited to serve as a comparison group for the…
11	MATERIALS AND METHODS — Participants — AN Trios study	Eating Attitudes Test [Garner et al., 1982]; (2) had a first degree relative with an eating…
12	MATERIALS AND METHODS — Participant Selection for Association Studies	From the three studies above, a total of 2,257 individuals were selected for these association…
13	MATERIALS AND METHODS — Participant Selection for Association Studies	above and each of these participants was related to one individual in the primary sample. Genomic…
14	MATERIALS AND METHODS — Participant Selection for Association Studies	Table I presents the abbreviations and definitions of illness on which we based our samples for…
15	MATERIALS AND METHODS — Participant Selection for Association Studies	illness was chosen due to the fact that the presence of binge eating has been identified as a…
16	MATERIALS AND METHODS — Candidate Gene and SNP Selection	Candidate genes were selected by the investigators via a consensus process. First, genes residing…
17	MATERIALS AND METHODS — Candidate Gene and SNP Selection	SNP selection was conducted in two rounds. These 190 candidate genes were processed by TAMAL v2.0…
18	MATERIALS AND METHODS — SNP Quality Control	Despite favorable design scores, the SNP assay design process failed at Illumina for 480 SNPs. An…
19	MATERIALS AND METHODS — Statistical Analyses	PLINK [Purcell et al., 2007] was used to conduct all association analyses. The principal test for…

Name	Type
affected relatives local	cohort
Affected relatives local	cohort
Affected Relatives local	cohort
Agouti-related protein local	drug
alcohol abuse	phenotype
alcohol dependence	phenotype
All AN local	phenotype
All AN cohort local	cohort
All AN sample local	cohort
AN	phenotype
AN binge-purge local	phenotype
ANBN local	phenotype
AN cases local	cohort
anorexia nervosa	phenotype
Anorexia Nervosa Affected Relative Pair Study local	cohort
Anorexia Nervosa Trios Study local	cohort
AN Trios Study local	cohort
AN with No Binge Eating local	phenotype
AN with No Binge Eating cohort local	cohort
AN with No Binge Eating sample local	cohort
anxiety	phenotype
artificial sweeteners local	drug
axis I disorder	phenotype
BAN local	phenotype
Bdnf	gene
binge eating	phenotype
Binge-eating anorexia nervosa local	phenotype
binging local	phenotype
bipolar disorder	phenotype
BMI	phenotype
BN	phenotype
body mass index	phenotype
body weight	phenotype
brain	anatomy
brainstem	anatomy
breast cancer	phenotype
bulimia nervosa	phenotype
Bulimia Nervosa Affected Relative Pair Study local	cohort
Bulimia Nervosa (nonpurging type) local	phenotype
Bulimia Nervosa, non-purging type local	phenotype
Bulimia Nervosa (purging type) local	phenotype
Bulimia Nervosa, purging type local	phenotype
candidate genes	cohort
cannabinoids	drug
cardiovascular disease	phenotype
cases	cohort
control group	cohort
controls	cohort
Control women local	phenotype
Crohn’s disease	phenotype
dopamine	drug
Dorsal medial hypothalamic nucleus local	anatomy
drive for thinness local	phenotype
Eating Attitudes Test local	drug
Eating Attitudes Test local	phenotype
eating disorder	phenotype
eating disorder case–control dataset local	cohort
Eating disorder diagnoses other than AN local	phenotype
Eating disorder not otherwise specified local	phenotype
Eating Disorder Not Otherwise Specified local	phenotype
eating disorder participants local	cohort
eating disorders	phenotype
Epinephrine local	drug
estrogen	drug
European population	cohort
female participants	cohort
Five-nation consortium local	cohort
food intake	phenotype
full sample	cohort
genetic variants	cohort
genomic DNA	drug
ghrelin	drug
GLP2 local	drug
GLP2R local	gene
healthy control women	cohort
height	phenotype
hippocampus	anatomy
HTR1D local	gene
hypothalamic nucleus local	anatomy
Illumina	drug
Illumina Custom Infinium Genotyping Beadchips local	drug
KCNN3	gene
KCNN3 CAG repeat length local	variant
leptin	drug
long-term potentiation	phenotype
Melanocortin local	drug
mood disorders	phenotype
neuropeptide Y	drug
nicotine addiction	phenotype
No Binge Eating local	phenotype
Non-purging BN local	phenotype
norepinephrine	drug
obsessionality local	phenotype
opioid	drug
Oprd1	cohort
Other substance abuse local	phenotype
other substances	phenotype
PAH	gene
PAN local	phenotype
parents	cohort
phenylalanine	drug
phenylalanine hydroxylase local	drug
phenylketonuria	phenotype
potassium channels	drug
Price Foundation Genetic Studies of Eating Disorders local	cohort
Price Foundation Genetic Studies of Eating Disorders initiative local	cohort
Primary sample local	cohort
probands	cohort
prostate cancer	phenotype
Psychiatric Genomics Consortium	cohort
Psychiatric GWAS Consortium (PGC) local	cohort
psychosis	phenotype
purging local	phenotype
Purging anorexia nervosa local	phenotype
Purging Anorexia Nervosa local	phenotype
Purging BN local	phenotype
RAN local	phenotype
restricting AN	phenotype
Restricting anorexia nervosa local	phenotype
Restricting Anorexia Nervosa local	phenotype
Restricting AN sample local	cohort
restricting type of AN local	phenotype
rs4791362 local	variant
samples	cohort
schizophrenia	phenotype
Secondary samples local	cohort
serotonin	drug
siblings	cohort
SLC6A4	gene
SNP	cohort
Somatoform disorders local	phenotype
Structured Clinical Interview for DSM-IV (SCID) Screen Patient Questionnaire local	phenotype
Subthreshold AN local	phenotype
Subthreshold anorexia nervosa local	phenotype
Sub-threshold Anorexia Nervosa local	phenotype
Subthreshold Anorexia Nervosa local	phenotype
Subthreshold BN local	phenotype
Sub-threshold Bulimia Nervosa local	phenotype
Sub-threshold Mixed Eating Disorder local	phenotype
T1DM local	phenotype
T2DM	phenotype
top SNPs	cohort
tyrosine	drug

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In this knowledge base

Title	Year	PMID
Genome-wide association study of comorbid depressive syndrome and alcohol dependence.	2012	22064162

External

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